A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53 by Wong, Jin Huei, Alfatah, Mohammad, Sin, Mei Fang, Sim, Hong May, Verma, Chandra Shekhar, Lane, David P., Arumugam, Prakash

“…In the ABC9Δ strain, p53-Mdm2 interaction inhibitors, like AMG232 and MI-773, completely inhibited the p53-Mdm2 interaction at nanomolar concentrations in the Y2H assay. …”
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Voice conversion with parallel/non-parallel data and synthetic speech detection by Tian, Xiaohai

“…The objective of voice conversion techniques is to convert a source speaker's voice so that it sounds like that of a target speaker. Voice conversion belongs to a popular area of personalized speech generation. …”
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Populism in foreign policy by Chryssogelos, Angelos

“…The “people” for whom populists speak in international affairs can very well transcend national borders, as evidenced, for example, in the foreign policies of Hugo Chavez and Mahmud Ahmadinejad, who aimed to represent transnational constituencies like the Global South, the Islamic world, the world poor, etc. …”
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Le cinéma d’Afrique noire contemporaine: une impossible décolonisation? by Fouhba, H

“…The advent of independence then created a break, with the birth of “African cinema”, carried by pioneers like Paulin Soumanou Vieyra and Sembène Ousmane. …”

Investigating the role of CDK1 in governing the transcriptional landscape in cancer cells by Pluta, AJ

“…The work described in this thesis aimed to test the hypothesis that CDK1 dysregulation contributes to transcriptional re-programming during tumorigenesis by imposing a stem cell-like gene expression programme. An elegant method of examining this role is through the use of cell lines expressing an ATP analogue-sensitive CDK1 (AS-CDK1), which allows for rapid and specific inhibition of the kinase. …”

Evaluation of rabies awareness and the population dynamics of free-roaming and owned dogs in Herat city, Afghanistan by Nasiry, Zabihullah

“…Although the dog density is considered low, the dog bites rate and economic costs are considerable, so it still warrants caution since a proportion of the population is not well-versed about dogs and their importance of them in the transmission of zoonotic diseases like rabies. The information generated by this research can help to identify considerations for the design and implementation of dogs and rabies control programs.…”
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Transcriptome analysis of ischemic stroke recovery induced by neural stem cell preconditioned with baicalein-enriched fraction of oroxylum indicum by Satar, Asmaa’ Mohd

“…The key regulated pathways such as cAMP signaling pathway, Toll-like receptor signaling pathway, B-cell receptor signaling pathway and Fc gamma R-mediated phagocytosis were associated with the improvement of neurological behavior in the ischemic stroke rat model. …”
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Savings and Investment Behaviour of the Consumer of Financial Services and Their Service Expectations from Banks (S/O 12349) by Ahmad, Nor Hayati, Saha, Asish, Eam, Lim Hock, Katib, Mohamed Nasser, Musa, Muhammad Muhaizam, Yeok, Siew Goh

“…Other self-perceived factors like market price and infrastructure have a significant and negative impact on the saving in physical assets. …”
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50 Years of quantum chromodynamics by Gross, Franz, Klempt, Eberhard, Brodsky, Stanley J., Buras, Andrzej J., Burkert, Volker D., Heinrich, Gudrun, Jakobs, Karl, Meyer, Curtis A., Orginos, Kostas, Strickland, Michael, Stachel, Johanna, Zanderighi, Giulia, Brambilla, Nora, Braun-Munzinger, Peter, Britzger, Daniel, Capstick, Simon, Cohen, Tom, Crede, Volker, Constantinou, Martha, Davies, Christine, Del Debbio, Luigi, Denig, Achim, DeTar, Carleton, Deur, Alexandre, Dokshitzer, Yuri, Dosch, Hans Günter, Dudek, Jozef, Dunford, Monica, Epelbaum, Evgeny, Escobedo, Miguel A., Fritzsch, Harald, Fukushima, Kenji, Gambino, Paolo, Gillberg, Dag, Gottlieb, Steven, Grafstrom, Per, Grazzini, Massimiliano, Grube, Boris, Guskov, Alexey, Iijima, Toru, Ji, Xiangdong, Karsch, Frithjof, Kluth, Stefan, Kogut, John B., Krauss, Frank, Kumano, Shunzo, Leinweber, Derek, Leutwyler, Heinrich, Li, Hai-Bo, Li, Yang, Malaescu, Bogdan, Mariotti, Chiara, Maris, Pieter, Marzani, Simone, Melnitchouk, Wally, Messchendorp, Johan, Meyer, Harvey, Mitchell, Ryan Edward, Mondal, Chandan, Nerling, Frank, Neubert, Sebastian, Pappagallo, Marco, Pastore, Saori, Peláez, José R., Puckett, Andrew, Qiu, Jianwei, Rabbertz, Klaus, Ramos, Alberto, Rossi, Patrizia, Rustamov, Anar, Schäfer, Andreas, Scherer, Stefan, Schindler, Matthias, Schramm, Steven, Shifman, Mikhail, Shuryak, Edward, Sjöstrand, Torbjörn, Sterman, George, Stewart, Iain W., Stroth, Joachim, Swanson, Eric, de Téramond, Guy F., Thoma, Ulrike, Vairo, Antonio, van Dyk, Danny, Vary, James, Virto, Javier, Vos, Marcel, Weiss, Christian, Wobisch, Markus, Wu, Sau Lan, Young, Christopher, Yuan, Feng, Zhao, Xingbo, Zhou, Xiaorong

