PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism by Salvadó, Laia, Barroso, Emma, Gómez-Foix, Anna Maria, Palomer, Xavier, Michalik, Liliane, Wahli, Walter, Vázquez-Carrera, Manuel

“…In this study, we assessed whether peroxisome proliferator-activated receptor (PPAR)β/δ prevented ER stress-associated inflammation and insulin resistance in skeletal muscle cells. Methods Studies were conducted in mouse C2C12 myotubes, in the human myogenic cell line LHCN-M2 and in skeletal muscle from wild-type and PPARβ/δ-deficient mice and mice exposed to a high-fat diet. …”
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Leucine-rich α-2-glycoprotein 1 suppresses endothelial cell activation through ADAM10-mediated shedding of TNF-α receptor by Pang, Kuin Tian, Ghim, Mean, Liu, Chenghao, Tay, Hui Min, Fhu, Chee Wai, Chia, Rui Ning, Qiu, Beiying, Sarathchandra, Padmini, Chester, Adrian H., Yacoub, Magdi H., Wilkinson, Fiona L., Weston, Ria, Warboys, Christina M., Hou, Han Wei, Weinberg, Peter D., Wang, Xiaomeng

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On the composition of Sr₂Fe₁.₅Mo₀.₅O₆₋δ – Sm₀.₂Ce₀.₈O₂₋δ composite as fuel electrodes for hydrogen reversible solid oxide cells by Li, Hao-Yang, Kamlungsua, Kittiwat, Ng, Kelvin, Shin, Ji-Yoon, Su, Pei-Chen

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Improved mobility and photovoltaic performance of two-dimensional Ruddlesden−Popper (ThMA)₂(MA)₂M₃I₁₀ perovskites applied in perovskite solar cells by Sun, Ping-Ping, Kripalani, Devesh Raju, Chi, Weijie

“…Two-dimensional Ruddlesden−Popper (2DRP) perovskites have received extensive attention for perovskite solar cells (PSCs) application due to their enhanced thermal and light stability, high photoluminescence quantum yield, and long carrier lifetime. …”
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Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells by Kitajima, Shojiro, Lee, Kian Leong, Fujioka, Masaki, Sun, Wendi, You, Jia, Chia, Grace Sushin, Wanibuchi, Hideki, Tomita, Shuhei, Araki, Marito, Kato, Hiroyuki, Poellinger, Lorenz

“…In addition, the expression of CD70 and colony forming efficiency in soft agar were decreased by knockdown of HIF-2α. These findings indicate that CD70 expression and an aggressive phenotype of cancer cells is driven under hypoxic conditions and mediated by HIF-2α functions and epigenetic modifications. …”
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Assessing nanotoxicity of food-relevant particles: a comparative analysis of cellular responses in cell monolayers versus 3D gut epithelial cultures by Gautam, Archana, Lim, Hui Kheng, Li, Jasmine Jia’En, Hughes, Christopher Owen, Yeo, Calvin Wee Sing, Rakshit, Moumita, Leavesley, David Ian, Lim, Michelle Jing Sin, Tan, Joseph Choon Wee, Tan, Li Yi, Chan, Joanne Sheot Harn, Smith, Benjamin Paul Chapman, Ng, Kee Woei

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Cytotoxicity assessment of α helix Antarctic yeast oriented antifreeze peptide (Afp1m) on M. dunni (Clone III8C) cells by Khan, Muhammad Shuaib, Abdul Rahman, Mohd Basyaruddin, Abu Bakar, Mohd Zuki, Noordin, Mohammed Mustapha, Ullah, Shakeeb, Abdul Abubakar, Adamu, Rehman, Saifur, Saddiqua, Aisha, Mohammad Yusof, Loqman

“…Development was observed, albeit more slowly than in the positive control and treated with lesser concentrations. The findings of this work indicate that Afp1m exhibits cryoprotective properties without inducing toxicity when used for the cryopreservation of M. dunni (Clone III8C) cells.…”
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DNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells by Ye, Y, Xie, W, Wang, X, Tan, S, Yang, L, Ma, Z, Zhu, Z, Chen, X, Liu, X, O’Neill, E, Chang, L, Zhang, W

“…Here we show the impact of ionizing irradiation on the maintenance and early differentiation of mouse embryonic stem cells (ESCs). Our findings demonstrate that irradiation induces the upregulation of the p53 family genes, including p53, p63, and p73, resulting in elevated expression of the E3 ubiquitin ligases Itch and Trim32. …”

A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression by Fisher, KD, Ulbrich, K, Subr, V, Ward, CM, Mautner, V, Blakey, D, Seymour, LW

“…The resulting nanoparticulate vectors resist attack by serum proteins and can be modified for cell-specific delivery by incorporation of targeting ligands onto the polymer coating. …”

Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling by Witmer, Kathrin, Schmid, Christoph D., Brancucci, Nicolas M. B., Luah, Yen-Hoon, Preiser, Peter Rainer, Bozdech, Zbynek, Voss, Till S.

