The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in the piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster by Patil, Veena S., Anand, Amit, Chakrabarti, Alisha, Kai, Toshie

“…In the current study, we identified the paralog of the Drosophila tej gene, tapas (tap), which is an ortholog of vertebrate Tdrd7. Like Tej, Tap is localized at the nuage. Alone, tap loss leads to a mild increase in transposon expression and decrease in piRNAs targeting transposons expressed in the germline. …”
Get full text
Get full text

Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans by Xu, Luang, Liu, Xinyu, Sheng, Na, Oo, Kyaw Soe, Liang, Junxin, Chionh, Yok Hian, Xu, Juan, Ye, Fuzhou, Gao, Yong-Gui, Dedon, Peter C., Fu, Xin-Yuan

“…We found that methyltransferase-like (METTL) 2 and 6 contribute m3C in specific tRNAs and that METTL8 only contributes m3C to mRNA. …”
Get full text
Get full text

Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype–anti-idiotype Fab complex by Wong, Yee Hwa, Goh, Boon Chong, Lim, She Yah, Teo, En Wei, Lim, Angeline P. C., Dedon, Pete C., Hanson, Brendon J., MacAry, Paul A., Lescar, Julien

“…We show that E1 can be utilized to detect HM14c10-like antibodies in sera from patients who recovered from DENV-1, infection suggesting that this is a public (common) idiotype. …”
Get full text
Get full text

Epithelial-mesenchymal transition of cancer cells using bioengineered hybrid scaffold composed of hydrogel/3D-fibrous framework by Pal, Mintu, Chen, Huizhi, Lee, Bae Hoon, Lee, Justin Yin Hao, Yip, Yun Sheng, Tan, Nguan Soon, Tan, Lay Poh

“…Cancer cells undergoing epithelial-mesenchymal transition (EMT) acquire stem cell-like phenotype associated with malignant behaviour, chemoresistance, and relapse. …”
Get full text
Get full text

The magnitude and risk factors of intestinal parasitic infection in relation to human immunodeficiency virus infection and immune status, at ALERT hospital, Addis Ababa, Ethiopia by Taye, Biruhalem, Desta, Kassu, Ejigu, Selamawit, Dori, Geme Urge

“…Human Immunodeficiency Virus (HIV) and intestinal parasitic infections are among the main health problems in developing countries like Ethiopia. Particularly, co-infections of these diseases would worsen the progression of HIV to Acquired Immunodeficiency Syndrome (AIDS). …”
Get full text
Get full text

Maternal infections during pregnancy and the risk of childhood leukaemia in the offspring: Evidence from large-scale cohort studies by He, J

“…In the I4C analysis, maternal urinary tract infection (HR, 1.68; 95% CI, 1.10-2.58) and respiratory tract infection (HR, 1.54; 95% CI, 1.05-2.26) were associated with increased risk of childhood leukaemia. Influenza-like illness showed a similar pattern but with less precise estimates (HR, 1.62; 95% CI, 0.76-3.42). …”

Financial elites and the spatial variation of inequality: examining the intersection of gender, race and class in Frankfurt, London, and New York by Kaempfer, K

“…Finally, it seeks to assess the influence of external stakeholders like executive search firms (ESFs) and regulators on the formation and reproduction of financial elites. …”

Development of image-based method for the quantitative assessment of cartilage damage from CT as a biomarker in osteoarthritis by Zheng, J-Q

“…<p>Preclinical studies, like those for drug development, require quantitative methods to assess osteoarthritis (OA). …”

Metabolic maturation of induced pluripotent stem cells derived cardiomyocytes by Lopez, C

“…By simultaneously targeting both maturation methods we have shown a degree of maturation through an increased movement towards reduced glycolysis and increased FAO in our iPSC-CMs.</p> <p>Like others this thesis has shown that iPSC-CMs mature slowly over time with changes in structural genes occurring during the first month of differentiation and continuing to increase up to 3 months, whereas metabolic changes took longer to develop. 3D culture on collagen-derived scaffolds and engineered heart tissue (EHT) accelerated this maturation time and increased mitochondrial oxidative metabolism while decreasing anaerobic glycolysis. …”

