Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya by Osoti, V, Wamae, K, Ndwiga, L, Gichuki, PM, Okoyo, C, Kepha, S, Keitany, K, Kandie, R, Aricha, S, Kiplagat, R, Mwandawiro, C, Bejon, P, Snow, RW, Ochola-Oyier, LI

“…The Pfdhfr 51I and 108 N pyrimethamine-resistance mutations were at fixation (100% frequency), and the Pfmdr1 Y184F mutation, which is linked to reduced susceptibility to several antimalarial drugs, especially those used in combination therapies for malaria treatment, was detected in 97.5% of the samples as mixed-genotype infections. …”

Identifying factors mediating the carnivore richness-productivity relationship across a precipitation-driven ecotone by Sultaire, S, Millspaugh, J, Montgomery, R

“…We fit additional community models linking carnivore species richness to vegetation and land cover variables to identify factors that mediate the relationship between carnivore richness and productivity.…”

The sustainable use of species-rich grasslands for forage and biogas production by French, K

“…Finally, by combining palaeoecological and modern vegetation data I demonstrate that grassland biodiversity was temporally and spatially linked to long-term human management and would revert to oscillating between open grassland and woodland if this management ceases. …”

Survey of healthcare-associated sink infrastructure, and sink trap antibiotic residues and biochemistry, in 29 UK hospitals by Rodger, G, Chau, K, Aranega Bou, P, Moore, G, Roohi, A, The SinkBug Consortium, Walker, AS, Stoesser, N

“…<p><strong>Background</strong></p> Hospital sinks are linked to healthcare-associated infections. Antibiotics and chemicals in sink traps can select for pathogens and antimicrobial resistance (AMR). …”

Most of the world's largest flowers (genus Rafflesia) are now on the brink of extinction by Malabrigo Jr, P, Tobias, AB, Witono, J, Mursidawati, S, Susatya, A, Siti-Munirah, MY, Wicaksono, A, Raihandhany, R, Edwards, S, Thorogood, CJ

“…We suggest action devolved to local communities and awareness campaigns linked to social media networks will be crucial outside of protected jurisdictions. …”

Engineering modular platforms for rapid vaccine development by Brune, K

“…I demonstrate the modularity of this approach by covalently linking several complex, cysteine-rich malarial antigens to SpyCatcher-VLPs, such as the transmission-blocking antigen Pfs25 and the blood-stage antigen CIDR. …”

Functional genetics of cancer and congenital disorders by Zak, J

“…In summary, this work identified novel candidate pathogenic variants in developmental disorders and cancer, and explored the mechanisms underlying their respective genotype-phenotype links.</p>…”

Barriers and opportunities for WHO ‘best buys’ non-communicable disease policy adoption and implementation from a political economy perspective: a complexity systematic review by Loffreda, G, Arakelyan, S, Bou-Orm, I, Holmer, H, Allen, LN, Witter, S, Ager, A, Diaconu, K

“…</p> <p><strong>Results:</strong> Our CLD highlights a central feedback loop encompassing three vital variables: (1) the ability to define, (re)shape, and pass appropriate policy into law; (2) the ability to implement the policy (linked to the enforceability of the policy and to addressing NCD local burden); and (3) ability to monitor progress, evaluate and correct the course. …”

Characterising the functional role of GATA1short isoform in normal and malignant haematopoiesis by Cruz Hernandez, D

“…Both TAM and ML-DS are driven by mutations in the gene encoding the X-linked erythroid-megakaryocyte transcription factor GATA1 that result in truncation of 83 N-terminal amino acids to produce GATA1short (GATA1s). …”

External validation of the QCovid risk prediction algorithm for risk of COVID-19 hospitalisation and mortality in adults: national validation cohort study in Scotland by Simpson, CR, Robertson, C, Kerr, S, Shi, T, Vasileiou, E, Moore, E, McCowan, C, Agrawal, U, Docherty, A, Mulholland, R, Murray, J, Ritchie, LD, McMenamin, J, Hippisley-Cox, J, Sheikh, A

“…Primary care data were linked to reverse-transcription PCR (RT-PCR) virology testing, hospitalisation and mortality data. …”

