Expediting treatments in the 21st century: orphan drugs and accelerated approvals by Domike, Reuben, Raju, G. K., Sullivan, Jamie, Kennedy, Annie

“…The re-use of surrogate markers for oncological diseases has been an advantage in a way that may not be scientifically feasible in many other disease areas that have greater differentiation across disease etiology. For non-oncological diseases, applicability of AA is, in part, dependent upon greater focus on characterization and acceptance of novel surrogate markers.…”
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First international conference on RASopathies and neurofibromatoses in Asia : identification and advances of new therapeutics by Rauen, Katherine A, Alsaegh, Abeer, Ben-Shachar, Shay, Berman, Yemima, Blakeley, Jaishri, Cordeiro, Isabel, Elgersma, Ype, Evans, D Gareth, Fisher, Michael J, Frayling, Ian M, George, Joshi, Huson, Susan M, Kerr, Bronwyn, Khire, Uday, Korf, Bruce, Legius, Eric, Messiaen, Ludwine, van Minkelen, Rick, Nampoothiri, Sheela, Ngeow, Joanne, Parada, Luis F, Phadke, Shubha, Pillai, Ashok, Plotkin, Scott R, Puri, Ratna, Raji, Anup, Ramesh, Vijaya, Ratner, Nancy, Shankar, Suma P, Sharda, Sheetal, Tambe, Anant, Vikkula, Miikka, Widemann, Brigitte C, Wolkenstein, Pierre, Upadhyaya, Meena

“…Due to their common underlying pathogenetic etiology, all these syndromes have significant phenotypic overlap of which one common feature include a predisposition to tumors, which may be benign or malignant. …”
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Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging by Baik, Sang-Ha, Selvaraji, Sharmelee, Fann, David Y., Poh, Luting, Jo, Dong-Gyu, Herr, Deron R., Zhang, Shenpeng R., Kim, Hyun Ah, Silva, Michael De, Lai, Mitchell K. P., Chen, Christopher Li- Hsian, Drummond, Grant R., Lim, Kah-Leong, Sobey, Christopher G., Arumugam, Thiruma V.

“…Vascular dementia (VaD) is a progressive cognitive impairment of vascular etiology. VaD is characterized by cerebral hypoperfusion, increased blood-brain barrier permeability and white matter lesions. …”
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Maternal infections during pregnancy and the risk of childhood leukaemia in the offspring: Evidence from large-scale cohort studies by He, J

“…<p><b>Background:</b> Leukaemia is the most common childhood cancer, but its aetiology remains unclear. Maternal infection during pregnancy might lead to chromosomal or immunological alterations in the fetus and could be a risk factor for childhood leukaemia. …”

Long Covid: a global health issue – a prospective, cohort study set in four continents by Pazukhina, E, Garcia-Gallo, E, Reyes, LF, Kildal, AB, Jassat, W, Dryden, M, Holter, JC, Chatterjee, A, Gomez, K, Søraas, A, Puntoni, M, Latronico, N, Bozza, FA, Edelstein, M, Gonçalves, BP, Kartsonaki, C, Kruglova, O, Gaião, S, Chow, YP, Doshi, Y, Duque Vallejo, SI, Ibáñez-Prada, ED, Fuentes, YV, Hastie, C, O'Hara, ME, Balan, V, Menkir, T, Merson, L, Kelly, S, Citarella, BW, Semple, MG, Scott, JT, Munblit, D, Sigfrid, L

“…Further research into the aetiology of Long Covid and the burden in LMICs is critical to implement effective, accessible treatment and support strategies to improve COVID-19 outcomes for all.…”

Cardiac-sympathetic dysfunction in hypertension by Bardsley, E

“…This chapter focussed specifically on the role of the sympathetic nervous system as a primary causative factor in the aetiology of hypertension, and presented evidence highlighting a critical role for impaired cyclic nucleotide signalling in sympathetic over-activity.…”

Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults by Ho, Vanda W. T., Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki Y. J., Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa F. P., Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K., Ong, Catherine W. M., Macary, Paul A.

“…Further exploration into the aetiology is needed and would be integral in developing novel vaccination strategies and improving infection outcomes in older adults.…”
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Metasomatism of the continental crust and its impact on surface uplift: insights from reactive‐transport modelling by Worthington, JR, Chin, EJ, Palin, RM

“…Here, we develop a series of petrological models that describe the petrological and topographic effects of fluid–rock interaction in non-deforming continental crust of varying composition. …”

Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2 by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca S. W., Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M., Tan, Nikki Y. J., Preiser, Peter Rainer, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A., Smith, Kenneth G. C., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Young, Barnaby E., MacAry, Paul A.

“…The scale and duration of neutralizing antibody responses targeting SARS-CoV-2 viral variants represents a critically important serological parameter that predicts protective immunity for COVID-19. …”
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A tymovirus from Calopogonium mucunoides in Malaysia is not clitoria yellow vein tymovirus: brief report by Gibbs, A.J., Mackenzie, A.M., Abdul-Samad, N.