Molecular characterisation of methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in cats, dogs and pet owners in a Veterinary Hospital by Afshar, Mohammad Farzad

“…Having close contact with animals like allowing them to lick face and having other animals had a significant association with carriage of staphylococci in this study. …”
Get full text

Impact of BPL penalty functions and PSF models in PET/CT radial spatial resolution recovery by Si, Wang Jie

“…Advanced reconstruction algorithms like TOF, BPL, and PSF models, along with OSEM have shown spatial resolution enhancements based on the FWHM measured. …”
Get full text

Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition by Flower, Cameron Timothy

“…By leveraging targeted and untargeted mass spectrometry (MS) of endogenous tyrosine-phosphorylated proteins, which enables phosphosite-specific quantification of TK signaling networks, I report several cell line-specific vulnerabilities not predicted to exist at the genetic level, and the consensus observation that sustained activity of SRC family kinases (SFKs), or of the SRC-like kinases ABL1/2, is an important contributor to GM-TKI tolerance in all lines. …”
Get full text
Get full text

Fluid-fluid displacement in porous-media microfluidics by Qiu, Yu

“…Many questions remain, however, regarding how the macroscopic displacement patterns are controlled by the microscale interactions between the fluid interface and the solid surface in systems under geometric confinement like microfluidic devices and porous media. This fluid-solid interaction—exacerbated by the roughness inherent to all natural and engineered surfaces—introduces a large energy dissipation near the solid boundary that challenges our ability to interpret laboratory experiments and develop mathematical models. …”
Get full text
Get full text

Smart window for tuning transparency and noise absorption by Shrestha, Milan

“…As a tunable optical surface scatter, it turns transparent with a smooth surface like a flat glass; but it turns ‘opaque’ (translucent) with the micro-rough surface. …”
Get full text
Get full text

VR-CFD : interactive simulation of computational fluid dynamics by Yang, Sida

“…The developed VR-CFD application utilized an attractive design with bright colours, familiar game characters and game-like user interface aimed to make the introductory CFD class fun, interactive and engaging, helping students intuitively grasp the physics concepts. …”
Get full text

Phase transitions by an abundant protein in the anammox extracellular matrix mediate cell-to-cell aggregation and biofilm formation by Seviour, Thomas, Wong, Lan Li, Lu, Yang, Mugunthan, Sudarsan, Yang, Qiaohui, Chanda Segaran, Uma Shankari, Bessarab, Irina, Liebl, David, Williams, Rohan B. H., Law, Yingyu, Kjelleberg, Staffan

“…The Brosi_A1236 structure was computationally predicted to consist of immunoglobulin-like anti-parallel β-strands, and circular dichroism conducted on the isolated surface protein indicated that β-strands are the dominant higher-order structure. …”
Get full text

An NKX2-1GFP and TP63tdTomato dual fluorescent reporter for the investigation of human lung basal cell biology by Goh, Kim Jee, Tan, Ee Kim, Lu, Hao, Roy, Sudipto, Dunn, Norris Ray

Get full text

Functional metagenomic analysis of quorum sensing signaling in a nitrifying community by Tan, Chuan Hao, Yeo, Yee Phan, Muhammad Hafiz Ismail, Ng, Noele Kai Jing, Subramoni, Sujatha, Taj, Shireen, Tay, Martin, Chao, Xie, Kjelleberg, Staffan, Rice, Scott A.

Get full text

Cryogelation of human hair keratins by Chua, Huei Min

“…Microarchitecture analysis revealed that FT cycling rendered a change from sheet-like lamellae in FT0 sponges to interconnected polygonal pores in freeze-thawed sponges. …”
Get full text

High mobility 3D Dirac semimetal (Cd₃As₂) for ultrafast photoactive terahertz photonics by Dai, Zijie, Manjappa, Manukumara, Yang, Yunkun, Tan, Thomas CaiWei, Qiang, Bo, Han, Song, Wong, Liang Jie, Xiu, Faxian, Liu, Weiwei, Singh, Ranjan

Get full text