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Whole genome analysis of Hawksbill turtles in Singapore reveals their genetic adaptations to disease and sensory perception by Desai, Archita Sanjay

“…These genes are mainly associated with disease response, olfactory system, cell signalling and cellular transport. This study's findings explain how Hawksbill turtles are adapted to navigate using olfaction, fight against infections, and survive during their unique life-cycles and large-scale migrations. …”
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Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019 by Ward, Joseph L., Azzopardi, Peter S., Francis, Kate L., Santelli, John S., Skirbekk, Vegard, Sawyer, Susan M., Kassebaum, Nicholas J., Mokdad, Ali H., Hay, Simon I., Abd-Allah, Foad, Abdoli, Amir, Mohammad Abdollahi, Abedi, Aidin, Abolhassani, Hassan, Abreu, Lucas Guimaraes, Abrigo, Michael R. M., Abu-Gharbieh, Eman, Abushouk, Abdelrahman I., Adebayo, Oladimeji M., Adekanmbi, Victor, Adham, Davoud, Advani, Shailesh M., Afshari, Khashayar, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Keivan, Ahmed, Anwar E., Aji, Budi, Akombi-Inyang, Blessing, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alanezi, Fahad Mashhour, Alanzi, Turki M., Alcalde-Rabanal, Jacqueline Elizabeth, Alemu, Biresaw Wassihun, Al-Hajj, Samar, Alhassan, Robert Kaba, Ali, Saqib, Alicandro, Gianfranco, Alijanzadeh, Mehran, Aljunid, Syed Mohamed, Almasi-Hashiani, Amir, Almasri, Nihad A., Al-Mekhlafi, Hesham M., Alonso, Jordi, Al-Raddadi, Rajaa M., Altirkawi, Khalid A., Alvis-Guzman, Nelson, Amare, Azmeraw T., Amini, Saeed, Aminorroaya, Arya, Amit, Arianna Maever L., Amugsi, Dickson A., Ancuceanu, Robert, Anderlini, Deanna, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Fereshteh, Ansari, Iman, Antonio, Carl Abelardo T., Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Ärnlöv, Johan, Asaad, Malke, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A., Atout, Maha Moh'd Wahbi, Ausloos, Marcel, Avenyo, Elvis Korku, Avila-Burgos, Leticia, Quintanilla, Beatriz Paulina Ayala, Ayano, Getinet, Aynalem, Yared Asmare, Azari, Samad, Azene, Zelalem Nigussie, Bakhshaei, Mohammad Hossein, Bakkannavar, Shankar M., Banach, Maciej, Banik, Palash Chandra, Barboza, Miguel A., Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Basu, Sanjay, Baune, Bernhard T., Bayati, Mohsen, Bedi, Neeraj, Beghi, Ettore, Bekuma, Tariku Tesfaye, Bell, Arielle Wilder, Bell, Michelle L., Benjet, Corina, Bensenor, Isabela M., Berhe, Abadi Kidanemariam, Berhe, Kidanemaryam, Berman, Adam E., Bhagavathula, Akshaya Srikanth, Car, Lorainne Tudor

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Application of COLD-PCR for improved detection of EGFR mutations in clinical samples. by Zhang, Zhi Xuan.