“…A tymovirus isolated from Malaysian crops of Calopogonium mucunoides has been shown to have virions that are serologically indistinguishable from those of clitoria yellow vein tymovirus. …”

Characterization of Salmonella spp. isolated from patients below 3 years old with acute diarrhoea by Shobirin, M.H. Anis, Shuhaimi, M., Abu‐Bakar, F., Ali, A.M., Ariff, A., Nur‐Atiqah, N.A., Yazid, A.M.

“…The isolates were tested for their susceptibility to a range of antimicrobial agents, and typed by serological tests and randomly amplified polymorphic DNA (RAPD) fingerprinting. …”
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Anticholinergic burden and cognitive function in psychosis: a systematic review and meta-analysis by Mancini, V, Latreche, C, Fanshawe, J, Varvari, I, Chambrez-Zita, Z, McGinn, N, Ana, C, Pillinge, T, McGuire, PK, McCutcheon, RA

“…</p> <p><strong>Results:</strong> Of 1,337 citations retrieved, 40 met inclusion criteria, comprising 25 anticholinergic burden studies (4,620 patients), six serological anticholinergic activity studies (382 patients), and nine tapering studies (186 patients). …”

Progressive encephalomyelitis with rigidity: a Taiwanese case and review of literature by Chang, A, Lin, K-Y, Chuang, K-J, Waters, P, Irani, SR, Mgbachi, V, Yeh, H-L, Lien, L-M, Chiu, H-C, Chen, W-H

“…However, the outcome is still variable with different serological and tumor associations, and the elements to good response with less relapse is yet to be elucidated. …”

In Children, N -Methyl-D-Aspartate Receptor Antibody Encephalitis Incidence Exceeds That of Japanese Encephalitis in Vietnam by Huong, NHT, Toan, ND, Thien, TB, Khanh, TH, Tuan, NM, Truc, TT, Nghia, NA, Thinh, LQ, Thoa, NTK, Nhan, LNT, Minh, NNQ, Turner, HC, Thwaites, CL, Hung, NT, Tan, LV, Irani, SR, Quy, DT

“…Results: We recruited 164 children with a clinical diagnosis of encephalitis. Etiologies were determined as NMDAR antibody encephalitis in 23 of 164 cases (14.0%), Japanese encephalitis virus in 14 of 164 (8.5%), and herpes simplex virus in 4 of 164 (2.4%). …”

Spectrum on non-surgical causes of internal jugular vein thrombosis in otorhinolaryngology practice by Mohamed, Mohd Hazmi, Ishak, Azlan Iskandar, Wan Sulaiman, Wan Aliaa

“…Internal jugular vein thrombosis is an uncommon entity secondary to various aetiologies. In the pre-antibiotic era, it was commonly associated with Lemierre syndrome, a septic thrombophlebitis of the internal jugular vein secondary to oropharyngeal infection. …”
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Autoimmune encephalitis by Irani, SR

“…In turn, these clinical features in combination with serologic findings and selective paraclinical testing, direct the rationale for the administration of immunotherapies. …”

Psychotropic taxonomies: constructing a therapeutic framework for psychiatry by McCutcheon, RA, Cowen, P, Nour, MM, Pillinger, T

“…Finally, we consider how data-driven methods might address the issue of classification at an intermediate level, based around transdiagnostic neurobiological and psychopathological markers.</p>…”

Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity by Yao, S, Harder, A, Darki, F, Chang, Y, Li, A, Nikouei, K, Volpe, G, Lundström, JN, Zeng, J, Wray, NR, Lu, Y, Sullivan, PF, Hjerling-Leffler, J

“…Identifying cell types and brain regions critical for psychiatric disorders and brain traits is essential for targeted neurobiological research. By integrating genomic insights from genome-wide association studies with a comprehensive single-cell transcriptomic atlas of the adult human brain, we prioritized specific neuronal clusters significantly enriched for the SNP-heritabilities for schizophrenia, bipolar disorder, and major depressive disorder along with intelligence, education, and neuroticism. …”

Molecular and immunological profiling of Bartonella spp. in shelter cat population in Peninsular Malaysia by Alias, Nurul Najwa Ainaa

“…A total of 122 serum collected were subjected to serological detection of IgM and IgG while 110 whole blood that were kept in -80°C freezer were subjected for immunophenotyping of CD4 and CD8. …”
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Experimental Constraints on Melting Processes in the Earth and Small Rocky Bodies by Hoyos Muñoz, Susana

“…This thesis investigates large-scale igneous processes in the Earth, the Moon, and the Angrite Parent Body using a multidisciplinary approach that integrates high-pressure experiments, geochemical analysis, and petrologic modeling. In Chapter 1, I examine the mantle source lithology of Hawaiian pre-shield tholeiitic volcanism through high-pressure equilibrium experiments and geochemical modeling. …”
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