Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes by de Jesus, Daniel S., Mak, Tracy C. S., Wang, Yi-Fang, von Ohlen, Yorrick, Bai, Ying, Kane, Eva, Chabosseau, Pauline, Chahrour, Catherine M., Distaso, Walter, Salem, Victoria, Tomas, Alejandra, Stoffel, Markus, Rutter, Guy A., Latreille, Mathieu

“…We carried out loss- and gain-of-function experiments in MIN6 and EndoC-bH1 cell lines. We analysed previously published mouse andhuman T2D data sets.Results:Bulk RNA-seq revealed thatb-cell dedifferentiation is associated with the induction of genes associated with epithelial-to-mesenchymal transition (EMT) in prediabetic (2-week-old) and diabetic (12-week-old) Tg7 mice. …”
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大时代小人物的命运: 论新加坡教育改革下华校师生对语言的情意结 = Fate of individuals in a revolutionary era: a study on the language attachment of Chinese school teachers and students under Singapore's education... by 李瑞君 Lee, Rui Jun

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Conformational design characterization of a truncated diamine oxidase by Razali, Nur Nadia

“…By maintaining the native protein’s pH profile, the mini protein was highly active at 40 °C and stable at pH 7, with a half-life of 80 min at 50 °C. Results from the kinetic studies showed that the Km value for native diamine oxidase was 0.274 mM and 1.3 mM for the mini protein. …”
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Tropical peat subsidence, nutrient losses and oil palm seedling growth due to different water table depths by Abubakar, Safiyanu Hashim

“…The system was made of exchange chamber of air pump with the flow rate ranges between 1 and 3.5 L min-1, exchange chamber of (2670 mL plastic container) and a trap (250 mL Erlenmeyer flask). …”
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Nanoscale Origins of Thermal Transport Phenomena for Hybrid Layered Perovskites by Dahod, Nabeel S.

“…This probe identifies the persistence of bulk-like phonons even in the atomically thin 2D LHPs, in addition to identifying coherent acoustic phonons in lead iodide 2D LHPs potentially capable of carrying thermal energy across the organic-inorganic interfaces without scattering. …”
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Exploring the utility of silane cross-linkers for synthesis of superhydrophobic antibacterial fabrics by Agrawal, Neha

“…Functionalization of the textiles with additional properties like superhydrophobicity and antibacterial activity can greatly improve their performance, especially in clothing and healthcare sectors. …”
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Postprandial glucose, insulin and incretin responses differ by test meal macronutrient ingestion sequence (pattern study) by Sun, Lijuan, Goh, Hui Jen, Govindharajulu, Priya, Leow, Melvin Khee-Shing, Henry, Christiani Jeyakumar

“…Results: There were significant food intake sequence × time interaction effects on plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) concentrations (P < 0.001). …”
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A general method for the synthesis of hybrid nanostructures using MoSe2 nanosheet-assembled nanospheres as templates by Han, Shikui, Zhou, Kai, Yu, Yifu, Tan, Chaoliang, Chen, Junze, Huang, Ying, Ma, Qinglang, Chen, Ye, Cheng, Hongfei, Zhou, Weijia, Zhang, Hua

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Towards automated damage detection for in-situ remanufacturing by Nguyen, Keith Wei Liang

“…Remanufacturing is the restoration of used products to a like-new condition, with warranty matching the original product. …”
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Sequence- and structure-specific probing of RNAs by short nucleobase-modified dsRNA-binding PNAs incorporating a fluorescent light-up uracil analog by Krishna, Manchugondanahalli Shivakumar, Toh, Desiree-Faye Kaixin, Meng, Zhenyu, Ong, Alan Ann Lerk, Wang, Zhenzhang, Lu, Yunpeng, Xia, Kelin, Prabakaran, Mookkan, Chen, Gang

“…Compared to DNA and RNA, peptide nucleic acids (PNAs) are chemically stable and have a neutral peptide-like backbone, and thus, they show significantly enhanced binding to natural nucleic acids. …”
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Two-step machine learning enables optimized nanoparticle synthesis by Mekki-Berrada, Flore, Ren, Zekun, Huang, Tan, Wong, Wai Kuan, Zheng, Fang, Xie, Jiaxun, Tian, Isaac Parker Siyu, Jayavelu, Senthilnath, Mahfoud, Zackaria, Bash, Daniil, Hippalgaonkar, Kedar, Khan, Saif, Buonassisi, Tonio, Li, Qianxiao, Wang, Xiaonan

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A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system by Shen, Yunbing, Jiang, Long, Iyer, Vaishnavi Srinivasan, Raposo, Bruno, Dubnovitsky, Anatoly, Boddul, Sanjaykumar V., Kasza, Zsolt, Wermeling, Fredrik

“…As proof of principle, we present examples studying various aspects related to hematopoietic cells (T cell development in vivo and activation in vitro, differentiation of macrophages and dendritic cells, as well as a leukemia-like phenotype induced by overexpressing a proto-oncogene). …”
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Strain-relaxed GeSn-on-insulator (GeSnOI) microdisks by Burt, Daniel, Joo, Hyo-Jun, Jung, Yongduck, Kim, Youngmin, Chen, Melvina, Huang, Yi-Chiau, Nam, Donguk

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Hodge theory and its applications to molecular data analysis by Koh, Ronald Joon Wei

“…Furthermore, disruption of TAD boundaries are associated with several diseases like cancer. Nevertheless, there are currently many methods to call TADs, all of which are not based on a rigorous topological mathematical model. …”
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Whence came these plants most foul? Phylogenomics and biogeography of Lowiaceae (Zingiberales) by Niissalo, Matti A., Gardner, Elliot M., Khew, Gillian S., Šída, Otakar, Poulsen, Axel Dalberg, Leong-Škornicková, Jana

“…They are known for possessing orchid-like flowers that are smelly, apparently mimicking dead animals, feces, or mushrooms. …”
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Lithium-doped two-dimensional perovskite scintillator for wide-range radiation detection by Xie, Aozhen, Hettiarachchi, Chathuranga, Maddalena, Francesco, Witkowski, Marcin E., Makowski, Michal, Drozdowski, Winicjusz, Arramel, Arramel, Wee, Andrew T. S., Springham, Stuart Victor, Vuong, Phan Quoc, Kim, Hong Joo, Dujardin, Christophe, Coquet, Philippe, Birowosuto, Muhammad Danang, Dang, Cuong

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Development of an application to improve mental health (A) by Khor, Chin Yi

“…Generally, most of these applications present features that offer ways to stay engaged with the user, like daily reminders, feelings trackers, abundant learning materials, and search for therapists and treatments via the apps. …”
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Waffle-inspired hydrogel-based macrodevice for spatially controlled distribution of encapsulated therapeutic microtissues and pro-angiogenic endothelial cells by Pham, Chi H. L., Zuo, Yicong, Chen, Yang, Tran, Nam M., Nguyen, Dang T., Dang, Tram T.

“…The waffle-inspired grid-like micropattern of the "lock" component effectively entraps insulin-secreting microtissues in controlled locations while the interlocking design places them in a co-planar spatial arrangement with close proximity to vascular-inductive cells. …”
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Grid optimization and demand side mangement for electric vehicles penetration in remote area by Zhang, Yixiao, Ng, Eddie Yin Kwee, Li, Ning

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Molecular recognition in protein-DNA assemblies by Davey, Curt Alexander

“…This holds significance for genomic activities, like retroviral integration, that exploit extreme distortion of nucleosomal DNA, and provides additional evidence that nucleosomal DNA is rich in conformational character, which we can potentially take advantage of. …”
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