NHC-catalyzed enantioselective access to β-cyano carboxylic esters via in situ substrate alternation and release by Wang, Qingyun, Wu, Shuquan, Zou, Juan, Liang, Xuyang, Mou, Chengli, Zheng, Pengcheng, Chi, Robin Yonggui

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A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging by Kovács, Tibor, Szinyákovics, Janka, Billes, Viktor, Murányi, Gábor, Varga, Virginia B., Bjelik, Annamária, Légrádi, Ádám, Szabó, Melinda, Sándor, Sára, Kubinyi, Enikő, Szekeres-Paracky, Cecília, Szocsics, Péter, Lőke, János, Mulder, Jun, Gulyás, Balázs, Renner, Éva, Palkovits, Miklós, Gulya, Károly, Maglóczky, Zsófia, Vellai, Tibor

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Genetic analysis of normal human phenotypes within the people of the British Isles by Meena, D

“…</p> <p>The last part of this thesis provides new insights into the field of olfactory perception and argues for the potential link between neurological disorders and olfactory impairment. …”

Biomarkers and cognition study, Singapore (BIOCIS): protocol, study design, and preliminary findings by Leow, Yi Jin, Wang, J. D. J., Vipin, Ashwati, Sandhu, Gurveen Kaur, Soo, See Ann, Kumar, Dilip, Mohammed, Adnan Azam, Zailan, Fatin Zahra, Lee, Faith Phemie Hui En, Ghildiyal, Smriti, Liew, Shan Yao, Dang, Chao, Tanoto, Pricilia, Tan, Isabelle Yu Zhen, Chong, Wayne Freeman Weien, Kandiah, Nagaendran

“…Design, Setting, Participants: BIOCIS is a 5-year longitudinal study where participants are assessed annually. 2500 participants aged 30 to 95 will be recruited from the community in Singapore. …”
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Evaluating conversational agents for mental health: scoping review of outcomes and outcome measurement instruments by Jabir, Ahmad Ishqi, Martinengo, Laura, Lin, Xiaowen, Torous, John, Subramaniam, Mythily, Car, Lorainne Tudor

“…The studies reported 203 outcome measurement instruments used to measure clinical outcomes (123/203, 60.6%), user experience outcomes (75/203, 36.9%), technical outcomes (2/203, 1.0%), and other outcomes (3/203, 1.5%). Most of the outcome measurement instruments were used in only 1 study (150/203, 73.9%) and were self-reported questionnaires (170/203, 83.7%), and most were delivered electronically via survey platforms (61/203, 30.0%). …”
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Hybrid mesoporous microbeads based on sheets-like sulfur-doped copper oxide embedded in calcium alginate-derived carbon for batch and columnar adsorption of cationic dye by Naggar, Ahmed H., Alshammari, Mutairah S., Seaf-Elnasr, Tarek A., Chong, Kwok Feng, Bakr, Zinab H., Alotaibi, N. F., Ali, Hazim M., El-Nasser, Karam S., Thabet, Mahmoud, Abd El-Monaem, Eman M., Goda, Adel E. S., Gomaa, Hassanien

“…The adsorbent maintained high removal efficiency (about 93 %) after five reuse cycles through batch and fixed-bed columnar approaches. …”
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Space weather radiation effects on geostationary satellite solid-state power amplifiers by Lohmeyer, W. Q., Cahoy, K. L.

“…From 1996 to 2009, the average of the 1.8-3.5MeV electron flux was 1.98 #/(cm(2)s st keV). …”
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Modeling downward counterfactual events : unrealized disasters and why they matter by Lin, Yolanda C., Jenkins, Susanna F., Chow, Jun Rui, Biass, Sébastien, Woo, Gordon, Lallemant, David

“…As such, the framework is demonstrated in the context of Singapore, a city-nation that has historically had limited recorded natural hazards events, through five case studies on past anthropogenic, environmental, seismic, volcanic, and storm hazard events. …”
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Boon or bane? : The role of filial piety, relationship quality, caregiver gender on work-family interface among working caregivers of the elderly by Leong, Anthony Xueheng

“…Participants completed an initial survey followed by three daily surveys over five consecutive working days. Data were analysed using multi-level modelling. …”
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Predicting the work function of 2D MXenes using machine-learning methods by Roy, Pranav, Rekhi, Lavie, Koh, See Wee, Li, Hong, Choksi, Tej S.

