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2861
Performance-based identity in a BIM environment : An architect’s perceptions and experiences
Published 2022“…Consequently, architects' failing to adapt their core identity to the varying circumstances may lead to their irrelevance and being side-lined merely as aesthetic building surgeons. The current study therefore seeks a better understanding of their perceptions and experiences in manifesting their identities in the phenomenon. …”
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Article -
2862
Regulation of microRNA degradation in Caenorhabditis elegans via the E3 ubiquitin ligase EBAX-1
Published 2024“…TDMD underlies the instability of many miRNAs in diverse cell lines and animals. In this work, I probe the biological scope of TDMD as a regulatory mechanism in the nematode Caenorhabiditis elegans, which tolerates homozygous loss of the ZSWIM8 ortholog, EBAX-1, and expresses some miRNAs that are subject to rapid, developmentally regulated decay. …”
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Thesis -
2863
Development of immunomodulatory RNA therapeutics for immune disorders
Published 2022“…We show that these ASOs can modulate T cell behavior in human cell lines and human primary cells, validating the potential of ASOs as a therapeutic approach for immune diseases. …”
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Thesis-Doctor of Philosophy -
2864
Data-driven distributionally robust CVaR portfolio optimization under a regime-switching ambiguity set
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Journal Article -
2865
Financial forecasting using meta-cognitive fuzzy neural networks
Published 2014“…The primary meta-cognitive strategies are Sample deletion, Sample Learning and Sample Reserve. Following on the lines of Technical Analysis carried out by traders and investors on the historical prices of a company’s stock, the project makes use of various Financial Indicators to decide whether a particular instance of time is good for investment, disinvestment or to remain idle. …”
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Final Year Project (FYP) -
2866
Taliban resurgence in Afghanistan : the role of post-conflict reconstruction
Published 2015“…Under the auspices of Bonn-I, the international community initiated a process of post-conflict reconstruction on both security and non-security lines. Bonn-I provided a framework for setting up an interim government tasked with drafting a constitution, convening a Loya Jirga (grand assembly), holding presidential and parliamentary elections by 2005, strengthening the Afghan police and military forces, and establishing a judicial system. …”
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Thesis -
2867
Multi-spectral polarimetry imaging for early gastric cancer diagnosis
Published 2016“…Gastric cancer, which develops from the lining of stomach, is the fifth most severe disease worldwide. …”
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Thesis -
2868
The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells
Published 2020“…Methods: The functional expression of Ca2+-activated (KCa3.1, also known as KCNN4) and voltage-dependent (Kv11.1, also known as KCNH2 or hERG1) K+ channels was determined in two CRC cell lines (HCT-116 and HCT-8) by molecular and electrophysiological techniques. …”
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Journal Article -
2869
Design and Synthesis of Stimuli-Responsive Polymers with Programmable Cleavability
Published 2024“…The second chapter reports the first synthesis of peptide-containing bivalent bottlebrush (co)polymers (BBPs), featuring caspase-3-cleavable peptides linked to fluorogenic probes that provide a “turnon” signal upon enzymatic cleavage. …”
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Thesis -
2870
Mapping the Cellular Landscape of the Brain: A Scalable Approach to Comprehensive Microscopy Data Analysis
Published 2024“…Given that cellular morphology is strongly linked to distinct functional states of cells, in-depth morphological analysis of such data offers immense potential for understanding their roles in brain development and disease. …”
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Thesis -
2871
Design of Cleavable Monomers and Cross-Linkers for the Synthesis of Degradable Polymer Architectures
Published 2024“…A brief introduction to the current strategies utilized to impart chemical deconstruction to cross-linked polymer networks prepared by radical polymerization is presented (Chapter 4). …”
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Thesis -
2872
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2873
新加坡和 “一带一路” :国家与社会的视角和策略 = Singapore and the belt and road initiative : perspectives and strategies from the state and society
Published 2021“…It argues that the two key factors for Singapore’s fruitful participation in the BRI are the state’s leadership and the transnational network’s coordination. These are in turn linked with effective institutional mechanisms and smooth implementation of transnational networks. …”
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Thesis-Doctor of Philosophy -
2874
Organic solvent-assisted control of hydrogel structures and properties
Published 2024“…Hydrogels are three-dimensional (3D) cross-linked polymeric networks containing a significant amount of water and have found their applications in various fields, including tissue engineering, drug delivery, etc. …”
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Thesis-Doctor of Philosophy -
2875
Development of novel chemical ligation methods for the synthesis of posttranslationally modified proteins
Published 2012“…In chapter 4, we modify and improve our dual chemical ligation approach and apply it in the synthesis of a K48-linked diubiquitin. This demonstrated the feasibility of our methodology in synthesizing ubiquitinated proteins. …”
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Thesis -
2876
Distributed droop schemes for standalone and interlinked AC microgrids
Published 2014“…The formed microgrids can certainly be controlled by centralized management systems, but for widely dispersed DGs where communication links are not viable, autonomous droop schemes might be more appropriate. …”
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Thesis -
2877
Gene expression regulation by well-known non-coding RNAs
Published 2015“…In one project, we attempted to insert a second Xist gene into the single X chromosome of male murine embryonic stem (ES) cells to cause ectopic XCI upon differentiation, leading to cell lethality as important X-linked genes were inactivated. From there, we could screen for genes important for XCI by rescuing the differentiated transgenic ES cells by gene silencing. …”
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Thesis -
2878
Robust cooperative control and optimization of multi-agent systems
Published 2018“…Nodes connected with a positive edge can be viewed as “friends” and linked with a negative edge can be viewed as “enemies”. …”
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Thesis -
2879
An epigenetic locus associated with loss of smell in COVID-19
Published 2024“…Previous studies, including genome-wide association studies (GWAS), have identified genetic variants near the UGT2A1 and UGT2A2 genes that are linked to anosmia in COVID-19 patients. However, the role of epigenetic changes in the development and persistence of smell loss has not been well explored. …”
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Article -
2880
Impact of co-morbid common mental disorder symptoms in people with epilepsy in Ethiopia on quality of life and functional disability: cohort study
Published 2024“…Structural equation modelling (SEM) was employed to examine direct and indirect pathways linking co-morbid CMD symptoms with QoL or functional disability.…”
Internet publication