Response to clozapine in treatment resistant schizophrenia is related to alterations in regional cerebral blood flow by Sun, J, Zelaya, F, Sendt, K, McQueen, G, Gillespie, AL, Lally, J, Howes, OD, Barker, GJ, McGuire, P, MacCabe, JH, Egerton, A

“…Longitudinal reductions in CBF in the ACC and thalamus were associated with less improvement in negative (ACC), positive (thalamus), and total (thalamus) symptoms. These findings suggest that changes in CBF on clozapine administration in TRS may accompany symptomatic improvement, and that CBF prior to clozapine initiation may determine the degree of clinical response.…”

Current data science capacity building initiatives for health researchers in LMICs: global & regional efforts by Kiosia, A, Boylan, S, Retford, M, Marques, LP, Bueno, FTC, Kirima, C, Islam, MS, Naheed, A, Wozencraft, A

“…Articles were screened based on inclusion criteria. Findings: From 212 records, 85 met inclusion criteria, with 20 from PubMed and Scopus, and 65 from grey literature. …”

The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2 by Nuccetelli, V, Mghezzi-Habellah, M, Deymier, S, Roisin, A, Gérard-Baraggia, F, Rocchi, C, Coureux, P, Gouet, P, Cimarelli, A, Mocquet, V, Fiorini, F

“…Furthermore, we characterized how this interaction affects UPF1’s enzymatic function. Our findings demonstrate that Np inhibits the unwinding activity of UPF1 by physically obstructing its access to structured nucleic acid substrates. …”

An exploratory study on the development of a sensory wheel affiliated with the emotional lexicon for chrysanthemum infusion by Xia, Y, Hou, J, Chen, J, Spence, C, Qian, J, Zhao, F, Dong, G, Zhong, F

“…For this analysis, the emotion lexicon from EsSense25 was clustered into six dimensions: pleasant, tame, warm, active, negative, and bored. Our findings indicate that attributes such as smoothness and chrysanthemum-cucumber flavour induce calm and reassuring emotions (e.g., secure, understanding, calm, and tame). …”

Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis by Beter, M, Pulkkinen, HH, Örd, T, Sormunen, A, Kilpeläinen, L, Dunford, JE, Kaikkonen, MU, Aavik, E, Laham-Karam, N, Oppermann, U, Laakkonen, JP, Ylä-Herttuala, S

“…In contrast TMP-269, a selective class IIa HDAC inhibitor, exhibited anti-angiogenic effects by downregulating angiogenesis-related proteins and upregulating pro-inflammatory signaling. These findings highlight the suitability of the modified TeloHAEC fibrin bead assay for drug screening purposes and reveal both pro-angiogenic and anti-angiogenic drug candidates with therapeutic potential.…”

From demonetisation to Covid-19: Insights on the dynamics between informality and financial inclusion from the city of Kolkata, India by Ma, T

“…</p> <p>Empirical research finds that while Demonetisation and Covid-19 managed to reduce some forms of financial informality associated with the use of cash in saving, payment, and borrowing through their catalytic effects on digitalisation, other informal financial practices persisted or even increased, serving as substitutes for or supplements to insufficient and dysfunctional formal ones. …”

Ultrafast laser writing of liquid crystal waveguides by Chen, B, Xie, P, Zhao, Z, Salter, PS, Li, M, Xue, L, Qiu, X, Booth, MJ, Elston, SJ, Morris, SM

“…Characteristics of the waveguide are investigated for different fabrication conditions and geometrical configurations, including the dimensions of the waveguide and laser writing power. Our findings reveal that smaller waveguide geometries result in reduced intensity attenuation. …”

Development of HDX-MS methods to further investigate complex protein samples by Smith, L

“…The thesis also includes several case studies of protein complexes analysed using HDX-MS, which had not previously been investigated with this technique. These findings were corroborated with complementary methods and aligned with expectations based on prior research.…”

Words of liberty: the origins and evolution of constitutional ideas by Versteeg, M

“…</p> <p>This thesis's most important finding is that constitutions are inherently “transnational” documents. …”

Multiple independent genetic code reassignments of the UAG stop codon in phyllopharyngean ciliates by McGowan, J, Richards, TA, Hall, N, Swarbreck, D

“…Furthermore, we show that the function of UAA is firmly fixed as the preferred stop codon. These findings shed light on the evolvability of the genetic code in understudied microbial eukaryotes.…”

A multimodal neural signature of face processing in autism within the fusiform gyrus by Floris, DL, Llera, A, Zabihi, M, Moessnang, C, Jones, EJH, Mason, L, Haartsen, R, Holz, NE, Mei, T, Elleaume, C, Vieira, BH, Pretzsch, CM, Forde, NJ, Baumeister, S, Dell’Acqua, F, Durston, S, Banaschewski, T, Ecker, C, Holt, RJ, Baron-Cohen, S, Bourgeron, T, Charman, T, Loth, E, Murphy, DGM, Beckmann, CF

