Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and is Activated by PPARβ/δ Deficiency by Zarei, Mohammad, Barroso, Emma, Leiva, Rosana, Barniol-Xicota, Marta, Pujol, Eugènia, Escolano, Carmen, Vázquez, Santiago, Palomer, Xavier, Pardo, Virginia, González-Rodríguez, Águeda, Valverde, Ángela M., Quesada-López, Tania, Villarroya, Francesc, Wahli, Walter, Vázquez-Carrera, Manuel

“…Moreover, pharmacological activation of HRI increased Fgf21 expression and reduced lipid-induced hepatic steatosis and glucose intolerance and these effects were not observed in Fgf21-null mice. Overall, these findings suggest that HRI is a potential target for regulating hepatic FGF21 levels.…”
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Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells by Kitajima, Shojiro, Lee, Kian Leong, Fujioka, Masaki, Sun, Wendi, You, Jia, Chia, Grace Sushin, Wanibuchi, Hideki, Tomita, Shuhei, Araki, Marito, Kato, Hiroyuki, Poellinger, Lorenz

“…In addition, the expression of CD70 and colony forming efficiency in soft agar were decreased by knockdown of HIF-2α. These findings indicate that CD70 expression and an aggressive phenotype of cancer cells is driven under hypoxic conditions and mediated by HIF-2α functions and epigenetic modifications. …”
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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Ferrari, AJ, Santomauro, DF, Aali, A, Lacey, BWH, Rodriguez, JAB

“…A global epidemiological transition remains underway. Our findings suggest that prioritising non-communicable disease prevention and treatment policies, as well as strengthening health systems, continues to be crucially important. …”

Halal beauty supply chain and sustainable operational excellence: A moderator of the post-SARS-CoV-2 mitigation strategy by Fernando, Yudi, Mergeresa, Fineke, Ika Sari, Wahyuni-TD, Nurul Sabrina, Hazarasim

“…This study used a structural equation modeling technique to test the validity of the research model and hypotheses. Findings: This study found that halal transportation, halal manufacturing, halal packaging and post-SARS-CoV-2 mitigation strategies had a significant and direct effect on SOE. …”
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Performance-based identity in a BIM environment : An architect’s perceptions and experiences by Syafizal, Shahruddin, Mohd, Zairul, Ahmad Tarmizi, Haron, Meor Mohammad, Fared

“…The study was conducted in a Malaysian architectural consultancy practice (ACP) setting. Findings: The data analysis resulted in the following five performance identity themes that revolve around the core identity of a successful designer: “performing as a design strategist”, “performing as a design translator”, “performing as a design facilitator”, “reinstating the identity of a design coordinator” and “performing as a design innovator”. …”
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Heat transfer and energy performance analysis of photovoltaic thermal system using functionalized carbon nanotubes enhanced phase change material by Rajamony, Reji Kumar, Pandey, A. K., Mahendran, Samykano, Johnny Koh, Siaw Paw, Kareri, Tareq, Laghari, Imtiaz Ali, Tyagi, V. V.

“…Furthermore, the total efficiency of the PVT system, phase change materials integrated PVT system, and NePCM integrated PVT system were determined to be 81.9 %, 84.5 %, and 85.05 %, respectively. These findings underscore the potential of NePCM-integrated PVT systems for enhancing performance and expanding their practical application.…”
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Evaluating the rheological, chemical and mechanical properties of hybrid asphalt binders and mixtures for enhanced performance by Wan Noor Hin, Mior Sani, Putra Jaya, Ramadhansyah, Khairil Azman, Masri, Amar, Dulaimi

“…Consequently, the hybrid asphalt mixture demonstrated favourable outcomes in improving the hot mix asphalt characteristics. These findings suggested that the hybrid contents (0% as control, 3%, 6%, and 9%) produced a significant performance impact on the hybrid asphalt mixture. …”
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Measuring ethical behavior of accounting graduates in Malaysia: Comparison between perceptual statements and vignettes by Hasnah, Hj Haron, Nurul Nazlia, Jamil, Nathasa Mazna, Ramli, Fatin Arissa, Parsimin, Azim Azuan, Osman

“…This study involved 344 samples of accounting graduates from MIA-accredited universities, and path analysis was performed to test the hypotheses. The findings demonstrate a positive relationship between the ethical workplace culture and ethical behavior among accounting graduates, regardless of whether the ethical behavior was measured using vignette scenarios or perceptual statements. …”
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Data-driven brain emotional learning-based intelligent controller-PID control of MIMO systems based on a modified safe experimentation dynamics algorithm by Shahrizal, Saat, Mohd Ashraf, Ahmad, Mohd Riduwan, Ghazali

“…The comparative results demonstrated that the MSEDA-BELBIC-PID consistently performed better than the original approach and had improved fitness function values, reduced total integral square error, and lower total integral square input. These findings underscored the MSEDA suitability as a data-driven tool for controller design parameter optimization. …”
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Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism by Pujadas Liwag, Emily M., Wei, Xiaolong, Acosta, Nicolas, Carter, Lucas M., Yang, Jiekun, Almassalha, Luay M., Jain, Surbhi, Daneshkhah, Ali, Rao, Suhas S. P., Seker-Polat, Fidan, MacQuarrie, Kyle L., Ibarra, Joe, Agrawal, Vasundhara, Aiden, Erez Lieberman, Kanemaki, Masato T., Backman, Vadim, Adli, Mazhar

