The association of sleep duration with the risk of chronic kidney disease: a systematic review and meta-analysis by Koh, Jin Hean, Yeo, Brian Sheng Yep, Tan, Timothy Wei En, See, Mark Yong Siang, Ng, Adele Chin Wei, Loh, Shaun Ray Han, Gooley, Joshua, Tan, Chieh Suai, Toh, Song Tar

“…Compared with a reference range of 7 to 8 hours of sleep, short sleep durations of ≤4 hours (RR 1.41, 95% CI: 1.16 to 1.71, P < 0.01), ≤5 hours (RR 1.46, 95% CI: 1.22 to 1.76, P < 0.01), ≤6 hours (RR 1.18, 95% CI: 1.09 to 1.29, P < 0.01), and ≤7 hours (RR 1.19, 95% CI: 1.12 to 1.28, P < 0.01) were significantly associated with an increased risk of incident chronic kidney disease. …”
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Synthesis and properties of amino- and guanidino-peptoid peptide nucleic acids by Lu, Xiao Wei

“…The AP-PNA monomers of different side chain length (2, 3, 4, 5 or 6 carbon) were synthesized with the exocyclic amines of their four natural nucleobases protected by an acyl or Bhoc protecting group. …”
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Removal of redundant gabor features using genetic algorithm by Dang, Ngoc Minh

“…From Matlab simulation, we find out that, using 40 Gabor filters from 80 Gabor filters of 8 frequencies x 10 orientations is better than using 40 Gabor filters of 5 frequencies x 8 orientations.…”
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A parametric study of Proton Electrolyte Membrane (PEM) fuel cell performances by Lim, Adrian Eu Chun

“…For the stoichiometric flow ratio of 5.0 and above, the improvement in the fuel cell performance is negligible. …”
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Combined effects of meal frequency and exercise on postprandial lipaemia by Mok, Alexander

“…On day-2 mornings, venous blood triacylglycerol concentrations were measured fasting and 7-hours postprandially, after consuming 1-large or 2-smaller high-fat meals (1.21 g fat, 0.62 g carbohydrate, 0.29 g protein and 14.5 kcal/kg/bodymass). We hypothesised PPL will be lowest with EX-2 < EX-1 < CON-2 < CON-1. …”
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Biochemical characterisation of NS2B-NS3 protease from flaviviruses by Nah, Jojo Qian Hui

“…The virus genome encodes for seven non-structural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) and three structural proteins (envelope (E), capsid (C), membrane (M). …”
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An experimental and simulation study of chip transportation behaviour in gundrilling by Tnay, Guan Leong

“…The experiments were conducted in vertical square tube filled with the water-glycerine solutions which have properties similar to the coolant properties with concentration of 85 % oil to 5 % oil. From the experiments, terminal velocities of typical gun drill chips at different range of particle Reynolds number were determined to construct the unique drag curve. …”
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Aerodynamics modelling of floating offshore wind turbines by Singapore Wala, Abdulqadir Aziz

“…Different unsteady aerodynamic phenomena associated with FOWTs are analysed, with corrective models developed for an accurate analysis of FOWT aerodynamics. The NREL 5MW virtual wind turbine was studied in axial flow and sinusoidal surge motions at different frequencies and amplitudes, usingfull-3D computational fluid dynamics simulations. …”
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Study of natural gas storage on activated carbon and MIL-101(cr) blend by Tan, Cheong Heng

“…The US Department of Energy (DOE) has set a challenging adsorption target for methane storage at 0.5 g/g under ambient conditions, hence the ideal MOF has to be synthesized in order to achieve the target. …”
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Investigation of Ni as Zn substitute in CZTS thin film solar cell by Quek, Ka Jun

“…The highest efficiency achieved was around 5.45% for pure Cu2ZnSnS4 (CZTS) device using static mode, meanwhile the nickel-substituted samples behave like a metal instead of semiconductor when the Ni is substituted. …”
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Integration of multiple ultra-capacitor banks in DC microgrid part I by Ahamad Fareed

“…Each branch will feature a bi-directional DC-DC boost converter to realize the desired 170V rated voltage of the DC Mg. The report will conclude from the results drawn from the output power sharing in the HEMS with all the needed control algorithms in place. …”
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Toward a neuroscientific understanding of play: a dimensional coding framework for analyzing infant–adult play patterns by Neale, Dave, Clackson, Kaili, Georgieva, Stanimira, Dedetas, Hatice, Scarpate, Melissa, Wass, Sam, Leong, Victoria

“…Here, we illustrate the sensitivity and utility of the proposed coding framework using two contrasting dyadic corpora (N = 5) of mother-infant object-oriented interactions during experimental conditions that were either non-conducive (Condition 1) or conducive (Condition 2) to the emergence of playful behavior. …”
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The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW) : study protocol for a randomised controlled trial by Cooper, Daniel J., Plewes, Katherine, Grigg, Matthew J., Rajahram, Giri S., Piera, Kim A., William, Timothy, Chatfield, Mark D., Yeo, Tsin Wen, Dondorp, Arjen M., Anstey, Nicholas M., Barber, Bridget E.

