Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8⁺ T cells by Kang, Xing, Liu, Changan, Ding, Yanqiang, Ni, Yunbi, Ji, Fenfen, Lau, Harry Cheuk Hay, Jiang, Lanping, Sung, Joseph Jao Yiu, Wong, Sunny Hei, Yu, Jun

“…R. intestinalis or butyrate also significantly improved antiprogrammed cell death protein 1 (anti-PD-1) efficacy in mice bearing MSI-low CT26 tumours. Mechanistically, butyrate directly bound to toll-like receptor 5 (TLR5) receptor on CD8(+) T cells to induce its activity through activating nuclear factor kappa B (NF-& kappa;B) signalling. …”
Get full text

Biological characterization of RNA polymerase proteins from human 2009 pandemic H1N1 and low pathogenic avian H5N2 and H9N2 influenza viruses by Myaing, Myint Zu

“…In our gene reassortment study, a single reassortant bearing a human-origin PA or PB2 subunit against an avian polymerase background could overcome the host range barrier of avian polymerase in human 293T cells, indicating the PA or PB2 as a major determinant of species tropism and pathogenicity. …”
Get full text

南洋理工大学在籍华族学生婚姻观 = Chinese undergraduates' views on marriage : a case study of Nanyang Technological University by 吴起慧 Goh, Qi Hui

“…Since 1980s, Singapore has been persistently facing the problems of later marriages and delayed child-bearing. These trends could bring much detriment to the country; particularly to the economy and society. …”
Get full text

Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer by Chen, Manling, Liu, Yidu, Li, Yang, Liu, Xue

“…In studies with A549 tumor-bearing mice, the combination of low-dose 2-DG and metformin did not impede tumor growth, whereas 2-DG@MA-dots markedly decreased tumor volume, with the mean final tumor volume in the combination treatment group being approximately 89 times greater than that in the 2-DG@MA-dot group. …”
Get full text

Progressive collapse behaviour of precast concrete structures with advanced joints by Nguyen, Van Hung

“…Secondly, the pull-out test results highlighted a pivotal role of bearing force in anchorage strength of headed bars and strain behaviour. …”
Get full text

Design and investigation of block copolymers for dispersion of carbon nanotubes in polymer matrices by Liu, Chengyin

“…To further improve the tensile properties of the SWNTs/epoxy nanocomposites, we fabricated another series of PI-derived block copolymers via ring-opening polymerization initiated from hydroxyl-terminated polyimide of lactide and allyl-bearing 2-methyl-2-(allyloxycarbonyl)propylene carbonate) (MAC) to produce PLA-b-PI-b-PLA (TB1) and PMAC-b-PI-b-PMAC (TB2) which are polyester and poly(ester-carbonate)-derived, respectively. …”
Get full text

Synthesis of heavy cyanide analogs for the design of novel Prussian blue analogs by Yang, E

“…In order to provide illustrative points of comparison, analogous metal complexes bearing various strong-field ligands are also synthesized and analyzed using the same approach.…”

Bacteria-mediated anti-cancer therapy by Bhave, Madhura Satish

“…However, IB significantly inhibited the growth of the tumors and improved the survival rate of immunocompetent CT26 tumor-bearing mice. Histological analysis showed that IB increased the necrotic area in HCT116 tumors. …”
Get full text
Get full text

Synthesis of epoxidized poly(ester carbonate)-b-polyimide-b-poly(ester carbonate) : reactive single-walled carbon nanotube dispersants enable synergistic reinforcement around multi... by Liu, Bo, Liu, Chengyin, De Luca, Hugo G., Raman Pillai, Suresh Kumar, Anthony, David B., Li, Jianghua, Bismarck, Alexander, Shaffer, Milo S. P., Chan-Park, Mary Bee Eng

“…Herein, PI-derived block copolymers are synthesized via ring-opening copolymerization of lactide (LA) (a control monomer) and allyl-bearing 2-methyl-2-(allyloxycarbonyl)-propylene carbonate (MAC) from the OH-terminal ends of the PI block to produce PLA-PI-PLA (TB1, a control) and PMAC-PI-PMAC (TB2). …”
Get full text

Fabrication and characterization of graphene and carbon nanotube reinforced bioceramic nanocomposites by Hu, Huanlong

“…Bioceramics play an important role in the replacement and regeneration of human tissues, but their intrinsic brittleness and low wear resistance make the monolithic bioceramics still problematic for load-bearing applications. The two dimensional (2D) graphene and one dimensional (1D) carbon nanotube (CNT), as the secondary strong and tough biocompatible nanofillers, are popular nanocarbons to reinforce bioceramics. …”
Get full text

Engineered terahertz emission from spintronic heterostructures: amplitude, phase and chirality by Agarwal, Piyush

“…To summarize, the thesis aims to contribute to the synergies of spintronics and photonics for advanced applications in developing scalable devices bearing low-cost fabrication with on-chip compatibility.…”
Get full text

Amino-functionalised β-diketiminate ligands (N-nacnacs): Synthesis and coordination chemistry with Main Group elements by Huan, D

“…The establishment of a library of germylenes and stannylenes bearing different N-bound aromatic substituents with varying degrees of steric bulk allows for a systematic study of the steric effects of the flanking aryl groups on the overall molecular metrics of these complexes. …”

Stability improvement and control optimization of isolated two-stage AC-DC-DC converter systems by Feng, Fan

“…The analysis results offer instructive implications to fine-tune the design rules of the DAB converters. Bearing the mind that the impedance model of the DAB converter is closely related to the modulation schemes, the impacts of three typical modulation methods on the DAB impedances are analyzed and compared. …”
Get full text