Adverse events of common psychiatric medications: an umbrella review by Bartellas, K

“…Many medications were linked to adverse events through a weak or moderate strength of association and additional factors contributed to the variability in adverse outcome reporting aside from patient characteristics. …”

HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease by Yogeshwar, SM, Muñiz-Castrillo, S, Sabater, L, Peris-Sempere, V, Mallajosyula, V, Luo, G, Yan, H, Yu, E, Zhang, J, Lin, L, Fagundes Bueno, F, Ji, X, Picard, G, Rogemond, V, Pinto, AL, Heidbreder, A, Höftberger, R, Graus, F, Dalmau, J, Santamaria, J, Iranzo, A, Schreiner, B, Giannoccaro, MP, Liguori, R, Shimohata, T, Kimura, A, Ono, Y, Binks, S, Mariotto, S, Dinoto, A, Bonello, M, Hartmann, CJ, Tambasco, N, Nigro, P, Prüss, H, McKeon, A, Davis, MM, Irani, SR, Honnorat, J, Gaig, C, Finke, C, Mignot, E

“…HLA sequences and binding cores for these three DQ heterodimers were similar, unlike those of linked DRB1 alleles, supporting a causal link to HLA-DQ. …”

Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro,... by Yang, Z, Sheehan, AM, Messer, AE, Tsui, S, Sparrow, A, Redwood, C, Kren, V, Gould, IR, Marston, SB

“…Phosphorylation causes a 2-3 fold decrease of affinity of cTn for Ca2+ associated with a higher rate of Ca2+ dissociation from cTnC leading to a faster relaxation rate of the cardiac muscle (lusitropy). Cardiomyopathy-linked mutations primarily affect Ca2+ regulation or the PKA-dependent modulatory system, such that Ca2+-sensitivity becomes independent of phosphorylation level (uncoupling) and this could be sufficient to induce cardiomyopathy. …”

Enhancement of lentiviral vector production through alteration of virus-cell interactions by Gelinas, J

“…To support this aim, viruses have been modified, with elements linked to viral pathogenicity removed from their genome and replaced by the genetic material to be delivered. …”

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases by Vinogradova, Y, Coupland, C, Hippisley-Cox, J

“…Setting: UK general practices contributing to QResearch or Clinical Practice Research Datalink (CPRD), linked to hospital, mortality, social deprivation, and cancer registry (QResearch only) data. …”

Managing risks to the media from emerging networked technologies by Shere, ARK

“…The countermeasures are linked to phases of the overarching editorial workflow, to ensure that their implementation is feasible and that they are clearly useful by and for specific role categories within the media.…”

Management and outcomes of thoracic sarcomas - a collaboration between Orthopaedic Oncology and cardiothoracic surgery: seven-year clinical data from a tertiary referral centre by Shamsi, ZA, Paraoan, V, Kim, C, Saifuddin, SR, Cosker, TDA, Whitwell, D, Gibbons, CLMH, Stavroulias, D, DiChiara, F

“…Both surgical intervention (p < 0.0001) and clear margins (p = 0.0051) were significantly linked to improved survival. Local recurrence was noted in 28.6% of the 77 surgical cases, and predominantly in the high-grade sarcomas (81.8%). …”

In-silico trials with human modelling and simulation for guiding optimal stratification of atrial fibrillation patients to catheter ablation and pharmacological therapy by Dasí i Martinez, A

“…Different mechanisms of the arrhythmia (i.e., stable micro-re-entries, wavefront meandering, transient rotors and wave breakups) have been linked to specific ionic current dysregulations and their relationship with the structurally-remodelled substrate (i.e., presence of low voltage areas and atrial enlargement).…”

Spatio-temporal variations and El Niño modulation of meteorological droughts in Malaysia by Zakaria, Nurul Ain Basirah, Tangang, Fredolin, Salimun, Ester, Amirudin, Abdul Azim, Xiang, Chung Jing, Juneng, Liew, Tan, Mou Leong, Zulkafli, Zed, Marzuki, Marzuki, Santisirisomboon, Jerasorn, Akhir, Mohd Fadzil, Abdullah, Muhamammad Firdaus Ammar, Jamaluddin, Ahmad Fairudz, Mohd, Mohd Syazwan Faisal

“…Drought characteristics exhibit a strong seasonality linked to changes in the Walker circulation and the strengthening and weakening of anticyclonic circulations associated with Rossby waves induced by heating in the Pacific Ocean. …”

Synthesis and optical study of lead halide perovskites for opto-electronic applications by Ha, Son Tung

“…These methods usually result in polycrystalline film with many pin-holes and defects. As a physicist, my first aim is to find a way to prepare highest quality, single crystal samples for studying their intrinsic and fundamental properties. …”
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Single-molecule diagnostics to support curative interventions for tuberculosis and HIV by Dougan, Tyler J.