“…In autistic individuals, multimodal components were associated with cognitive and clinical features linked to social, but not nonsocial, functioning. These findings underscore the importance of elucidating multimodal neural associations of social functioning in autism, offering potential for the identification of mechanistic and prognostic biomarkers.…”

Image segmentation with minimal human supervision by Shin, G

“…</p> <br> <p>In the first part, we demonstrate that considering a model's uncertainty in predictions can significantly reduce the number of annotations required to train a segmenter that performs nearly as well as a fully-supervised one. This finding underscores the critical role of pixels around semantic boundaries in helping the model to learn representations suitable for segmentation.…”

Clinical presentation and outcome of ribavirin treated RT-PCR confirmed Lassa fever patients in ISTH Irrua: a pilot study by Asogun, AD, Ochei, O, Moody, V, Abejegah, C, Okoh, E

“…</p> <p><b>Aim:</b> To review the clinical features, laboratory findings of Lassa fever and the outcome of confirmed cases treated with Ribavirin.…”

SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections by Rosenheim, J, Gupta, RK, Thakker, C, Mann, T, Bell, LCK, Broderick, CM, Madon, K, Papargyris, L, Dayananda, P, Kwok, AJ, Greenan-Barrett, J, Wagstaffe, HR, Conibear, E, Fenn, J, Hakki, S, Lindeboom, RGH, Dratva, LM, Lemetais, B, Weight, CM, Venturini, C, Kaforou, M, Levin, M, Kalinova, M, Mann, AJ, Knight, JC

“…Another ISG, IFI27, shows a delayed but sustained response restricted to myeloid cells, attributable to gene and cell-specific epigenetic regulation. These findings are reproducible in experimental and naturally acquired infections with influenza, respiratory syncytial virus and rhinovirus. …”

Rhetoric on trial: an aristotelian insight into Najib Razak’s corruption case by Syaza Fuhat, Juliana Abdul Wahab

“…Through a qualitative content analysis of 21 news broadcasts from ASTRO Awani, the study applies Aristotle’s triadic model of persuasion—ethos, pathos, and logos. The findings indicate that Najib predominantly relies on logos and pathos, strategically leveraging logical reasoning and emotional appeal while minimising the use of ethos¾ethical credibility. …”
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Key competencies among engineering leaders in the Malaysian construction industry by Alim Maktar, Khairun Nisa Khairuddin, Ummi Naiemah Saraih

“…By cultivating these competencies, organizations can enhance leadership capabilities and improve project outcomes. The findings suggest that focusing on strategic vision, problem-solving, and resource management can help foster better leadership in engineering projects. …”
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Pendekatan pembelajaran berasaskan simposium: mengasah pemikiran kritis dan komunikasi dalam melahirkan graduan kompetitif by Wan Fathul Hakim W Zamri, Nurhasyimah Aziz, Muhamad Faiz Md Din, Azhari Shamsudeen

“…The symposium provided an opportunity for students to present their research findings, exchange ideas, as well as receive constructive feedback from peers, lecturers, and industry panelists which indirectly enhanced their confidence and communication skills. …”
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Challenges of online collaborative learning among special needs university students by Hidayu Shafie, Ireena Nasiha Ibnu, Noori, Abdullah, Nurhilleny Rosly, Nadia Anuar, Nur Husna Serip Mohamad

“…Analysis of data was performed using SPSS, specifically employing descriptive statistics analysis. Based on the findings of the study, it was found that the SNS in this study mostly had problems communicating with their peers during online collaborative learning. …”
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Stability of the tyrosyl radical in the beta subunit of Arcobacter bivalviorum ribonucleotide reductase by Alqurashi, Abdulmajeed

“…The results provide some important details about the radical site and its surrounding residues, highlighting the influence of the protein structure on the stability of the radical. These findings may guide the development of novel inhibitors targeting this enzyme in A. bivalviorum.…”
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Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer by Sulistyowaty, Melanny Ika, Fitri, Suciati, Yuliati, Ninis, Amrillah, Tahta, Che Azurahanim Che Abdullah, Setyawan, Dwi

“…It shows that the solubility of the samples synthesized using microwave-assisted and solvent evaporation increases about 3.30 and 3.12 times, respectively, whereas the dissolution rate profile increases 2.50 and 2.39 times, respectively, compared to pure APMS. Our findings explain the importance of the cocrystal formation strategy to enhance the solubility of active material pMCA. …”
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