“…Due to the significance of mutation status of the epidermal growth factor receptor (EGFR) gene in non-small-cell lung cancer (NSCLC) affecting patient response to tyrosine kinase inhibitors (TKI), the more sensitive and robust the method used to detect the mutations, the better. …”
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Selection against domestication alleles in introduced rabbit populations by Andrade, P, Alves, JM, Pereira, P, Rubin, C-J, Silva, E, Sprehn, CG, Enbody, E, Afonso, S, Faria, R, Zhang, Y, Bonino, N, Duckworth, JA, Garreau, H, Letnic, M, Strive, T, Thulin, C-G, Queney, G, Villafuerte, R, Jiggins, FM, Ferrand, N, Andersson, L, Carneiro, M

“…This limited parallelism is probably explained by extensive standing genetic variation resulting from domestication together with the complex mixed ancestry of introduced populations. Our findings shed light on the selective and molecular mechanisms that enable domestic animals to re-adapt to the wild and provide important insights for the mitigation and management of invasive populations.…”

International differences in conservation priorities are more complicated than Global North-Global South divisions by Mutinhima, Y, Sibanda, L, Rono, B, Kulunge, S, Kimaili, D, Dickman, A, Madsen, E, Mandoloma, L, Tacey, J, Allred, S, Hare, D

“… Two enduring ideological divisions in biodiversity conservation concern whether conservation should prioritise a) the interests of people or wild animals, and b) the interests of individual animals or groups of animals. …”

A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system by Shen, Yunbing, Jiang, Long, Iyer, Vaishnavi Srinivasan, Raposo, Bruno, Dubnovitsky, Anatoly, Boddul, Sanjaykumar V., Kasza, Zsolt, Wermeling, Fredrik

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Vision-language-model-based video quality assessment by Zhang, Erli

