Cell-free biomimetic polyurethane-based scaffold for breast reconstruction following non-malignant lesion resection. A first-in-human study by Mariniello, Maria D., Ghilli, Matteo, Favati, Benedetta, Gerges, Irini, Colizzi, Livio, Tamplenizza, Margherita, Tocchio, Alessandro, Martello, Federico, Ghilardi, Maria, Cossu, Maria C., Danti, Serena, Roncella, Manuela

“…We evaluated incidence of adverse events (AEs), changes in breast appearance (using photographs and anthropomorphic measurements), interference with ultrasound and MRI (assessed by two independent investigators), investigator’s satisfaction (through a VAS scale), patient’s pain (through a VAS scale) and quality of life (QoL) (using the BREAST-Q© questionnaire). Data reported are the results of the interim analysis on the first 5 patients. …”
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Use of artificial intelligence in critical care: opportunities and obstacles by Pinsky, Michael R., Bedoya, Armando, Bihorac, Azra, Celi, Leo, Churpek, Matthew, Economou-Zavlanos, Nicoleta J., Elbers, Paul, Saria, Suchi, Liu, Vincent, Lyons, Patrick G., Shickel, Benjamin, Toral, Patrick, Tscholl, David, Clermont, Gilles

“…Machine learning-based artificial intelligence (AI) techniques to define states and predict future events are commonplace activities of modern life. However, their penetration into acute care medicine has been slow, stuttering and uneven. …”
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Microneedle‐mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune‐Mediated Alopecia by Younis, Nour, Puigmal, Núria, Kurdi, Abdallah El, Badaoui, Andrew, Zhang, Dongliang, Morales, Claudia, Saad, Anis, Cruz, Diane, Rahy, Nadim Al, Daccache, Andrea, Huerta, Triana, Deban, Christa, Halawi, Ahmad, Choi, John, Dosta, Pere, Lian, Christine, Artzi, Natalie, Azzi, Jamil R.

“…The MN patch offered high‐loading capacity and shelf‐life stability for prospective clinical translation. …”
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Artificial Neural Network Language Models Predict Human Brain Responses to Language Even After a Developmentally Realistic Amount of Training by Hosseini, Eghbal A., Schrimpf, Martin, Zhang, Yian, Bowman, Samuel, Zaslavsky, Noga, Fedorenko, Evelina

“…We consider the 100-million-word model to be developmentally plausible in terms of the amount of training data given that this amount is similar to what children are estimated to be exposed to during the first 10 years of life. Second, we test the performance of a GPT-2 model trained on a 9-billion-token dataset to reach state-of-the-art next-word prediction performance on the human benchmark at different stages during training. …”
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Structural insights into microbial one-carbon metabolic enzymes: Ni–Fe–S-dependent carbon monoxide dehydrogenases and acetyl-CoA synthases by Biester, Alison

“…These carbon-fixing enzymes are thought to be among the oldest on earth, dating back to the last universal common ancestor based on strong conservation of these enzymes between bacterial and archaeal domains of life. In this thesis, we present structural characterizations of bacterial and archaeal CODHs. …”
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From Shipyard to Sea: A Flexible System Design Approach to the Transition from Shipbuilding to Operations A Case Study Using the United States Coast Guard Offshore Patrol Cutter P... by Kime, Jeremy A.

“…The analysis recommends a three-phased strategy that could yield cost savings on the order of $400 million over the OPC Program’s lifespan, significantly mitigate risks associated with unforeseen shipbuilding developments, and enhance organizational outcomes regarding workforce, operational availability, and life cycle sustainment. The staffing of pre-commissioning crews is pinpointed as a pivotal discretionary event that triggers an exponential increase in system complexity and a surge in scope by introducing interdependent yet organizationally disparate requirements. …”
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On the non-microbial sources and sinks of dissolved metabolites in seawater by Germolus, Noah Paul

“…This thesis begins to interrogate that assumption, asking if there are other processes that could change the seawater exometabolome on time scales that are relevant to microbial life. In Chapter 1 I discuss the ways ambient metabolite pools could be affected by animals, chemistry, and physics. …”
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Robust Reinforcement Learning Strategies with Evolving Curriculum for Efficient Bus Operations in Smart Cities by Tang, Yuhan, Qu, Ao, Jiang, Xuan, Mo, Baichuan, Cao, Shangqing, Rodriguez, Joseph, Koutsopoulos, Haris N, Wu, Cathy, Zhao, Jinhua

