Granulocyte-macrophage colony-stimulating factor neutralisation in patients with axial spondyloarthritis in the UK (NAMASTE): a randomised, double-blind, placebo-controlled, phase... by Worth, C, Al-Mossawi, MH, MacDonald, J, Fisher, BA, Chan, A, Sengupta, R, Packham, J, Gaffney, K, Gullick, N, Cook, JA, Corn, TH, Teh, J, Machado, PM, Taylor, PC, Bowness, P

“…<p><strong>Methods</p></strong> This proof-of-concept, randomised, double-blind, placebo-controlled, phase 2, Bayesian (NAMASTE) trial was done at nine hospitals in the UK. Participants aged 18–75 years with axial spondyloarthritis, meeting the Assessment in SpondyloArthritis international Society (ASAS) criteria and the ASAS-defined MRI criteria, with active disease as defined by a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), were eligible. …”

History education for transitional justice: how students understand and construct historical legacies in the post-apartheid South African history classroom by Robinson, N

“…</p> <p>This dissertation focuses on how young South Africans learn to construct legacies of historical injustices in the context of their history classrooms. It draws on nine months of ethnographic research in four Grade 9 history classrooms in Cape Town, each with a different racial composition. …”

Magrolimab in combination with azacitidine in patients with higher-risk myelodysplastic syndromes: final results of a phase Ib study by Sallman, DA, Al Malki, MM, Asch, AS, Wang, ES, Jurcic, JG, Bradley, TJ, Flinn, IW, Pollyea, DA, Kambhampati, S, Tanaka, TN, Zeidner, JF, Garcia-Manero, G, Jeyakumar, D, Komrokji, R, Lancet, J, Kantarjian, HM, Gu, L, Zhang, Y, Tan, A, Chao, M, O'Hear, C, Ramsingh, G, Lal, I, Vyas, P, Daver, NG

“…Revised International Prognostic Scoring System risk was intermediate/high/very high in 27%, 52%, and 21%, respectively. Fifty-nine (62%) had poor-risk cytogenetics and 25 (26%) had TP53 mutation. …”

Anticholinergic burden and cognitive function in psychosis: a systematic review and meta-analysis by Mancini, V, Latreche, C, Fanshawe, J, Varvari, I, Chambrez-Zita, Z, McGinn, N, Ana, C, Pillinge, T, McGuire, PK, McCutcheon, RA

“…</p> <p><strong>Results:</strong> Of 1,337 citations retrieved, 40 met inclusion criteria, comprising 25 anticholinergic burden studies (4,620 patients), six serological anticholinergic activity studies (382 patients), and nine tapering studies (186 patients). A negative correlation was identified between anticholinergic burden and global cognition (r=−0.37, 95% CI=−0.48, −0.25), verbal learning (r=−0.28, 95% CI=−0.36, −0.21), visual learning (r=−0.17, 95% CI=−0.28, −0.06), working mem- ory (r=−0.22, 95% CI=−0.29, −0.14), processing speed (r=−0.24, 95% CI=−0.35, −0.13), attention (r=−0.19, 95% CI=−0.29, −0.08), executive functions (r=−0.17, 95% CI=−0.27, −0.06), and social cognition (r=−0.12, 95% CI=−0.19, −0.05), and between serological anticholinergic activity and verbal learning (r=−0.26, 95% CI=−0.38, −0.14), working memory (r=−0.19, 95% CI=−0.35, −0.03), and executive functions (r=−0.16, 95% CI=−0.27, −0.04). …”

Virulence gene profiles and antimicrobial susceptibility of Salmonella Brancaster from chicken by Khoo, Evie, Roslee, Roseliza, Zakaria, Zunita, Ahmad, Nur Indah

“…Antimicrobial susceptibility assessment was conducted by disc diffusion method on nine selected antibiotics for the S. Brancaster isolates. …”
Get full text

21W.742J / SP.575J / WGS.575J Writing About Race, Spring 2003 by Faery, Rebecca Blevins

“…Du Bois wrote that "…the problem of the Twentieth Century is the problem of the color line." A century after Du Bois penned those words, most Americans would agree that at the beginning of the twenty-first century, the color line remains one of our most pressing social issues. …”
Get full text

Emergence of spatio-temporal variations in chemotherapeutic drug efficacy : in-vitro and in-silico 3D tumour spheroid studies by Sheraton, Muniraj Vivek, Chiew, Geraldine Giap Ying, Melnikov, Valentin, Tan, E. Y., Luo, K. Q., Verma, N., Sloot, Peter M. A.