“…Methods: PACKNOW is a two-arm, open-label randomised controlled trial of adjunctive paracetamol versus no paracetamol in patients aged ≥ 5 years with knowlesi malaria, conducted over a 2-year period at four hospital sites in Sabah, Malaysia. …”
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Mixed tree nuts, cognition and gut microbiota: a 4-week, placebo-controlled, randomized crossover trial in healthy non-elderly adults by Haskell-Ramsay, Crystal, Dodd, Fiona L., Smith, Darren, Cuthbertson, Lewis, Nelson, Andrew, Lodge, John K., Jackson, Philippa A.

“…Results: Mixed model analysis indicated that nut consumption led to significant improvements to accuracy (placebo M = 92.2% vs. NUTS M = 94.5%; p = 0.019) and speed of response (placebo M = 788 ms vs. …”
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Goblet cell differentiation in colorectal cancer by Abdullayeva, G

“…We assessed MUC2 and TFF3 protein expression levels in 100 CRC cell lines and categorised them into 5 distinct groups. These groups included high, medium, and low MUC2/TFF3-expressing cell lines, cell lines with no/very low MUC2 but high TFF3 expression, and cell lines completely lacking these proteins. …”

Survey of healthcare-associated sink infrastructure, and sink trap antibiotic residues and biochemistry, in 29 UK hospitals by Rodger, G, Chau, K, Aranega Bou, P, Moore, G, Roohi, A, The SinkBug Consortium, Walker, AS, Stoesser, N

“…The median sink-to-patient distance was 1.5m (IQR: 1.00- 2.21m). Sink design varied widely; it was deemed “optimal” for 65/122 (53%) sinks in patient bays/side-rooms and “optimal” design was associated with side-room location (p-value=0.04). …”

Statistical methods and analyses in autoimmune diseases by Inshaw, J

“…Variants within the human leucocyte anti- gen (HLA) region, as expected, showed association with age-at-diagnosis, but I also found a novel T1D region on chromosome 6q22.33, which associated with both age-at-diagnosis and also disease risk if examining only cases diagnosed at &lt; 5 years. </p> <p>Based on prior pancreas histology results, which showed cases diagnosed at &lt; 7 years have a distinct immune cell infiltration signature to those diagnosed at ≥ 13 years, I then predefined specific age-at-diagnosis groups, &lt; 7, 7-13 and ≥ 13, and restricted my analysis to examine only known T1D regions, thereby reducing the multiple testing adjustment required in genome-wide studies. …”

The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…</p> <p><strong>Methods and analysis:</strong> Patients with newly diagnosed PsA and at least one poor prognostic factor (polyarthritis, C-reactive protein >5 mg/dL, health assessment questionnaire >1, radiographic erosions) were randomized equally and open-label to either standard care with ‘step-up’ csDMARD therapy, initial therapy with combination csDMARDs (methotrexate with either sulfasalazine or leflunomide) or to early biologics induction therapy (adalimumab plus methotrexate). …”

Developing small molecule ligands for the study of bromodomain-histone interactions by Brand, M

“…</p> <p>A second project in this dissertation reports the development of a small, modular photo affinity based probe based on a 3,5-dimethylisoxazole acetyl lysine mimic. This probe could be crosslinked to purified bromodomain proteins with up to 30% efficiency and subsequently modified <em>via</em> CuAAc chemistry to attach a fluorophore or biotin tag. …”

Self-supervised machine learning to characterise step counts from wrist-worn accelerometers in the UK Biobank by Small, SR, Chan, S, Walmsley, R, von Fritsch, L, Acquah, A, Mertes, G, Feakins, BG, Creagh, A, Strange, A, Matthews, CE, Clifton, DA, Price, AJ, Khalid, S, Bennett, D, Doherty, A

“…</p> <br> <p><strong>Results:</strong> The algorithm substantially outperformed reference models (free-living mean absolute percent error of 12.5%, versus 65-231%). Our data indicate an inverse dose-response association, where taking 6,430-8,277 daily steps was associated with 37% [25-48%] and 28% [20-35%] lower risk of fatal CVD and all-cause mortality up to seven years later, compared to those taking fewer steps each day.…”