Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds by Wamhoff, Eike-Christian, Ronsard, Larance, Feldman, Jared, Knappe, Grant A., Hauser, Blake M., Romanov, Anna, Case, James Brett, Sanapala, Shilpa, Lam, Evan C., Denis, Kerri J. St., Boucau, Julie, Barczak, Amy K., Balazs, Alejandro B., Diamond, Michael S., Schmidt, Aaron G., Lingwood, Daniel, Bathe, Mark

“…Here, we investigate thymus-independent DNA origami as an alternative material for multivalent antigen display using the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, the primary target of neutralizing antibody responses. …”
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Analysis and reduction of mismatch in silicon neurons by Shuo, Sun, Basu, Arindam

“…The method presented allows the corrected neurons to compute both rate codes and spike time codes in a mismatch resilient fashion…”
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Generation of self-replicating airway organoids from the cave nectar bat Eonycteris spelaea as a model system for studying host-pathogen interactions in the bat airway epithelium by Chan, Louisa L. Y., Gamage, Akshamal M., Tan, Chee Wah, Tan, Kai Sen, Liu, Jing, Tay, Douglas Jie Wen, Foo, Randy Jee Hiang, Rénia, Laurent, Wang, De Yun, Wang, Lin-Fa

“…However, these ALI-AECs did not support SARS-CoV-2 infection, despite E. spelaea ACE2 receptor being capable of mediating SARS-CoV-2 spike pseudovirus entry. This work provides critical model systems for assessing bat species-specific virus susceptibility and the reservoir likelihood for emerging infectious agents.…”
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Binuclear oxidative addition of Sb-Cl bonds : a facile synthetic route to main group transition element clusters and rings by Li, Ying-Zhou, Ganguly, Rakesh, Leong, Weng Kee

“…The analogous reaction of SbPhCl2 with 1, on the other hand, afforded the spiked triangular cluster Os3(CO)11(Cl)2(μ3-SbPh), 7, which also existed as two isomers. …”
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Analysing the effect of screw configuration using a stochastic twin-screw granulation model by McGuire, Andrew D., Mosbach, Sebastian, Reynolds, Gavin K., Patterson, Robert I. A., Bringley, Eric, Eaves, Nick, Dreyer, Jochen A. H., Kraft, Markus

“…However, the model has a tendency to over-predict the amount of fines in the final product. Nevertheless, the model qualitatively captures the reduction in fines associated with an increase in the number of kneading elements, as observed experimentally. …”
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Driving mechanism development for autonomous hospital bed by Tan, Jia Liang

“…Demand is foreseen to spike and a range of healthcare services that range from acute to community care is necessary for a holistic healthcare system. …”
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Development of a novel colorimetric immunoassay for C-Reactive Protein using colloidal nanoparticles by Tjitra, Niklas Lesmana

“…Colour changes in the assay from pinkish red to violet were observed and scaled with increasing CRP concentration. Upon CRP spiking at 1 µg mL-1, affimer-functionalized Au NPs showed improvement in sensitivity, and the LOD was calculated to be 0.2 µg mL-1. …”
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Media bias in Singapore in 2011 by Lee, Matthew Wenjun, Michell Devina Ngan, Park So Jin

“…Intuitively, the induced demand from readers of the paper could have spiked due to the spurred debate and increased diversity of motions propositioned between Members-of-Parliament during the novel year of the Opposition’s election to Parliament. …”
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Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, JN.1.4, and KP.3.1.1 using samples from two health demographic surveillance systems in K... by Lugano, D, Kutima, B, Kimani, M, Sigilai, A, Gitonga, J, Karani, A, Akech, D, Karia, B, Ziraba, AK, Maina, A, Lambisia, A, Omuoyo, D, Mugo, D, Lucinde, R, Owuor, S, Konyino, G, Newman, J, Bailey, D, Nduati, E, Githinji, G, Agoti, CN, Bejon, P, Scott, JAG, Agweyu, A, Warimwe, GM

“…The majority of these mutations mainly target the spike protein, allowing the new variants to escape the immunity previously raised by vaccination and/or infection by earlier variants of SARS-CoV-2. …”

An immunoinformatic approach for identifying and designing conserved multi-epitope vaccines for coronaviruses by Ong, Yu Chuan, Tejo, Bimo Ario, Yap, Wei Boon

