Regulation of microRNA degradation in Caenorhabditis elegans via the E3 ubiquitin ligase EBAX-1 by Stubna, Michael William

“…TDMD underlies the instability of many miRNAs in diverse cell lines and animals. In this work, I probe the biological scope of TDMD as a regulatory mechanism in the nematode Caenorhabiditis elegans, which tolerates homozygous loss of the ZSWIM8 ortholog, EBAX-1, and expresses some miRNAs that are subject to rapid, developmentally regulated decay. …”
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Development of immunomodulatory RNA therapeutics for immune disorders by Iyer, Vaishnavi Srinivasan

“…We show that these ASOs can modulate T cell behavior in human cell lines and human primary cells, validating the potential of ASOs as a therapeutic approach for immune diseases. …”
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Data-driven distributionally robust CVaR portfolio optimization under a regime-switching ambiguity set by Pun, Chi Seng, Wang, Tianyu, Yan, Zhenzhen

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Financial forecasting using meta-cognitive fuzzy neural networks by Singh Akhand Pratap

“…The primary meta-cognitive strategies are Sample deletion, Sample Learning and Sample Reserve. Following on the lines of Technical Analysis carried out by traders and investors on the historical prices of a company’s stock, the project makes use of various Financial Indicators to decide whether a particular instance of time is good for investment, disinvestment or to remain idle. …”
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Taliban resurgence in Afghanistan : the role of post-conflict reconstruction by Sadia Sulaiman

“…Under the auspices of Bonn-I, the international community initiated a process of post-conflict reconstruction on both security and non-security lines. Bonn-I provided a framework for setting up an interim government tasked with drafting a constitution, convening a Loya Jirga (grand assembly), holding presidential and parliamentary elections by 2005, strengthening the Afghan police and military forces, and establishing a judicial system. …”
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Multi-spectral polarimetry imaging for early gastric cancer diagnosis by Wang, Wenfeng

“…Gastric cancer, which develops from the lining of stomach, is the fifth most severe disease worldwide. …”
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Cellular studies on the role of OGFOD1, a 2-oxoglutarate-dependent dioxygenase by Attwood, M

“…The transcriptional regulator, Thanatos associated protein 11 (THAP11) was identified as a novel high stoichiometry OGFOD1-interacting protein across a range of cell lines. Analysis of the THAP11 transcriptional programme in SW620 cells defined a repressive action of OGFOD1 overexpression on THAP11 DNA binding and target gene expression. …”

The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells by Pillozzi, Serena, D'Amico, Massimo, Bartoli, Gianluca, Gasparoli, Luca, Petroni, Giulia, Crociani, Olivia, Marzo, Tiziano, Guerriero, Angela, Messori, Luigi, Severi, Mirko, Udisti, Roberto, Wulff, Heike, Chandy, Kanianthara George, Becchetti, Andrea, Arcangeli, Annarosa

“…Methods: The functional expression of Ca2+-activated (KCa3.1, also known as KCNN4) and voltage-dependent (Kv11.1, also known as KCNH2 or hERG1) K+ channels was determined in two CRC cell lines (HCT-116 and HCT-8) by molecular and electrophysiological techniques. …”
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Induction of apoptosis and the signalling pathways involved by dillenia suffruticosa dichloromethane root extract in mcf-7 and mda-mb-231 breast cancer cells by Foo, Jhi Biau

“…DCMDS induced apoptosis and oxidative stress in these two cell lines. Treatment with α- tocopherol reduced the cytotoxicity of DCM-DS at 50 µg/mL in the cells, suggesting that DCM-DS induced lipid peroxidation to destroy the cancer cells. …”
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Biogenic amines and urocanic acid in keropok lekor, and their effects on cytotoxicity and proinflammatory mediator secretion of macrophage cell culture by Hussain, Husniza

“…Future research on in vitro cytotoxicity effects of BAs in fishery products or other foods using different cell lines to resemble in vivo study is warranted.…”
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Three essays on national and organizational cultures by Kawasaki, Shota

