Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus by Tam, Zhi Yang, Ng, Sean Pin, Tan, Ling Qiao, Lin, Chih-Hsien, Rothenbacher, Dietrich, Klenk, Jochen, Boehm, Bernhard Otto, Goh, Kelvin Kau Kiat, Suwanchaikasem, Pipob, Tipthara, Pornpimol, Koenig, W., Riepe, M., Peter, R., Geiger, H., Ludolph, A., Arnim, C. v., Denkinger, M. D., Yang, Song Yi, Nagel, G., Weinmayr, G., Rapp, K., Dallmeier, D., Steinacker, J. M., Laszlo, R., Becker, T., Stingl, J.

Get full text
Get full text

Phase-controllable growth of ultrathin 2D magnetic FeTe crystals by Kang, Lixing, Ye, Chen, Zhao, Xiaoxu, Zhou, Xieyu, Hu, Junxiong, Li, Qiao, Liu, Dan, Das, Chandreyee Manas, Yang, Jiefu, Hu, Dianyi, Chen, Jieqiong, Cao, Xun, Zhang, Yong, Xu, Manzhang, Di, Jun, Tian, Dan, Song, Pin, Kutty, Govindan, Zeng, Qingsheng, Fu, Qundong, Deng, Ya, Zhou, Jiadong, Ariando, Ariando, Miao, Feng, Hong, Guo, Huang, Yizhong, Pennycook, Stephen J., Yong, Ken-Tye, Ji, Wei, Wang, Renshaw Xiao, Liu, Zheng

Get full text

The impact of death and dying on the personhood of medical students : a systematic scoping review by Ho, Chong Yao, Kow, Cheryl Shumin, Chia, Joshua Chin Howe, Low, Jia Ying, Lai, Melvin Yong Hao, Lauw, Sarah-Kei, How, Ashley Ern Hui, Tan, Lorraine Hui En, Ngiam, Lisa Xin Ling, Chan, Natalie Pei Xin, Kuek, Joshua Tze Yin, Nur Haidah Ahmad Kamal, Chia, Jeng Long, Ahmad Hanifah Marican Abdurrahman, Chiam, Min, Ong, Yun Ting, Chin, Annelissa Mien Chew, Toh, Ying Pin, Mason, Stephen, Krishna, Lalit Kumar Radha

Get full text

Synaptic plasticity in VLSI : a floating-gate approach by Gopalakrishnan, Roshan

“…Potentiation occurs when a postsynaptic spike succeeds a presynaptic spike; otherwise depression happens. …”
Get full text

SARS-CoV-2 evolution during treatment of chronic infection by Kemp, SA, Collier, DA, Datir, RP, Ferreira, IATM, Gayed, S, Jahun, A, Hosmillo, M, Rees-Spear, C, Mlcochova, P, Lumb, IU, Roberts, DJ, Chandra, A, Temperton, N, Sharrocks, K, Blane, E, Modis, Y, Leigh, KE, Briggs, JAG, van Gils, MJ, Smith, KGC, Bradley, JR, Smith, C, Doffinger, R, Ceron-Gutierrez, L, Barcenas-Morales, G, Pollock, DD, Goldstein, RA, Smielewska, A, Skittrall, JP, Gouliouris, T, Goodfellow, IG, Gkrania-Klotsas, E, Illingworth, CJR, McCoy, LE, Gupta, RK

“…The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2 protein1 and is a major antibody target. …”

A systems biology approach to define SARS-CoV-2 correlates of protection in non-human primates by Brady, C

“…The relationship between spike antibody isotype, IgG subclass, glycosylation and functional responses, and the relationship between these properties and protection, was explored. …”

Existence and Analysis of a Rotating Stall Inception Continuum & Development of Concept Questions in Fluid Dynamics by Cherry, Maranda F.

