Changes in cerebrospinal fluid balance of TNF and TNF receptors in naïve multiple sclerosis patients : early involvement in compartmentalised intrathecal inflammation by Magliozzi, Roberta, Pezzini, Francesco, Pucci, Mairi, Rossi, Stefania, Facchiano, Francesco, Marastoni, Damiano, Montagnana, Martina, Lippi, Giuseppe, Reynolds, Richard, Calabrese, Massimiliano

“…In order to explore whether this feature may be present from the early stages of MS and may be associated with the clinical outcome, the protein levels of TNF, sTNF-R1 and sTNF-R2 were assayed in CSF collected from 122 treatment-naïve MS patients and 36 subjects with other neurological conditions at diagnosis. Potential correlations with other CSF cytokines/chemokines and with clinical and imaging parameters at diagnosis (T0) and after 2 years of follow-up (T24) were evaluated. …”
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Preclinical development of antisense conjugates for the treatment of myotonic dystrophy 1 by Stoodley, J

“…However, no therapy has yet been specifically developed that aims to additionally penetrate the CNS and treat the neurological symptoms experienced by patients. Furthermore, cell-penetrating peptide ASO conjugates (CPP-ASOs) can be associated with nephrotoxicity at higher doses, resulting in a trade-off between efficacy and toxicity, highlighting the need for further optimization to broaden their therapeutic window.…”

Molecular detection, risk factor and public awareness of avian bornavirus from captive and non-captive birds in Peninsular Malaysia by Mohd Lutpi, Syamsiah

“…Birds with PDD may show signs of gastrointestinal tract deficit (e.g., weight loss, regurgitation, passage of undigested food in faeces), or neurological dysfunction (e.g., ataxia, abnormal gait, proprioceptive defects) or even both. …”
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Using machine learning to discover candidate localised transcripts from microscopy and genome-wide bioinformatics data by Kiourlappou, M

“…Proper mRNA localisation is vital for the correct functioning of the entirety of a glial cell and dysregulation of mRNA localisation in glial cells has been implicated in neurodegenerative and neurological diseases and some types of cancer. Therefore, gaining a deeper understanding of the mechanisms that mediate mRNA localisation is of paramount value.…”

Genetic analysis of normal human phenotypes within the people of the British Isles by Meena, D

“…</p> <p>The last part of this thesis provides new insights into the field of olfactory perception and argues for the potential link between neurological disorders and olfactory impairment. Most, if not all, novel variants (suggestive genome-wide significant) presented in this research have strong functional biological support behind the preliminary statistical observations and will be helpful in understanding the visible pigmentation differences among humans as well as the genetics underlying food preferences.…”

A Digital Phenotypic Assessment in Neuro-Oncology (DANO): A Pilot Study on Sociability Changes in Patients Undergoing Treatment for Brain Malignancies by Siddi, Francesca, Emedom-Nnamdi, Patrick, Catalino, Michael P., Rana, Aakanksha, Boaro, Alessandro, Dawood, Hassan Y., Sala, Francesco, Onnela, Jukka-Pekka, Smith, Timothy R.

“…Abstract Background: The digital phenotyping tool has great potential for the deep characterization of neurological and quality-of-life assessments in brain tumor patients. …”
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