“…Then, with the discovery of charmonium in 1974 and the explanation of its excited states using the Cornell potential, consisting of the sum of a Coulomb-like attraction and a long range linear confining potential, the theory was suddenly widely accepted. …”
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(宋代「武夷棹歌」中的地景空間與文化意蘊) = Landscape and culture in the Wu-yi Zhao Ge (Wu-yi boat song) of Song dynasty by 衣若芬 I, Lo-fen

“…People believed that the Wu-yi Jun were Peng Zu Qian Keng’s two sons: the first son being “Wu” while the second son was “Yi”; and that both of them took charge in military and death related issues. …”
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Isotopes as a Tool for Exploring Exoplanet Atmospheres by Glidden, Ana

“…I simulated observations of CO₂ isotopologues in the H₂-dominated atmospheres of our nearest (< 40 pc), temperate (equilibrium temperature of 250-350 K) sub-Neptunes with M dwarf host stars. I find Earth-like fractionation of ¹³CO₂ to be distinguishable only if the atmosphere is H₂-dominated with a few percentage points of CO₂. …”
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Conductive materials stimulated direct interspecies electron transfer and application in anaerobic digestion by Yan, Wangwang

“…The study revealed the improved methane generation was attributed to the stimulated hydrolysis of organic matters and greater degradation of humic-like substances. Microbial community analysis showed electro-active strains, and bacteria that are capable of degrading complex organics were greatly enriched in CM groups. …”
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Functional characterisation guides classification of novel BAP1 germline variants by Hong, Jing Han, Chong, Siao Ting, Lee, Po-Hsien, Tan, Jing, Heng, Hong Lee, Nur Diana Ishak, Chan, Sock Hoai, Teh, Bin Tean, Ngeow, Joanne

“…In this study, we functionally characterise known BAP1 pathogenic and likely benign germline variants out of these six patients to aid in the evaluation and classification of unknown BAP1 germline variants. …”
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Filamentous oligomer structure reconstruction and a new filament picking method for Cryo-EM micrographs by Xu, Chenrui

“…In one example, Uromodulin (UMOD) is a secretory protein that belongs to the zona pellucida-like domain family. It is the most abundant protein in normal human urine, which forms filament and captures uropathogens, principally serving as decoys to gram-negative bacteria. …”
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The development of empathy in the healthcare setting: a qualitative approach by Yu, Chou Chuen, Tan, Laurence, Le, Mai Khanh, Tang, Bernard, Liaw, Sok Ying, Tierney, Tanya, Ho, Yun Ying, Lim, Evelyn Beng Eng, Lim, Daphne, Ng, Reuben, Chia, Siew Chin, Low, James Alvin

“…Findings suggest empathy is more trait-like and stable in nature but is also susceptible to fluctuation depending on the circumstances faced by healthcare professionals. …”
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Efficient optimization of network metrics in large uncertain graphs by Saha, Arkaprava

“…Graphs constitute an omnipresent data structure that can model objects and their relationships in a wide variety of real-world applications like social networks and geo-spatial road networks. …”
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Tunable metasurfaces for active nanophotonics by Omar Abdelrahman Mohamed Abdelraouf

“…The future prospect of the conducted research work can be done by incorporating atomically thin materials (2D materials) that support ultrafast carrier dynamics and large optical properties contrast for dynamic quantum optics applications such as tunable single-photon emitters and on-chip photonic systems like a neuromorphic chip.…”
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Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis by Tan, Bryan, Pan, Xin-Hui, Chew, Jocelyn Han Shi, Goh, Rachel Sze Jen, Lin, Chaoxing, Anand, Vickram Vijay, Lee, Ethan Cheng Zhe, Chan, Kai En, Kong, Gwyneth, Ong, Christen En Ya, Chung, Charlotte Hui, Young, Dan Yock, Chan, Mark Y., Khoo, Chin Meng, Mehta, Anurag, Muthiah, Mark Dhinesh, Noureddin, Mazen, Ng, Cheng Han, Chew, Nicholas W. S., Chin, Yip Han

“…Background: Recent studies suggest that tirzepatide, a dual glucose-dependent insulinotropic-peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has significant weight loss effects. …”
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Investigation of the reliability of nano-nickel/niobium oxide-based multilayer thin films deposited on polymer substrates for flexible electronic applications by Sahay, Rahul, Tu, Yen-Cheng, Aziz, Izzat, Budiman, Arief S., Tan, Cher Ming, Lee, Pooi See, Thomas, Olivier, Raghavan, Nagarajan

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Evaluation of keratin templates on dermal regeneration of full-thickness burns by Moay, Zi Kuang

“…Seeding HHK foams with a TIME-EC:HDF co-culture revealed that the cells adapted well to the foams, although vessel-like networks were not observed in the foams. In vivo, HHK foams did not impede wound regeneration from full-thickness burns on pig skin. …”
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