Biological corneal inlay for presbyopia derived from small incision lenticule extraction (SMILE) by Liu, Yu-Chi, Teo, Ericia Pei Wen, Ang, Heng Pei, Seah, Xin Yi, Lwin, Nyein Chan, Yam, Gary Hin Fai, Mehta, Jodhbir Singh

“…The lenticule implantation effectively resulted in central corneal steepening (simulated keratometric values increased by 1.8–2.3 diopters), central hyper-prolate changes (asphericity Q values changed by −0.26 to −0.36), corneal anterior surface elevation (7.7–9.3 μm) and reasonable effective zone (1.5–1.8 times of the lenticule physical diameter), with no differences among the three groups. …”
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A case for energy-efficient acceleration of graph problems using embedded FPGA-based SoCs by Moorthy, Pradeep, Kapre, Nachiket

“…Across a set of benchmark graphs, we show that 32-node embedded SoC cluster can exceed the energy efficiency of an Intel E5-2407 by as much as 1.7× at a total graph processing capacity of 91–95 MTEPS for graphs as large as 32 million nodes and edges.…”
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Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus by Tam, Zhi Yang, Ng, Sean Pin, Tan, Ling Qiao, Lin, Chih-Hsien, Rothenbacher, Dietrich, Klenk, Jochen, Boehm, Bernhard Otto, Goh, Kelvin Kau Kiat, Suwanchaikasem, Pipob, Tipthara, Pornpimol, Koenig, W., Riepe, M., Peter, R., Geiger, H., Ludolph, A., Arnim, C. v., Denkinger, M. D., Yang, Song Yi, Nagel, G., Weinmayr, G., Rapp, K., Dallmeier, D., Steinacker, J. M., Laszlo, R., Becker, T., Stingl, J.

“…Lower levels of phenylalanine, acetylhistidine, and cyclic adenosine monophosphate (cAMP) were found in urine samples of T2D subjects validated with commercial standards. Elevated levels of 5′-methylthioadenosine (MTA), which previously has only been implicated in animal model of diabetes, was found in urine of older people with T2D.…”
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Succession of biofilm communities responsible for biofouling of membrane bio-reactors (MBRs) by Luo, Jinxue, Lv, Pengyi, Zhang, Jinsong, Fane, Anthony Gordon, McDougald, Diane, Rice, Scott A.

“…Based on qPCR data, bacteria were the dominant taxa of the biofilm (92.9–98.4%) relative to fungi (1.5–6.9%) and archaea (0.03–0.07%). NMDS analysis indicated that during the initial stages of operation, the biofilm communities were indistinguishable from those found in the sludge. …”
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Ultra low-power UWB-RFID system for precise location-aware applications by Zhou, Yuan, Law, Choi Look, Xia, Jingjing

“…When 1 s sleep mode is incorporated with 0.72 ms active mode, the tag consumes on average 6.8 uA when pulsing at 3.3 MHz rate with 15.5 dBm peak transmit power. The transmitted pulse is captured by low-cost energy-detection receivers at the locator. …”
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The Brazilian disc test for rock mechanics applications : review and new insights by Li, Diyuan, Wong, Louis Ngai Yuen

“…The maximum tensile stress and the maximum tensile strain are both found to occur about 5 mm away from the two loading points along the compressed diameter of the disc, instead of at the center of the disc surface. …”
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An ultra-low power asynchronous-logic in-situ self-adaptive VDD system for wireless sensor networks by Lin, Tong, Chong, Kwen-Siong, Chang, Joseph Sylvester, Gwee, Bah Hwee

“…The effort to achieve the lowest possible power operation is by means of adjusting VDD to the minimum voltage (within 50 mV) for said conditions. High robustness is achieved by adopting the Quasi-Delay-Insensitive (QDI) asynchronous-logic protocols where the circuits therein are self-timed, and by the embodiment of our proposed Pre-Charged-Static-Logic (PCSL) design approach; when compared against competing approaches, the PCSL is most competitive in terms of energy/operation, delay and IC area. …”
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Natural and synthetic homoisoflavonoids and related compounds for the treatment of macular degeneration by Schwikkard, S., Hiles, J., Opara, Elizabeth, Whitmore, H., Corson, T., Mulholland, D.

“…Macular conditions affect around 1.5 million people in the UK, with most of them suffering from age-related macular degeneration. …”

Agarose as a tissue mimic for the porcine heart, kidney, and liver: measurements and a springpot model by Mishra, A, Cleveland, RO

“…Frequency sweep tests were performed from 0.1 Hz to a maximum of 9.5 Hz at a shear strain amplitude of 0.1% for agarose and porcine organs. …”

Exome-wide evidence of compound heterozygous effects across common phenotypes in the UK Biobank by Lassen, FH, Venkatesh, SS, Baya, N, Hill, B, Zhou, W, Bloemendal, A, Neale, BM, Kessler, BM, Whiffin, N, Lindgren, CM, Palmer, DS

“…We phased rare variants (MAF ∼0.001%) in the UK Biobank (UKBB) exome-sequencing data to characterize recessive effects in 175,587 individuals across 311 common diseases. A total of 6.5% of individuals carry putatively damaging CH variants, 90% of which are only identifiable upon phasing rare variants (MAF < 0.38%). …”

