Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana by Brooks, Rhiannon L., Mistry, Chandni S., Dixon, Ann M.

“…We recently demonstrated that Reticulon-like protein B13 (RTNLB13) from Arabidopsis thaliana contains a curvature-responsive amphipathic helix (APH) important for the proteins’ ability to induce curvature in the ER membrane, but incapable of generating curvature by itself. …”
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In vitro and in silico investigation of TRPC3 mechanism and dynamics by Collingridge, J

“…Using a combination of in silico and in vitro approaches, this thesis proposes the vanilloid-like transmembrane domain S4/5 pocket as the binding site of a novel TRPC3 inhibitor, GSK-2820986A (GSK-986). …”

A renewal-equation approach to estimating Rt and infectious disease case counts in the presence of reporting delays by Bajaj, S, Thompson, R, Lambert, B

“…Our research highlights the value of keeping historical time series of cases since changes to these data can help to characterise nuisance processes, like reporting delays, which allow these to be accounted for when estimating key epidemic quantities.…”

Competitive overlap as a signal in expert partner choice: evidence from patent law firm selection by Borchhardt, G, Kovacs, B, Rogan, M

“…We found that firms are more likely to choose patent law firms who work with their competitors. …”

Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards in vivo malignant cell states by Van Essen, M, Nicheperovich, A, Schuster-Böckler, B, Becker, E, Jacob, J

“…Other sub-populations expressed transcriptional determinants consistent with a cancer stem cell (CSC)-like state that resembled cell states identified in vivo.…”

Genetic, natal, and spatial drivers of social phenotypes in wild great tits by Satarkar, D, Sepil, I, Sheldon, BC

“…<ol start="1"> <li>In social animals, group dynamics profoundly influence collective behaviours, vital in processes like information sharing and predator vigilance. …”

MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress by Rodrigues, B, Leitão, RA, Santos, M, Trofimov, A, Silva, M, Inácio, ÂS, Abreu, M, Nobre, RJ, Costa, J, Cardoso, AL, Milosevic, I, Peça, J, Oliveiros, B, Pereira de Almeida, L, Pinheiro, PS, Carvalho, AL

“…Additionally, viral overexpression of miR-186-5p in the PFC of naïve mice induces anxiety- and depressive-like behaviours. The upregulation of miR-186-5p through prolonged glucocorticoid receptor activation in vitro, or in a mouse model of chronic stress, differentially affects glutamatergic and GABAergic synaptic transmission, causing an imbalance in excitation/inhibition that leads to altered neuronal network activity. …”

Studying the metal sites of metallo-proteins by electrochemistry and spectroelectrochemistry by Sun, Y

“…</p> <p>Through these advanced methods, significant insights were gained into the stability of all-ferrous states and the environmental factors influencing them in proteins like NifH and AnfH. Challenges encountered with redox mediators in the presence of nucleotides underscored the need for novel mediators to avoid unwanted interactions during redox titrations. …”

Lightweight transformers for clinical natural language processing by Rohanian, O, Nouriborji, M, Jauncey, H, Kouchaki, S, Nooralahzadeh, F, Clifton, L, Merson, L, Clifton, DA

“…Many of these models are overparametrised and resource-intensive, but thanks to techniques like knowledge distillation, it is possible to create smaller versions that perform almost as well as their larger counterparts. …”

Stereoselective cyclisation cascades mediated by carbon electrophiles to access novel polycyclic scaffolds by Aynetdinova, DA

“…Finally, the developed methodology is applied for the synthesis of steroid-like compounds, including the formal synthesis of (±)-nor-estradiol.…”

Ottoman painting and painters during the First World War by Tongo, G

“…This study details the diverse institutions, exhibitions, patrons, collectors, critics, and artists who made up wartime Ottoman art world, as well as the rich variety of visual images produced during the war years, from popular illustrations to easel paintings. During the war, like other belligerent governments, the Ottoman state and semi-official patriotic associations commissioned artists to produce war-related works for internal and international propaganda purposes and, as the war progressed, as a historical record of national endeavour. …”

Magnetic field amplification in laser-produced plasmas by Meinecke, J

“…In the early universe, matter was nearly homogeneously distributed; today, as a result of gravitational instabilities, it forms a web-like structure of clusters, filaments, and voids. …”

Quantitative proteomics reveals CLR interactome in primary human cells by Manolis, D, Hasan, S, Maraveyas, A, O'Brien, DP, Kessler, BM, Kramer, H, Nikitenko, LL

“…The G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) mediates essential functions in several cell types and is implicated in cardiovascular pathologies, skin diseases, migraine and cancer. …”

The peacemakers: envisioning a Pax Americana in the age of empires by Suchak, N

“…Between 1895 and 1906, the United States, much like its European counterparts, was beset with imperial crises; it violently acquired an insular empire and jostled for position with other empires, as the global imperial system grew to its most expansive and fractious.…”

Another world is possible: reconceptualizing the “safe space”metaphor at a feminist safer space in New York City by Dlugatch, R

“…However, the potential of sites like these to offer cultural critique and provoke new ways of thinking about safety (and violence) has been overlooked. …”

The KDEL receptor by Bräuer, P

“…Comparison with other membrane proteins suggests how the KDELR likely evolved from an ancestral secondary active transporter, demonstrating that transporter-like architectures may have been adapted to transmit signals across cell membranes.…”

A pure world: moral cognition and spiritual experiences in Chinese World of Warcraft by Hornbeck, R

“…Chapter 4 argues that social agencies operant in the lives of C<em>WoW</em> players motivated players to utilise these morally relevant aspects of gameplay as a 'religion-like tool for group cohesion' (following Sosis &amp; Alcorta, 2008). …”

Role of spatial and sociodemographic variation on SARS-CoV-2 transmission and public health interventions in England by Bajaj, S

“…</p> <br> <p>In conclusion, this thesis contributes to the broader understanding of how infectious diseases like SARS-CoV-2 spread within a population and underscores the importance of equitable public health interventions. …”

Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA by Kelly, DM, Jones, ESW, Barday, Z, Arruebo, S, Caskey, FJ, Damster, S, Donner, J, Jha, V, Levin, A, Nangaku, M, Saad, S, Tonelli, M, Ye, F, Okpechi, IG, Bello, AK, Johnson, DW

“…There was reduced capacity for the management of CKD mineral bone disease in low-income countries (LICs) - serum parathyroid hormone was available in only 26% (n = 5) of LICs and the ability to administer non-calcium-based phosphate binders and cinacalcet was also very limited in LICs [16% (n = 3) and 5% (n = 1), respectively]. Nutritional services like oral supplements were accessible in 32% (n = 6) of LICs versus 97% (n = 61) of high-income countries. …”

Artificial intelligence, rationalization, and the limits of control in the public sector: the case of tax policy optimization by Mökander, J, Schroeder, R

“…Our analysis shows that building a machine-like tax system that promotes social and economic equality is possible. …”