In vitro and in silico studies of Lawsone on inflammation-induced skin cells for development of skin anti-inflammatory treatment by Abdullah, Shazleen Sofea, Mohammad Latif, Muhammad Alif, Md Tohid, Siti Farah

“…In silico works predicted lawsone’s ability to bind to TNF-α with good binding affinity without disruption to the protein’s structure stability.Lawsone is proven to be safe towards non-pathological cells. …”
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A faster chemical bath deposition method for SnO2 ETLs in perovskite solar cells by Wong, Zi Sheng

“…However, more studies are still required to find out the chemical reaction mechanisms and growth mechanisms to further improve yield.…”
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Cytotoxic effect of Bajong LN rice methanol extract on human squamous cell Carcinoma, ORL-48 by Vivi Noryati Ahmad, Nur Aliana Hidayah Mohamed, Zulkhairi Amom, Khor, Goot Heah, Nurhayati Mohamad Zain, Indah Mohd Amin

“…Morphological analysis and the Trypan blue exclusion assay corroborated the MTS assay's findings. Our preliminary findings provide the first scientific evidence of the cytotoxic effect of BLN-ME specifically against human squamous cell carcinoma, ORL-48 cells. …”
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High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin by Fu, Afu, Ma, Shijun, Wei, Na, Tan, Blanche Xiao Xuan, Tan, Ern Yu, Luo, Kathy Qian

“…Specific siRNA-mediated MnSOD knockdown reversed all three phenotypes. Our findings therefore suggest that MnSOD plays an important integrative role in supporting cancer cell survival in circulation, metastasis, and doxorubicin resistance. …”
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Phytochemical analysis and cytotoxic effects of mango (Mangifera indica L) kernel on breast cancer cell lines by Abdullah, Al-Shwyeh Hussah

“…It is suggested that the anticancer effect of the M.indica extract is via modulation of redox status through its antioxidant constituents and induction of apoptosis. These findings suggest that M. indica kernel extract, with antiproliferative properties towards cancer cells, while relatively innocuous to normal cells, is a good candidate as an alternative to or for supplementation for current chemotherapies in the treatment of breast cancers, without showing the side-effects associated with these anticancer drugs.…”
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Computational modeling of light processing in the habenula and dorsal raphe based on laser ablation of functionally-defined cells by Cheng, Ruey-Kuang, Jagannathan, N. Suhas, Kathrada, Ahmad Ismat, Jesuthasan, Suresh, Tucker-Kellogg, Lisa

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Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib by Miettinen, Teemu P., Peltier, Julien, Härtlova, Anetta, Gierliński, Marek, Jansen, Valerie M., Trost, Matthias, Björklund, Mikael

“…In order to identify a molecular mechanism responsible for palbociclib‐induced senescence, we performed thermal proteome profiling of MCF7 breast cancer cells. In addition to affecting known CDK4/6 targets, palbociclib induces a thermal stabilization of the 20S proteasome, despite not directly binding to it. …”
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Contribution of zeolitic imidazolate framework-8 in improving the performance of polymer electrolyte membrane for direct methanol fuel cell by Junoh, Hazlina, Awang, Nuha, Ahmad, Siti Nur Afifi, Azhar, Masaud, Jaafar, Juhana, Md. Nordin, Nik Abdul Hadi, Ismail, Ahmad Fauzi, Qtaishat, Mohammed Rasool, Matsuura, Takeshi, Othman, Mohd. Hafiz Dzarfan, Abdul Rahman, Mukhlis, Mohd. Zainoodin, Azran

Ligand-specific factors influencing GLP-1 receptor post-endocytic trafficking and degradation in pancreatic beta cells by Fang, Zijian, Chen, Shiqian, Manchanda, Yusman, Bitsi, Stavroula, Pickford, Philip, David, Alessia, Shchepinova, Maria M., Corrêa, Ivan R., Jr., Hodson, David J., Broichhagen, Johannes, Tate, Edward W., Reimann, Frank, Salem, Victoria, Rutter, Guy A., Tan, Tricia, Bloom, Stephen R., Tomas, Alejandra, Jones, Ben

“…Experiments were performed in primary islet cells, INS-1 832/3 clonal beta cells and HEK293 cells, using biorthogonal labelling of GLP-1R to determine its localisation and degradation after treatment with GLP-1, exendin-4 and several further GLP-1R agonist peptides. …”
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Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity by Yao, S, Harder, A, Darki, F, Chang, Y, Li, A, Nikouei, K, Volpe, G, Lundström, JN, Zeng, J, Wray, NR, Lu, Y, Sullivan, PF, Hjerling-Leffler, J

“…Using functional MRI connectivity, we further confirmed the significance of the central and lateral amygdala, hippocampal body, and prefrontal cortex in distinguishing schizophrenia cases from controls. Our findings underscore the value of single-cell transcriptomics in understanding the polygenicity of psychiatric disorders and suggest a promising alignment of genomic, transcriptomic, and brain imaging modalities for identifying common biological targets.…”

Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells by Carré, A, Samassa, F, Zhou, Z, Perez-Hernandez, J, Lekka, C, Manganaro, A, Oshima, M, Liao, H, Parker, R, Nicastri, A, Brandao, B, Colli, ML, Eizirik, DL, Aluri, J, Patel, D, Göransson, M, Burgos Morales, O, Anderson, A, Landry, L, Kobaisi, F, Scharfmann, R, Marselli, L, Marchetti, P, You, S, Ternette, N

“…Interferon (IFN)-α is the earliest cytokine signature observed in individuals at risk for type 1 diabetes (T1D), but the effect of IFN-α on the antigen repertoire of HLA Class I (HLA-I) in pancreatic β-cells is unknown. Here we characterize the HLA-I antigen presentation in resting and IFN-α-exposed β-cells and find that IFN-α increases HLA-I expression and expands peptide repertoire to those derived from alternative mRNA splicing, protein cis-splicing and post-translational modifications. …”

Functionalized sp2 carbon-conjugated covalent organic frameworks for interfacial modulation of inverted perovskite solar cells by Abuzeid, Hesham R., Tay, Darrell Jun Jie, Febriansyah, Benny, Kanwat, Anil, Salim, Teddy, Zhumekenov, Ayan A., Pullarkat, Sumod A., Mathews, Nripan

“…Interfacial modulation utilizing functional materials is proven to be crucial for obtaining high photovoltaic performance in lead halide perovskite solar cells (PSCs). This study investigates, for the first time, the utilization of a pyrene-based sp2 carbon-conjugated covalent organic framework (sp2c-COF) as an interfacial layer in inverted PSCs. …”
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REST targets JAK–STAT and HIF-1 signaling pathways in human Down syndrome brain and neural cells by Huang, Tan, Fakurazi, Sharida, Cheah, Pike-See, Ling, King-Hwa

“…We found that REST-targeted DEGs in DS were enriched for the JAK–STAT and HIF-1 signaling pathways across multiple distinct brain regions, ages, and neural cell types. We also identified REST-targeted DEGs involved in nervous system development, cell differentiation, fatty acid metabolism and inflammation in the DS brain. …”
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Single cell hydrodynamic stretching and microsieve filtration reveal genetic, phenotypic and treatment-related links to cellular deformability by Li, Fenfang, Cima, Igor, Vo, Jess Honganh, Tan, Min-Han, Ohl, Claus-Dieter

“…We also find that the drug docetaxel leads to an increase in the size of A549 lung cancer cells. …”
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Insight into proton transfer in phosphotungstic acid functionalized mesoporous silica-based proton exchange membrane fuel cells by Zhou, Yuhua, Yang, Jing, Su, Haibin, Zeng, Jie, Jiang, San Ping, Goddard, William A

“…We have developed for fuel cells a novel proton exchange membrane (PEM) using inorganic phosphotungstic acid (HPW) as proton carrier and mesoporous silica as matrix (HPW-meso-silica) . …”
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Enhancing indoor photovoltaic performance of inverted type organic solar cell by controlling photoactive layer solution concentration by Mohamed Nafeer Wajidh, Nour Attallah Issa, Kam, Sheng Lau, Sin, Tee Tan, Chin, Hua Chia, Muslizainun Mustapha, Mohammad Hafizuddin Hj Jumali, Chi, Chin Yap

“…With the development of various low-power indoor electronic devices, indoor photovoltaics, particularly organic solar cells (OSCs) have attracted a lot of interest in recent years. …”
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Direct reuse of electronic plastic scraps from computer monitor and keyboard to direct stem cell growth and differentiation by Shi, Pujiang, Tan, Chiew Kei, Wu, Zhuoran, Gabriel, Jean-Christophe P., Srinivasan, Madhavi, Lee, Jong-Min, Tay, Chor Yong

“…Our findings point to the real possibility of utilizing discarded computer plastics as a "waste-to-resource" material to programme stem cell fate without further processing nor biochemical modification, thus providing an innovative second-life option for E-plastics from personal computers.…”
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Characterising the T cell responses to SARS-CoV-2 including variants of concern induced by natural infection and vaccines by Adele, S

“…</p> <p>Together, these findings underscore the importance of T cell immunity in sustaining protection against SARS-CoV-2 variants. …”

Spatiotemporal coordination of FGF and Shh signaling underlies the specification of myoblasts in the zebrafish embryo by Yin, Jianmin, Lee, Raymond, Ono, Yosuke, Ingham, Philip William, Saunders, Timothy E.

“…Somitic cells give rise to a variety of cell types in response to Hh, BMP, and FGF signaling. …”
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TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR4 Interacts with WRINKLED1 to mediate seed oil biosynthesis by Kong, Que, Singh, Sanjay K., Mantyla, Jenny J., Pattanaik, Sitakanta, Guo, Liang, Yuan, Ling, Benning, Christoph, Ma, Wei

“…We screened a TF library using Arabidopsis (Arabidopsis thaliana) WRI1 (AtWRI1) as bait in yeast two-hybrid assays and identified three TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR (TCP) family TFs, namely TCP4, TCP10, and TCP24, as AtWRI1-interacting partners. …”
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