The Response Regulator OmpR Negatively Controls the Expression of Genes Implicated in Tilimycin and Tilivalline Cytotoxin Production in Klebsiella oxytoca by Varela-Nájera, Ramón G., De la Cruz, Miguel A., Soria-Bustos, Jorge, González-Horta, Carmen, Delgado-Gardea, Ma Carmen E., Yáñez-Santos, Jorge A., Cedillo, María L., Hirakawa, Hidetada, Fox, James G., Sánchez-Ramírez, Blanca, Ares, Miguel A.

“…Our research highlights the pivotal role of OmpR, a key regulator within the EnvZ/OmpR two-component system, in controlling the virulence factors associated with K. oxytoca. Our findings strongly indicate that OmpR is a repressor of the aroX and npsA genes, the first genes of aroX and NRPS operons, respectively, which are indispensable for producing these enterotoxins. …”
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Sitetack: a deep learning model that improves PTM prediction by using known PTMs by Gutierrez, Clair S, Kassim, Alia A, Gutierrez, Benjamin D, Raines, Ronald T

“…Moreover, knowing PTM locations can increase the predictability of a different PTM. Our findings highlight the importance of PTMs for the installation of additional PTMs. …”
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A new method for the control of size of pellets in the melt pelletization process with a high shear mixer by Heng, Paul Wan Sia, Wong, Tin Wui, Shu, Jian Jun, Wan, Lucy Sai Cheong

“…The predictions of pellet growth by the mathematical model are in agreement with the experimental findings.…”
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Arbitrary-shape object localization using adaptive image grids by Yuan, Junsong, Zhou, Chunluan

“…First, a test image is partitioned into n×n grids and the object is localized by finding a set of connected grids which maximize the classifier's response. …”
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Dynamics of localized waves in one-dimensional random potentials : statistical theory of the coherent forward scattering peak by Lee, Kean Loon, Miniatura, Christian, Grémaud, Benoît

“…This is in perfect agreement with recent findings based on the nonlinear sigma model. In the stationary regime, the width of the CFS peak in momentum space is inversely proportional to the localization length, reflecting the exponential decay of the eigenfunctions in real space, while its height is exactly twice the background, reflecting the Poisson statistical properties of the eigenfunctions. …”
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Consistent effects of biodiversity loss on multifunctionality across contrasting ecosystems by Fanin, Nicolas, Gundale, Michael J., Farrell, Mark, Ciobanu, Marcel, Baldock, Jeff A., Nilsson, Marie-Charlotte, Kardol, Paul, Wardle, David A.

“…However, the context-dependency of biodiversity effects also worked in opposing directions for different individual functions, meaning that similar multifunctionality values across contrasting ecosystems could potentially mask important differences in the effects of biodiversity on functioning among ecosystems. Our findings highlight that an understanding of the relative contribution of species or functional groups to individual ecosystem functions among contrasting ecosystems and their interactions (that is, complementarity versus competition) is critical for guiding management efforts aimed at maintaining ecosystem multifunctionality and the delivery of multiple ecosystem services.…”
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Natural IgG antibodies provide innate protection against ficolin-opsonized bacteria by Panda, Saswati, Zhang, Jing, Tan, Nguan Soon, Ho, Bow, Ding, Jeak Ling

“…Thus, we have proven that natural IgG is not quiescent; rather, it plays a vital and immediate role in immune defense. Our findings provide a fresh perspective on natural antibodies, opening new avenues to explore host–microbe interaction. …”
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Understanding critical variables contributing to competitive advantages of international high-speed railway contractors by Niu, Yanliang, Deng, Xiaopeng, Zhang, Limao, Duan, Xiaochen

“…The case study indicated that the factor framework was suitable and tractable for the application. The findings of this paper could (1) assist international HSR contractors in obtaining a better understanding of the deeper determinates of competitive advantages and (2) serve as a valuable reference for developing their competitive advantages in the international HSR market.…”
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Targeting the cytochrome oxidases for drug development in mycobacteria by Lee, Bei Shi, Sviriaeva, Ekaterina, Pethe, Kevin

“…The identification of small-molecule inhibitors of the cytochrome bcc-aa3 under numerous experimental conditions reflects the essentiality of the pathway for the optimum growth of M. tuberculosis. Recent findings on the biology of the cytochrome bcc-aa3 as well as the report of the first high-resolution structure of a mycobacterial cytochrome bcc-aa3 complex will help in the characterization and further development of potent inhibitors. …”
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Atomic-scale mechanisms of defect- and light-induced oxidation and degradation of InSe by Kistanov, Andrey A., Cai, Yongqing, Zhou, Kun, Dmitriev, Sergey V., Zhang, Yong-Wei