“…Using 15 different features of the MXene as inputs, the neural network model predicts the work function of MXenes with a mean absolute error of 0.12 eV on the training data and 0.25 eV on the testing data. …”
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The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture by Eilers, Kira, Yam, Joey Kuok Hoong, Liu, Xianghui, Goh, Yu Fen, To, Ka-Ning, Paracuellos, Patricia, Morton, Richard, Brizuela, Jaime, Yong, Adeline Mei Hui, Givskov, Michael, Freibert, Sven-Andreas, Bange, Gert, Rice, Scott A., Steinchen, Wieland, Filloux, Alain

“…It was reported that deletion of the EAL/GGDEF dual enzyme PA0285, one of five c-di-GMP-related enzymes conserved across all Pseudomonas species, impacts biofilms. …”
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The novel quinoline derivative SKA-346 as a KCa3.1 channel selective activator by Wong, Brandon Han Siang, Shim, Heesung, Goay, Stephanie Shee Min, Ong, Seow Theng, Nur Ayuni Binte Muhammad Taib, Chai, Kelila Xin Ye, Lim, Kerry, Huang, Dachuan, Ong, Choon Kiat, Vaiyapuri, Thamil Selvan, Cheah, Yeong Cheng, Wang, Yulan, Wulff, Heike, Webster, Richard David, Shelat, Vishalkumar G., Verma, Navin Kumar

“…Here, we aimed to identify and characterize an activator that would augment KCa3.1 currents without affecting other channels. We synthesized five quinoline derivatives and used electrophysiology to screen them on KCa3.1 and a panel of 14 other ion channels. …”
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Occurrence, human exposure and dynamics of phthalates in ACMV indoor environments : method development and field studies by Chen, Ailu

“…The study investigates occurrence of five typical phthalates in 24 ACMV indoor environments that are covered with different flooring materials. …”
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新加坡高校人才战略的理念建构和实践运作 - 以南洋理工大学为例 = Formulation and implementation of talent strategy in higher education : a case study of Nanyang Technological University in Singapore... by 刘宏 Liu Hong, 贾丽华 Jia Lihua, 范昕 Fan Xin

“…This article is structured into five parts. The first section discusses the formulation of talent strategies in Singapore. …”
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Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study... by Dyson, ZA, Ashton, PM, Khanam, F, Chunga Chirambo, A, Shakya, M, Meiring, JE, Tonks, S, Karkey, A, Msefula, C, Clemens, JD, Dunstan, SJ, Baker, S, Dougan, G, Pitzer, VE, Basnyat, B, Qadri, F, Heyderman, RS, Gordon, MA, Holt, KE, Pollard, AJ, STRATAA Study Group

“…Azithromycin-resistance mutations in acrB were rare, appearing only in Dhaka (five [1%] of 452). Phylogenetic analyses showed that most cases derived from pre-existing, locally established pathogen variants; 702 (98%) of 713 drug-resistant infections resulted from local circulation of AMR variants, not imported variants or recent de novo emergence; and pathogen variants circulated across age groups. 479 (66%) of 731 cases clustered with others that were indistinguishable by point mutations; individual clusters included multiple age groups and persisted for up to 2·3 years, and AMR determinants were invariant within clusters.…”

A preliminary study on the effects of substituting fishmeal with defatted black soldier fly (Hermetia illucens) larval meal on Asian seabass (Lates calcarifer) juveniles: Growth pe... by Liu, Yun, Andin, Victor Charlie, Chor, Wei-Kang, Gunasekaran, Baskaran, Chong, Chou-Min, Lee, Po-Tsang, Loh, Jiun-Yan

“…After a 7-day challenge test with V. parahaemolyticus, the cumulative mortality rates of the BSFL5 and BSFL10 groups, respectively, dropped to 5.20%, 5.28% compared to the control group's 16.88%; however, the mortality rates of BSFL15 (34.67%) and BSFL20 (41.77%) groups were found to be significantly (p < 0.05) increased. …”

Cytotoxicity and mechanisms of action of Zerumbone-loaded nanostructured lipid carrier in triple negative breast cancer cells, MDA-MB-231 by Hosseinpour, Mahnaz

“…According to the Malaysian National Cancer Registry (2006), breast cancer is one of the five most common cancers amongst Malaysian women. …”
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RNA interference silencing of interleukin-6 in mesenchymal stromal cells and antitumour efficacy against multiple myeloma cells by Teoh, Hoon Koon

“…MSC transduced with IL-6 shRNA also inhibited U266 growth significantly to 53.1% and 74.4% by day five through cell-substrate and cell-cell interactions respectively (P<0.05, ANOVA). …”
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Rapid eye movement sleep deprivation induces vascular endothelial dysfunction in rats: roles of oxidative stress-mediated nitric oxide signalling and vitamin c supplementation by Nawi, Afifah

“…The beneficial effects of vitamin C were also evaluated. Thirty-five (35) adult male Sprague-Dawley rats were equally divided into 5 groups (n=7): free-moving control rats (FMC), REM sleep-deprived rats for 72-h (72-h REMsd), tank control rats (TC), sleep recovered for 72-h after 72-h of REMsd (SR), and 72-h REMsd pretreated with vitamin C (RVC). …”
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Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT) by Kusuma, Frances Karla, Prabhu, Aishvaryaa, Tieo, Galen, Syed Moiz Ahmed, Dakle, Pushkar, Yong, Wai Khang, Pathak, Elina, Madan, Vikas, Jiang, Yan Yi, Tam, Wai Leong, Kappei, Dennis, Dröge, Peter, Koeffler, H. Phillip, Jeitany, Maya

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