Understanding the disease mechanisms of cerebellar ataxia through induced pluripotent stem cell models by Wong, M

“…Accumulating evidence has suggested that subtypes of autosomal dominant ataxias (SCAs) are likely to be caused by shared pathogenic pathways. …”

‘An unimaginable challenge’: a cross-cultural qualitative study of ethics and decision-making around tracheostomy ventilation in patients with amyotrophic lateral sclerosis by Ozeki-Hayashi, R, Wilkinson, D

“…US participants were likely to prioritize patient autonomy over other ethical principles, and Japanese participants were likely to limit patient autonomy indirectly. …”

Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8+ T cell clone size and cytotoxicity by Watson, RA, Tong, O, Cooper, R, Taylor, CA, Sharma, PK, de Los Aires, AV, Mahé, EA, Ruffieux, H, Nassiri, I, Middleton, MR, Fairfax, BP

“…Cytotoxic CD8⁺ effector clones were more likely to persist following ICB and were more likely to correspond with public tumor-infiltrating lymphocyte clonotypes. …”

Extreme rainfall and landslides as a response to human-induced climate change: a case study at Baixada Santista, Brazil, 2020 by Couto de Souza, D, Crespo, NM, Vieira da Silva, D, Harada, LM, Parrode de Godoy, RM, Domingues, LM, Luiz, R, Bortolozo, CA, Metodiev, D, Magalhaes de Andrade, MR, Hartley, A, Cesario de Abreu, R, Li, S, Lott, F, Sparrow, S

“…In the scenario including both natural and human-induced factors the antecedent 60 day rainfall became 74% more likely, while the short-term trigger was 46% more likely. …”

Improved performance of 1.3-μm multilayer P-doped InAs/InGaAs quantum dot lasers using rapid thermal annealing by Cao, Qi, Tong, Cunzhu, Yoon, Soon Fatt, Liu, Chongyang, Ngo, Chun Yong

“…Defect reduction is thought to be the most likely mechanism contributing to the improved performance according to the electroluminescence and improved characteristic temperature behavior.…”
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Religious restrictions, country wealth, and religious violence : a global analysis by Tan, Malcolm Si-An

“…Utilising cross-national time-series analysis of data from 175 countries spanning 1991 – 2018, this study finds that countries which spend a larger share of their wealth to impose restrictions on minority, majority, or all religions are more likely to experience higher levels of religious hostilities and violence. …”
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Digital libraries and multi-disciplinary research skills by Thelwall, Mike

“…With the use of insights from cultural studies and the history and philosophy of science, it is argued that one likely outcome is a change in the acceptable standards for literature reviews, leading to changes in article contents to reflect a broader academic basis. …”
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Underrepresentation of Asia-focused articles in the top 10 economics journals by Ang, Roy Athanasius Tjin Shane, Teong, Xiu Yi, Tham, Weng Leon

“…This study highlights this fact and has found tenure to be a likely cause for the lack of Asia-focused articles. …”
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Subtle, natural and socially acceptable interaction techniques for ringterfaces : finger-ring shaped user interfaces by Pang, Natalie, Rissanen, Mikko J., Vu, Samantha, Fernando, Owen Noel Newton, Foo, Schubert

“…Through this analysis we show which kind of ringterfaces are likely to become general-purpose user interfaces and what factors drive their development toward commercial applications. …”
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Putting their best foot forward : emotional disclosure on Facebook by Qiu, Lin, Lin, Han, Tov, William, Leung, Angela K.-y.

“…We conducted two studies, and results from both self-report and observer rating show that individuals are more likely to express positive relative to negative emotions and present better emotional well-being on Facebook than in real life. …”
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A deep learning-based fault detection and classification in smart electrical power transmission system by Khaleefah, Shihab Hamad, Mostafa, Salama A., Gunasekaran, Saraswathy Shamini, Khattak, Umar Farooq, Siti Salwani, Yaacob, Alanda, Alde

“…Electrical Power Transmission Networks (EPTN) are made of many complex, dynamic, and interrelated components. The transmission lines are essential components of the EPTN, and their fundamental duty is to transport electricity from the source area to the distribution network. …”
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Gum Arabic and breast cancer biology: Biotechnology perspective

