Multilayered siRNA nanoparticles as a delivery system for extended gene silencing effect by Ng, Alice Jie Ying

“…For instance, an elevated expression of secreted protein acidic and rich in cysteine (SPARC) is linked with fibrosis and the inhibition of SPARC expression reduces fibrosis. …”
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Lipid-mediated resolution of inflammation and survival in amyotrophic lateral sclerosis by Yildiz, O, Hunt, GP, Schroth, J, Dhillon, G, Spargo, TP, Al-Chalabi, A, Koks, S, Turner, MR, Shaw, PJ, Henson, SM, Iacoangeli, A, Malaspina, A

“…Low levels of resolvins and downregulation of their membrane receptors in blood mononuclear cells are linked to a faster progression of ALS. Higher mononuclear cell expression of resolvin receptors is a predictor of longer survival. …”

Histone lysine and DNA methylation: dynamic marks in the chromatin by Belle, R

“…A common post translational modification is Nε-lysine methylation which is linked to transcriptional silencing or activation depending on the location within the nucleosome. …”

Association between self-reported napping and risk of cardiovascular disease and all-cause mortality: a meta-analysis of cohort studies by Wang, Meng, Xiang, Xin, Zhao, Zhengyan, Liu, Yu, Cao, Yang, Guo, Weiwei, Hou, Linlin, Jiang, Qiuhuan

“…However, napping for 1 hour or more was linked to a 1.37-fold increased risk of CVD (HR: 1.37; 95% CI: 1.09–1.71; I2 = 68.3%; P = 0.007). …”
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Minimum Wage Policy Effects on Economic Efficiency and Poverty (S/O 12183) by Abd Karim, Mohd Zaini, Hassan, Sallahuddin, Gee, Chan Sok

“…However, there is no study linking minimum wage on efficiency. Hence, the objective of this study is to analyze the effect of minimum wage policy on a country's efficiency and also its effect on poverty. …”
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MAAD: A Model and Dataset for "Attended Awareness" in Driving by Gopinath, Deepak, Rosman, Guy, Stent, Simon, Terahata, Katsuya, Fletcher, Luke, Argall, Brenna, Leonard, John

“…We define attended awareness to be those parts of a potentially dynamic scene which a person has attended to in recent history and which they are still likely to be physically aware of. Our model takes as input scene information in the form of a video and noisy gaze estimates, and outputs visual saliency, a refined gaze estimate, and an estimate of the person's attended awareness. …”
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Spectral, spatial, and temporal characteristics of underwater ambient noise in the Beaufort Sea in 1994 and 2016 by Chen, R., Poulsen, A., Schmidt, H.

“…Spectral comparison shows noise within 20–350 Hz is ∼30 dB louder in 1994 than 2016; however, this is likely due to higher array self noise during SIMI94. …”
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Prototypical career paths in urban, suburban, and rural locations in the United States by Setor, Tenace, Joseph, Damien

“…What are the prototypical career paths thus formed? Who are the likely incumbents of these career paths? What are the consequences of pursuing these career paths? …”
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The role of online media in mobilizing large-scale collective action by Chen, Zhuo, Oh, Poong, Chen, Anfan

“…The results showed that messages generated by users who occupied peripheral positions (i.e., lower k-coreness) and by those connecting others within closed communities (i.e., lower brokerage) were more likely to diffuse than those generated by central users or those who bridged different communities. …”
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Identification of GABAergic neurons innervating the zebrafish lateral habenula by Ramaswamy, Mahathi, Cheng, Ruey-Kuang, Jesuthasan, Suresh

“…Mechanisms governing release of GABA from the neurons in the posterior hypothalamus, which are likely to be in the tuberomammillary nucleus, remain to be defined.…”
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Self-Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging by Xie, Chen, Zhen, Xu, Lei, Qunli, Ni, Ran, Pu, Kanyi

“…Despite the advantages of semiconducting polymer nanoparticles (SPNs) over other inorganic nanoparticles for photoacoustic (PA) imaging, their synthetic method is generally limited to nanoprecipitation, which is likely to cause the issue of nanoparticle dissociation. …”
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Three-dimensional hydraulic modeling of particle deposition on the patterned isopore membrane in crossflow microfiltration by Choi, Dong-Chan, Jung, Seon-Yeop, Won, Young-June, Jang, Jun Hee, Lee, Jaewoo, Chae, Hee-Ro, Ahn, Kyung Hyun, Lee, Sangho, Park, Pyung-Kyu, Lee, Chung-Hak

“…CFD modeling studies were carried out to elucidate the anti-fouling effect of patterned membranes However, patterned membranes prepared usually by a phase inversion method are more likely to have broad pore size distributions and most modeling studies are based on two-dimensional space despite the three-dimensional pattern geometry. …”
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Governing failure mode of unsaturated soil slopes under rainwater infiltration by Huang, Wengui, Leong, Eng-Choon, Rahardjo, Harianto

