Structure of the C-terminal domain of the multifunctional ICP27 protein from herpes simplex virus 1 by Nordlund, Par, Patel, Vidhi, Dahlroth, Sue-Li, Rajakannan, Venkatachalam, Ho, Hai Ting, Cornvik, Tobias

“…The structure reveals the C-terminal half of ICP27 to have a novel fold consisting of -helices and long loops, along with a unique CHCC-type of zinc-binding motif. …”
Get full text
Get full text

Electric field modulation of the tetragonal domain orientation revealed in the magnetic ground state of quantum paraelectric EuTiO3 by Kato, Y., Sunku, S. S., Ito, T., Spalek, L., Shimuta, M., Katsufuji, T., Saxena, S. S., Batista, Cristian D., Petrovic, A. P., Sengupta, Pinaki, Panagopoulos, Christos

“…Signatures of metastability are visible in the heat capacity below the cubic-tetragonal phase transition at 283 K, supporting the evidence for a mismatch between long and short range structural order from previous x-ray diffraction studies. …”
Get full text
Get full text

Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells by Zhu, Pengcheng, Tong, Benny Meng Kiat, Wang, Runze, Chen, Jiapeng, Foo, Selin, Chong, Han Chung, Wang, Xiao Ling, Ang, Gim Yean, Chiba, Shunsuke, Tan, Nguan Soon

“…Although endoperoxide-containing compounds have long been suggested as anticancer drugs, few have been clinically employed due to their instability, complex synthesis procedure or low tumor cell selectivity. …”
Get full text
Get full text

High-protein, low-glycaemic meal replacement improves physical health-related quality of life in high-risk persons for metabolic syndrome—a subanalysis of the randomised-controlled... by Kempf, Kerstin, Röhling, Martin, Banzer, Winfried, Braumann, Klaus-Michael, Halle, Martin, Schaller, Nina, McCarthy, H. David, Predel, Hans-Georg, Schenkenberger, Isabelle, Tan, Susanne, Toplak, Hermann, Martin, Stephan, Berg, Aloys

“…Stronger improvements in the physical component summary (PCS) were observed in the intervention compared to the control group, peaking after 3 months (estimated treatment difference 2.7 [1.2; 4.2]; p 0.0001), but also in the long-term. Multiple regression analysis demonstrated that insulin levels and the achieved weight loss were associated with the mental component summary (MCS) after 12 months (p 0.05). …”
Get full text

Seizure amelioration effect of omega-3 EPA and DHA fatty acid supplementation on patients with drug resistant epilepsy: a scoping review using the GOED clinical study database by Abuknesha, Nada R., Searle, Andrew J.

“…Additional RCTs are required to determine the optimal dosage for patients, the effect of long-term treatment duration and separately enriched preparations of EPA/DHA on seizure frequency and severity.…”
Get full text

An update of a systematic review and meta-analyses exploring flavours in intervention studies of e-cigarettes for smoking cessation by Lindson, N, Livingstone-Banks, J, Butler, A, Levy, D, Barnett, P, Theodoulou, A, Notley, C, Rigotti, N, Chen, Y, Hartmann-Boyce, J

“…One included study randomised participants to two different flavour conditions and found similar cessation rates and long-term e-cigarette use between arms at 12 months. …”

中国成年人文化程度与体格指标的长期变化关系 by Tan, Y, Shen, Z, Yu, C, Guo, Y, Bian, Z, Pei, P, Du, H, Chen, J, Chen, Z, Lyu, J, Li, L

“…<p><b>Objective: </b>To evaluate the association of educational level with anthropometric measurements at different adult stages and their long-term changes in adults who participated in the second re-survey of China Kadoorie Biobank (CKB).…”

Field relations, petrogenesis and emplacement of the Bhagirathi leucogranite, Garhwal Himalaya by Searle, M, Metcalfe, RP, Rex, AJ, Norry, MJ

“…</p> <p>The northward-dipping Bhagirathi leucogranite was intruded syn-tectonically during the ductile to brittle transition and has been deformed into linked, en echelon bodies within the extensional shear zone at the interface between the Vaikrita Group gneisses and the Tethyan sedimentary cover. The long axes of the leucogranite lenses lie parallel to the y-z plane of the finite strain ellipsoid for this extensional duplex. …”

Signal processing for next generation coriolis flow metering by Li, M

“…Two/multi-phase flow metering is a long established problem in many applications (e.g. the oil &amp; gas, chemical, biotech, pharmaceutical industries) and no perfect solution is available. …”

Mobile health (mHealth) interventions for health promotion during the perinatal period in India: a scoping review by Small, Z, Thompson, SE, Sharma, A, Majumdar, S, Thout, SR, Praveen, D, Hirst, JE

“…However, current interventions lack evidence of long term behavioural change and fail to report on features important in sustainability and scalability, namely network infrastructure, data security and interoperability. …”