“…Methods: This study utilized an immunoinformatic approach to identify evolutionarily conserved CD4+ (HTL) and CD8+ (CTL) T cells, and B-cell epitopes in the coronaviral spike (S) glycoprotein. Results: A total of 132 epitopes were identified, with the majority of them found to be conserved across the bat CoVs, pangolin CoVs, endemic coronaviruses, SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV). …”
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High wavenumber coherent structures in low re apg-boundary-layer transition flow—a numerical study by Lo, Edmond Yat-Man, Chen, Weijia

“…Both parts are imbedded at the primary Λ-vortex stage and spatially coincide with the spike region and high shear layer. The tip part is associated with the later first ring-like vortex, while the rear part with the remainder of the Λ-vortex. …”
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Unraveling the Dynamics of Mental and Visuospatial Workload in Virtual Reality Environments by Bernal, Guillermo, Jung, Hahrin, Yassı, İsmail Emir, Hidalgo, Nelson, Alemu, Yodahe, Barnes-Diana, Tyler, Maes, Pattie

“…Our findings indicate a broadband increase in EEG power just prior to a helper event, followed by a spike of visuospatial engagement (parietal alpha and beta 0-1-3 s) occurring concurrently with a decrease in mental workload (frontal theta 2–4 s), and subsequent decreases in visuospatial engagement (parietal theta at 14 s) and physiological arousal (HRV at 20 s). …”
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A high efficiency buck converter for IoT sensors by Mo, Mingwei

“…When the system is activated for data collection and processing, the load current may spike to tens of milliamperes. Thus, it's essential for the DC-DC converter to accommodate a broad spectrum of load currents, ensuring versatility and reliability in various operational states. …”
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Synaptic devices towards neuromorphic electronics by Datta, Indira

“…Area Transfer curves, gate voltage hysteresis loops, and multilevel resistance modulation were studied, and biological functions including long-term potentiation and Depression (LTP and LTD), Excitatory and Inhibitory Postsynaptic Current (EPSC and IPSC), Spike Amplitude and Duration Dependent Plasticity (SADP and SDDP), Paired Pulse Facilitation and Depression (PPF and PPD), and repeated learning and forgetting curves were emulated by our novel device. …”
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Modeling of functional materials : perovskite solar cells by Aruj Shukla

“…However, for a more holistic analysis of perovskite light harvesters as replacement to the existing TiO2 nano particles, a more nuanced modeling and analysis which incorporates a study of transport properties such as trapping effects (for further spike in efficiency), photo catalytic reaction kinetics and surface & bulk defects (for easier fabrication) is demanded as an integral part of future research plans.…”
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The impacts of US Fed interest rate liftoff on Southwest Asia stock markets, sovereign bond and currencies by Ooi, Teik Khim

“…Based on the more reliable model I (using FFF), it implies the negative effect of spike in VIX dominated the positive effect from lower market expectation on interest rate lift-off, which led to decline in ASEAN financial market during 2015 A SEAN slump.…”
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Point of care assay for blood aripiprazole concentrations: development, validation and utility by Atkins, M, Taylor, D, Catalan, A, Desouza, N, Chesney, E, Reilly, TJ, Baburina, I, Hilaire, MR, Dratcu, L, Harland, R, Salamone, SJ, McGuire, P

“…</p> <p><strong>Method:&nbsp;</strong>Analytical performance (sensitivity, precision, recovery and linearity) of the assay were established using spiked whole blood and control samples of varying aripiprazole concentration. …”

Time to fill up India’s strategic oil reserves by Narula, K

“…Although oil stocks are generally not released to manage oil prices (the IEA’s intention is to stabilize the market and release stocks only in case of physical shortages), it may be possible to use the stored oil to offset a spike in oil prices, especially for developing countries which have administered oil prices.…”

Modelling Malaysia air quality data using Bayesian Structural Time Series models by Aeshah Mohammed, Mohd Aftar Abu Bakar, Mahayaudin M. Mansor, Noratiqah Mohd Ariff

“…The BSTS model integrates three main techniques: The structural model, which employs the Kalman filter approach to model trend and seasonality components; spike and slab regression for variable selection; and Bayesian model averaging to estimate the best-performing prediction model while accounting for uncertainty. …”
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Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool by Puarattana-aroonkorn, Sitthiphol, Tharakaraman, Kannan, Suriyawipada, Disapan, Ruchirawat, Mathuros, Fuangthong, Mayuree, Sasisekharan, Ram, Artpradit, Charlermchai

“…We employed the membrane, envelope, and highly immunogenic spike proteins of SARS-CoV-2 to produce virus-like particles (VLPs) using the HEK293-F cell line as a host system with an economical transfection reagent. …”
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