Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1 by Li, Yan, Pillay, Shubhadra, Frolova, Ludmila, Pervushin, Konstantin, Wong, Leo E.

“…By solving the solution structures of the wild-type N-domain of human eRF1 exhibited omnipotent specificity, i.e. recognition of all three stop codons, and its unipotent mutant with UGA-only specificity, we found the conserved GTS loop adopting alternate conformations. …”
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Rewilding in Southeast Asia: Singapore as a case study by Lamperty, Therese, Chiok, Wen Xuan, Khoo, Max D. Y., Amir, Zachary, Baker, Nick, Chua, Marcus A. H., Chung, Yi Fei, Chua, Yen Kheng, Koh, Joshua J.-M, Lee, Benjamin P. Y.-H., Lum, Shawn K. Y., Mendes, Calebe P., Ngiam, Jonathan, O Dempsey A., Png, Kenny G. C., Sovie, Adia R., Tan, Lorraine, Teo, Robert, Thomas, Noel, Li, Tianjiao, Lim, Bryan Tze-Ming, Loo, Adrian H. B., Wardle, David A., Luskin, Matthew Scott

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Development of metal complexes for specific targeting G-quadruplexes and the application studies by He, Lei

“…Metal complexes with extensive aromatic ligands could bind GQ with high specificity and possess unique features in biomedicine, biotechnology and nanotechnology. …”
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Exploring the kinetics of the interactions controlling the gating of the Ca2+-release activated Ca2+ channel by Zhang, Ai

“…Calcium- release activated calcium channels (ORAI) are essential for sustained cytosol [Ca2+] elevation which is required for T cell activation and adaptive immunity. Upon ER luminal Ca2+ depletion, ER Ca2+ sensor STIM1 aggregates and translocates to the ER-PM junction, where it binds and activates ORAI1 channel. …”
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Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila by Fitz-James, MH, Sabarís, G, Sarkies, P, Bantignies, F, Cavalli, G

Mixed lead-tin perovskite films with >7 μs charge carrier lifetimes realized by maltol post-treatment by Hu, S, Truong, MA, Otsuka, K, Handa, T, Yamada, T, Nishikubo, R, Iwasaki, Y, Saeki, A, Murdey, R, Kanemitsu, Y, Wakamiya, A

“…Mixed lead–tin (Pb–Sn) halide perovskites with optimum band gaps near 1.3 eV are promising candidates for next-generation solar cells. However, the performance of solar cells fabricated with Pb–Sn perovskites is restricted by the facile oxidation of Sn(II) to Sn(IV), which induces self-doping. …”

Establishment of optimise strategies in production of recombinant Hepatitis B surface antigen for chip-based antibody detection approach by Tam, Yew Joon

“…From the results, an optimised cell disruption strategy with up-scale adaptability consisted of a number of passes set at 20 times, biomass concentration of 7.70 g/L of dry cell weight (DCW) and pulse pressure at 1,029 bar was demonstrated and was shown to increase cell disruption efficiency by 2- fold and 4-fold for specific protein release of HBsAg when compared to glass bead method yielding 75.68% cell disruption rate (CDR) and HBsAg concentration of 29.20 mg/L, respectively. …”
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Vypal2: a versatile peptide ligase for precision tailoring of proteins by Zhang, Dingpeng, Wang, Zhen, Hu, Side, Lescar, Julien, Tam, James P., Liu, Chuan-Fa

“…The labelled or cyclized protein ligands remained functionally active in binding to their target receptors. We also demonstrated on-cell labelling of protein ligands pre-bound to cellular receptors and cell-surface engineering via modifying a covalently anchored peptide substrate pre-installed on cell-surface glycans. …”
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Co-translational integration of the light harvesting complex II and its associated pigments into polymeric membranes by Zapf, Thomas

“…Surface Plasmon Resonance after cell-free synthesis on tethered polymer membranes indicates that LHCII is able to integrate functionally into planar bilayers. …”
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PRMT5 controls the innate immune response by Zhang, C

“…It is known that PRMT5-mediated methylation of E2 promoter binding factor 1 (E2F1) not only supports cancer cell growth but also influences RNA splicing. …”

Role of BAR domain proteins in myogenesis by Bhawana, George

“…The cellular steps involved in myotube formation are cell-extracellular matrix (ECM) adhesion, change of cell shape from fibroblast-like to elongated morphology, migration towards other fusing partners, cell-cell adhesion followed by membrane breakdown. …”
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Structural characterization of vaccinia-related kinase 1 (VRK1), a histone mitotic kinase by Ngow, Yeen Shian

“…The human vaccinia-related kinase 1 (VRK1), is a mitotic kinase, involved in cell division regulation and carcinogenesis. VRK1 phosphorylates the histone H3 at Thr3 and Ser10, which is a critical event for initiating chromosome condensation during mitosis. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…This simple and specific strategy was based on the conjugation of protophophyrin IX (PpIX), a photosensitizer (PS), with lipopolysaccharide (LPS) binding peptides through a divalent manner. The fluorescent imaging and photodynamic antimicrobial chemotherapy (PACT) studies indicated that the divalent PpIX-peptide conjugate could really serve as a fluorescence probe to image the bacterial cells. …”
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Crosstalk of immune signaling in regulating host effector-triggered immunity by Loh, Yu Thong

“…The first layer of immune response is PAMP-triggered immunity which is initiated by cell surface-localized pattern recognition receptors. …”
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ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition by Ly, Phuong Thao, Xu, Shaohai, Wirawan, Melissa, Luo, Dahai, Roca, Xavier

“…Human ZAP inhibits many viruses, including HIV and coronaviruses, by binding to viral RNAs to promote their degradation and/or translation suppression. …”
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Halide perovskite-based indoor photovoltaics: recent development and challenges by Bening Tirta Muhammad, Kar, Shaoni, Stephen, Meera, Leong, Wei Lin

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Negative auto-regulation of myostatin expression is mediated by SMAD3 and microRNA-27 by Ge, XiaoJia, McFarlane, Craig, Vajjala, Anuradha, Arigela, Harikumar, Lokireddy, Sudarsanareddy, Bonala, Sabeera, Manickam, Ravikumar, Kambadur, Ravi, Sharma, Mridula

“…Therefore, miR-27a/b, through negatively regulating Mstn, plays a role in promoting satellite cell activation, myoblast proliferation and preventing muscle wasting.…”
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The study of radiotherapy resistance of hypoxic tumour for improving survival of cancer patient. by Goh, Yeek Teck.

“…Functional annotation and classification revealed the up-regulation of two significant groups of proteins involved in calcium-binding/signalling and actin regulation. These proteins are likely to promote cell survival pathways such as DNA repairs in hypoxic cells upon radiation exposure. …”
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Cellular studies on the role of OGFOD1, a 2-oxoglutarate-dependent dioxygenase by Attwood, M

“…The transcriptional regulator, Thanatos associated protein 11 (THAP11) was identified as a novel high stoichiometry OGFOD1-interacting protein across a range of cell lines. Analysis of the THAP11 transcriptional programme in SW620 cells defined a repressive action of OGFOD1 overexpression on THAP11 DNA binding and target gene expression. …”

Interaction-mediating sequences within class I viral fusion glycoproteins : their roles in viral infection and in applications by Zhang, Simin

“…Class I viral fusion glycoproteins facilitate fusion of the viral envelope with cell membranes and entry of the virus into the cell, through extensive short sequence-specific interactions. …”
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