“…The divergence of stall inception from two-dimensionality is suggested as a distinguishing feature of spike type stall inception compared to modal type stall inception. …”
Get full text

Discovery of COVID-19 protein inhibitors in phenolic acids of azadirachta indica (neem) using docking and pharmacokinetics by Roney, Miah, Huq, AKM Moyeenul, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…The most attractive antiviral targets of SARS-CoV-2 are the spike protein and main protease (Mpro). In this work, sixteen phenolic acids of Azadirachta indica were docked into the active site of the spike protein and Mpro. …”
Get full text

B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination by Kotagiri, P, Mescia, F, Rae, WM, Bergamaschi, L, Tuong, ZK, Turner, L, Hunter, K, Gerber, PP, Hosmillo, M, Hess, C, Clatworthy, MR, Goodfellow, IG, Matheson, NJ, McKinney, EF, Wills, MR, Gupta, RK, Bradley, JR, Bashford-Rogers, RJM, Lyons, PA, Smith, KGC

“…Infection generates a broad distribution of SARS-CoV-2-specific clones predicted to target the spike protein, while a more focused response after vaccination mainly targets the spike's receptor-binding domain. …”

Improved margin multi-class classification using dendritic neurons with morphological learning by Hussain, Shaista, Liu, Shih-Chii, Basu, Arindam

“…We present an architecture of a spike based multiclass classifier using neurons with non-linear dendrites and sparse synaptic connectivity where each synapse takes a binary value. …”
Get full text
Get full text

Seroprevalence of SARS-CoV-2 in children and adolescents by Ratcliffe, H

“…The results showed a high prevalence of pre-existing immunity against seasonal coronaviruses when measuring IgG concentration of antibodies against spike protein but did not confer protection against SARS-CoV-2.…”

Numerical modelling of detonation reaction zone of nitromethane by EXPLO5 code and wood and kirkwood theory by Štimac, Barbara, Chan, Serene Hay Yee, Kunzel, Martin, Muhamed Suceska

“…The measured particle velocity profile of NM shows the existence of a sharp spike followed by a rapid drop over the first 5-10 ns (fast reaction). …”
Get full text

Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Chapter 4 focuses on the site-specific glycosylation occupancy, and N- and O-glycan structures attached to virion derived SARS-CoV-2 spike glycoproteins. This glycan signature was compared to a stabilised prefusion trimeric spike, to a monomeric subunit of spike (S1) and to an antigen of a non-stabilised vaccine candidate, revealing subunit shedding of the S1 glycoprotein for the vaccine candidate. …”

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…However, only the LRR-specific mAbs increased the number of action potential firing together with enhanced initial instantaneous frequency and promoted spike-frequency adaptation, which were less pronounced after the EPTP mAb. …”

Multiscale topological indices for the quantitative prediction of SARS CoV-2 binding affinity change upon mutations by Bi, Jialin, Wee, JunJie, Liu, Xiang, Qu, Cunquan, Wang, Guanghui, Xia, Kelin

“…Biologically, protein-protein interactions between SARS-CoV-2 surface spike (S) protein and human ACE2 protein are the key mechanism behind the COVID-19 disease. …”
Get full text

Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1) by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Tay, Matthew Zirui, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Lee, I. Russel, Rao, Suma, Chia, Po Ying, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee Sin, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

“…Results: We found significantly lower fold change in serum binding IgA responses against BA.1, BA.5 and EG.5.1 spike in the bivalent booster group, compared with the monovalent (WT) booster group, following vaccination. …”
Get full text

Towards a computer that functions like the human brain by Lee, Seow Wei

“…Spike-Timing-Dependent Plasticity and unsupervised learning in the network is researched in this report. …”
Get full text

Synaptic CMOS transistor by Chai, Zhen Hong

“…In this work, electrical measurements were conducted on commercial level TiN/HfO2 gated n-channel MOSFET transistor (with an equivalent oxide thickness of 1.7nm) to demonstrate that it can exhibit some critical synaptic characteristics of a biological synapse such as excitatory and inhibitory postsynaptic current (EPSC and IPSC), short-term plasticity (STP) and long-term potentiation (LTP), metaplasticity, and spike timing dependent plasticity (STDP). The mechanism behind the output characteristic of MOSFET to exhibit synaptic-like response is the charge trapping and de-trapping at defects in the oxide and oxide/semiconductor interface. …”
Get full text

A scalable variational inference approach for increased mixed-model association power by Loya, H, Kalantzis, G, Cooper, F, Palamara, PF

“…We developed Quickdraws, a method that increases association power in quantitative and binary traits without sacrificing computational efficiency, leveraging a spike-and-slab prior on variant effects, stochastic variational inference and graphics processing unit acceleration. …”

Dengue death rate higher among women than men in Bangladesh by Roney, Miah, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Given the atypical seasonality of the epidemic and the sudden spike in cases early on, it is noteworthy that mosquito and potential hotspot densities were at an all-time high throughout the previous years.…”
Get full text