Synergistic effect of 5-fluorouracil and the small molecule Wnt/β-catenin inhibitor iCRT3 on Caco-2 colorectal cancer cells in vitro by Smarslik, Maren, Inal, Jameel

“…In this study, the cytotoxic effects of 5-FU and iCRT3 were investigated using the Caco-2 colon adenocarcinoma cell line, marking the first investigation of their combined effects. …”
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An analysis of contact stiffness and frictional receding contacts by Parel, KS

“…Then, a fundamental 2D frictional receding contact problem involving a homogeneous linear elastic infinite layer pressed by a line load onto a half-plane of the same material was analysed. …”

The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…Early use of biologics has also been shown to be superior to methotrexate but these drugs are costly and not usually funded first line. However, if a short course of biologics can rapidly suppress inflammation allowing treatment to be withdrawn and response maintained on methotrexate, this may be a cost-effective model for early use.…”

Implementing strategies to improve uptake of patient-reported outcome measures (PROMs) in gender-affirming care: a mixed-methods implementation study by Kamran, R, Jackman, L, Goodwin, C, Laws, A, Stepney, M, Harrison, C, Jain, A, Rodrigues, J

“…</p> <p><strong>Main outcome(s) and measure(s)</strong> Response rates were calculated at 2-week intervals, in line with the deployment of each implementation strategy. …”

Ultra-thin oxide films by Hu, X

“…Various sizes have been found, and sides of these equilateral triangles all show a double-line feature aligned along the 〈 1 ^ˉ<sub style="position: relative; left: -.4em;">1</sub> 0〉 directions of the Au(111) lattice. …”

Tinospora crispa ethanolic extract downregulates Protein Kinase genes expression and activity during Toxoplasma gondii infection: a prospective drug target for lytic cycle inhibiti... by Abdullahi, Sharif Alhassan, Nordin, Norshariza, Unyah, Ngah Zasmy, Basir, Rusliza, Daneji, Isa Muhammad, Nasiru, Wana Mohammed, Majid, Roslaini Abd

“…The aim of this study was to evaluate the in vitro activities of ethanolic extract of Tinospora crispa (EETC) on protein kinases involved in the lytic cycle of T. gondii infection in Vero cell line. The EETC was obtained through the maceration of dried stem powder. …”
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Identification of novel functional compounds from forest onion and its biological activities against breast cancer by Nurkolis, Fahrul, Kurniatanty, Isma, Wiyarta, Elvan, Permatasari, Happy Kurnia, Mayulu, Nelly, Taslim, Nurpudji Astuti, Tjandrawinata, Raymond Rubianto, Hardinsyah, Hardinsyah, Tallei, Trina Ekawati, Tsopmo, Apollinaire, Radu, Son, Hadinata, Edwin, Kim, Bonglee, Ribeiro, Rosy Iara Maciel Azambuja, Syahputra, Rony Abdi

“…Therefore, this study focuses on metabolite profiling, in silico or pharmacoinformatic activity and mechanisms, as well as advanced validation on in vitro cell lines. Ten compounds identified in E. bulbosa bulb ethanolic extract (EBE) showed cancer receptor and radical inhibitory activity via network pharmacology and molecular docking simulation. …”
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Design, synthesis and activity studies of antifreeze peptide derived from type I shorthorn sculpin by Asmawi, Azren Aida

“…Furthermore, these peptides have been proved to be non-cytotoxic on 3T3 cell line with IC50 value >100 μg/mL and have a positive impact on ice crystal growth in ice cream mixes. …”
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PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism by Salvadó, Laia, Barroso, Emma, Gómez-Foix, Anna Maria, Palomer, Xavier, Michalik, Liliane, Wahli, Walter, Vázquez-Carrera, Manuel

“…Methods Studies were conducted in mouse C2C12 myotubes, in the human myogenic cell line LHCN-M2 and in skeletal muscle from wild-type and PPARβ/δ-deficient mice and mice exposed to a high-fat diet. …”
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Barnacle cement protein as an efficient bioinspired corrosion inhibitor by Bui, My Hanh, Hiew, Shu Hui, Salim, Teddy, Saw, Wan Geok, Webster, Richard David, Grüber, Gerhard, Mu, Yuguang, Miserez, Ali