“…Conclusions Our findings suggest that, while B-type lamin degradation does not significantly change genome topology, it has major implications for three-dimensional chromatin conformation at the single-cell level both at the lamina-associated periphery and the non-LAD-associated nuclear interior with concomitant genome-wide transcriptional changes. …”
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Rheo-PIV of yield-stress fluids in a 3D-printed fractal vane-in-cup geometry by Medina-Bañuelos, Esteban F., Marín-Santibáñez, Benjamín M., Chaparian, Emad, Owens, Crystal E., McKinley, Gareth H., Pérez-González, José

“…We describe the velocity distributions in all cases and show that the fVIC produces an almost axisymmetric flow field and rotation rate-independent “effective radius” when used with both the Newtonian fluid and the microgel. These findings are supported by 2D simulation results and enable the safe use of both the Couette analogy and the torque-to-stress conversion scheme for a 24-arm fVIC as well as validate it as a reliable rheometrical tool for characterization of a variety of complex fluids. …”
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Mental-LLM: Leveraging Large Language Models for Mental Health Prediction via Online Text Data by Xu, Xuhai, Yao, Bingsheng, Dong, Yuanzhe, Gabriel, Saadia, Yu, Hong, Hendler, James, Ghassemi, Marzyeh, Dey, Anind K., Wang, Dakuo

“…We also conduct an exploratory case study on LLMs' capability on mental health reasoning tasks, illustrating the promising capability of certain models such as GPT-4. We summarize our findings into a set of action guidelines for potential methods to enhance LLMs' capability for mental health tasks. …”
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Solar-Induced Chlorophyll Fluorescence (SIF): Towards a Better Understanding of Vegetation Dynamics and Carbon Uptake in Arctic-Boreal Ecosystems by Cheng, Rui

“…Additionally, this review proposes applications of SIF across scales in support of other observational and modeling platforms for better understanding Arctic-Boreal vegetation dynamics and carbon fluxes. Recent Findings Cross-scale SIF measurements complement each other, offering valuable perspectives on Arctic-Boreal ecosystems, such as vegetation phenology, carbon uptake, carbon-water coupling, and ecosystem responses to disturbances. …”
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Compressed sensing: a discrete optimization approach by Bertsimas, Dimitris, Johnson, Nicholas A. G.

“…We study the Compressed Sensing (CS) problem, which is the problem of finding the most sparse vector that satisfies a set of linear measurements up to some numerical tolerance. …”
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Time-series metagenomics reveals changing protistan ecology of a temperate dimictic lake by Krinos, Arianna I., Bowers, Robert M., Rohwer, Robin R., McMahon, Katherine D., Woyke, Tanja, Schulz, Frederik

“…Our study identified long-term changes in the abundance of eukaryotic microbes and provided context for the known establishment of an invasive species that catalyzes a trophic cascade involving protists. Our findings are important for decoding potential long-term consequences of human interventions, including invasive species introduction.…”
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Spatial structure of workplace and communication between colleagues: A study of E-mail exchange and spatial relatedness on the MIT campus by Sevtsuk, Andres, Chancey, Bahij, Basu, Rounaq, Mazzarello, Martina

“…Building on prior studies of both physical and electronic communication networks, we present the results of a study conducted on the MIT campus using an anonymized dataset of e-mail communication to examine how spatial relatedness between faculty, staff, and researchers’ office locations impact E-mail communication between them. Our findings suggest that (a) people whose offices are closer to each other by walking are more likely to exchange E-mails, (b) on the campus as a whole, people who are more likely to walk past each other’s offices on the way to or from work are more likely to exchange E-mails, and (c) people who share access to similar eating venues around their offices are more likely to exchange E-mails. …”
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Predicting drivers’ route trajectories in last-mile delivery using a pair-wise attention-based pointer neural network by Mo, Baichuan, Wang, Qingyi, Guo, Xiaotong, Winkenbach, Matthias, Zhao, Jinhua

“…Results from an extensive case study on real operational data from Amazon’s last-mile delivery operations in the US show that our proposed method can significantly outperform traditional optimization-based approaches and other machine learning methods (such as the Long Short-Term Memory encoder–decoder and the original pointer network) in finding stop sequences that are closer to high-quality routes executed by experienced drivers in the field. …”
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Ex Post Path Choice Estimation for Urban Rail Systems Using Smart Card Data: An Aggregated Time-Space Hypernetwork Approach by Mo, Baichuan, Ma, Zhenliang, Koutsopoulos, Haris N, Zhao, Jinhua

“…Solving the decomposed problem is equivalent to finding a fixed point. We prove that the solution to the original problem is the same as the decomposed problem (i.e., the fixed point) when passenger path choices follow the predefined behavior model. …”
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Dynamic Expansion and Merging of the Equatorial Ionization Anomaly During the 10–11 May 2024 Super Geomagnetic Storm by Aa, Ercha, Chen, Yanhong, Luo, Bingxian

“…The investigation utilizes multi-instrument datasets, including ground-based observations (GNSS TEC, ionosonde, and Fabry–Perot interferometer) as well as space-borne satellite measurements (GOLD, Swarm, DMSP, and TIMED). Our findings reveal significant day-to-day variations in the storm-time equatorial ionization anomaly (EIA), summarized as follows: (1) During the main phase of the storm, the low- and mid-latitude ionosphere experienced a positive storm, with TEC drastically enhanced by 50–100% within a few hours. …”
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Empathy Toward Artificial Intelligence Versus Human Experiences and the Role of Transparency in Mental Health and Social Support Chatbot Design: Comparative Study by Shen, Jocelyn, DiPaola, Daniella, Ali, Safinah, Sap, Maarten, Park, Hae Won, Breazeal, Cynthia

“…Objective: We aim to understand how empathy shifts across human-written versus AI-written stories, and how these findings inform ethical implications and human-centered design of using mental health chatbots as objects of empathy. …”
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