Molecular pathways leading to sleep and wakefulness in Drosophila by Christodoulou, K

“…Activation of the receptor likely feeds into a small GTPase cascade that involves Cv-c and Sandman.…”

Climate worry: associations with functional impairment, pro-environmental behaviors and perceived need for support by Lenhard, F, Fernández de la Cruz, L, Wahlund, T, Andersson, E, Åhlén, J, Fuso Nerini, F, Akay, H, Mataix-Cols, D

“…Individuals in this group (high severity and frequency of climate worry as well as significant functional impairment) were more likely to experience depressed mood and sleep problems and were more interested in receiving support, specifically concerning strategies for worry management and sustainable behavior change. …”

The influence of metabolic hormones on lactation by Rostom, H

“…My work showed that GH signals through the Janus kinase 2 (Jak2)- signal transducer and activator of transcription 5 (STAT5) pathway, while transcriptomic evaluation of GH-treated HC11 cells demonstrated that GH promotes synthesis of milk proteins and proteins associated with lipid synthesis. GH is therefore likely to augment the milk-synthesising actions of prolactin at lactation onset.…”

Self-reported pain and osteoarthritis of the hip and spine in retired elite rowers by Baynham-Williams, M

“…No significant differences were found between rowing training duration or hatchet blade use in retired rowers with poor outcomes at the hip, spine or combined hip-spine. However, it is likely that this study was underpowered to detect statistical differences. …”

Cost-utility analysis of molnupiravir plus usual care versus usual care alone as early treatment for community-based adults with COVID-19 and increased risk of adverse outcomes in... by Png, ME, Harris, V, Grabey, J, Hart, ND, Jani, BD, Butler, D, Carson-Stevens, A, Coates, M, Cureton, L, Dobson, M, Dorward, J, Evans, P, Francis, N, Gbinigie, OA, Hayward, G, Holmes, J, Hood, K, Khoo, S, Ahmed, H, Lown, M, McKenna, M, Mort, S, Nguyen-Van-Tam, J, Rahman, N, Richards, DB, Thomas, N, van Hecke, O, Hobbs, FR, Little, P, Yu, L-M, Butler, CC, Petrou, S

“…Threshold analysis explored the price for molnupiravir consistent with likely reimbursement. <p><strong> Results </p></strong>In the base-case analysis, molnupiravir had higher mean costs of £449 (95% confidence interval [CI] = 445 to 453) and higher mean QALYs of 0.0055 (95% CI = 0.0044 to 0.0067) than usual care (mean incremental cost per QALY of £81 190). …”

Malaria elimination challenges in countries approaching the last mile: a discussion among regional stakeholders by Lek, D, Shrestha, M, Lhazeen, K, Tobgyel, T, Kandel, S, Dahal, G, Ghimire, YC, Shrestha, B, Ghimire, P, Hein, PS, Peto, TJ, Callery, JJ, Tripura, R, von Seidlein, L, Amaratunga, C, Lynch, CA, Dondorp, AM, Adhikari, B

“…The National Center for Parasitology, Entomology and Malaria Control (CNM) worked with stakeholders to contain the outbreak, which was likely to have originated in forest goers. Community-based village malaria workers (VMWs) were augmented with the additional resources required to test and treat malaria among forest goers under the supervision of health centres and district hospitals. …”

Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis by Shan, D, Wang, C, Crawford, T, Holland, C

“…Discussion: Under normal circumstances, we believe that COVID-19 infection is likely to be a risk factor for developing NOD in older adults over time. …”

Place-based household vouchers for locally supplied fruit and vegetables: the Fresh Street pilot cluster randomised controlled trial by Relton, C, Blake, MK, Bridge, G, Umney, D, Taylor, SJC, Adams, J, Mihaylova, B, Griffiths, C, Hooper, R, Phillips, R, Palmer, L, Gamston, A, Williamson, K

“…Background: Households in areas of socio-economic deprivation are more likely to consume diets low in fruit and vegetables. …”

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions by Sun, J, Aikawa, M, Ashktorab, H, Beckmann, ND, Enger, ML, Espinosa, JM, Gai, X, Horne, BD, Keim, P, Lasky-Su, J, Letts, R, Maier, CL, Mandal, M, Nichols, L, Roan, NR, Russell, MW, Rutter, J, Saade, GR, Sharma, K, Shiau, S, Thibodeau, SN, Yang, S, Miele, L, NIH Researching COVID to Enhance Recovery (RECOVER) Consortium

“…PASC has highly variable clinical presentations, and likely includes multiple molecular subtypes, but it remains poorly understood from a molecular and mechanistic standpoint. …”

Taxonomic significance of pollen, anatomical and morphological characteristics of red and green leaves Christia vespertilionis (L.f.) Bakh. f. (Fabaceae) by Talip, Noraini, Che Amri, Che Nurul Aini, Abdul Rahman, Mohamad Ruzi, Ahmad Juhari, Muhammad Amirul Aiman, Ghazalli, Mohd. Norfaizal, Zohari, Ahmad Fitri, Bunawan, Hamidun

