Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease by Bhosle, Amrisha, Bae, Sena, Zhang, Yancong, Chun, Eunyoung, Avila-Pacheco, Julian, Geistlinger, Ludwig, Pishchany, Gleb, Glickman, Jonathan N, Michaud, Monia, Waldron, Levi, Clish, Clary B, Xavier, Ramnik J, Vlamakis, Hera, Franzosa, Eric A, Garrett, Wendy S, Huttenhower, Curtis

“…One of these, nicotinamide riboside, reduced colitis scores in DSS-treated mice. The method, MACARRoN, is generalizable with the potential to improve microbial community characterization and provide therapeutic candidates.…”
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Actuated tissue engineered muscle grafts restore functional mobility after volumetric muscle loss by Rousseau, Erin, Raman, Ritu, Tamir, Tigist, Bu, Angel, Srinivasan, Shriya, Lynch, Naomi, Langer, Robert, White, Forest M., Cima, Michael J.

“…Here we show that targeted actuation of implanted grafts, via non-invasive transcutaneous light stimulation of optogenetic engineered muscle, restores motor function to levels similar to healthy mice 2 weeks post-injury. Furthermore, we conduct phosphoproteomic analysis of actuated engineered muscle in vivo and in vitro to show that repeated muscle contraction alters signaling pathways that play key roles in skeletal muscle contractility, adaptation to injury, neurite growth, neuromuscular synapse formation, angiogenesis, and cytoskeletal remodeling. …”
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Silicone cryogel skeletons enhance the survival and mechanical integrity of hydrogel-encapsulated cell therapies by Jeang, William J, Bochenek, Matthew A, Bose, Suman, Zhao, Yichao, Wong, Bryan M, Yang, Jiawei, Jiang, Alexis L, Langer, Robert, Anderson, Daniel G

“…Composite implants containing xenogeneic cells engineered to secrete erythropoietin significantly outperform unsupported alginate implants in therapeutic delivery over 8 weeks in immunocompetent mice. By improving mechanical resiliency and sustaining denser cell populations, silicone cryogel skeletons enable more durable and miniaturized therapeutic implants.…”
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Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy by Volpatti, Lisa R, Bochenek, Matthew A, Facklam, Amanda L, Burns, Delaney M, MacIsaac, Corina, Morgart, Alexander, Walters, Benjamin, Langer, Robert, Anderson, Daniel G

“…Material composition and formulation are tuned in each of these contexts to enable glycemic control in diabetic mice. For injectable, glucose‐responsive insulin delivery, 0.5 mm 2.5% oxidized alginate microgels facilitate repeat dosing and consistently provide 10 days of glycemic control. …”
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A dual-modal molecular probe for near-infrared fluorescence and photoacoustic imaging of peroxynitrite by Zhang, Jianjian, Zhen, Xu, Zeng, Jianfeng, Pu, Kanyi

“…Thus, CySO3CF3 not only specifically detects ONOO- in solution and cells with the limit of detection down to 53 nM but also allows for NIRF and photoacoustic dual-modal imaging of ONOO- in the tumors of living mice.…”
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Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells by Choi, Bo-Hwa, Kim, Wanil, Wang, Qiuxia Chelsia, Kim, Dong-Chan, Tan, Swee Ngin, Yong, Jean Wan Hong, Kim, Kyong-Tai, Yoon, Ho Sup

“…Bad were upregulated while Bcl-2 was down-regulated under KR exposure. A tumor growth in mice was dramatically suppressed by KR. In contrast, human skin fibroblast CCL-116 and bovine primary fibroblast cells show resistances to KR and no significant changes in Bad, Bcl-XL, and cleaved PARP were observed. …”
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Animal models of human disease 2.0 by Lange, Sigrun, Inal, Jameel

“…A total of twenty-two papers were published, including two comprehensive reviews on the use of diverse animal models to advance translational research and twenty original research papers using more common and conventional laboratory animal models (mice, rats, rabbits) or other less frequent comparative models (dogs and plateau pikas). …”
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Ex vivo analysis of the association of GFP-expressing L. aethiopica and L. mexicana with human peripheral blood-derived (PBD) leukocytes over 24 hours by Ranatunga, Medhavi, Deacon, Andrew, Harbige, Laurence S., Dyer, Paul, Boateng, Joshua, Getti, Giulia

“…These parasites can infect phagocytic cells (macrophages, dendritic cells, and neutrophils) and non-phagocytic cells (B cells and fibroblasts). In mice models, the disease development or resolution is linked to T cell responses involving inflammatory cytokines and the activation of macrophages with the M1/M2 phenotype. …”
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Evaluating new malaria vaccine candidates by Noé, A

“…This thesis explores the early response, kinetics and transcriptomics of CD8+ T cells in mice vaccinated with prime-target. Adoptively transferred liver TRM preferentially homed to the liver and <em>Plasmodium</em>-specific CD8+ T cells peaked shortly after intravenous boost. …”

Space use patterns and population dynamics in two common European rodents, Apodemus sylvaticus and Myodes glareolus by Dressen, S

“…In chapter 4, I analyse the density dependence of body weight and life history parameters in our wood mice population by constructing an integral projection model. …”

Germinal centre B cell and T follicular helper cell responses to viral vector and protein-in-adjuvant vaccines by Wang, C, Hart, M, Chui, C, Ajuogu, A, Brian, IJ, de Cassan, SC, Borrow, P, Draper, SJ, Douglas, AD

“…</p> <p>Here, using ovalbumin as a model antigen, we assessed the magnitude of the primary and anamnestic antigen-specific IgG responses of mice to four clinically-relevant vaccine formulations: replication-deficient adenovirus; modified vaccinia Ankara (MVA, a poxvirus); protein with alum; and protein in the squalene oil-in-water adjuvant Addavax. …”

Internal capital market of China I & II by Cheng, Yao Ling

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Development of a general-purpose motion control systems for robots and vehicles by Pang, Ching Hui

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Islands in jeopardy : how Singapore's offshore islands lost their heritage. by Lee, Jocelyn Yu Ying., Lim, Colin Ke Long., Loh, See Mun., Yeo, Irwin Chuan Siang.

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Translanguaging in translation as resistance : 《M40》by 谢裕民 by Ho, Zhi Hui

“…This paper focuses on the Singaporean writer Chia Joo Ming‘s M40, which contains a mixture of English and Chinese. …”
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Design and development of UAV for robotx challenge by Yong, Xun Hao

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Coexistence of harmony and freedom in the Zhuangzi by Li, Luyao

“…Zhuangzian harmony can be described as “collaborative individuals harmonize by responding to others to achieve flourishing,” while Zhuangzian freedom is defined as “an individual is free with ming (命) to pursue one’s intention.” Finally, this thesis elucidates how the tensions between harmony and freedom in Zhuangzi are resolved and how harmony and freedom can mutually enhance each other.…”
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Synthesis of CIGS nanoparticles for the application of low cost solar cells by Wong, Li Ting.

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Thermoelectric refrigerator by Keh, Yao Long.

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Drag of generic round-shaped bodies in supersonic flow by Song, Dennis Shao Hui.

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