Development of immune-modulatory RNAS to regulate RIG-I-like receptors mediated antiviral immune response for therapy and vaccination by Yong, Hui Yee

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Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and is Activated by PPARβ/δ Deficiency by Zarei, Mohammad, Barroso, Emma, Leiva, Rosana, Barniol-Xicota, Marta, Pujol, Eugènia, Escolano, Carmen, Vázquez, Santiago, Palomer, Xavier, Pardo, Virginia, González-Rodríguez, Águeda, Valverde, Ángela M., Quesada-López, Tania, Villarroya, Francesc, Wahli, Walter, Vázquez-Carrera, Manuel

“…Overall, these findings suggest that HRI is a potential target for regulating hepatic FGF21 levels.…”
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Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P by Dong, Rui, Saheki, Yasunori, Swarup, Sharan, Lucast, Louise, Harper, J. Wade, De Camilli, Pietro

“…Here, we report that by regulating PI4P levels on endosomes, VAP affects WASH-dependent actin nucleation on these organelles and the function of the retromer, a protein coat responsible for endosome-to-Golgi traffic. …”
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Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor by Chung, Hwa Hwa, Sze, Siu Kwan, Woo, Amanda Rui En, Sun, Yang, Sim, Kae Hwan, Dong, Xue Ming, Lin, Valerie Chun-Ling

“…Mutational analysis revealed the remarkable importance of Lys-464 in regulating PR activity. Single point mutation K464Q or K464A led to ligand-independent PR gel upshift similar to the ligand-induced gel upshift. …”
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Up-regulation of Mcl-1 and Bak by coronavirus infection of human, avian and animal cells modulates apoptosis and viral replication by Zhong, Yanxin., Liao, Ying., Fang, Shouguo., Tam, James P., Liu, Ding Xiang.

“…Furthermore, IBV infection-induced up-regulation of GADD153 regulated the expression of Mcl-1. …”
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Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis by Alvarez-Martinez, M, Cox, LS, Pearson, CF, Branchett, WJ, Chakravarty, P, Wu, X, Slawinski, H, Al-Dibouni, A, Samelis, VA, Gabryšová, L, Priestnall, SL, Suárez-Bonnet, A, Mikolajczak, A, Briscoe, J, Powrie, F, O'Garra, A

“…Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq of purified CD4⁺ T cells to show that the transcription factors Blimp-1 (encoded by Prdm1) and c-Maf co-dominantly regulate Il10 while negatively regulating proinflammatory cytokines in effector T cells. …”

Enhancing representation of data-scarce reservoir-regulated river basins using a hybrid DL-process based approach by Deng, L, Zhang, X, Slater, LJE

“…River discharge estimation in regulated river basins requires the inclusion of specific reservoir operation modules. …”

Investigating the use of neurofeedback to promote self-regulation of cortical motor activities as a potential rehabilitation tool post-stroke by Huang, Y

“…Therefore, a potential rehabilitative strategy for post-stroke motor recovery is promoting self-regulation of cortical motor activity to rebalance this abnormal brain activation pattern.…”

Deadbeat control for a single-inductor multiple-input multiple-output dc-dc converter by Wang, Benfei, Zhang, Xinan, Ye, Jian, Gooi, Hoay Beng

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Partial desensitization of MYC2 transcription factor alters the interaction with jasmonate signaling components and affects specialized metabolism by Hou, Xin, Singh, Sanjay Kumar, Werkman, Joshua R., Liu, Yongliang, Yuan, Qinghua, Wu, Xia, Patra, Barunava, Sui, Xueyi, Lyu, Ruiqing, Wang, Bingwu, Liu, Xiaoyu, Li, Yongqing, Ma, Wei, Pattanaik, Sitakanta, Yuan, Ling

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Exploring the moderating role of expressive suppression in the relationship between psychopathy and aggression by Maria, Dayla

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Relationships among emotion regulation, depression, anxiety, stress, and physical health-related quality of life in coronary heart disease patients by Ng, Min Geng

“…Coronary heart disease (CHD) is the third leading cause of death in Singapore. Although emotion regulation is a significant determinant of CHD patient’s quality of life, not many studies have assessed the impact of change in emotion regulation on physical functioning over time. …”
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Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology by Ahmed, Syed Moiz, Dröge, Peter

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Guiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapy by Dong, Shuming, Dong, Yushan, Liu, Bin, Liu, Jing, Liu, Shikai, Zhao, Zhiyu, Li, Wenting, Tian, Boshi, Zhao, Ruoxi, He, Fei, Gai, Shili, Xie, Ying, Yang, Piaoping, Zhao, Yanli

“…This work presents a powerful paradigm to achieve intensive NCDT efficacy by simultaneously regulating multi-enzymatic activities of Ce-based nanozymes and perturbing the H2O2 homeostasis in tumor microenvironment.…”
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Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma by Xiong, Sinan, Zhou, Jianbiao, Tan, Tze King, Chung, Tae-Hoon, Tan, Tuan Zea, Toh, Sabrina Hui-Min, Tang, Nicole Xin Ning, Jia, Yunlu, See, Yi Xiang, Fullwood, Melissa Jane, Sanda, Takaomi, Chng, Wee-Joo

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A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling by Deng, H, Zhang, J, Wang, Y, Joshi, D, Pi, X, De Val, S, Schwartz, MA

“…Here we report that high FSS suppresses Smad1/5 by elevating KLF2, which induces the bone morphogenetic protein (BMP) pathway inhibitor, BMP-binding endothelial regulator (BMPER), thereby de-inhibiting Akt. In mice, surgically induced high FSS elevated BMPER expression, inactivated Smad1/5 and induced vessel outward remodeling. …”

Congenital myasthenic syndromes: characterisation of a new animal model, exploring potential novel therapies and assessing the outcome of COVID-19 infection by Alabaf, S

Subjects: “…Allosteric regulation…”

The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture by Eilers, Kira, Yam, Joey Kuok Hoong, Liu, Xianghui, Goh, Yu Fen, To, Ka-Ning, Paracuellos, Patricia, Morton, Richard, Brizuela, Jaime, Yong, Adeline Mei Hui, Givskov, Michael, Freibert, Sven-Andreas, Bange, Gert, Rice, Scott A., Steinchen, Wieland, Filloux, Alain

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Identification of potential common cyclic-di-GMP regulated biomarkers among three gram negative bacteria via transcriptomic and metabolomic profiling by Cai, Zhao

“…The results indicated that RpoN modulates virulence secretion through a PQS quorum sensing regulator, pqsR. This study provides evidence for the possible detection and diagnosis of biofilm infections in clinical prospective using c-di-GMP regulated metabolites; it also demonstrates the complex connections and regulations among global regulators at the same time.…”
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The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in the piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster by Patil, Veena S., Anand, Amit, Chakrabarti, Alisha, Kai, Toshie

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