Fracture prediction in rheumatoid arthritis: validation of FRAX with bone mineral density for incident major osteoporotic fractures by Richards, C, Stevens, R, Lix, LM, McCloskey, EV, Johansson, H, Harvey, NC, Kanis, JA, Leslie, WD

“…</p> <p><strong>Methods:</strong> Administrative data from patients receiving BMD testing were linked to the Manitoba Population Health Research Data Repository. …”

Brain markers of cumulative stress response and allostatic load in the ageing Whitehall II cohort by Zsoldos, E

“…</p> <p>This thesis thus provides some empirical support for the concept of allostatic load, linking 'everyday' stress and features of the ageing human brain.…”

Participation and cooperation in global climate governance by Rowan, SS

“…First, state participation in climate institutions is linked to their dissatisfaction. Second, patterns of participation are associated with the ambition of countries’ greenhouse gas mitigation targets in the Paris Agreement. …”

Spontaneous ventricular tachyarrhythmias in β2-adrenoceptor transgenic mice in relation to cardiac interstitial fibrosis by Nguyen, M-N, Kiriazis, H, Ruggiero, D, Gao, X-M, Su, Y, Jian, A, Han, L-P, McMullen, JR, Du, X-J

“…The number of VEBs or VT episodes correlated with age (r = 0.83 and r = 0.73) and the content of total or cross-linked collagen (r = 0.62∼0.66, all P &lt;0.01). While having no effect in younger β2-TG mice, β2-AR blockade reduced the frequency of VTA in old β2-TG mice with more severe fibrosis. …”

How economic crises affect alcohol consumption and alcohol-related health problems: A realist systematic review by de Goeij, MCM, Suhrcke, M, Toffolutti, V, van de Mheen, D, Schoenmakers, TM, Kunst, AE

“…Medical, psychological, social, and economic databases were used to search for peer-reviewed qualitative or quantitative empirical evidence (published January 1, 1990-May 1, 2014) linking economic crises or stressors with alcohol consumption and alcohol-related health problems. …”

Temporal evolution of mechanical properties in PDMS: A comparative study of elastic modulus and relaxation time for storage in air and aqueous environment by Zhang, Y, Adam, C, Rehnstrom, H, Contera, S

“…Polydimethylsiloxane (PDMS) is a soft, biocompatible polymer extensively employed in biomedical research, notable for its tunable mechanical properties achieved through cross-linking. While many studies have assessed the mechanical properties of PDMS utilizing macroscopic and microscopic methods, these analyses are often limited to freshly prepared samples. …”

Global marine flyways identified for long-distance migrating seabirds from tracking data by Davies, T, Guilford, T

“…Generally, the flyways were used bidirectionally, and individuals either followed sections of a flyway, a complete flyway, or their movements linked two or more flyways. Transhemispheric figure-of-eight routes in the Atlantic and Pacific oceans, and a circumnavigation flyway in the Southern Ocean correspond with major wind-driven ocean currents.…”

Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve by DiGregorio, H, Mansoorshahi, S, Carlisle, SG, Tovar Pensa, C, Watts, A, McNeely, C, Sabate-Rotes, A, Yetman, A, Michelena, HI, De Backer, JFA, Mosquera, LM, Bissell, MM, Andreassi, MG, Foffa, I, Hui, DS, Caffarelli, A, Kim, YY, Citro, R, De Marco, M, Tretter, JT, McBride, KL, Body, SC, Milewicz, DM, Prakash, SK

“…This study is aimed to assess the role of rare 22q11.2 CNVs in patients with early-onset BAV (EBAV) and to determine whether these variants are linked to an increased risk of complications. Methods: Whole genome microarray genotyping was conducted on 272 patients with BAV with early onset valve or aortic disease (EBAV) and 272 biological relatives. …”

Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…I apply this assay to investigate a specific mRNA, <em>shot</em>, previously identified as encoding important protein regulators of synaptic development and linked to neurodevelopmental disorders.…”

Antiquity as authority: Jesus and the patriarchs in the Gospel of John by Van Dyk, SL

“…In each instance, the challenge directed to Jesus is contextually linked with his authority to offer eternal life (John 4:10, 13-14; 8:51-52). …”