“…We reveal that these anti-corrosion properties are linked to the protein’s biophysical properties, namely its strong adsorption to surfaces combined with its interaction with Fe ions released by steel substrates, which forms a stable layer that increases the coating’s impedance and delays corrosion. Our findings highlight the synergistic action of rMrCP20 in preventing corrosion and provide molecular-level guidelines to develop alternative green corrosion inhibitor additives.…”
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Organic and inorganic sublattice coupling in two-dimensional lead halide perovskites by Fu, Jianhui, Bian, Tieyuan, Yin, Jun, Feng, Minjun, Xu, Qiang, Wang, Yue, Sum, Tze Chien

“…Further evidence of the mechanical coupling between these two sublattices is revealed through the slow heat transfer process, where the resultant lattice tensile strain launches coherent longitudinal acoustic phonons. Our findings explicate the intimate electronic and mechanical couplings between the organic and inorganic sublattices, crucial for tailoring the optoelectronic properties of two-dimensional halide perovskites.…”
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Detection of road markings for advanced driver assistance by Suchitra Sathyanarayana

“…Evaluation of the AHPD on the 101 CMU object database confirms that it can successfully detect the major line features of interest, including lines of close proximity and lines of varying lengths amidst noise. …”
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Executive's Cybersecurity Program Handbook : A comprehensive guide to building and operationalizing a complete cybersecurity program / by Brown, Jason, author 656359, Packt Publishing (Online service) 656336

“…What you will learn Explore various cybersecurity frameworks such as NIST and ISO Implement industry-standard cybersecurity policies and procedures effectively to minimize the risk of cyberattacks Find out how to hire the right talent for building a sound cybersecurity team structure Understand the difference between security awareness and training Explore the zero-trust concept and various firewalls to secure your environment Harden your operating system and server to enhance the security Perform scans to detect vulnerabilities in software Who this book is for This book is for you if you are a newly appointed security team manager, director, or C-suite executive who is in the transition stage or new to the information security field and willing to empower yourself with the required knowledge. …”
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Functional alterations of the prefrontal circuit underlying cognitive aging in mice by Chong, Huee Ru, Ranjbar-Slamloo, Yadollah, Ho, Malcolm Zheng Hao, Ouyang, Xuan, Kamigaki, Tsukasa

“…Optogenetic inactivation reveals that the middle-aged mPFC exhibits heightened vulnerability to perturbations. These findings elucidate functional alterations of the prefrontal circuit that unfold in middle age and deteriorate further as a hallmark of cognitive aging.…”
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Investigating customers' continuous trust towards mobile banking apps by Che, Maohao, Say, Ashley Sze Yee, Yu, Han, Zhou, Qingji, Shu, Jared, Sun, Wen, Luo, Xi, Xu, Hong

“…The data were analysed using structural equation modelling (SEM) based on a proposed model that predicts trust. The findings successfully validated the model and its reduced form. …”
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Mechanism design for internet of things services market by Jiao, Yutao

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Active control of broadband sound through the open aperture of a full-sized domestic window by Lam, Bhan, Shi, Dongyuan, Gan, Woon-Seng, Elliott, Stephen J., Nishimura, Masaharu

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Data-driven approach to spatiotemporal dynamic risk assessment of urban flooding based on shared socio-economic pathways by Wang, Mo, Chen, Furong, Zhang, Dongqing, Chen, Zijing, Su, Jin, Zhou, Shiqi, Li, Jianjun, Chen, Jintang, Li, Jiaying, Tan, Soon Keat

“…The finding of this study will shed a comprehensive insight into the identification of spatial and temporal distribution of urban flooding vulnerability to facilitate the exploration of flood mitigation measures associated with dynamic changes in urban land use.…”
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The role of ports in supply chain disruption management by Loh, Hui Shan

“…The management model is operationalized in three tiers, from the top management level to the front-line employees, with characteristics from risk management, business continuity management and quality management theories. …”
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Modelling of traffic control delays at priority junctions using artificial neural network by Mohammad Ali Sahraei

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