The prognostic impact of minimally invasive esophagectomy on survival after esophagectomy following a delayed interval after chemoradiotherapy; a secondary analysis of the DICE stu... by Markar, SR, Sgromo, B, Evans, R, Griffiths, EA, Alfieri, R, Castoro, C, Gronnier, C, Gutschow, CA, Piessen, G, Capovilla, G, Grimminger, PP, Low, DE, Gossage, J, Gisbertz, SS, Ruurda, J, van Hillegersberg, R, D'journo, XB, Phillips, AW, Rosati, R, Hanna, GB, Maynard, N, Hofstetter, W, Ferri, L, Berge Henegouwen, MI, Owen, R

“…<p><strong> Background: </strong></p> Previously, we established that a prolonged interval after CRT prior to esophagectomy was associated with poorer long-term survival.<p><strong> Methods: </strong></p> This was an international multi-center cohort study involving seventeen tertiary centers, including patients who received CRT followed by surgery between 2010-2020. …”

“Encouraged to be your true self”: an interpretative phenomenological study of medical students’ experiences of role models in shaping sexual minority identity at medical school... by Zacharias, A, Aitken, D

“…Greater explicit institutional support of studentled SM societies, and facilitation of the presence and discussion of SM symbols and personal identities within professional spaces, may go a long way in redefining ‘normativity’ in medical schools.…”

Analyses of human vaccine-specific circulating and bone marrow-resident B cell populations reveal benefit of delayed vaccine booster dosing with blood-stage malaria antigens by Barrett, JR, Silk, SE, Mkindi, CG, Kwiatkowska, KM, Hou, MM, Lias, AM, Kalinga, WF, Mtaka, IM, McHugh, K, Bardelli, M, Davies, H, King, LDW, Edwards, NJ, Chauhan, VS, Mukherjee, P, Rwezaula, S, Chitnis, CE, Olotu, AI, Minassian, AM, Draper, SJ, Nielsen, CM

“…Notably, a higher frequency of vaccine-specific (putatively long-lived) plasma cells was detected in the bone marrow of these delayed boosting vaccinees by ELISPOT and correlated strongly with serum IgG. …”

Blind quantum computing with trapped ions and single photons by Drmota, P

“…</p> <br> <p>Our experimental platform consists of a trapped-ion quantum server and a client-side photonic detection system networked via a fibre-optic quantum link. We integrate a long-lived memory qubit into a trapped-ion quantum network node to enable simultaneous storage and manipulation of multiple entangled states across a network of quantum processors. …”

Ultra-thin oxide films by Hu, X

“…Special attention has been paid to the uniform (2 × 2) Ti₂O₃ HC phase including its regular structure and imperfections such as domain boundaries (DBs) and point defects. Linear DBs with long-range repeating units have been observed; density functional theory (DFT) modelling has been used to simulate their atomic structures and calculate their formation energies. …”

Self-reported pain and osteoarthritis of the hip and spine in retired elite rowers by Baynham-Williams, M

“…Little research has investigated the long-term effects of rowing participation on the musculoskeletal health and risk of OA in rowers. …”

Qualitative evaluation of the implementation and national roll-out of the NHS App in England by Reidy, C, Papoutsi, C, KC, S, Gudgin, B, Laverty, AA, Greaves, F, Powell, J

“…NHS staff viewed the app as constituting core NHS infrastructure in the long term which made it appealing, even though initially there was less recognition of its immediate value. …”

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions by Sun, J, Aikawa, M, Ashktorab, H, Beckmann, ND, Enger, ML, Espinosa, JM, Gai, X, Horne, BD, Keim, P, Lasky-Su, J, Letts, R, Maier, CL, Mandal, M, Nichols, L, Roan, NR, Russell, MW, Rutter, J, Saade, GR, Sharma, K, Shiau, S, Thibodeau, SN, Yang, S, Miele, L, NIH Researching COVID to Enhance Recovery (RECOVER) Consortium

“…Post-Acute Sequelae of SARS-CoV-2 infection (PASC or “Long COVID”), includes numerous chronic conditions associated with widespread morbidity and rising healthcare costs. …”

Estimating risk factor time paths among people with Type 2 Diabetes and QALY gains from risk factor management by Gao, N, Dakin, HA, Holman, RR, Lim, L-L, Leal, J, Clarke, P

“…</p> <br> <p><strong>Discussion:</strong> Incorporating updated risk factor time path equations into diabetes simulation models could give more accurate predictions of long-term health, costs, QALYs and cost-effectiveness estimates, as well as a more precise understanding of the impact of diabetes on patients’ health, expenditure and quality of life.…”

Co-application of inorganic fertilizers with charcoal and sago bark ash to improve soil nitrogen availability, uptake, use efficiency, and dry matter production of sorghum cultivat... by Hamidi, Nur Hidayah, Ahmed, Osumanu Haruna, Omar, Latifah, Ch’ng, Huck Ywih, Johan, Prisca Divra, Paramisparam, Puvan, Musah, Adiza Alhassan, Jalloh, Mohamadu Boyie

“…Although the effects of co-applying charcoal and sago bark ash on soil total N were not glaring, this practice increased soil pH and total C, and reduced exchangeable acidity and Al3+. A long-term field study is recommended to confirm the effects of co-applying inorganic fertilizers with charcoal and sago bark ash on sorghum productivity, economic viability, and soil nutrient residual effects.…”
Get full text