Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P by Dong, Rui, Saheki, Yasunori, Swarup, Sharan, Lucast, Louise, Harper, J. Wade, De Camilli, Pietro

“…Here, we report that by regulating PI4P levels on endosomes, VAP affects WASH-dependent actin nucleation on these organelles and the function of the retromer, a protein coat responsible for endosome-to-Golgi traffic. …”
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Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor by Chung, Hwa Hwa, Sze, Siu Kwan, Woo, Amanda Rui En, Sun, Yang, Sim, Kae Hwan, Dong, Xue Ming, Lin, Valerie Chun-Ling

“…Mutational analysis revealed the remarkable importance of Lys-464 in regulating PR activity. Single point mutation K464Q or K464A led to ligand-independent PR gel upshift similar to the ligand-induced gel upshift. …”
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Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis by Alvarez-Martinez, M, Cox, LS, Pearson, CF, Branchett, WJ, Chakravarty, P, Wu, X, Slawinski, H, Al-Dibouni, A, Samelis, VA, Gabryšová, L, Priestnall, SL, Suárez-Bonnet, A, Mikolajczak, A, Briscoe, J, Powrie, F, O'Garra, A

“…Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq of purified CD4⁺ T cells to show that the transcription factors Blimp-1 (encoded by Prdm1) and c-Maf co-dominantly regulate Il10 while negatively regulating proinflammatory cytokines in effector T cells. …”

Investigating the use of neurofeedback to promote self-regulation of cortical motor activities as a potential rehabilitation tool post-stroke by Huang, Y

“…Therefore, a potential rehabilitative strategy for post-stroke motor recovery is promoting self-regulation of cortical motor activity to rebalance this abnormal brain activation pattern.…”

Deadbeat control for a single-inductor multiple-input multiple-output dc-dc converter by Wang, Benfei, Zhang, Xinan, Ye, Jian, Gooi, Hoay Beng

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Partial desensitization of MYC2 transcription factor alters the interaction with jasmonate signaling components and affects specialized metabolism by Hou, Xin, Singh, Sanjay Kumar, Werkman, Joshua R., Liu, Yongliang, Yuan, Qinghua, Wu, Xia, Patra, Barunava, Sui, Xueyi, Lyu, Ruiqing, Wang, Bingwu, Liu, Xiaoyu, Li, Yongqing, Ma, Wei, Pattanaik, Sitakanta, Yuan, Ling

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Exploring the moderating role of expressive suppression in the relationship between psychopathy and aggression by Maria, Dayla

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Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma by Xiong, Sinan, Zhou, Jianbiao, Tan, Tze King, Chung, Tae-Hoon, Tan, Tuan Zea, Toh, Sabrina Hui-Min, Tang, Nicole Xin Ning, Jia, Yunlu, See, Yi Xiang, Fullwood, Melissa Jane, Sanda, Takaomi, Chng, Wee-Joo

“…It remains poorly understood how chromatin rewiring of regulatory elements contributes to tumorigenesis and therapy resistance in myeloma. …”
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A LDO regulator with weighted current feedback technique for 0.47nF-10nF capacitive load by Tan, Xiao Liang, Chong, Sau Siong, Chan, Pak Kwong, Dasgupta, Uday

“…Besides, it provides good regulator loop gain and fast transient response. Validated by UMC 65 nm CMOS process, the simulation and measurement results have shown that the WCF LDO regulator can operate at a load capacitance (CL) range from 470 pF to 10 nF with only 3.8 pF compensation capacitor. …”
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Relationships among emotion regulation, depression, anxiety, stress, and physical health-related quality of life in coronary heart disease patients by Ng, Min Geng

“…Coronary heart disease (CHD) is the third leading cause of death in Singapore. Although emotion regulation is a significant determinant of CHD patient’s quality of life, not many studies have assessed the impact of change in emotion regulation on physical functioning over time. …”
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Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology by Ahmed, Syed Moiz, Dröge, Peter

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Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr by Zhang, Yingdan, Chew, Alvin Bing Liang, Wang, Jing, Yuan, Mingjun, Yam, Joey Kuok Hoong, Luo, Dahai, Yang, Liang

“…Here, we identify P. aeruginosa's global virulence factor regulator Vfr as one target of auranofin. We report the mechanistic insights into the inhibitory mechanism of auranofin and gold(I) analogues to Vfr through structural, biophysical, and phenotypic inhibition studies. …”
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The design of a CMOS only low-power low-voltage low-dropout voltage regulator (LDO) with an embedded voltage reference by Xie, Xinzhe

Subjects: “…Low-dropout (LDO) voltage regulator…”
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A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling by Deng, H, Zhang, J, Wang, Y, Joshi, D, Pi, X, De Val, S, Schwartz, MA

“…Here we report that high FSS suppresses Smad1/5 by elevating KLF2, which induces the bone morphogenetic protein (BMP) pathway inhibitor, BMP-binding endothelial regulator (BMPER), thereby de-inhibiting Akt. In mice, surgically induced high FSS elevated BMPER expression, inactivated Smad1/5 and induced vessel outward remodeling. …”

A 0.9-µ A quiescent current output-capacitorless LDO regulator with adaptive power transistors in 65-nm CMOS by Chong, Sau Siong, Chan, Pak Kwong

“…An ultra-low quiescent current output-capacitorless low-dropout (OCL-LDO) regulator with adaptive power transistors technique is presented in this paper. …”
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Increasing international students’ autonomy and boosting their engagement via the use of active self-correction in writing: a transformative approach to sustainable self-regulated learning in business schools by Meletiadou, Eleni

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Congenital myasthenic syndromes: characterisation of a new animal model, exploring potential novel therapies and assessing the outcome of COVID-19 infection by Alabaf, S

Subjects: “…Allosteric regulation…”

The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture by Eilers, Kira, Yam, Joey Kuok Hoong, Liu, Xianghui, Goh, Yu Fen, To, Ka-Ning, Paracuellos, Patricia, Morton, Richard, Brizuela, Jaime, Yong, Adeline Mei Hui, Givskov, Michael, Freibert, Sven-Andreas, Bange, Gert, Rice, Scott A., Steinchen, Wieland, Filloux, Alain

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Enhancing E. coli tolerance towards oxidative stress via engineering its global regulator cAMP Receptor Protein (CRP) by Basak, Souvik, Jiang, Rongrong

“…Here, we aim to improve E. coli performance under oxidative stress via engineering its global regulator cAMP receptor protein (CRP), which can directly or indirectly regulate redox-sensing regulators SoxR and OxyR, and other ~400 genes in E. coli. …”
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Voltage and frequency stability enhancement with an automatic voltage regulator and power system stabilizer in a ring-structured power system post generator loss by Zetty Adibah, Kamaruzzaman, Nur Zahirah, Mohd Ali, Ahmad Syahiman, Mohd Shah

“…This study analyses the transient stability of the IEEE 9-bus test system in the context of generator loss and delayed circuit breaker response, emphasizing the impact of Automatic Voltage Regulator (AVR) and Power System Stabilizer (PSS) on damping reduction and transient recovery time. …”
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