The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells by Pillozzi, Serena, D'Amico, Massimo, Bartoli, Gianluca, Gasparoli, Luca, Petroni, Giulia, Crociani, Olivia, Marzo, Tiziano, Guerriero, Angela, Messori, Luigi, Severi, Mirko, Udisti, Roberto, Wulff, Heike, Chandy, Kanianthara George, Becchetti, Andrea, Arcangeli, Annarosa

“…Methods: The functional expression of Ca2+-activated (KCa3.1, also known as KCNN4) and voltage-dependent (Kv11.1, also known as KCNH2 or hERG1) K+ channels was determined in two CRC cell lines (HCT-116 and HCT-8) by molecular and electrophysiological techniques. …”
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Design and Synthesis of Stimuli-Responsive Polymers with Programmable Cleavability by Zafar, Hadiqa

“…The second chapter reports the first synthesis of peptide-containing bivalent bottlebrush (co)polymers (BBPs), featuring caspase-3-cleavable peptides linked to fluorogenic probes that provide a “turnon” signal upon enzymatic cleavage. …”
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Mapping the Cellular Landscape of the Brain: A Scalable Approach to Comprehensive Microscopy Data Analysis by Kim, Minyoung E.

“…Given that cellular morphology is strongly linked to distinct functional states of cells, in-depth morphological analysis of such data offers immense potential for understanding their roles in brain development and disease. …”
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Design of Cleavable Monomers and Cross-Linkers for the Synthesis of Degradable Polymer Architectures by Cardoso da Costa, Leticia

“…A brief introduction to the current strategies utilized to impart chemical deconstruction to cross-linked polymer networks prepared by radical polymerization is presented (Chapter 4). …”
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Phonological and semantic influences on auditory word perception in children with and without reading impairments using magnetoencephalography (MEG) and electroencephalography (EEG... by Wehner, Daniel T

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新加坡和 “一带一路” ：国家与社会的视角和策略 = Singapore and the belt and road initiative : perspectives and strategies from the state and society by 范昕 Fan, Xin

“…It argues that the two key factors for Singapore’s fruitful participation in the BRI are the state’s leadership and the transnational network’s coordination. These are in turn linked with effective institutional mechanisms and smooth implementation of transnational networks. …”
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Organic solvent-assisted control of hydrogel structures and properties by Zhou, Quan

“…Hydrogels are three-dimensional (3D) cross-linked polymeric networks containing a significant amount of water and have found their applications in various fields, including tissue engineering, drug delivery, etc. …”
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Development of novel chemical ligation methods for the synthesis of posttranslationally modified proteins by Yang, Renliang

“…In chapter 4, we modify and improve our dual chemical ligation approach and apply it in the synthesis of a K48-linked diubiquitin. This demonstrated the feasibility of our methodology in synthesizing ubiquitinated proteins. …”
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Distributed droop schemes for standalone and interlinked AC microgrids by Inam Ullah

“…The formed microgrids can certainly be controlled by centralized management systems, but for widely dispersed DGs where communication links are not viable, autonomous droop schemes might be more appropriate. …”
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Gene expression regulation by well-known non-coding RNAs by Tan, Jiazi

“…In one project, we attempted to insert a second Xist gene into the single X chromosome of male murine embryonic stem (ES) cells to cause ectopic XCI upon differentiation, leading to cell lethality as important X-linked genes were inactivated. From there, we could screen for genes important for XCI by rescuing the differentiated transgenic ES cells by gene silencing. …”
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Robust cooperative control and optimization of multi-agent systems by Sun, Chao

“…Nodes connected with a positive edge can be viewed as “friends” and linked with a negative edge can be viewed as “enemies”. …”
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An epigenetic locus associated with loss of smell in COVID-19 by Aslan, Elif Sibel, White, Kenneth, Meral, Gulsen, Akcay, Zeyneb Nur, Altundag, Aytug, Gur, Savas, Dokur, Mehmet, Baktir, Mehmet Akif, Batur, Lutfiye Karcioglu

“…Previous studies, including genome-wide association studies (GWAS), have identified genetic variants near the UGT2A1 and UGT2A2 genes that are linked to anosmia in COVID-19 patients. However, the role of epigenetic changes in the development and persistence of smell loss has not been well explored. …”
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Impact of co-morbid common mental disorder symptoms in people with epilepsy in Ethiopia on quality of life and functional disability: cohort study by Tsigebrhan, R, Medhin, G, Belina, M, Newton, C, Hanlon, C

“…Structural equation modelling (SEM) was employed to examine direct and indirect pathways linking co-morbid CMD symptoms with QoL or functional disability.…”

Joint modelling of longitudinal data: a scoping review of methodology and applications for non-time to event data by Ouko, RK, Mukaka, M, Ohuma, EO

“…The random effect was the most commonly applied association structure for linking two sub-models (63 studies; 85%). Estimation of model parameters was commonly done using Markov Chain Monte Carlo with Gibbs sampler algorithm (10 studies; 38%) for the Bayesian approach, whereas maximum likelihood was the most common (33 studies; 68.75%) for the frequentist approach. …”

Health economic aspects of childhood excess weight by Onyimadu, O

“…Additionally, electronic health records extracted from the Clinical Practice Research Datalink (CPRD), linked with Hospital Episode Statistics (HES), were analysed to estimate direct healthcare costs attributable to childhood excess weight.…”

Adverse events of common psychiatric medications: an umbrella review by Bartellas, K

“…Many medications were linked to adverse events through a weak or moderate strength of association and additional factors contributed to the variability in adverse outcome reporting aside from patient characteristics. …”

Human agency and instrumental rationality: applying human capital to gender inequalities and intergenerational stratification by Luo, H

“…</p></br> <p><strong>Contributions</strong></p> <p>Theoretically, this thesis contributes to linking human agency and instrumental rationality to the persistence and transformation of structural inequalities; it also sheds light on education’s potential and limitations as an equalizer. …”

Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro,... by Yang, Z, Sheehan, AM, Messer, AE, Tsui, S, Sparrow, A, Redwood, C, Kren, V, Gould, IR, Marston, SB

“…Phosphorylation causes a 2-3 fold decrease of affinity of cTn for Ca2+ associated with a higher rate of Ca2+ dissociation from cTnC leading to a faster relaxation rate of the cardiac muscle (lusitropy). Cardiomyopathy-linked mutations primarily affect Ca2+ regulation or the PKA-dependent modulatory system, such that Ca2+-sensitivity becomes independent of phosphorylation level (uncoupling) and this could be sufficient to induce cardiomyopathy. …”

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases by Vinogradova, Y, Coupland, C, Hippisley-Cox, J

“…Setting: UK general practices contributing to QResearch or Clinical Practice Research Datalink (CPRD), linked to hospital, mortality, social deprivation, and cancer registry (QResearch only) data. …”

Managing risks to the media from emerging networked technologies by Shere, ARK

“…The countermeasures are linked to phases of the overarching editorial workflow, to ensure that their implementation is feasible and that they are clearly useful by and for specific role categories within the media.…”