Get full text

Deep learning based solder joint defect detection on industrial printed circuit board X-ray images by Zhang, Qianru, Zhang, Meng, Gamanayake, Chinthaka, Yuen, Chau, Geng, Zehao, Jayasekara, Hirunima, Woo, Chia-wei, Low, Jenny, Liu, Xiang, Guan, Yong Liang

“…With the improvement of electronic circuit production methods, such as reduction of component size and the increase of component density, the risk of defects is increasing in the production line. Many techniques have been incorporated to check for failed solder joints, such as X-ray imaging, optical imaging and thermal imaging, among which X-ray imaging can inspect external and internal defects. …”
Get full text

PARP1 resolves DNA replication defects in PCNA-associated DNA repair disorder by Wang, L

“…</p> <p>An isogenic PCNAS^228I knock-in hTERT RPE-1 cell line was generated using CRISPR-Cas9 technique. Phenotypes observed in patient-derived cells were recapitulated in the knock-in cell line. …”

Predicting the work function of 2D MXenes using machine-learning methods by Roy, Pranav, Rekhi, Lavie, Koh, See Wee, Li, Hong, Choksi, Tej S.

“…MXenes, which are graphene-like two-dimensional transition metal carbides and nitrides, have tunable compositions and exhibit rich surface chemistry. …”
Get full text

E2 protein nanocage as a pickering emulsifier and its applications by Sarker, Mridul

“…The increase in oil fraction in the emulsion composition results in the formation of gel-like structure. The rheological analysis of Pickering emulsion and gel-like structure confirmed the higher mechanical strength, long-term stability and elasticity of the gel-like structure compared to the emulsion. …”
Get full text

Japan's quest for security by Satake, Tomohiko

“…Japan has sought to break away from its previous low-profile security posture and to strengthen its defence capabilities through strategic use of military assets and supply lines, advanced technologies, economic security, and partnerships with like-minded countries.…”
Get full text

A comparative analysis of ENCODE and Cistrome in the context of TF binding signal by Perna, Stefano, Pinoli, Pietro, Ceri, Stefano, Wong, Limsoon

“…Results: We provide evidence that data points with high signalValue(s) (top 25% of values) are more likely to be consistent between ENCODE and Cistrome in human cell lines K562, GM12878, and HepG2. …”
Get full text

Ultrafast Terahertz Spectroscopy for the Manipulation and Elucidation of Correlated Quantum Materials by Allington, Clifford

“…To this end, experimental efforts to demonstrate and understand the interplay between different degrees of freedom in a material (spin, charge, lattice, and orbital) are essential for progressing in this direction. …”
Get full text

Optical characteristics of p-type GaAs-based semiconductors towards applications in photoemission infrared detectors by Lao, Y. F., Perera, A. G. U., Wang, H. L., Zhao, J. H., Jin, Y. J., Zhang, Dao Hua

“…The hole transition from the heavy-hole (HH) band to the spin-orbit split-off (SO) band has demonstrated potential applications for 3–5 μm detection without the need of cooling. …”
Get full text
Get full text

Love, Lucie x / by Conlon-McKenna, Marita, author 539569

“…Lucie feels like her world is falling apart; her mother has just died of cancer and she is facing the most difficult time of her life. …”

Our Tethered Skates / by Naadhira Zahari, author 655828, Naadhira Zahari, editor 655828

“…Will she succeed as the warrior like her predecessors? Or will she crumble under all the pressure?…”

Towards natural and realistic E7 GUTs in F-theory by Li, Shing Yan, Taylor, Washington

“…We consider phenomenological aspects of a natural class of Standard Model-like supersymmetric F-theory vacua realized through flux breaking of rigid E7 gauge factors. …”
Get full text

Prediction of future customer requirements and application in product planning by Liu, Guan Cheng.

“…A prototype framework is then proposed for an investigation into a more methodical way of modeling and forecasting qualitative CR types, which up till now have been forecasted using tools like market research. This framework incorporates the use of the quantitative techniques as well as non-CR related qualitative techniques like genetic algorithms. …”
Get full text

Mathematical modelling of a crop irrigation problem by Lye, Wei De

“…Over the years of technological advancement, human-induced factors like Urbanisation and Industrialisation have been developing at a rate ever faster than before. …”
Get full text