“…Chapter 2 illustrates a novel pathway linking employees’ perceptions of organizational cultural strength to job satisfaction and organizational commitment via organizational nostalgia (i.e., one’s sentimental longing or wistful affection for past organizational events). …”
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Towards Synergistic Understanding of Language Processing in Biological and Artificial Systems by Hosseini Asl, Eghbal

“…Furthermore, the average degree of sentence straightening in the deep layers of the model correlates with corpus-based estimates of sentence surprisal, which are linked to human comprehension difficulty (e.g., as reflected in reading times). Collectively, these lines of work provide essential ingredients for building a more computationally precise model of language processing in the human brain, leveraging synergies with artificial neural network language models.…”
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Development of an application to improve mental health (A) by Khor, Chin Yi

“…As the mental health concern grew, most countries developed new mental health information and phone support lines, offering tips to the public on coping measures. …”
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杜牧“‘秋’意象诗”研究 = Research on Du Mu’s autumn imagery poems by 林宛仪 Lim, Wan Yi

“…Close reading will be used to uncover the emotions between the lines in Du Mu’s poems that may contain feelings other than grief. …”
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The effect of the amyloid-beta peptide on the fluidity of cell membranes : a study by fluorescence correlation spectroscopy by Ng, Justin Wei Qing

“…To this end, we used imaging TIRF-fluorescence correlation spectroscopy (ITIR-FCS) to make measurements of fluidity of one bulk membrane probe, DiI, and two ordered/raft-type membrane probes, a transiently expressed GPI-linked GFP and cholera toxin subunit B, on the membranes of living cells that were exposed to Aβ. Three cell lines – SH-SY5Y human neuroblastoma, U87 human glioma and Neuro-2a mouse neuroblastoma – were selected for our study based on their origin in brain tissue and previous use in Aβ-related studies. …”
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Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes by de Jesus, Daniel S., Mak, Tracy C. S., Wang, Yi-Fang, von Ohlen, Yorrick, Bai, Ying, Kane, Eva, Chabosseau, Pauline, Chahrour, Catherine M., Distaso, Walter, Salem, Victoria, Tomas, Alejandra, Stoffel, Markus, Rutter, Guy A., Latreille, Mathieu

“…We carried out loss- and gain-of-function experiments in MIN6 and EndoC-bH1 cell lines. We analysed previously published mouse andhuman T2D data sets.Results:Bulk RNA-seq revealed thatb-cell dedifferentiation is associated with the induction of genes associated with epithelial-to-mesenchymal transition (EMT) in prediabetic (2-week-old) and diabetic (12-week-old) Tg7 mice. …”
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Engineering Mechanical Counter Pressure Spacesuits and Compression Garments: Active Pressurization and Design for Mobility by Kothakonda, Akshay

“…The process of estimating the optimum fabric pattern will be iterative and the resulting pattern may comprise of a composite of different fabric types with varying parameters. Mapping skin Lines of Non-Extension (LoNE’s) informs contours for inextensible cables in such a way that they do not impede movements. …”
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Content-based image retrieval with statistical machine learning. by Zhang, Lining.

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Investigating the neural substrates of Chinese character processing by Wu, Chiao-Yi

“…The research framework consisted of two levels: direct and converging evidence, through three lines of investigations. Study 1 and Study 2 provided direct evidence of the neural mechanisms for Chinese character processing. …”
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ESBL and AmpC β-lactamase encoding genes in E. coli from pig and pig farm workers in Vietnam and their association with mobile genetic elements by Hounmanou, Yaovi Mahuton Gildas, Bortolaia, Valeria, Dang, Son Thi Thanh, Truong, Duong, Olsen, John E., Dalsgaard, Anders

“…The isolates carrying the plasmids, even those with plasmids of similar types, showed wide genetic variation with high number of SNPs, suggesting horizontal spread of plasmids into different clonal lines. Their virulence profiles did not confirm to known pathotypes, suggesting that unrelated commensals are a main reservoir for ESBL and AmpC β-lactamases in both humans and pigs. …”
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