“…In this thesis, I describe the advancement of digital enzyme-linked immunosorbent assay (ELISA) protein detection methods in service of curing these two deadly infectious diseases. …”
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Assessing the origin of and potential for international spread of Chikungunya virus from the Caribbean by Khan, Kamran, Bogoch, Isaac, Brownstein, John S., Miniota, Jennifer, Nicolucci, Adrian, Hu, Wei, Nsoesie, Elaine O., Cetron, Martin, Creatore, Maria Isabella, German, Matthew, Wilder-Smith, Annelies

“…Conclusion: The rapidly evolving outbreak of chikungunya in the Caribbean poses a growing risk to countries and areas linked by air travel, including the United States where competent Aedes mosquitoes exist. …”
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Effect of a high strength chemical industry wastewater on microbial community dynamics and mesophilic methane generation by Venkatakrishnan, Harish, Tan, Youming, Majid, Maszenan bin Abdul, Pathak, Santosh, Sendjaja, Antonius Yudi, Li, Dongzhe, Liu, Jerry Jian Lin, Zhou, Yan, Ng, Wun Jern

“…This study suggested that the degradation of organic components within the high strength industrial wastewater is closely linked with the activity of certain niche microbial communities within eubacteria and methanogens.…”
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Multilayered siRNA nanoparticles as a delivery system for extended gene silencing effect by Ng, Alice Jie Ying

“…For instance, an elevated expression of secreted protein acidic and rich in cysteine (SPARC) is linked with fibrosis and the inhibition of SPARC expression reduces fibrosis. …”
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Age-related bone loss is associated with FGF21 but not IGFBP1 in healthy adults by Lee, Shuen Yee, Fam, Kai Deng, Chia, Kar Ling, Yap, Margaret M. C., Goh, Jorming, Yeo, Kwee Poo, Yap, Eric Peng Huat, Chotirmall, Sanjay Haresh, Lim, Chin Leong

“…The purpose of this study was to explore the FGF21-regulatory axis in bone turnover and the age-related decline in bone mineral density (BMD). Twenty ‘genetically linked’ family (parent and child) pairs were recruited. …”
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DropLab: an automated magnetic digital microfluidic platform for sample-to-answer point-of-care testing-development and application to quantitative immunodiagnostics by Hu, Xuyang, Gao, Xiangyu, Chen, Songlin, Guo, Jinhong, Zhang, Yi

“…Although other immunodiagnostic assays, such as enzyme-linked immunosorbent assays (ELISAs), offer more sensitive and quantitative results, they require complex liquid manipulations that are difficult to implement in POCT settings by conventional means. …”
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Barnacle cement protein as an efficient bioinspired corrosion inhibitor by Bui, My Hanh, Hiew, Shu Hui, Salim, Teddy, Saw, Wan Geok, Webster, Richard David, Grüber, Gerhard, Mu, Yuguang, Miserez, Ali

“…We reveal that these anti-corrosion properties are linked to the protein’s biophysical properties, namely its strong adsorption to surfaces combined with its interaction with Fe ions released by steel substrates, which forms a stable layer that increases the coating’s impedance and delays corrosion. …”
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Novel nitric oxide donors for the dispersal and control of Pseudomonas aeruginosa biofilms by Poh, Wee Han

“…In the second study, the application of cephalosporin-linked diazeniumdiolate NO donors, which are stable until activation by bacterial specific β-lactamases present within biofilms, were evaluated. …”
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Complexities of the San Andreas fault near San Gorgonio Pass : implications for large earthquakes by Yule, Doug, Sieh, Kerry

“…We infer that this step has been produced by slip on the linked San Gorgonio Pass-Garnet Hill-Coachella Valley Banning (SGP-GH-CVB) fault. …”
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Lipid-mediated resolution of inflammation and survival in amyotrophic lateral sclerosis by Yildiz, O, Hunt, GP, Schroth, J, Dhillon, G, Spargo, TP, Al-Chalabi, A, Koks, S, Turner, MR, Shaw, PJ, Henson, SM, Iacoangeli, A, Malaspina, A

“…Low levels of resolvins and downregulation of their membrane receptors in blood mononuclear cells are linked to a faster progression of ALS. Higher mononuclear cell expression of resolvin receptors is a predictor of longer survival. …”