A novel method for segmenting growth of cells in sheared endothelial culture reveals the secretion of an anti-inflammatory mediator by Ghim, Mean, Pang, Kuin T., Arshad, Mehwish, Wang, Xiaomeng, Weinberg, Peter D.

“…In one paradigm, endothelial cells are cultured in devices that produce spatially varying shear stress profiles, and the local profile is compared with the properties of cells at the same position. …”
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Epithelial-mesenchymal transition of cancer cells using bioengineered hybrid scaffold composed of hydrogel/3D-fibrous framework by Pal, Mintu, Chen, Huizhi, Lee, Bae Hoon, Lee, Justin Yin Hao, Yip, Yun Sheng, Tan, Nguan Soon, Tan, Lay Poh

“…Our findings revealed that 3D hybrid scaffold enhances cell proliferation and induces cancer cells to undergo EMT, as demonstrated by significant up-regulation of EMT associated transcriptional factors including Snail1, Zeb1, and Twist2; and mesenchymal markers whereas epithelial marker, E-Cadherin was downregulated. …”
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A Model of Fuel Cell Based Electricity Generation in Malaysia: Life Cycle Approach (S/O 14199) by Mohd Shafie, Shafini, Othman, Zakirah, Hami, Norsiah, Omar, Salmah

“…Moving toward 2050, the fuel cell energy system is targeting to be one of potential green energy. …”
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In vitro and in silico studies of Lawsone on inflammation-induced skin cells for development of skin anti-inflammatory treatment by Abdullah, Shazleen Sofea, Mohammad Latif, Muhammad Alif, Md Tohid, Siti Farah

“…In silico works predicted lawsone’s ability to bind to TNF-α with good binding affinity without disruption to the protein’s structure stability.Lawsone is proven to be safe towards non-pathological cells. …”
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High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin by Fu, Afu, Ma, Shijun, Wei, Na, Tan, Blanche Xiao Xuan, Tan, Ern Yu, Luo, Kathy Qian

“…Specific siRNA-mediated MnSOD knockdown reversed all three phenotypes. Our findings therefore suggest that MnSOD plays an important integrative role in supporting cancer cell survival in circulation, metastasis, and doxorubicin resistance. …”
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Cytotoxic effect of Bajong LN rice methanol extract on human squamous cell Carcinoma, ORL-48 by Vivi Noryati Ahmad, Nur Aliana Hidayah Mohamed, Zulkhairi Amom, Khor, Goot Heah, Nurhayati Mohamad Zain, Indah Mohd Amin

“…Morphological analysis and the Trypan blue exclusion assay corroborated the MTS assay's findings. Our preliminary findings provide the first scientific evidence of the cytotoxic effect of BLN-ME specifically against human squamous cell carcinoma, ORL-48 cells. …”
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A faster chemical bath deposition method for SnO2 ETLs in perovskite solar cells by Wong, Zi Sheng

“…Perovskite Solar Cells (PSC) has been a topic of interest in recent times. …”
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Phytochemical analysis and cytotoxic effects of mango (Mangifera indica L) kernel on breast cancer cell lines by Abdullah, Al-Shwyeh Hussah

“…It is suggested that the anticancer effect of the M.indica extract is via modulation of redox status through its antioxidant constituents and induction of apoptosis. These findings suggest that M. indica kernel extract, with antiproliferative properties towards cancer cells, while relatively innocuous to normal cells, is a good candidate as an alternative to or for supplementation for current chemotherapies in the treatment of breast cancers, without showing the side-effects associated with these anticancer drugs.…”
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Computational modeling of light processing in the habenula and dorsal raphe based on laser ablation of functionally-defined cells by Cheng, Ruey-Kuang, Jagannathan, N. Suhas, Kathrada, Ahmad Ismat, Jesuthasan, Suresh, Tucker-Kellogg, Lisa

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Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib by Miettinen, Teemu P., Peltier, Julien, Härtlova, Anetta, Gierliński, Marek, Jansen, Valerie M., Trost, Matthias, Björklund, Mikael

“…In order to identify a molecular mechanism responsible for palbociclib‐induced senescence, we performed thermal proteome profiling of MCF7 breast cancer cells. In addition to affecting known CDK4/6 targets, palbociclib induces a thermal stabilization of the 20S proteasome, despite not directly binding to it. …”
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Contribution of zeolitic imidazolate framework-8 in improving the performance of polymer electrolyte membrane for direct methanol fuel cell by Junoh, Hazlina, Awang, Nuha, Ahmad, Siti Nur Afifi, Azhar, Masaud, Jaafar, Juhana, Md. Nordin, Nik Abdul Hadi, Ismail, Ahmad Fauzi, Qtaishat, Mohammed Rasool, Matsuura, Takeshi, Othman, Mohd. Hafiz Dzarfan, Abdul Rahman, Mukhlis, Mohd. Zainoodin, Azran