“…This work not only advances the state-of-the-art in VQA but also sets the stage for future research in evaluating and enhancing the quality of in-the-wild videos.…”
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits by Evangelou, Evangelos, Warren, Helen R., Mosen-Ansorena, David, Mifsud, Borbala, Pazoki, Raha, Gao, He, Ntritsos, Georgios, Dimou, Niki, Cabrera, Claudia P., Ibrahim Karaman, Ng, Fu Liang, Evangelou, Marina, Witkowska, Katarzyna, Tzanis, Evan, Hellwege, Jacklyn N., Giri, Ayush, Edwards, Digna R. Velez, Sun, Yan V., Cho, Kelly, Gaziano, J. Michael, Wilson, Peter W. F., Tsao, Philip S., Kovesdy, Csaba P., Esko, Tonu, Mägi, Reedik, Milani, Lili, Almgren, Peter, Boutin, Thibaud, Debette, Stéphanie, Ding, Jun, Giulianini, Franco, Holliday, Elizabeth G., Jackson, Anne U., Li-Gao, Ruifang, Lin, Wei-Yu, Luan, Jian'an, Mangino, Massimo, Oldmeadow, Christopher, Prins, Bram Peter, Qian, Yong, Sargurupremraj, Muralidharan, Shah, Nabi, Surendran, Praveen, Thériault, Sébastien, Verweij, Niek, Willems, Sara M., Zhao, Jing-Hua, Amouyel, Philippe, Connell, John, de Mutsert, Renée, Doney, Alex S. F., Farrall, Martin, Menni, Cristina, Morris, Andrew D., Raymond Noordam, Paré, Guillaume, Poulter, Neil R., Shields, Denis C., Stanton, Alice, Thom, Simon, Abecasis, Gonçalo, Najaf Amin, Arking, Dan E., Ayers, Kristin L., Barbieri, Caterina M., Batini, Chiara, Bis, Joshua C. M., Blake, Tineka, Bochud, Murielle, Boehnke, Michael, Boerwinkle, Eric, Boomsma, Dorret I., Bottinger, Erwin P., Braund, Peter S., Brumat, Marco, Campbell, Archie, Campbell, Harry, Chakravarti, Aravinda, Chambers, John Campbell, Chauhan, Ganesh, Ciullo, Marina, Cocca, Massimiliano, Collins, Francis, Cordell, Heather J., Davies, Gail, de Borst, Martin H., de Geus, Eco J., Deary, Ian J., Deelen, Joris, Del Greco M., Fabiola, Demirkale, Cumhur Yusuf, Dörr, Marcus, Ehret, Georg B., Elosua, Roberto, Enroth, Stefan, Erzurumluoglu, A. Mesut, Ferreira, Teresa, Frånberg, Mattias, Franco, Oscar H., Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Goel, Anuj, Gow, Alan J., Gudnason, Vilmundur, Guo, Xiuqing, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Harris, Sarah E., Hartman, Catharina A., Havulinna, Aki S., Hicks, Andrew A., Hofer, Edith, Hofman, Albert, Hottenga, Jouke-Jan, Huffman, Jennifer E., Hwang, Shih-Jen, Ingelsson, Erik, James, Alan, Jansen, Rick, Jarvelin, Marjo-Riitta, Joehanes, Roby, Johansson, Åsa, Johnson, Andrew D., Joshi, Peter K., Jousilahti, Pekka, Jukema, J. Wouter, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Keavney, Bernard D., Khaw, Kay-Tee, Knekt, Paul, Knight, Joanne, Kolcic, Ivana, Kooner, Jaspal S., Koskinen, Seppo, Kristiansson, Kati, Kutalik, Zoltan, Laan, Maris, Larson, Marty, Launer, Lenore J., Lehne, Benjamin, Lehtimäki, Terho, Liewald, David C. M., Lin, Li, Lind, Lars, Lindgren, Cecilia M., Liu, YongMei, Loos, Ruth J. F., Lopez, Lorna M., Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamasoula, Chrysovalanto, Marrugat, Jaume, Marten, Jonathan, Milaneschi, Yuri, Morgan, Anna, Morris, Andrew P., Morrison, Alanna C., Munson, Peter J., Nalls, Mike A., Nandakumar, Priyanka, Nelson, Christopher P., Niiranen, Teemu, Nolte, Ilja M., Nutile, Teresa, Oldehinkel, Albertine J., Oostra, Ben A., O'Reilly, Paul F., Org, Elin, Padmanabhan, Sandosh, Palmas, Walter, Palotie, Aarno, Pattie, Alison, Penninx, Brenda W. J. H., Perola, Markus, Peters, Annette, Polasek, Ozren, Pramstaller, Peter P., Nguyen, Quang Tri, Raitakari, Olli T., Ren, Meixia, Rettig, Rainer, Rice, Kenneth, Ridker, Paul M., Ried, Janina S., Riese, Harriëtte, Ripatti, Samuli, Robino, Antonietta, Rose, Lynda M., Rotter, Jerome I., Rudan, Igor, Ruggiero, Daniela, Saba, Yasaman, Sala, Cinzia F., Salomaa, Veikko, Samani, Nilesh J., Sarin, Antti-Pekka, Schmidt, Reinhold, Schmidt, Helena, Shrine, Nick, Siscovick, David, Smith, Albert V., Snieder, Harold, Sõber, Siim, Sorice, Rossella, Starr, John M., Stott, David J., Strachan, David P., Strawbridge, Rona J., Sundström, Johan, Swertz, Morris A., Taylor, Kent D., Teumer, Alexander, Tobin, Martin D., Tomaszewski, Maciej, Toniolo, Daniela, Traglia, Michela, Trompet, Stella, Tuomilehto, Jaakko, Tzourio, Christophe, Uitterlinden, André G., Vaez, Ahmad, van der Most, Peter J., van Duijn, Cornelia M., Vergnaud, Anne-Claire, Verwoert, Germaine C., Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Vuckovic, Dragana, Watkins, Hugh, Wild, Sarah H., Willemsen, Gonneke, Wilson, James F., Wright, Alan F., Yao, Jie, Zemunik, Tatijana, Zhang, Weihua, Attia, John R., Butterworth, Adam S., Chasman, Daniel I., Conen, David, Cucca, Francesco, Danesh, John, Hayward, Caroline, Howson, Joanna M. M., Laakso, Markku, Lakatta, Edward G., Langenberg, Claudia, Melander, Olle, Mook-Kanamori, Dennis O., Palmer, Colin N. A., Risch, Lorenz, Scott, Robert A., Scott, Rodney J., Sever, Peter, Spector, Tim D., van der Harst, Pim, Wareham, Nicholas J., Zeggini, Eleftheria, Levy, Daniel, Munroe, Patricia B., Newton-Cheh, Christopher, Brown, Morris J., Metspalu, Andres, Hung, Adriana M., O'Donnell, Christopher J., Edwards, Todd L., Psaty, Bruce M., Tzoulaki, Ioanna, Barnes, Michael R., Wain, Louise V., Elliott, Paul, Caulfield, Mark J.

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Global response of Vibrio cholerae to predation by heterotrophic protists by Hu, Jie

“…Indeed, a pigmented mutant, disrupted in VC1345 (hmgA), survived 100-fold better intracellularly in amoebae than did the wild type. The biomass of V. cholerae biofilms increased when the cell-free supernatant from a T. pyriformis culture was added, indicating that there may be chemical cues involved. …”
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Understanding droplet jetting on varying substrate for biological applications by Lee, Jia Min, Huang, Xi, Goh, Guo Liang, Tran, Tuan, Yeong, Wai Yee

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