Developing a personalized heterologous prime boost vaccination strategy for tumor therapy by Ramirez-Valdez, RA

“…The limited success of therapeutic cancer vaccines to date is likely due to sub-optimal generation of anti-tumor CD8 T cells and insufficient tumor microenvironment (TME) modulation. …”

Maternal postpartum six-week check and short-term health outcomes for women with hypertensive disorders in pregnancy: an observational study using the Clinical Practice Research Da... by Ramakrishnan, R, Korb, D, Li, Y, Knight, M, Carson, C

“…The proportion of women who received a SWC check was highest in 2007 (66.8%) but subsequently decreased. Women were less likely to have a SWC record if they were younger, of a minoritised ethnicity, living in more deprived areas, were multiparous, had severe HDP, preterm birth, caesarean birth, or had a low birthweight baby. …”

Industrial policy refraction: how corporate strategy shapes development outcomes in Brazil by Zylberberg, E

“…</p> <p>I introduce the inductively derived concept of <em>industrial policy refraction</em>, proposing that foreign firms respond to host countries' industrial policies in ways that are consonant with their corporate strategies; that centralized firms are less likely to comply with a host government's demands than are decentralized firms. …”

Molecular and physiological consequences of prematurity and blood pressure elevation on the young adult left ventricular stress response by Huckstep, O

“…Collectively, these findings suggest preterm-born young adults have reduced myocardial functional reserve which likely contributes to risk of future disease including heart failure. …”

Early Neoarchean geodynamic regime in the North China Craton: constraints from 2.7 Ga granitoids in the southern Jilin terrane by Liu, J, Zhang, H, Palin, RM, Liu, Z, Zhang, J, Cheng, C, Liu, X, Zhao, C

“…Combined with previous studies, we suggest that the North China Craton underwent significant crustal growth during the early Neoarchean, which was likely attributed to the synergistic effects of waning mantle plume activity and the coeval onset of plate tectonics.…”

Belgrave's quest for moral order in Bahrain, 1926-1957 by Fakhro, E

“…It shows how colonial officials responsible for exercising authority over Bahrain viewed these trends with alarm, as likely to spur a broader process of social decline, and ultimately bring about challenges to Britain’s political legitimacy in Bahrain.…”

Building fabric improvement and heat pump deployment: a set of policy conundrums by Killip, G, Topouzi, M, Fawcett, T

“…Setting minimum quality standards for deployment, and a policy framework which allows for local decision-making within nationally (and internationally) determined targets is likely to be part of the answer. This paper sets out the challenge for policy in devolution and coordination, providing a set of unresolved conundrums that future policy needs to meet. …”

Perceptions of a Buruli ulcer controlled human infection model: How, who, and why? by Muhi, S, Schmidt, S, Marshall, JL, O’Brien, DP, Johnson, PDR, McCarthy, JS, Jamrozik, E, Osowicki, J, Stinear, TP

“…An M. ulcerans controlled human infection model (MuCHIM) is likely to accelerate our understanding of this otherwise neglected disease, and may be an efficient platform for testing vaccines and other interventions. …”

Controls on present-day and future rainfall over southern Africa in coupled climate models by Munday, C

“…<p>Global climate change will likely alter rainfall at a regional scale. This is a particular concern in southern Africa, where rainfall is central to socioeconomic wellbeing and where we do not understand the full complexity of the climate system. …”

The molecular pathogenesis of FUS mutations in amyotrophic lateral sclerosis using in vivo and in vitro models by Kent, L

“…</p> <p>This work suggests that mutations in <em>FUS</em> are likely to affect motor neurons even when expressed at very low levels. …”

Concept of Computational Fluid Dynamics Design and Analysis Tool for Food Industry: A Bibliometric by M. Muktiarni, M. Muktiarni, Nur Indri Rahayu, Nur Indri Rahayu, Ai Nurhayati, Ai Nurhayati, Andika Dutha Bachari, Andika Dutha Bachari, Affero Ismail, Affero Ismail

“…Completing this research will likely provide information regarding publication sources and contributions made by several scientists from various affiliates and countries worldwide.…”
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3D printed magnetic digital microfluidics for biomedical applications by Kanitthamniyom, Pojchanun

“…Here, the detection of hepatitis B surface antigen using enzyme-linked immunosorbent assay (ELISA) was demonstrated on the new platform for the potential diagnostics of hepatitis. …”
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Community noise measure via crowd sourcing by Lim, Yun Jie

“…Noise pollution is linked to a range of health problems that impairs health and worsens living standards, resulting in both intangible (psychological, health) and physical (financial) losses. …”
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Cross-layer host-network co-design for QoS in streamed video data networking by Nan, Ya

“…The proposed design faces the challenge of constraints of both computation resources at the edge servers and network bandwidth of the edge-cloud links. An accuracy gradient-based resource allocation algorithm is proposed to allocate the limited computation and network resources across different video streams to achieve the maximum overall performance. …”
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The role of filamentous phage in the development of Pseudomonas aeruginosa biofilms by Manisha Mukherjee

“…These effects were primarily linked to the appearance of a superinfective form of the Pf4, which was observed at the time of dispersal. …”
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Biomolecular hydration in protein-protein interaction, protein stability and aggregation and lead optimization : computational studies by Mohan Rajan Pradhan

“…After providing a brief overview of biomolecular hydration and outlining the need for new insights to explain experimental observations such as aggregation (Chapter 1), a hydration metric is identified that is linked to Aggregation Prone Regions (APRs) in proteins. …”
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Investigating S-acylation in the metabolic dysfunction of the T2D heart by Dennis, KMJH

“…The lipid post translational modification <em>S</em>-acylation has been linked to regulating CD36 trafficking. However, it remains unknown whether CD36 is <em>S</em>-acylated in the heart and whether CD36 <em>S</em>-acylation levels are altered in T2D.…”

Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain by Platt, MA

“…</p> <br> <p>Given the close proximity of the PHD and BRD, and lack of TRIM24 PHD ligands, it was decided that a TRIM24 BRD ligand would be linked to a H3-mimicking peptide containing a KMe₃ isostere, to generate bivalent peptide-drug conjugates (PDCs) (Figure 0.1a). …”

Production and characterization of collagen and gelatin from edible jellyfish (Acromitus hardenbergi Stiasny, 1934) for fabrication of biofunctional scaffold by Khong, Nicholas Mun Hoe

“…The combinations of different jellyfish collagen and gelatin concentrations were observed to have significant effects on the cross-section morphology and the molecular integrity of the cross-linked scaffolds. Proportional combination of jellyfish collagen into the ternary scaffolds was found to significantly (p < 0.05) increase mean pore size and porosity. …”
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Analysis of Poly(ethylene terephthalate) degradation kinetics of evolved IsPETase variants using a surface crowding model by Zhong-Johnson, En Ze Linda, Dong, Ziyue, Canova, Christopher T, Destro, Francesco, Cañellas, Marina, Hoffman, Mikaila C, Maréchal, Jeanne, Johnson, Timothy M, Zheng, Maya, Schlau-Cohen, Gabriela S, Lucas, Maria Fátima, Braatz, Richard D, Sprenger, Kayla G, Voigt, Christopher A, Sinskey, Anthony J

“…Based on total internal reflectance fluorescence microscopy and adsorption experiments, IsPETase is likely experiencing crowded conditions on PET films. …”
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