Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration by James, Rachel E., Schalks, Renee, Browne, Eleanor, Eleftheriadou, Ioanna, Munoz, Carmen Picon, Mazarakis, Nicholas D., Reynolds, Richard

“…Here we tested the hypothesis that persistent production of these cytokines in the meningeal compartment and diffusion into underlying GM can drive chronic MS-like GM pathology. Lentiviral transfer vectors were injected into the sagittal sulcus of DA rats to deliver continuous expression of TNF + IFNγ transgenes in the meninges and the resulting neuropathology analysed after 1 and 2 months. …”
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Local rainfall is more likely than distant thunderstorms to affect movement behaviour in Northern Kenyan elephants by Mulder, T, Mortimer, B, Ferwerda, J, Vollrath, F

“…We conclude that climate change makes a strong case for studying elephant behaviours in response to environmental cues during the day and night, especially in dry-land study sites like Northern Kenya.…”

Enriching the methanol generation via CO2 photoconversion over the cockscomb-like fibrous silica copper by Mahadi, Bahari, Che Rozid, Mamat, Aishah, Abdul Jalil, Shing, Lo Sook, Nurul Sahida, Hassan, F. F.A., Aziz, Alhassan, Mansur, Mohd Ghazali, Mohd Nawawi, Kamarizan, Kidam, Herma Dina, Setiabudi

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Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors by Luo, Dahai

“…The RIG-I-like receptors (RLRs)—RIG-I, MDA5, and LGP2—detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. …”
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Chrysanthemum-like Au@Polydopamine synthesized using one-pot method and its advantage in immunochromatographic assay by Zhang, Gang-gang, Lai, Xiao-cui, Ding, Neng-shui, Xiong, Qirong, Hou, Shuai, Duan, Hongwei, Lai, Wei-hua

“…Flower-like gold nanoparticle (AuNF) is widely used as a probe. …”
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Functional characterization of plasmodium falciparum reticulocyte binding like protein homologue 1 (PfRH1) by Yap, Sally Shu Lin

“…One of the protein families involved in invasion, reticulocyte binding like protein homologues (PfRHs) has been suggested to be involved in host cell selection. …”
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Genes for carnivory : a comparative study on the local duplication of papain-like cysteine proteases in carnivorous plants by Tan, Qiao Wen

“…Thus, the presence of protein degrading enzymes such as papain-like cysteine proteases (PLCPs) in trap fluids is not surprising. …”
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Bio-inspired Flow Sensing and Prediction for Fish-like Undulating Locomotion: A CFD-aided Approach by Zhou, Han, Hu, Tianjiang, Low, Kin Huat, Shen, Lincheng, Ma, Zhaowei, Wang, Guangming, Xu, Haijun

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Functional comparison of human Adenomatous Polyposis Coli (APC) and APC-like in targeting beta-catenin for degradation by Schneikert, Jean, Chandra, Shree Harsha Vijaya, Ruppert, Jan Gustav, Ray, Suparna, Wenzel, Eva Maria, Behrens, Jürgen

“…Using RNA interference and domain swapping experiments, we show that APCL benefits from the 15R of truncated APC to target β-catenin for degradation, in a process likely involving heterodimerization of the two partners. …”
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GOLDEN2-like1 is sufficient but not necessary for chloroplast biogenesis in mesophyll cells of C4 grasses by Lambret-Frotte, J, Smith, G, Langdale, J

“…In land plants, chloroplast biogenesis is regulated by a family of transcription factors named GOLDEN2-like (GLK). In C4 grasses, it has been hypothesized that genome duplication events led to the sub-functionalization of GLK paralogs (GLK1 and GLK2) to control chloroplast biogenesis in two distinct cell types: mesophyll and bundle sheath cells. …”

Finding and performing an efficient rigging production workflow for 3D which can be transferred to different aspects apart from character rigging by Oen, Nicholas Weng Wah

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Re-thinking arts engagement in COVID-19: findings from a hybrid-delivered participatory arts intervention for Singapore's older adults by Yam, Jodie

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Characterization on three-dimensional trajectory of disk-like gold-nickel-platinum nanomotor using digital holographic imaging by Hu, Liangxing, Rehman, Shakil, Tao, Kai, Miao, Jianmin

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Ligand-specific factors influencing GLP-1 receptor post-endocytic trafficking and degradation in pancreatic beta cells by Fang, Zijian, Chen, Shiqian, Manchanda, Yusman, Bitsi, Stavroula, Pickford, Philip, David, Alessia, Shchepinova, Maria M., Corrêa, Ivan R., Jr., Hodson, David J., Broichhagen, Johannes, Tate, Edward W., Reimann, Frank, Salem, Victoria, Rutter, Guy A., Tan, Tricia, Bloom, Stephen R., Tomas, Alejandra, Jones, Ben

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Intensity of stress singularity for the circumferential V-shape corner front of a three-dimensional diamond-like defect by Ping, X. ., Zhang, Y. X., Guo, Y. B., Xiao, Z. M., Jalde, J., Chen, M. C.

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Effect of solvent state and isothermal conditions on gelation of methylcellulose hydrogels by Joshi, Sunil Chandrakant, Liang, C. M., Lam, Yee Cheong

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The natural rate of output, supply-side potential and the long-term sustainable growth band for the Singapore economy by Joseph Edison Junior

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Long-term effects of early life rainfall shocks on foundational cognitive skills: evidence from Peru by Pazos, N, Favara, M, Sánchez, A, Scott, D, Behrman, J

“…Global warming is changing precipitation patterns, particularly harming communities in low-and-middle income countries (LMICs). Whilst the long-term effects of being exposed to rainfall shocks early in life on school-achievement tests are well-established, there is little population-based evidence from LMICs on the mechanisms through which these shocks operate. …”

Proposed Design for Electromechanical Telescoping Actuator to Replace Hydraulics in Extreme High Force and Long Stroke Applications by Sleight Crawford, Carmen, Smyk, Mariia, Cheung, Sophia, Coughran, Doug, Costello, Jeffrey, Liang, ZhiYi, Winter, Amos G

“…Our group was able to successfully develop and evaluate the design and build a scaled-down prototype that could likely serve as a direct replacement for currently used long-stroke high-force hydraulics. …”
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Long Covid: a global health issue – a prospective, cohort study set in four continents by Pazukhina, E, Garcia-Gallo, E, Reyes, LF, Kildal, AB, Jassat, W, Dryden, M, Holter, JC, Chatterjee, A, Gomez, K, Søraas, A, Puntoni, M, Latronico, N, Bozza, FA, Edelstein, M, Gonçalves, BP, Kartsonaki, C, Kruglova, O, Gaião, S, Chow, YP, Doshi, Y, Duque Vallejo, SI, Ibáñez-Prada, ED, Fuentes, YV, Hastie, C, O'Hara, ME, Balan, V, Menkir, T, Merson, L, Kelly, S, Citarella, BW, Semple, MG, Scott, JT, Munblit, D, Sigfrid, L

“…<p><strong>Introduction </p></strong>A proportion of people develop Long Covid after acute COVID-19, but with most studies concentrated in high-income countries (HICs), the global burden is largely unknown. …”