Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation by Nakagawa, R, Llorian, M, Varsani-Brown, S, Chakravarty, P, Camarillo, JM, Barry, D, George, R, Blackledge, NP, Duddy, G, Kelleher, NL, Klose, RJ, Turner, M, Calado, DP

“…Mechanistically, miR-155 regulates H3K36me2 levels in hypoxic conditions by directly repressing the histone lysine demethylase, Kdm2a, whose expression increases in response to hypoxia. …”

The role of calcium dependent neurotransmission in axon path finding, myelination and maintenance of specified cortical projection neuron populations by Korrell, K

“…<p>The thesis examines the mechanisms involved in regulation of myelination during mammalian cortical development and the subsequent maintenance of the myelin in cortical projection neurons during adult life. …”

Journalism, media and technology trends and predictions 2017 by Newman, N

“…<br> More widely there’ll be heated debate about the role and size of tech platforms and the extent to which their activities should be regulated. Artificial Intelligence (AI) takes over from mobile as the hottest topic in technology, though the practical and ethical dilemmas around how it will be used become ever more apparent through the year.…”

Host genotype and microbiome associations in co-occurring clonal and non-clonal kelp, Ecklonia radiata by Gonzalez, Sebastian Vadillo, Vranken, Sofie, Coleman, Melinda A., Wernberg, Thomas, Steinberg, Peter D., Marzinelli, Ezequiel Miguel

“…A fundamental question in holobiont biology is the extent to which microbiomes are determined by host characteristics regulated by their genotype. Studies on the interactions of host genotype and microbiomes are emerging but disentangling the role that host genotype has in shaping microbiomes remains challenging in natural settings. …”
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Fishing skill in developing country fisheries: The Kedah, Malaysia trawl fishery by Viswanathan, K. Kuperan, Omar, Ishak, Jeon, Yongil, Kirkley, James, Squires, Dale, Susilowati, Indah

“…The question arises for fishery managers as to whether or not there are observable and measurable attributes of the skipper or vessel that can be monitored and regulated to account for skipper skill and, hence, this source of fishing capacity. …”

Financial option insurance by Wang, Qi-Wen, Shu, Jian-Jun

“…The option is a financial derivative, which is regularly employed in reducing the risk of its underlying securities. …”
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Predicting the performance of cryptocurrency market by Tibrewal, Shrey

“…As these currencies are not regulated by financial institutions, they are regarded as highly volatile. …”
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Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes by Kerckhoffs, A, Ahmad, M, Langton, ML

“…Photo-regulated transmembrane ionophores enable spatial and temporal control over activity, offering promise as targeted therapeutics. …”

Everyday streets: inclusive approaches to understanding and designing streets by Clossick, Jane, Hausleitner, Birgit, Martire, Agustina

“…It offers an analysis of many aspects of everyday streets from cities around the globe. From the regular rectilinear urban blocks of Montreal to the military-regulated narrow alleyways of Naples, and from the resilient market streets of London to the crammed commercial streets of Chennai, the streets in this book were all conceived with a certain level of control. …”
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Competitive overlap as a signal in expert partner choice: evidence from patent law firm selection by Borchhardt, G, Kovacs, B, Rogan, M

“…<p><strong>Research Abstract:</strong> In market networks, firms regularly seek partners with needed expertise, but these partners often work with the firms’ competitors. …”

Of blood and belonging: the practice of antiretroviral treatment among HIV-positive youth in South Africa's Eastern Cape by Vale, B

“…By 'practice', I mean the volatile, situated and relational 'work' that goes into young people's everyday achievement of ART — into consuming daily medication, regularly attending health appointments, and participating in HIV programmes. …”

Territorial movements of African lions: can waterholes shape multiple central-place territories in a savanna ecosystem? by Dejeante, R, Loveridge, A, Macdonald, D, Madlamoto, D, Chamaille-James, S, Valeix, M

“…In territorial species, individuals need to regularly patrol their territory to display visual, auditory or olfactory signals, or to detect the presence of intruders. …”

Furniture form innovation and human–machine comfort evaluation model based on genetic algorithm by Yifan, Bai, Kamarudin, Khairul Manami, Alli, Hassan

“…Mechanization, specialization, and shrewd steering have been regularly added to indoor fixtures commercial enterprises due to their ever-growing clinical and technological capacities. …”
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A clinical perspective on muscle specific kinase antibody positive myasthenia gravis by Keritam, O, Vincent, A, Zimprich, F, Cetin, H

“…In healthy muscle, MuSK regulates a phosphorylation pathway, which is essential for the development and maintenance of acetylcholine receptor (AChR) clusters at the neuromuscular junction. …”

MicroRNA trimming in the nervous system by Lee, Li Ming

“…MicroRNAs are small, single-stranded RNAs about 22 nucleotides long which are involved in post-transcriptional regulation of mRNAs. MicroRNAs base-pair with regions on the 3’ UTR of target mRNAs which show partial complementarity to microRNA sequence and downregulate them by translational repression or mRNA cleavage. …”
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Novel nitric oxide donors for the dispersal and control of Pseudomonas aeruginosa biofilms by Poh, Wee Han

“…NO, as a free radical, is highly reactive and its production and metabolism is tightly regulated under physiological conditions. In addition, due to the involvement of NO in various pathological processes, several classes of NO donors with varying pharmacological properties have been developed for different treatments. …”
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Explore anomaly detection and localization methods for medical imaging data by Yu, Tianze

“…Motivated by this, we introduce Contrastive Learning guided GAN (CLGAN), which leverages unlabeled mixed data and contrastive learning to guide the generation process. CLGAN regulates the generator by aligning generated images with the normal distribution while pushing them away from potential anomalies present in the unlabeled images. …”
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Emergency depopulation of chicken farms during an avian influenza outbreak (Design and development of CO2 delivery system) by Chang, Wei Jun

“…Although the bird flu virus is endemic in the South East Asian region at the moment, the Agri-Food & Veterinary Authority of Singapore (AVA), a local statutory board that regulates food safety, has come up with several guidelines to not only prevent the introduction, but also to limit the spread of the virus. …”
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Structural modeling of LAG-3 protein and immunoglobulin domains by Lai, Marcel Chang Long

“…Lymphocyte-activation gene 3 (LAG3) is a protein that limits the activity of T-cells, which down regulates the immune system. The protein functions can be determined from its structure. …”
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The role of Wee1 in the hypoxia-induced DNA damage response and its potential as a therapeutic target by O'Brien, EM

“…Wee1 is involved in G₂-M progression; inhibitors of Wee1 force cells into premature mitosis causing damage as well as radiosensitising cells even under hypoxic conditions.</p> <p>Wee1 also regulates genomic stability via inhibition of the endonuclease Mus81-Eme1 in S phase cells. …”