“…In conclusion, this study proves that green and red leafy C. vespertilionis are likely different species, subspecies or varieties and accordingly a status study should be done on both green and red leafy to see their taxonomic position.…”
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Studies of seed-borne fungi of tropical pasture legume species by Nik, WZ, Parbery, DG

“…Abnormal and damaged seed were the most likely to carry pathogens and other fungi.…”

Indoor air quality in laboratories and its relationship with psychological performance among university students in Malaysia by Nazman, Muhammad, Mohd Hatta, Puteri Balqis, Suhaimi, Nur Faseeha

“…Students exposed to these conditions were 1.3 times more likely to experience distress (OR=1.3). Conclusion: Specific IAQ parameters, particularly CO and temperature, critically impact students’ psychological well-being. …”
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Assessing the role of internal phosphorus recycling on eutrophication in four lakes in China and Malaysia by Tay, Chai Jian, Koh, Hock Lye, Mohd Hafiz, Mohd, Teh, Su Yean

“…At moderate IPR, Sunway Lagoon is likely to exhibit stable equilibrium, accompanied by possible shifting between two stable steady states (hysteresis behaviour) and oscillations. …”
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Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor α via distinct mechanisms by Sun, Yang, Chung, Hwa Hwa, Woo, Amanda Rui En, Lin, Valerie C.-L.

“…In conclusion, PRMT6 requires its methyltransferase activity to enhance ERα's ligand-induced activity, but its effect on ligand-independent activity is likely mediated through competing with Hsp90 for binding to the C-terminal domain of ERα. …”
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Fluid fluxing and accumulation drive decadal and short-lived explosive basaltic andesite eruptions preceded by limited volcanic unrest by Utami, Sri Budhi, Costa, Fidel, Lesage, Ph., Allard, P., Humaida, H.

“…The textures and compositional zoning of orthopyroxene and plagioclase do not support intrusion of more primitive magma as the driver for the eruption, and we instead propose that pre-eruptive fluid accumulation and hightemperature fluid fluxing from depth (likely dominated by CO2) played a major role in priming the eruption to occur. …”
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A 15-year review of dengue hospitalizations in Singapore : reducing admissions without adverse consequences, 2003 to 2017 by Ang, Li Wei, Thein, Tun-Linn, Ng, Yixiang, Boudville, Irving Charles, Chia, Po Ying, Lee, Vernon Jian Ming, Leo, Yee-Sin

“…Further studies are needed to optimize dengue management in older adults who are more likely to be hospitalized with greater disease severity, given the higher proportions of hospitalizations and severe disease among older adults.…”
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Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility by Kurochkin, Igor V., Alkuraya, Fowzan S., Iwasa, Hiroyasu, Akita, Masumi, Tsukui, Tohru, Ito, Chizuru, Shimozawa, Nobuyuki, Iseki, Mioko, Mizuno, Yumi, Ninomiya, Yuichi, Nakachi, Yutaka, Toshimori, Kiyotaka, Nishimukai, Megumi, Hara, Hiroshi, Maeba, Ryouta, Okazaki, Tomoki, Alodaib, Ali Nasser Ali, Amoudi, Mohammed Al, Jacob, Minnie, Horai, Yasushi, Watanabe, Mitsuhiro, Motegi, Hiromi, Wakana, Shigeharu, Noda, Tetsuo, Mizuno, Yosuke, Schönbach, Christian, Okazaki, Yasushi

“…These phenotypic features are most likely the result of changes in the molecular species composition of choline and ethanolamine plasmalogens. …”
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Development and Application of a Data-Driven Signal Detection Method for Surveillance of Adverse Event Variability Across Manufacturing Lots of Biologics by Wilde, Joshua T., Springs, Stacy, Wolfrum, Jacqueline M., Levi, Retsef

“…Additionally, HMMScan indicates the particular lots most likely to be related to risky states of the manufacturing or supply chain condition. …”
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Insights from an Experiment Crowdsourcing Data from Thousands of US Amazon Users: The importance of transparency, money, and data use by Berke, Alex, Mahari, Robert, Pentland, Sandy, Larson, Kent, Calacci, Dana

“…Age, race, education, and gender also played a role, where female and less-educated participants were more likely to share. Our study design enables a unique empirical evaluation of the &#8220;privacy paradox&#8221;, where users claim to value their privacy more than they do in practice. …”
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Facilitating gamified lower-extremity rehabilitation through novel VR MI-BCI system by Pramotedham, Chavalit

“…Additionally, while the difference in BCI performance in VR vs. 2D was not deemed to be statistically significant (p = 0.38), this is likely due to the extremely small sample size (n = 12) within this preliminary study. …”
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