“…Moreover, under ambient conditions, the splitting of O2 enables the formation of substitutional (apical) oxygen atomic species, which further cause the trapping and subsequent rapid splitting of H2O molecules and ultimately the formation of hydroxyl groups. Our findings uncover the causes and underlying mechanisms of InSe surface degradation via defect-photo-promoted oxidations. …”
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Nanoplasmonic ruler for measuring separation distance between supported lipid bilayers and oxide surfaces by Abdul Rahim Ferhan, Spackova, Barbora, Jackman, Joshua A., Ma, Gamaliel J., Sut, Tun Naw, Homola, Jiri, Cho, Nam-Joon

“…The results indicate that there is a larger separation distance between SLBs and titania surfaces than silica surfaces, and the trend was consistent across three tested lipid compositions. We discuss these findings within the context of the interfacial forces underpinning bilayer–substrate interactions, and the nanoplasmonic ruler strategy provides the first direct experimental evidence comparing SLB separation distances on titania and silica surfaces.…”
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RoboTSP - a fast solution to the robotic task sequencing problem by Suárez-Ruiz, Francisco, Lembono, Teguh Santoso, Pham, Quang-Cuong

“…We discuss the relationship between RTSP and other Traveling Salesman Problem (TSP) variants, such as the Generalized Traveling Salesman Problem (GTSP), and show experimentally that our method finds motion sequences of the same quality but using several orders of magnitude less computation time than existing approaches.…”
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Leveraging nanocrystal HKUST-1 in mixed-matrix membranes for ethylene/ethane separation by Chuah, Chong Yang, Samarasinghe, Samarasinghe Arachchige Sulashi Chathushka, Li, Wen, Goh, Kunli, Bae, Tae-Hyun

“…Then, polyimide-based polymers, ODPA-TMPDA and 6FDA-TMPDA, were chosen as the matrices. Our findings revealed that 20 wt% loading of HKUST-1 was capable of improving C₂H₄ permeability (155% for ODPA-TMPDA and 69% for 6FDA-TMPDA) without excessively sacrificing the C₂H₄/C₂H₆ selectivity. …”
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Unconventional split aptamers cleaved at functionally essential sites preserve biorecognition capability by Wang, Ruoyu, Zhang, Qiansen, Zhang, Yi, Shi, Hanchang, Nguyen, Kim Truc, Zhou, Xiaohong

“…Our work highlights the important role of MD simulations in predicting the ligand binding potency with functional nucleic acids at the molecular level. The findings will greatly promote discovery of new SPAs and their applications in molecular sensing in many fields.…”
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Mechanical design and performance evaluation of active thermosiphon beam terminal units by Ji, Ke, Cai, Wenjian, Wu, Bingjie, Ou, Xianhua

“…Moreover, the sensible heat ratio (SHR) and heat transfer effectiveness of ATB can reach 42% and 27.3 respectively which validate the feasibility of the proposed terminal unit. The experimental findings provide a guideline for the design and operation of the ATB system.…”
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Take a “selfie” : examining how leaders emerge from leader self-awareness, self-leadership, and self-efficacy by Bracht, Eva M., Keng-Highberger, Fong T., Avolio, Bruce J., Huang, Yiming

“…We critically discuss our findings and provide ideas for future research.…”
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Motivation to lead as mediator of relations between the dark triad, big five, and leadership intention by Kennedy, Jeffrey C., Chan, Kim Yin, Ho, Ringo Moon-Ho, Uy, Marilyn A., Chernyshenko, Oleksander S.

“…Narcissism explains variance in leadership intentions over and above that explained by extraversion; this contrasts with the studies of leader emergence, where the effect of narcissism disappears once extraversion is controlled. Overall, our findings validate the three-factor conceptualization of motivation to lead and illuminate the roles of both bright and dark personality factors in understanding individual desire to attain leadership roles.…”
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Potential ago2/miR-3068-5p cascades in the nucleus accumbens contribute to methamphetamine-induced locomotor sensitization of mice by Liu, Dan, Liang, Min, Zhu, Li, Zhou, Ting-Ting, Wang, Yu, Wang, Rui, Wu, Fei-Fei, Goh, Eyleen Lay Keow, Chen, Teng

“…Knocking down miR-3068-5p, serving as an Ago2-dependent miRNA, strengthened the METH sensitization responses in mice. These findings demonstrated that dysregulated Ago2 in neurons in the NAc is capable of regulating METH sensitization and suggested a potential role of Ago2-dependent miR-3068-5p in METH sensitization.…”
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Remote monitoring of patient respiration with mask attachment—a pragmatic solution for medical facilities by Koh, Vivian Ci Ai, Ang, Yi Yang, Ser, Wee, Tan, Rex Xiao

“…The overall accuracy of the wheeze detection algorithm was 91.9%. The current findings support and suggest the use of the mask attachment in medical facilities.…”
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Superior cooling performance of a single channel hybrid magnetofluidic cooling device by Varma, Vijaykumar Babulalji, Pattanaik, M. S., Cheekati, S. K., Ramanujan, Raju Vijayaraghavan

“…We also developed a simulation model to describe the MFC process; the results are in good agreement with our experimental findings. The high cooling performance of our device was found to be due to high vorticity and mixing. …”
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