Ligand-specific factors influencing GLP-1 receptor post-endocytic trafficking and degradation in pancreatic beta cells by Fang, Zijian, Chen, Shiqian, Manchanda, Yusman, Bitsi, Stavroula, Pickford, Philip, David, Alessia, Shchepinova, Maria M., Corrêa, Ivan R., Jr., Hodson, David J., Broichhagen, Johannes, Tate, Edward W., Reimann, Frank, Salem, Victoria, Rutter, Guy A., Tan, Tricia, Bloom, Stephen R., Tomas, Alejandra, Jones, Ben

“…Experiments were performed in primary islet cells, INS-1 832/3 clonal beta cells and HEK293 cells, using biorthogonal labelling of GLP-1R to determine its localisation and degradation after treatment with GLP-1, exendin-4 and several further GLP-1R agonist peptides. …”
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Direct reuse of electronic plastic scraps from computer monitor and keyboard to direct stem cell growth and differentiation by Shi, Pujiang, Tan, Chiew Kei, Wu, Zhuoran, Gabriel, Jean-Christophe P., Srinivasan, Madhavi, Lee, Jong-Min, Tay, Chor Yong

“…Multiparametric analysis revealed that all the E-plastics could preserve stem-cell phenotype and maintain cell growth over 2 weeks, rivalling the performance of commercial tissue-culture treated plates as cell culture plastics. …”
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REST targets JAK–STAT and HIF-1 signaling pathways in human Down syndrome brain and neural cells by Huang, Tan, Fakurazi, Sharida, Cheah, Pike-See, Ling, King-Hwa

“…Differential expression analysis was performed on all datasets to produce differential expression genes (DEGs) between DS and control groups. …”
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Functionalized sp2 carbon-conjugated covalent organic frameworks for interfacial modulation of inverted perovskite solar cells by Abuzeid, Hesham R., Tay, Darrell Jun Jie, Febriansyah, Benny, Kanwat, Anil, Salim, Teddy, Zhumekenov, Ayan A., Pullarkat, Sumod A., Mathews, Nripan

“…Interfacial modulation utilizing functional materials is proven to be crucial for obtaining high photovoltaic performance in lead halide perovskite solar cells (PSCs). This study investigates, for the first time, the utilization of a pyrene-based sp2 carbon-conjugated covalent organic framework (sp2c-COF) as an interfacial layer in inverted PSCs. …”
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Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity by Yao, S, Harder, A, Darki, F, Chang, Y, Li, A, Nikouei, K, Volpe, G, Lundström, JN, Zeng, J, Wray, NR, Lu, Y, Sullivan, PF, Hjerling-Leffler, J

“…Using functional MRI connectivity, we further confirmed the significance of the central and lateral amygdala, hippocampal body, and prefrontal cortex in distinguishing schizophrenia cases from controls. Our findings underscore the value of single-cell transcriptomics in understanding the polygenicity of psychiatric disorders and suggest a promising alignment of genomic, transcriptomic, and brain imaging modalities for identifying common biological targets.…”

Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells by Carré, A, Samassa, F, Zhou, Z, Perez-Hernandez, J, Lekka, C, Manganaro, A, Oshima, M, Liao, H, Parker, R, Nicastri, A, Brandao, B, Colli, ML, Eizirik, DL, Aluri, J, Patel, D, Göransson, M, Burgos Morales, O, Anderson, A, Landry, L, Kobaisi, F, Scharfmann, R, Marselli, L, Marchetti, P, You, S, Ternette, N

“…Interferon (IFN)-α is the earliest cytokine signature observed in individuals at risk for type 1 diabetes (T1D), but the effect of IFN-α on the antigen repertoire of HLA Class I (HLA-I) in pancreatic β-cells is unknown. Here we characterize the HLA-I antigen presentation in resting and IFN-α-exposed β-cells and find that IFN-α increases HLA-I expression and expands peptide repertoire to those derived from alternative mRNA splicing, protein cis-splicing and post-translational modifications. …”

Single cell hydrodynamic stretching and microsieve filtration reveal genetic, phenotypic and treatment-related links to cellular deformability by Li, Fenfang, Cima, Igor, Vo, Jess Honganh, Tan, Min-Han, Ohl, Claus-Dieter

“…We also find that the drug docetaxel leads to an increase in the size of A549 lung cancer cells. …”
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Insight into proton transfer in phosphotungstic acid functionalized mesoporous silica-based proton exchange membrane fuel cells by Zhou, Yuhua, Yang, Jing, Su, Haibin, Zeng, Jie, Jiang, San Ping, Goddard, William A

“…We have developed for fuel cells a novel proton exchange membrane (PEM) using inorganic phosphotungstic acid (HPW) as proton carrier and mesoporous silica as matrix (HPW-meso-silica) . …”
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Enhancing indoor photovoltaic performance of inverted type organic solar cell by controlling photoactive layer solution concentration by Mohamed Nafeer Wajidh, Nour Attallah Issa, Kam, Sheng Lau, Sin, Tee Tan, Chin, Hua Chia, Muslizainun Mustapha, Mohammad Hafizuddin Hj Jumali, Chi, Chin Yap

“…With the development of various low-power indoor electronic devices, indoor photovoltaics, particularly organic solar cells (OSCs) have attracted a lot of interest in recent years. …”
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