Effect of intra-articular corticosteroid injections for osteoarthritis on the subsequent use of pain medications: a UK CPRD cohort study by Hawley, S, Prats Uribe, A, Matharu, GS, Delmestri, A, Prieto Alhambra, D, Judge, A, Whitehouse, MR

“…</p> <br> <p><strong>Conclusions:</strong> IACI for knee or hand osteoarthritis showed lower incidence of several pain medications over the longer-term relative to no IACI use. Secondary findings suggest IACI may be effective in reducing longer-term use of opioid-nonopioid analgesic combinations for patients with knee, hip, hand, or shoulder osteoarthritis.…”

Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study by Liu, D, Wang, N, Song, M, Chai, X, He, Q, Cao, T, Kong, D, Song, Z, Zhang, G, Liu, L, Wang, X, Chen, G, Yin, S, Yang, Y, Zhao, J

“…The best classification rate in the derivation cohort was achieved at a metabolic index of 3.32 (41% of the mean cortical metabolic index in healthy controls). Conclusion: Our findings demonstrate that conscious awareness requires a minimum of 41% of normal cortical activity, as indicated by metabolic rates.…”

The impact of psoriatic arthritis on quality of life: a systematic review by James, L, Hailey, L, Suribhatia, R, McGagh, D, Amarnani, R, Bundy, C, Kirtley, S, O'Sullivan, D, Steinkoenig, I, White, J, Vivekanantham, A, Coates, LC

“…</p> <br> <p><strong>Results:</strong> The study included 37 comprehensive studies that examined the impact of PsA on QoL and physical function. The findings revealed that the impact of PsA extends to various aspects of life, including activities of daily living, physical, and emotional aspects, such as fatigue, sleep disturbance, anxiety and depression. …”

Content learning in Japanese and English medium instruction: comparing chemistry learning outcomes in Japanese higher education by Aizawa, I

“…The study found that while the quantitative findings unveiled no differences in content learning outcomes according to the medium of instruction, the qualitative evidence revealed that EMI students encountered a greater level of challenges than their JMI counterparts. …”

Clinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory by Faizy, TD, Yedavalli, V, Salim, HA, Lakhani, DA, Musmar, B, Adeeb, N, Essibayi, MA, Daraghma, M, El Naamani, K, Henninger, N, Sundararajan, SH, Kuhn, AL, Khalife, J, Ghozy, S, Scarcia, L, Yeo, LL, Tan, BY, Regenhardt, RW, Heit, JJ, Cancelliere, NM, Rouchaud, A, Fiehler, J, Sheth, SA, Puri, AS, Dmytriw, AA

“…Conclusion: Unsuccessful MT for MeVO was linked to worse outcomes than best MM. These findings highlight the risks of prolonged attempts and emphasize the importance of efficient procedural decision-making to reduce complications and improve patient outcomes.…”

Exploring effects of calcitonin and procalcitonin in cardiomyocytes by Moreira, LMF

“…In contrast, I have not observed any evidence of PCT binding to CTRs, but instead uncovered, through PCT interactome studies, a previously unknown direct interaction of PCT with a subunit of L-type calcium channel, LTCC (α2δ3), which was also associated with a decrease in ERK1/2 phosphorylation.</p> <p>These findings suggest that CT and PCT exert opposite effects on the function of atrial CMs. …”

Combining detection dogs and camera traps improves minimally-invasive population monitoring for the cheetah, an elusive and rare large carnivore by Verschueren, S, Hofmann, T, Schmidt-Küntzel, A, Kakove, M, Munyandi, B, Bauer, H, Balkenhol, N, Leirs, H, Neumann, S, Cristescu, B, Marker, L

“…We showed that complementing detection dog surveys with camera trapping can comprehensively and efficiently inform occurrence patterns for an exceptionally wide-ranging terrestrial carnivore. Our findings provide practical guidance for designing effective minimally-invasive monitoring programs, which are important for empirically deriving distribution maps of cheetahs and other carnivores in data-poor regions.…”

Exploring population structure, antibiotic resistance and horizontal gene transfer in Neisseria gonorrhoeae by Unitt, A

“…</p> <p>Together, these results provide an improved understanding of <em>N. gonorrhoeae</em> genetics with implications for public health: informing efforts to survey and suppress the evolution of resistance inducing mosaic <em>penA</em> alleles, and describing how gonococcal population structure relates to features such as geographical location and antibiotic resistance, while providing a publicly available lineage nomenclature for future analyses. These findings highlight the advantages of using population-level analysis of bacterial whole genome sequence data to reveal new facets of pathogen biology.…”

Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Arman, BY, Clarke, R, Bharucha, T, Gomez Fernandez, L, Walsby-Tickle, J, Deats, M, Mosca, S, Lin, Q, Banerjee, S, Chunekar, S, Patil, K, Gairola, S, Dunachie, S, Merchant, H, Stokes, R, Kuwana, R, Maes, A, Charrier, J-P, Probert, F, Caillet, C, Matousek, P, McCullagh, J, Newton, P, Zitzmann, N, Gangadharan, B