Tailored dose baclofen in patients with alcoholic liver disease: A case series with 2-year follow-up of hospitalisation by Heydtmann, M, Macdonald, B, Lewsey, J, Masson, N, Cunningham, L, Irnazarow, A, Nardone, A, Cosgrave, J, Chick, J

“…</p> <p><strong>Methods:</strong> Fifty-three hospitalised patients with alcoholic liver disease started tailored dose baclofen (median: 5.05 months, median highest dose before tapering down: 60 mg). …”

Deubiquitinases in muscle physiology and disorders by Olie, CS, O'Brien, DP, Jones, HBL, Liang, Z, Damianou, A, Sur-Erdem, I, Pinto-Fernández, A, Raz, V, Kessler, BM

“…Several mutations in DUB encoding genes are linked to human NMDs, such as ATXN3, OTUD7A, UCHL1 and USP14, whilst other NMDs are associated with dysregulation of DUB expression. USP5, USP9X and USP14 are implicated in synaptic transmission and remodeling at the neuromuscular junction. …”

Establishing the association between traditional tobacco, e-cigarette and dual use and mental health problems among high school students: results from a 2022 behavioral surveillanc... by Thepthien, BO, Tinn, CS, Sharma, R

“…A secondary analysis was conducted using data from 2022 Bangkok Behavioral Surveillance Survey (BBSS) (6,000 invited, 5,740 completed). Among the respondents, approximately, 14.1% used EC only, 11.0% used CC only, and 7.9% used both in the past year. …”

Prevalence and risk factors for suicide attempts in prison by Favril, L, Shaw, J, Fazel, S

“…A total of 20 studies comprising 19,882 individuals (6.5% women) in 20 countries were eligible for inclusion. …”

Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics by Perochon, T, Krsnik, Z, Massimo, M, Ruchiy, Y, Romero, AL, Mohammadi, E, Li, X, Long, KR, Parkkinen, L, Blomgren, K, Lagache, T, Menassa, DA, Holcman, D

“…Additionally, we uncover an association between microglia and blood vessels in fetal brains exposed to maternal SARS-CoV-2. These findings offer insights into whether various microglial phenotypes form networks in the developing brain to occupy space, and in conditions involving haemorrhages, whether microglia respond to, or influence changes in blood vessel integrity. …”

A review of high-speed rotating HP turbine heat transfer and cooling studies over the last decade in the Oxford Turbine Research Facility by Falsetti, C, Beard, PF, Cardwell, DN, Chana, KS

“…Major upgrades include: (i) a combustor simulator able to produce engine radial and circumferential temperature profiles and inlet swirl simultaneously to study combustor-turbine interaction, (ii) fully film-cooled HP turbine designs and 1.5 stage configurations with a low-turning strut, (iii) novel rotor casing effusion cooling concepts, (iv) an advanced in-shaft data acquisition electronics system. …”

Additive manufacturing of tantalum scaffolds: processing, microstructure and process-induced defects by Aliyu, AAA, Poungsiri, K, Shinjo, J, Panwisawas, C, Reed, RC, Puncreobutr, C, Tumkanon, K, Kuimalee, S, Lohwongwatana, B

“…The presence of oxygen resulted in the formation of some oxide phases such as Ta2O5 and Ta2O3. Numerous process-induced defects, including solidification-induced micropores, pores-induced and solidification-induced microcracks were identified. …”

Strain‐modulated ferromagnetism at an intrinsic van der Waals heterojunction by Fujita, R, Gurung, G, Mawass, M, Smekhova, A, Kronast, F, Toh, AK, Soumyanarayanan, A, Ho, P, Singh, A, Heppell, E, Backes, D, Maccherozzi, F, Watanabe, K, Taniguchi, T, Mayoh, DA, Balakrishnan, G, van der Laan, G, Hesjedal, T

“…In this work, the piezoelectricity of the exfoliated van der Waals piezoelectric α-In2Se3 is utilized to modify the magnetic properties of exfoliated Fe3GeTe2, a van der Waals ferromagnet, resulting in increased domain wall density, reductions in the transition temperature ranging from 5 to 20 K, and an increase in the magnetic coercivity. …”

Board characteristics and financial performance: evidence from Bursa Malaysia Financial Times Stock Exchange (FTSE) top 100 index firms by Nur Hafizah Abdul Puhat, Suhaily Hasnan, Khairul Ayuni Mohd Kharuddin, Hafizah Marzuki, Mazurina Mohd Ali

“…The small percentage of politically-connected directors (19%) and military-experienced directors (5%) reported in this study can be viewed favourably in line with the recent MCCG 2021 recommendation that the appointment of the directors should be apolitical or politically neutral without having any executive powers in politics. …”
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Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics... by Ekowati, Juni, Tejo, Bimo A., Maulana, Saipul, Kusuma, Wisnu Ananta, Fatriani, Rizka, Ramadhanti, Nabila Sekar, Norhayati, Novianty, Kholis Amalia, Sulistyowaty, Melanny Ika, Zubair, Muhammad Sulaiman, Yamauchi, Takayasu, Hamid, Iwan Sahrial

“…Among tested compounds, chlorogenic acid (−6.90 kcal/mol), rosmarinic acid (−6.82 kcal/mol), and ellagic acid (−5.46 kcal/mol) exhibited the strongest binding affinity toward TNF-α convertase. …”