High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer by Palafox, Marta, Monserrat, Laia, Bellet, Meritxell, Villacampa, Guillermo, Gonzalez-Perez, Abel, Oliveira, Mafalda, Brasó-Maristany, Fara, Ibrahimi, Nusaibah, Kannan, Srinivasaraghavan, Mina, Leonardo, Herrera-Abreu, Maria Teresa, Òdena, Andreu, Sánchez-Guixé, Mònica, Capelán, Marta, Azaro, Analía, Bruna, Alejandra, Rodríguez, Olga, Guzmán, Marta, Grueso, Judit, Viaplana, Cristina, Hernández, Javier, Su, Faye, Lin, Kui, Clarke, Robert B., Caldas, Carlos, Arribas, Joaquín, Michiels, Stefan, García-Sanz, Alicia, Turner, Nicholas C., Prat, Aleix, Nuciforo, Paolo, Dienstmann, Rodrigo, Verma, Chandra Shekhar, Lopez-Bigas, Nuria, Scaltriti, Maurizio, Arnedos, Monica, Saura, Cristina, Serra, Violeta

“…Here, we show that p16 overexpression is associated with reduced antitumor activity of CDK4/6 inhibitors in patient-derived xenografts (n = 37) and estrogen receptor-positive breast cancer cell lines, as well as reduced response of early and advanced breast cancer patients to CDK4/6 inhibitors (n = 89). …”
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Characterizing the conformational landscape of MDM2-binding p53 peptides using molecular dynamics simulations by Yadahalli, Shilpa, Li, Jianguo, Lane, David P., Gosavi, Shachi, Verma, Chandra Shekhar

“…Complementing earlier observations, the current study suggests that the p53 peptides largely follow the ‘conformational selection’ paradigm in their recognition of and complexation by MDM2 while the 12/1 peptides likely undergo some element of conformational selection but are mostly driven by ‘binding induced folding’. …”
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Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore by Mina, Theresia, Xie, Wubin, Low, Dorrain Yanwen, Wang, Xiaoyan, Lam, Benjamin Chih Chiang, Sadhu, Nilanjana, Ng, Hong Kiat, Nur-Azizah Aziz, Tong, Terry Yoke Yin, Kerk, Swat Kim, Choo, Wee Lin, Low, Guo Liang, Halimah Ibrahim, Lim, Liming, Tai, E Shyong, Wansaicheong, Gervais, Dalan, Rinkoo, Yew, Yik Weng, Elliott, Paul, Riboli, Elio, Loh, Marie, Ngeow, Joanne, Lee, Eng Sing, Lee, Jimmy, Best, James, Chambers, John

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Aqueous-only exfoliation of pristine graphite to graphene : towards sustainable, multifunctional polymer nanocomposites by Seyed Ismail Seyed Shahabadi

“…This innate shape-conformality obviated the need for an additional skin-conformal layer. By adopting these strategies, organic liquid media and synthetic surfactants/stabilizers can be substituted by water and naturally-occurring lignin, or in case of the last study, lignin can be eliminated. …”
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Genetic analysis of normal human phenotypes within the people of the British Isles by Meena, D

“…This research, in addition to confirming known genetic associations, presents a number of suggestive novel variants associated with hair and skin pigmentation which influence these complex phenotypes. …”

Development of serum alternative with fermented soybean residue (okara): towards cultured meat production application by Teng, Ting Shien

“…The observed differences in the results suggested that cells may be stimulated by specific metabolites from the extract, and such interactions may vary from cell line to cell line. An in-depth study on the cellular metabolite interaction would be required to optimise the proliferative effects that the fermented okara extracts have on the cells. …”
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Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers by Takyi-Williams, John

“…The test compound, sunitinib, was stable in all conditions studied and analyte extraction and detection sensitivity could be improved with sufficient off-line or on-line pre-moistening of the dried spot prior to PS-MS analysis after longer storage period. …”
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Investigations into high resolution imaging of the aqueous outflow system and cornea by Hong, Jesmond Xun Jie

“…The imaging probe has resolutions of 10.08 line pairs per mm (~49.61 µm) at the iridocorneal angle region and 5.04 line pairs per mm (~99.21 µm) at the fundus. …”
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Soy-derived phytochemical genistein modifies chromatome topology to restrict cancer cell proliferation by Dutta, Bamaprasad, Park, Jung Eun, Qing, Ivan Toh Yi, Kon, Oi Lian, Sze, Siu Kwan