“…Furthermore, even if a falsified product contained polysorbate 80 at the same concentration as used in the genuine vaccine, the characteristic spectral profile of polysorbate 80 used in genuine products is a reliable internal marker for vaccine authenticity. Our findings demonstrate that MALDI-ToF MS analysis of extracts from vial labels and the vaccine excipients themselves can be used independently to detect falsified vaccines. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps and... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, KS

“…However, the majority of the present findings are based on linear cascade or low-speed rotational studies, due to the high cost of the experiments and difficulty in instrumentation at engine conditions. …”

Intersection between individual, household, environmental and system level factors in defining risk and resilience for children in Kenya’s ASAL: A qualitative study by Chongwo, EJ, Aoko, B, Kaniala, M, Esala, M, Magoma, P, Njoroge, E, Nyamanya, S, Marangu, J, Khamis, A, Ng’asike, J, Huizink, AC, Abubakar, A

“…Results: The mean age of the participants was 44years (SD = 11 years). The findings, viewed through the lens of Bronfenbrenner’s ecological systems theory, reveal a complex interplay of contextual factors impacting children’s development. …”

Technology integration in newborn care: examining communication and decision-making among health professionals in Kenyan hospitals by Ngaiza, GK

“…Combining inductive and deductive coding, the thematic data analysis identified key themes and built explanations.</p> <p>Findings reveal that physical context elements, such as adequate staffing, patient rooms in close proximity and health professionals’ communal congregation area promote more frequent and in-depth communication among health professionals using CPAP and phototherapy. …”

Combined electron imaging and diffraction methods for understanding disordered rocksalt cathodes by Hedley, E

“…</p> <br> <p>The aforementioned digression into optimising the handling of 4D-STEM data involves an in-depth investigating the feasibility of ptychographyic reconstructions from event-based binary data. The investigation finds the method effectively reduces the data storage and processing memory requirements. …”

Associations between snoring, body mass index and coronary artery diseases: observational and mendelian randomization study in Asia by Zhu, Y, Lan, Y, Lv, J, Sun, D, Pei, P, Yang, L, Millwood, IY, Walters, RG, Chen, Y, Du, H, Wang, J, Yang, X, Stevens, R, Chen, J, Chen, Z, Li, L, Yu, C

“…The causal associations were independent of BMI. These findings indicated that snoring intervention might contribute to the decrease of CAD risk among Asians.…”

CipherTrace: automatic detection of ciphers from execution traces by Hassanin, MA

“…Finally, we report the findings, observations, limitations, and assert the feasibility and scalability of the concept, the dynamic analysis approach, as well as the technique applied to identify cryptographic (crypto) elements to classify a cipher. …”

Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood by Rabcuka, J, Smethurst, P, Dammert, K, Saker, J, Aran, G, Walsh, G, Tan, J, Codinach, M, McTaggart, K, Marks, D, Bakker, S, McMahon, A, Di Angelantonio, E, Roberts, D, Blonski, S, Korczyk, P, Shirakami, A, Cardigan, R, Swietach, P

“…Experiments compared freshly-drawn RBCs with stored RBCs, wherein metabolic run-down and spherical remodelling hinder oxygen unloading. <p><strong> Findings: </p></strong>Multivariable regression related τ to a ratio of side- and forward-scatter, referred to herein as FlowScore. …”

Effectiveness of fludrocortisone plus hydrocortisone versus hydrocortisone alone in septic shock: a systematic review and network meta-analysis of randomized controlled trials by Teja, B, Berube, M, Pereira, TV, Law, AC, Schanock, C, Pang, B, Wunsch, H, Walkey, AJ, Bosch, NA

“…Although we undertook several sensitivity analyses and assessments, these findings should be considered while also acknowledging the heterogeneity of included trials.…”

Association between gestational bisphenol a exposure and maternofoetal outcomes: a cohort study in a single tertiary hospital in Klang Valley by Juliana Yusof, Sarah Zulkifli, Mohd Shahril Ahmad Saman, Danial Efendy Goon, Nurliana Abd Mutalib, Nur Izzaty Yusnazery, Izzuan Khirman Adnan, Siti Hamimah Sheikh Abdul Kadir

“…Babies who need NICU admission were born to mothers who exhibited significantly different urinary BPA levels compared to those whose babies were not admitted (p=0.049). Finding from this study suggestive of further investigation on level of gestational urinary BPA with NICU admission, ideally with a larger sample size to validate these results.…”
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Comparative study of modeling, drying kinetics and specific energy consumption of desiccated coconut during convective and infrared drying by S., Yahya, A., Mohd Shamsul, A.G., Nur Hamizah, M.N., Mohd Zuhair

“…Experimental drying curves displayed only a falling drying rate period. The experimental findings demonstrated that drying temperature, air velocity, and drying techniques had a substantial impact on drying kinetics. …”
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Exploring critical components of physician-patient communication: a qualitative study of lay and professional perspectives by Mohd Salim, Nurul, Roslan, Nurhanis, Hod, Rafidah, Zakaria, Syahiera, Adam, Siti

“…We also found that the patients and relatives had a lack of awareness on confidentiality issues. These findings provide an insight on the improvement of medical training and patient education to improve patient care. …”
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