“…The governing failure mode is likely to be affected by soil properties, slope geometry, depth of wetting front and contribution of matric suction to shear strength, which were investigated in this study. …”
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Computational cell fate modelling for discovery of rewiring in apoptotic network for enhanced cancer drug sensitivity by Chua, Huey Eng, Zhang, Fan, Zheng, Jie, Mishra, Shital Kumar, Bhowmick, Sourav Saha

“…Our method employs Genetic Algorithm to search for the most likely network topologies by iteratively generating simulated protein phosphorylation data using ODEs and the rewired network and then fitting the simulated data with real data of cancer signalling and cell fate. …”
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Fine-scale genetic structure and natural selection signatures of southwestern Hans inferred from patterns of genome-wide allele, haplotype, and haplogroup lineages by Wang, Mengge, Yuan, Didi, Zou, Xing, Wang, Zheng, Yeh, Hui-Yuan, Liu, Jing, Wei, Lan-Hai, Wang, Chuan-Chao, Zhu, Bofeng, Liu, Chao, He, Guanglin

“…Generally, we provided a case and ideal strategy to reconstruct the detailed demographic evolutionary history of Guizhou Hans, which provided new insights into the fine-scale genomic formation of one ethnolinguistically specific targeted population from the comprehensive perspectives of the shared unlinked alleles, linked haplotypes, and paternal and maternal lineages.…”
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Changes in cerebrospinal fluid balance of TNF and TNF receptors in naïve multiple sclerosis patients : early involvement in compartmentalised intrathecal inflammation by Magliozzi, Roberta, Pezzini, Francesco, Pucci, Mairi, Rossi, Stefania, Facchiano, Francesco, Marastoni, Damiano, Montagnana, Martina, Lippi, Giuseppe, Reynolds, Richard, Calabrese, Massimiliano

“…Finally, the CSF TNFR2-associated pattern (encompassing high CSF levels of IFN-β, IFN-λ2, sIL-6Rα) was linked to Th cell differentiation and regulatory cytokine signalling. …”
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Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... by Reitsma, M. B., Kendrick, P. J., Ababneh, E., Abbafati, C., Abbasi-Kangevari, M., Abdoli, A., Abedi, A., Abhilash, E. S., Abila, D. B., Aboyans, V., Abu-Rmeileh, N. M., Adebayo, O. M., Advani, S. M., Aghaali, M., Ahinkorah, B. O., Ahmad, S., Ahmadi, K., Ahmed, H., Aji, B., Akunna, C. J., Al-Aly, Z., Alanzi, T. M., Alhabib, K. F., Ali, L., Alif, S. M., Alipour, V., Aljunid, S. M., Alla, F., Allebeck, P., Alvis-Guzman, N., Amin T. T., Amini, S., Amu, H., Amul, G. G. H., Ancuceanu, R., Anderson, J. A., Ansari-Moghaddam, A., Antonio, C. A. T., Antony, B., Anvari, D., Arabloo, J., Arian, N. D., Arora, M., Asaad, M., Ausloos, M., Awan, A. T., Ayano, G., Aynalem, G. L., Azari, S., B, D.B., Badiye, A. D., Baig, A. A., Bakhshaei, M. H., Banach, M., Banik, P.C., Barker-Collo, S. L., Bärnighausen, T. W., Barqawi, H. J., Basu, S., Bayati, M., Bazargan-Hejazi, S., Behzadifar, M., Bekuma, T. T., Bennett, D. A., Bensenor, I. M., Berfield, K. S. S., Bhagavathula, A. S., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bibi, S., Bijani, A., Bintoro, B. S., Biondi, A., Birara, S., Braithwaite, D., Brenner, H., Brunoni, A. R., Burkart, K., Butt, Z. A., Caetano dos Santos, F. L., Car, Josip, Cárdenas, R., Carreras, G., Carrero, J. J., Castaldelli-Maia, J. M., Cattaruzza, M. S. S., Chang, J. C., Chen, S., Chu, D. T., Chung, S. C., Cirillo, M., Costa, V. M., Couto, R. A. S., Dadras, O., Dai, X., Damasceno, A. A. M., Damiani, G., Dandona, L.

“…We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. …”
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Lactate cross-feeding between Bifidobacterium species and Megasphaera indica contributes to butyrate formation in the human colonic environment by Zhao, Sainan, Lau, Raymond, Zhong, Yang, Chen, Ming-Hsu

“…Previously, the literature has explicated the butyrate-forming links between Bifidobacterium and Faecalibacterium prausnitzii and between Bifidobacterium and Eubacterium rectale. …”
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Low magnetic field exposure alters prostate cancer cell properties by Lange, Sigrun, Inal, Jameel, Kraev, Igor, Dart, Dafydd Alwyn, Uysal-Onganer, Pinar

“…Furthermore, we analysed alterations in matrix metalloproteinases (MMPs) and miRNAs linked to metastasis, as this is crucial in cancer aggressiveness. …”
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Reconciling the Accuracy-Diversity Trade-off in Recommendations by Peng, Kenny, Raghavan, Manish, Pierson, Emma, Kleinberg, Jon, Garg, Nikhil

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