Characterization and gene expression analysis of the cir multi-gene family of plasmodium chabaudi chabaudi (AS) by Lawton, Jennifer, Brugat, Thibaut, Yan, Yam Xue, Reid, Adam James, Böhme, Ulrike, Otto, Thomas Dan, Pain, Arnab, Jackson, Andrew, Berriman, Matthew, Cunningham, Deirdre, Preiser, Peter Rainer, Langhorne, Jean

“…Conclusions: In conclusion, the large number of cir genes and their expression throughout the intraerythrocytic cycle of development indicates that CIR proteins are likely to be important for parasite survival. In particular, the detection of dominant cir transcripts at the peak of P. chabaudi infection supports the idea that CIR proteins are expressed, and could perform important functions in the biology of this parasite. …”
Get full text
Get full text

Greater rate of weight loss predicts paediatric hospital admission in adolescent typical and atypical anorexia nervosa by Brennan, Cliona, Cini, Erica, Illingworth, Sarah, Chapman, Simon, Simic, Mima, Nicholls, Dasha, Chapman, Victoria, Simms, Conor, Hayes, Ellen, Fuller, Sarah, Orpwood, Jade, Tweedy, Nichola, Baksh, Tahmida, Astaire, Emma, Bhakta, Dee

“…Underweight adolescents with AN were equally likely to be admitted as non-underweight adolescents with AAN. …”
Get full text

Molecular characterization of microbial interactions with labile dissolved organic matter by Halloran, Kathryn H.

“…This substrate selectivity is likely driven by transporter specificity. The distinct fate of these structurally similar molecules emphasizes the importance of compound-specific characterization of labile DOM. …”
Get full text

Application of in vitro erythropoiesis from bone marrow derived progenitors to detect and study genotoxicity by Shuga, Joseph F. (Joseph Francis)

Get full text

Poisson discretizations of Wiener functionals and Malliavin operators with Wasserstein estimates by Privault, Nicolas, Yam, Phillip S. C., Zhang, Zheng

Get full text

A bilayer swellable drug-eluting stent for the treatment of fibrosis-induced ureteral stricture recurrence by Lim, Wei Shan

“…These observations were likely due to the high equilibrium water content hence promoting the drug release. …”
Get full text

Strategies to increase response rate and reduce non-response bias in population health research: a series of randomised controlled trials during a large COVID-19 study by Atchison, CJ, Gilby, N, Pantelidou, G, Clemens, S, Pickering, K, Chadeau-Hyam, M, Ashby, D, Barclay, WS, Cooke, G, Darzi, A, Riley, S, Donnelly, C, Ward, H, Elliott, P

“…Those receiving an additional text message were more likely to return a completed swab compared to those receiving the standard approach, 73.3% v 70.2%: percentage difference 3.1% (95% CI 2.2%, 4.0%).…”

Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity by Watson, R, Tong, O, Taylor, C, Kumar Sharma, P, Verge De Los Aires, A, Mahe, E, Ruffieux, H, Nassiri, I, Middleton, M, Fairfax, B

“…Cytotoxic effector clones were more likely to persist long-term following ICB and overlapped with public tumour-infiltrating lymphocyte clonotypes. …”

Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1c + Myeloid Dendritic Cell Maturation Arrest,... by Yeo, Tsin Wen, Woodberry, Tonia, Loughland, Jessica R., Minigo, Gabriela, Burel, Julie G., Amante, Fiona H., Piera, Kim A., McNeil, Yvette, Good, Michael F., Doolan, Denise L., Engwerda, Christian R., McCarthy, James S., Anstey, Nicholas M.

“…Induction of the kynurenine pathway and increased Treg activation, together with skewed mDC maturation, suggest P. vivax promotes an immunosuppressive environment, likely impairing the development of a protective host immune response.…”
Get full text
Get full text

The effect of the amyloid-beta peptide on the fluidity of cell membranes : a study by fluorescence correlation spectroscopy by Ng, Justin Wei Qing

“…Although there have been several studies done regarding this topic, the results have been conflicting and thus inconclusive, likely due to the drawbacks and biases introduced by techniques used in those studies. …”
Get full text

Understanding customer retrials in call centers: preferences for service quality and service speed by Hu, K, Allon, G, Bassamboo, A

“…<p><strong>Problem definition: </p></strong> Customers are likely to initiate retrial calls when their previous contact with a call center fails to deliver a satisfactory resolution. …”