“…We therefore investigated genistein effects on chromatin-bound proteins in the estrogen receptor-deficient cell line MDA-MB-231 which is insensitive to phytoestrogen signaling. …”
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Investigation of the fuel consumption of a ship considering the dynamic coupling effect among resistance, propeller torque and engine power under the control of a governor by Beh, Gerald Kah Hooi

“…Given the extensive costs involved to upgrade an existing ship in the fleet, it is likely that most ship owners will choose to reduce their ships’ speed. …”
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Behaviorally informed digital campaigns and their association with social media engagement and COVID-19 vaccine uptake in Belize by Daga, Giuliana, Kossuth, Lajos, Boruchowicz, Cynthia, Lopez Boo, Florencia, Largaespada Beer, Natalia

“…However, lack of trust in the vaccine and fear of side effects in regions like the Caribbean resulted in a low uptake despite enough vaccine supply. …”
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Creative AI : a data-driven design approach for creative online ad optimisation using artificial intelligence and big data by Phay, Han

“…Through the integration of Artificial Intelligence and Big Data with current industry processes, a new kind of advertising agency will emerge that is run like a tech company. Using Big Data to inform creative design and Artificial Intelligence to identify patterns, predictive analysis can be applied to creative online banner ads for the purpose of increasing user engagement through higher click-through rates. …”
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Highly stable and efficient planar perovskite solar cells using ternary metal oxide electron transport layers by Thambidurai, Mariyappan, Shini, Foo, Harikesh, Padinhare Cholakkal, Mathews, Nripan, Dang, Cuong

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Two sides of the same coin : boons and banes of machine learning in hardware security by Liu, Wenye, Chang, Chip Hong, Wang, Xueyang, Liu, Chen, Fung, Jason M., Mohammad Ebrahimabadi, Karimi, Naghmeh, Meng, Xingyu, Basu, Kanad

“…ML schemes have been extensively used to enhance the security and trust of embedded systems like hardware Trojans and malware detection. On the other hand, ML-based approaches have also been adopted by adversaries to assist side-channel attacks, reverse engineer integrated circuits and break hardware security primitives like Physically Unclonable Functions (PUFs). …”
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Geometry-mediated bridging drives nonadhesive stripe wound healing by Xu, Hongmei, Huo, Yucheng, Zhou, Quan, Wang, Abraham Lianghao, Cai, Pingqiang, Doss, Bryant, Huang, Changjin, Hsia, K. Jimmy

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Holocene relative sea-level histories of tropical islands by Tan, Fangyi

“…I demonstrate the utility of coral microatolls to serve as precise indicators of Late Holocene RSL in places like Singapore, where the lack of accommodation space due to RSL fall from GIA has formerly limited the use of sedimentary indicators like mangrove peat. …”
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Referring expression segmentation: from conventional to generalized by Liu, Chang

“…Traditional RES methods usually either use an FCN-like network that directly generates the segmentation mask from the image or first extract all instances using a standalone network and then select the target from targets. …”
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Multi-stage generative adversarial networks for generating pavement crack images by Han, Chengjia, Ma, Tao, Huyan, Ju, Tong, Zheng, Yang, Handuo, Yang, Yaowen

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PrimeNet: a framework for commonsense knowledge representation and reasoning based on conceptual primitives by Liu, Qian, Han, Sooji, Cambria, Erik, Li, Yang, Kwok, Kenneth

“…Commonsense knowledge acquisition and representation is a core topic in artificial intelligence (AI), which is crucial for building more sophisticated and human-like AI systems. However, existing commonsense knowledge bases organize facts in an isolated manner like bag of facts, lacking the cognitive-level connections that humans commonly possess. …”
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Spin-ice physics and phase transitions in cadmium cyanide by Coates, CS

“…Having confirmed the importance of spin-ice physics, chapter 6 explores the pressure and temperature dependence of the ice-like correlations. At least two phase transitions are identied at low pressure, kinetic trapping is observed and the extreme compressibility shown to be a function of cyanide reorientation and ice-like coordination. …”