“…The book also examines state-of-the-art breast cancer research, its impact on sustainable development goals, and the potential applications of AG's secondary metabolites in BC cell lines. Additionally, it discusses the opportunity to transfer cancer-on-a-chip technology to Islamic Development Bank member countries (IsDB-MCs) and explores the application of breast-on-a-chip technology using AGs-secondary metabolites (SME). …”
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Avoidance of Concave Obstacles Through Rotation of Nonlinear Dynamics by Huber, Lukas, Slotine, Jean-Jacques, Billard, Aude

“…Controlling complex tasks in robotic systems, such as circular motion for cleaning or following curvy lines, can be dealt with using nonlinear vector fields. …”
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Chasing the city that cannot stop: Exploring transportation and urban co-development in São Paulo’s history by Borges Costa, Adriano, Zegras, P Christopher, Biderman, Ciro

“…Examining São Paulo’s “streetcar era” we find joint development of streetcar lines and urban expansion – evidence of joint development consistent with “streetcar suburbs.” …”
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Alternate Imaginaries for the Kinara: River Ravi’s Edge as a Threshold by Khalil, Mahwish

“…Finally, this thesis questions how the river's edge can be remapped to allow for the dismantling of top-down visions while addressing an urgency embodied within the shallow, receding flows of a polluted river, whose uncertain future remains contingent on distinct lines.…”
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Water-stable all-inorganic perovskite nanocrystals with nonlinear optical properties for targeted multiphoton bioimaging by Chan, Kok Ken, Giovanni, David, He, Huajun, Sum, Tze Chien, Yong, Ken-Tye

“…The toxicity of the CsPbBr3/SiO2/mPEG-DSPE nanocrystals has been evaluated in various cell lines. Subsequently, the encapsulated nanocrystals were used for targeted single and multiphoton imaging of cancer cells. …”
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Towards better urban intelligence: representation learning techniques for geospatial data analytics by Chen, Yile

“…They include points (e.g., points-of-interest), lines (e.g., road network), and polygons (e.g., geographical grids). …”
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Investigating the human teashirt genes TSHZ2 and TSHZ3 in pancreatic and endocrine lineage commitment using genome modified human embryonic stem cells (hESC) by Eng, Shermaine Zi Hui

“…The CRISPR RNA-guided FokI-dCas9 nuclease (RFN) genome editing system was employed to create loss-of-function hESC lines. Two guide RNAs revealed successful editing in the 3’ end of TSHZ2 coding sequence while gRNAs tested for the 5’ end of TSHZ2 and for TSHZ3 were ineffective. …”
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Quantum dots-siRNA nanoplexes for gene silencing in central nervous system tumor cells by Lin, Guimiao, Chen, Ting, Zou, Jinyun, Wang, Yucheng, Wang, Xiaomei, Li, Jiefeng, Huang, Qijun, Fu, Zicai, Zhao, Yingying, Lin, Marie Chia-Mi, Xu, Gaixia, Yong, Ken-Tye

“…High gene transfection efficiency (>80%) was achieved on two glioblastoma cell lines, U87 and U251. The gene expression level (49.99 ± 10.23% for U87, 43.28 ± 9.66% for U251) and protein expression level (51.58 ± 7.88% for U87, 50.69 ± 7.59% for U251) of TERT is observed to decrease substantially after transfecting the tumor cells for 48 h. …”
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Crystal structure of the FK506 binding domain of plasmodium falciparum FKBP35 in complex with FK506 by Kotaka, Masayo, Ye, Hong, Alag, Reema, Hu, Guangan, Bozdech, Zbynek, Preiser, Peter Rainer, Yoon, Ho Sup, Lescar, Julien

“…Compared to the human FKBP12−FK506 complex reported earlier, the structure reveals structural differences in the β5−β6 segment that lines the FK506 binding site. The presence in PfFKBD of Cys-106 and Ser-109 (substituting for His-87 and Ile-90, respectively, in human FKBP12), which are 4−5 Å from the nearest atom of the FK506 compound, suggests possible routes for the rational design of analogues of FK506 with specific antiparasitic activity. …”
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