“…Public transit systems are critical to the quality of urban life, and enhancing their efficiency is essential for building cost-effective and sustainable smart cities. …”
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Accelerating throughput-aware runtime mapping for heterogeneous MPSoCs by Singh, Amit Kumar, Kumar, Akash, Srikanthan, Thambipillai

“…The presented approach is used to carry out a DSE case study for models of real-life multimedia applications: H.263 decoder, H.263 encoder, MPEG-4 decoder, JPEG decoder, sample rate converter, and MP3 decoder. …”
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Environmental perspectives of recycling various combustion ashes in cement production – a review by Yin, Ke, Ahamed, Ashiq, Lisak, Grzegorz

“…From sustainability perspective, life cycle assessment promises the overall strategy on ash utilization in cement industry.…”
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The application of nitric oxide to control biofouling of membrane bioreactors by Rice, Scott A., Luo, Jinxue, Zhang, Jinsong, Barnes, Robert J., Tan, Xiaohui, McDougald, Diane, Fane, Anthony G., Zhuang, Guoqiang, Kjelleberg, Staffan, Cohen, Yehuda

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Cathode material investigation towards high-performance aluminum batteries by Gong, Xuefei

“…Additionally, hybrid Al-Li-ion batteries, with Li+ intercalation/de-intercalation participation in the cathode materials and Al stripping/deposition at anode, is proposed to enhance kinetics, increase capacities and prolong cycling life as well as maintain dendrite-free . The improved electrochemical performance can be ascribed to the less electrostatic interactions between monovalent Li+ with the framework of cathode materials and the faster mobility of Li+ insertion/extraction into/from host materials.…”
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A new therapeutic avenue for bronchiectasis : dry powder inhaler of ciprofloxacin nanoplex exhibits superior ex vivo mucus permeability and antibacterial efficacy to its native cip... by Tran, The-Thien, Vidaillac, Celine, Yu, Hong, Yong, Valerie Fei Lee, Roizman, Dan, Chandrasekaran, Ravishankar, Lim, Albert Yick Hou, Low, Teck Boon, Tan, Gan Liang, Abisheganaden, John A., Koh, Mariko Siyue, Teo, Jeanette, Chotirmall, Sanjay Haresh, Hadinoto, Kunn

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Flame-made calcium phosphate nanoparticles with high drug loading for delivery of biologics by Tsikourkitoudi, Vasiliki, Karlsson, Jens, Merkl, Padryk, Loh, Edmund, Henriques-Normark, Birgitta, Sotiriou, Georgios A.

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Tissue-specific study across the stem reveals the chemistry and transcriptome dynamics of birch bark by Alonso-Serra, Juan, Safronov, Omid, Lim, Kean-Jin, Fraser-Miller, Sara J., Blokhina, Olga B., Campilho, Ana, Chong, Sun-Li, Fagerstedt, Kurt, Haavikko, Raisa, Helariutta, Ykä, Immanen, Juha, Kangasjärvi, Jaakko, Kauppila, Tiina J., Lehtonen, Mari, Ragni, Laura, Rajaraman, Sitaram, Räsänen, Riikka-Marjaana, Safdari, Pezhman, Tenkanen, Maija, Yli-Kauhaluoma, Jari T., Teeri, Teemu H., Strachan, Clare J., Nieminen, Kaisa, Salojärvi, Jarkko

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RNA G-quadruplex structures mediate gene regulation in bacteria by Shao, Xiaolong, Zhang, Weitong, Mubarak Ishaq Umar, Wong, Hei Yuen, Seng, Zijing, Xie, Yingpeng, Zhang, Yingchao, Yang, Liang, Kwok, Chun Kit, Deng, Xin

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Antibiotic resistance characteristics of Pseudomonas aeruginosa isolated from keratitis in Australia and India by Khan, Mahjabeen, Stapleton, Fiona, Summers, Stephen, Rice, Scott A., Willcox, Mark D. P.

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RNA thermosensors facilitate Streptococcus pneumoniae and Haemophilus influenzae immune evasion by Eichner, Hannes, Karlsson, Jens, Spelmink, Laura, Pathak, Anuj, Sham, Lok-To, Henriques-Normark, Birgitta, Loh, Edmund

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Characteristics and injury patterns of road traffic injuries in urban and rural Uganda—a retrospective medical record review study in two hospitals by Temizel, Selin, Wunderlich, Robert, Leifels, Mats

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Anomaly detection in multivariate time series using ensemble method by Liu, Yanling

“…Water distribution networks (WDNs) are essential services to people’s life and production. The identification of anomalies and mitigation of cyber-attacks are crucial to ensure uninterrupted water service. …”
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