Impact of host gut microbiome on pathogen colonization by Low, Wai Leong

“…Finally, we postulated that these colonization-promoting factors are being down-regulated by the commensal gut microbiota in the effort to resist the gut colonization by P. aeruginosa.…”
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Role of posttranslational modifications of histone proteins in epigenetics by Raj, R

“…<p>Nature has evolved an additional level of genetic regulation by-passing direct changes in genetic code through the means of posttranslational modifications (PTMs) of nucleobases and histone proteins. …”

Effects of problem-based learning on EFL learning: a systematic review by Guo, Qian, Jamil, Halimah, Ismail, Lilliati, Luo, Shujie, Sun, Zhubin

“…Problem-based learning (PBL) is an innovative pedagogical approach that facilitates students’ self-regulated learning, thereby improving their English proficiency. …”
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An isolated bipolar DC-DC converter for energy storage integration in marine vessels by Nag, Soumya Shubhra, Satpathi, Kuntal, Ukil, Abhisek, Pou, Josep, Zagrodnik, Michael Adam

“…A closed loop control system is developed in the MATLAB®/Simulink simulation platform which regulates the output of the isolated bipolar converter to its reference value. …”
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Novel loci and biomedical consequences of iron homoeostasis variation by Allara, E, Bell, S, Smith, R, Keene, SJ, Gill, D, Gaziano, L, Morselli Gysi, D, Wang, F, Tragante, V, Mason, A, Karthikeyan, S, Lumbers, RT, Bonglack, E, Ouwehand, W, Roberts, DJ, Dowsett, J, Ostrowski, SR, Larsen, MH, Ullum, H, Pedersen, OB, Brunak, S, Banasik, K, Erikstrup, C, Mitchell, J

“…Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. …”

Dysregulation of MMP2-dependent TGF-ß2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis by Singh, P, Sun, J, Cavalera, M, Al-Sharify, D, Matthes, F, Barghouth, M, Tengryd, C, Dunér, P, Persson, A, Sundius, L, Nitulescu, M, Bengtsson, E, Rattik, S, Engelbertsen, D, Orho-Melander, M, Nilsson, J, Monaco, C, Goncalves, I, Edsfeldt, A

“…Transforming growth factor-ß2 originates mostly from contractile vascular smooth muscle cells that interact with synthetic vascular smooth muscle cells in the cap, leading to collagen formation and vascular smooth muscle cell differentiation. This is regulated by free transforming growth factor-ß2 which is affected by hyperglycemia. …”

Comparative metabolic profiling of engineered Saccharomyces cerevisiae with enhanced flavonoids production by Lyu, Xiaomei, Ng, Kuan Rei, Mark, Rita, Lee, Jie Lin, Chen, Wei Ning

“…To understand the mechanism behind this, comparative metabolomic analysis was performed, to gain a global overview of the metabolic regulation. As a result, 20 important metabolites were found to be significantly altered. …”
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Epistemic oppression and the concept of coercion in psychiatry by Faissner, M, Braun, E, Hempeler, C

“…Psychiatric staff primarily employ the concept as referring to instances of formal coercion regulated by law, such as involuntary hospital admission or treatment. …”

Biologically-inspired spectrum sharing for cognitive radio by Li, Guang Fu.

“…Nowadays, spectrum access of the wireless networks is generally regulated by governments via a fixed spectrum assignment policy. …”
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A back-to-back converter system for aerospace applications by Hao Zhe, Chua

“…The ability to control the power flow allows the DC-link voltage to be regulated, which results in size reduction of the DC-link capacitor without affecting its performance. …”
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Modelling futility in the setting of fertility treatment by Polyakov, A, Gyngel, C, Savulescu, J

“…In the UK, government subsidized treatment with the couple's own gametes stops at the age of 42, while privately funded treatments are self-regulated by individual providers. In most European countries and the USA, the 'age of futility' is likewise managed by clinical consensus.…”

Characterisation of an “eat-me” signal on dying and HIV-1-infected T cells by Karaji, N

“…<p>The clearance of dying cells by phagocytes, termed efferocytosis, is regulated by a combination of “eat-me” and “don’t eat-me” signals expressed on the dying cell surface. …”

Position-space renormalization schemes for four-quark operators in HQET by Lin, Joshua, Detmold, William, Meinel, Stefan

“…X-space schemes are gauge-invariant, regulator-independent renormalization schemes that are defined by requiring position-space correlation functions of gauge-invariant operators to be equal to their noninteracting values at particular kinematic points. …”
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Mitochondrial dysfunction in Down Syndrome: from pathology to therapy by Tan, Kai-Leng, Lee, Han-Chung, Cheah, Pike-See, Ling, King-Hwa

“…The function of mitochondria is primarily regulated by genes encoded in the mitochondrion and nucleus. …”
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BswR controls bacterial motility and biofilm formation in Pseudomonas aeruginosa through modulation of the small RNA RsmZ by Wang, Chao, Ye, Fuzhou, Kumar, Veerendra, Gao, Yong-Gui, Zhang, Lian-Hui

“…Pseudomonas aeruginosa relies on cell motility and ability to form biofilms to establish infections; however, the mechanism of regulation remains obscure. Here we report that BswR, a xenobiotic response element-type transcriptional regulator, plays a critical role in regulation of bacterial motility and biofilm formation in P. aeruginosa. …”
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Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells by Head, Sarah A., Shi, Wei, Zhao, Liang, Gorshkov, Kirill, Pasunooti, Kalyan, Chen, Yue, Deng, Zhiyou, Li, Ruo-jing, Shim, Joong Sup, Tan, Wenzhi, Hartung, Thomas, Zhang, Jin, Zhao, Yingming, Colombini, Marco, Liu, Jun O.

“…Previous mechanistic studies have shown that itraconazole inhibits the mechanistic target of rapamycin (mTOR) signaling pathway, which is known to be a critical regulator of endothelial cell function and angiogenesis. …”
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Higher education and public good in England by Marginson, S, Yang, L

“…In the Anglophone jurisdictions, higher education policy is over-determined by economic policy and subjected to neoliberal regulation based on quasi-market competition between corporatised institutions, regulated by performative comparisons, tuition fees, and outputs imagined as commodities. …”

Deubiquitinases in muscle physiology and disorders by Olie, CS, O'Brien, DP, Jones, HBL, Liang, Z, Damianou, A, Sur-Erdem, I, Pinto-Fernández, A, Raz, V, Kessler, BM

“…In vivo, muscle and neuronal cells are post-mitotic, and their function is predominantly regulated by proteostasis, a multilayer molecular process that maintains a delicate balance of protein homeostasis. …”

Optimizing crystal size distribution based on different cooling strategies in batch crystallization process by Siti Zubaidah, Adnan, Noor Asma Fazli, Abdul Samad

“…Producing specified CSD in the crystallization process represents a main challenge as it depends on temperature control, which indirectly regulates the solution’s concentration and affects the crystal’s evolution. …”
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Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6 by Zhang, Xiulin, He, Yang, Zhang, Xiaolu, Fu, Bo, Song, Zidai, Wang, Liang, Fu, Rui, Lu, Xuancheng, Xing, Jin, Lv, Jianyi, Guo, Meng, Huo, Xueyun, Liu, Xin, Lu, Jing, Du, Xiaoyan

“…Mechanistically, we found that persistent infection with H. pylori reduces the sensitivity of TLR6 to bacterial components and regulates the expression of inflammatory cytokines in GES-1 cells through TLR6/JNK signaling. …”
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