Integrated transcriptomic and proteomic profiling of responses to clinical and novel bisphosphonates by Lu, J

“…Pre-clinical studies also indicate that the observed non-skeletal effects of bisphosphonates are likely due to mechanisms beyond inhibition of osteoclasts. …”

Long Covid: a global health issue – a prospective, cohort study set in four continents by Pazukhina, E, Garcia-Gallo, E, Reyes, LF, Kildal, AB, Jassat, W, Dryden, M, Holter, JC, Chatterjee, A, Gomez, K, Søraas, A, Puntoni, M, Latronico, N, Bozza, FA, Edelstein, M, Gonçalves, BP, Kartsonaki, C, Kruglova, O, Gaião, S, Chow, YP, Doshi, Y, Duque Vallejo, SI, Ibáñez-Prada, ED, Fuentes, YV, Hastie, C, O'Hara, ME, Balan, V, Menkir, T, Merson, L, Kelly, S, Citarella, BW, Semple, MG, Scott, JT, Munblit, D, Sigfrid, L

“…Participants in HICs were more likely to report not feeling fully recovered (54.3% vs 18.0%, p<0.001; 56.8% vs 40.1%, p<0.001), fatigue (42.9% vs 27.9%, p<0.001; 41.6% vs 27.9%, p<0.001), new/persistent fever (19.6% vs 2.1%, p<0.001; 20.3% vs 2.0%, p<0.001) and have a higher prevalence of anxiety/depression and impact on usual activities compared with participants in LMICs at 2 to <6 and 6 to <12 months post-COVID-19 hospital discharge, respectively. …”

Childhood bullying and mental health: understanding risk, resilience, and the role of anti-bullying interventions by Guzman Holst, C

“…Children and young people in these latter groups are more likely to have elevated levels of mental health problems (Singham et al., 2017). …”

Circadian rhythm and misalignment in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD): an experimental medicine approach by Marjot, T

“…I show that 3-night shifts are associated with profound hepatic insulin resistance, a pathological hallmark of MASLD. This is likely to be related to a combination of circadian misalignment, sleep deprivation, and elevated light exposure during sleep. …”

Using cluster analysis to reconstruct dengue exposure patterns from cross-sectional serological studies in Singapore by Sangkaew, Sorawat, Tan, Li Kiang, Ng, Lee Ching, Ferguson, Neil M., Dorigatti, Ilaria

“…Conclusion: Cluster analysis is an unsupervised machine learning technique that can be applied to analyse PRNT antibody titres (without pre-established cut-off thresholds to indicate protection) to explore common patterns of DENV infection and infer the likely history of dengue exposure in a population.…”
Get full text

Synergy of compress strain and antioxidant of platinum-copper for enhanced the oxygen reduction performance by Zhang, Jun, Liang, Pingjuan, Xu, Xinlan, Wang, Rong, Liu, Shuyue, Wang, Chunyuan, Liu, Boyu, Luo, Laizheng, Jin, Meng, Liu, Huan, Yi, Huan, Lu, Shi-Yu

“…Herein, we report a worm-liked PtCu nanocrystals dispersed on nitrogen-doped carbon hollow microspheres (Pt0.38Cu0.62/N-HCS). …”
Get full text

System-level design of low-carbon structures by Fang, Demi L.

“…“What is more likely to be associated with a reduction in emissions: switching from concrete to timber, or shortening the spans throughout the building?” …”
Get full text
Get full text

Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Further, they highlight multiple approaches for efficacy in SCID settings and optimal combinations for WT settings. This work is likely to aid in the development of clinical non-genotoxic HSCT conditioning approaches that could benefit millions of people world-wide.…”
Get full text

Dietary pattern trajectories in early childhood and their associations with patterns of maternal feeding practices in a multi-ethnic Asian cohort by Appannah, Geeta, Toh, Jia Ying, Lai, Jun Shi, Yong, Heng Yaw, Shariff, Zalilah Mohd, Tint, Mya Thway, Yuan, Wen Lun, Pang, Wei Wei, Godfrey, Keith M., Tan, Kok Hian, Yap, Fabian, Lee, Yung Seng, Eriksson, Johan G., Chong, Mary F. F.

“…Children whose mothers showed high adherence to the structured with autonomy support feeding practices at age 5 years were significantly more likely to be associated with the higher but decreasing ‘healthy’ DP trajectory group [OR = 3.62 (95% CI: 1.64, 7.99)]. …”
Get full text