Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers by Goncalves, T, Cunniffe, S, Ma, T, Mattis, N, Rose, A, Kent, T, Mole, D, Geiller, HB, van Bijsterveldt, L, Humphrey, T, Hammond, E, Gibbons, R, Clynes, D, Rose, A

“…We also demonstrate that elevation of ROS can trigger over-activity of the ALT pathway in osteosarcoma and glioma cell lines, resulting in excessive DNA damage and cell death. …”

Physical properties of keropok (fried crisps) in relation to the amylopectin content of the starch flours by Mohamed, Suhaila, Abdullah, Norakiah, Muthu, Mangayar Karasi

“…Linear expansion, oil absorption and elasticity were positively correlated to the total amylopectin content in the whole flour (r2 = 0.99, 0.97 and 0.97 respectively). The best fitted lines for prediction of linear expansion, oil absorption and elasticity of the fried crisps were 21y ≦ 0.35x ‐ 162, y=0.15x‐ 74 and y=0.0008x‐0.41 respectively, where x is the amylopectin content of the whole flour. …”

Potential biological control agents of Geosmithia morbida restrict fungal pathogen growth via mycoparasitism and antibiosis by Onufrak, Aaron J., Gazis, Romina, Gwinn, Kimberly, Klingeman, William, Khodaei, Sima, Perez Oñate, Luis I., Finnell, Autumn, Givens, Spencer, Chen, Cristine, Holdridge, David R., Hadziabdic, Denita

“…Additionally, one metabolite-producing Trichoderma isolate, TN4-47, completely inhibited the growth of all three G. morbida isolates across all tested metabolite concentrations and had comparatively greater tolerance to juglone compared to other Trichoderma isolates. Future lines of research should focus on characterizing the active antagonistic compound present in the metabolite filtrates, determine the mode of action of the active component(s), and elucidate how abiotic and biotic factors may influence the growth, persistence, and antagonistic activity of candidate biological control agents in planta.…”
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HiTrip: Historical trajectory interpolation for trawlers via deep learning on multi-source data by Zhao, Zhongning, Chen, Jiaxuan, Shi, Yuqi, Hong, Feng, Jiang, Guiyuan, Huang, Haiguang, Zhao, Jinhua

“…One inherent challenge for precise interpolation is the stark contrast between trawler movement patterns during steaming, characterized by straight lines, and fishing, which often involves consecutive turns. …”
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Rectified and Salt Concentration Dependent Wetting of Hydrophobic Nanopores by Polster, Jake W, Aydin, Fikret, de Souza, J Pedro, Bazant, Martin Z, Pham, Tuan Anh, Siwy, Zuzanna S

“…Nanopores lined with hydrophobic groups function as switches for water and all dissolved species, such that transport is allowed only when applying a sufficiently high transmembrane pressure difference or voltage. …”
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Induction of neuronal phenotypes from NG2+ glial progenitors by inhibiting epidermal growth factor receptor in mouse spinal cord injury by Ju, Peijun, Zhang, Si, Yeap, Yeeshan, Feng, Zhiwei

“…In addition, the neuronal differentiation of glial progenitors induced by EGFR inhibitor was further confirmed with two different cell lines either in vitro or through ex vivo transplantation experiment. …”
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Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells by Kitajima, Shojiro, Lee, Kian Leong, Fujioka, Masaki, Sun, Wendi, You, Jia, Chia, Grace Sushin, Wanibuchi, Hideki, Tomita, Shuhei, Araki, Marito, Kato, Hiroyuki, Poellinger, Lorenz

“…Most strikingly, we identified the emergence of CD70-expressing cells derived from CD70-negative cell lines upon prolonged hypoxia exposure or DNMT1 inhibition, both of which significantly reduced CpG-nucleotide methylations within CD70 promoter region. …”
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DevOps for Databases : A practical guide to applying DevOps best practices to data-persistent technologies / by Jambor, David, author 656261

“…Database administrators are no longer the only experts; site reliability engineers (SREs) and DevOps engineers are database experts as well. This blurring of the lines has led to increased responsibilities, making members of high-performing DevOps teams responsible for end-to-end ownership. …”
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Combining laser frequency combs and iodine cell calibration techniques for Doppler detection of exoplanets by Cahoy, K., Fischer, D., Spronck, J., Demille, D.

“…We propose a fiber-fed high precision spectrograph design that combines the existing ~5000-6000 A Iodine calibration system with a high-precision Laser Frequency Comb (LFC) system from ~6000-7000 A that just meets the redward side of the Iodine lines. The scientific motivation for such a system includes: a 1000 A span in the red is currently achievable with LFC systems, combining the two calibration methods increases the wavelength range by a factor of two, and moving redward decreases the 'noise' from starspots. …”
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Sequence-Dependent & -Independent Effects of Intron-Mediated Enhancement (IME) by Kowal, Emma J. K.

“…In this study we report the design and execution of several massively parallel reporter assays (MPRAs), interrogating the effect of tens of thousands of synthetic and natural intron sequences on gene expression in the human HEK293T and HeLa cell lines. We observe that even with random internal sequence, most of these introns splice well and trigger IME. …”
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Multi-criteria re-entrant jobs scheduling problems using GA and AHP by Lin, Danping.

“…The validation is conducted in two experiments, firstly single GA is implemented for the re-entrant lines and later a new combination of GA and AHP is carried out. …”
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Study of cascade failures of power grids by Ng, Jason Wei Long.

“…The substations and the transmission lines are denoted as the nodes and edges of the complex network respectively. …”
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EMS of hybrid AC/DC micro grid by Zhao, Yi

“…The issues coming along with traditional power system can be terrible for the environments, such as large use of fossil fuels, coal; long distance of transmission lines also will cause the cost of money and fuels for the electricity transmission process. …”
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Barriers and leverage points for seeing alcohol differently in integrated care systems in England: a senior stakeholder interview study by Madden, Mary, Stewart, Duncan, McCambridge, Jim

“…Results: ICS formation occurred when services had been under sustained pressures with lines of communication and accountability emergent and unclear. …”
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The role of CD1a in dengue infection by Yang, J

“…To investigate the effect of dengue infection on the function of CD1a-reactive T cells, polyclonal blood T cells from patients and controls, and CD1a-autoreactive T cells clone/lines were utilised. The production of IFN-γ and GM-CSF by CD1a-autoreactive T cells was reduced when co-cultured with dengue-infected presenting cells. …”

Development of coherent detector technologies for sub-millimetre wave astronomy observations by Tan, B-K

“…</p> <p>Using the current 16-pixel 350 GHz SIS receiver, HARP-B, we have observed the ¹²CO J=3→2 emission lines from two nearby galaxies. An important result we found is that the ¹²CO J=3→2 correlates strongly with the 8 μm Polycyclic Aromatic Hydrocarbon emission.…”

Structure and inhibition of novel cyclin-dependent kinases by Dixon-Clarke, S

“…Preliminary trials using these relatively non-selective compounds to inhibit CDK16 in melanoma and medulloblastoma cancer cell lines revealed rebastinib as the more efficacious drug causing loss of cell proliferation in the 1-2 micromolar range. …”

Dwelling encounters: migration, diversity and ambivalence in an Istanbul neighborhood by Biehl, K

“…In this dissertation I apply a novel theoretical approach drawing on the concept of dwelling for understanding how residents of Kumkapı relate to their environment and make sense of it. I propose three lines of argument that unfold sequentially through the organizing structure of the thesis. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps, an... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, K

“…Steady and unsteady casing static pressure measurements were acquired, using pneumatic lines and high-frequency response (∼100 kHz) Kulite pressure transducers, respectively. …”

Key transcriptional regulators of neutrophil function in inflammation by Ai, Z

“…</p> <p>To investigate the regulatory role of the selected TFs in neutrophils, I utilised HoxB8 myeloid progenitors as a model system for in vitro production of neutrophils and generated stable knockout lines for JUNB, RELB, IRF5, RFX2, KLF6, and RUNX1 in Hoxb8 myeloid progenitors, using the CRISPR/Cas9 mediated system. …”