HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease by Yogeshwar, SM, Muñiz-Castrillo, S, Sabater, L, Peris-Sempere, V, Mallajosyula, V, Luo, G, Yan, H, Yu, E, Zhang, J, Lin, L, Fagundes Bueno, F, Ji, X, Picard, G, Rogemond, V, Pinto, AL, Heidbreder, A, Höftberger, R, Graus, F, Dalmau, J, Santamaria, J, Iranzo, A, Schreiner, B, Giannoccaro, MP, Liguori, R, Shimohata, T, Kimura, A, Ono, Y, Binks, S, Mariotto, S, Dinoto, A, Bonello, M, Hartmann, CJ, Tambasco, N, Nigro, P, Prüss, H, McKeon, A, Davis, MM, Irani, SR, Honnorat, J, Gaig, C, Finke, C, Mignot, E

“…Further, a deamidated peptide from the Ig2-domain of IgLON5 activated T cells in two patients, compared with one control carrying <em>HLA-DQA1*01:05∼DQB1*05:01</em>.…”

Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening by Leung, Ka-Ho, Liu, Li-Juan, Lin, Sheng, Lu, Lihua, Zhong, Hai-Jing, Susanti, Dewi, Rao, Weidong, Wang, Modi, Che, Weng Ian, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Chan, Philip Wai Hong, Ma, Dik-Lung

“…STAT3 modulates the transcription of a wide variety of regulatory genes involved in cell proliferation, differentiation, migration, apoptosis, and other critical cellular functions. …”
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Legal translation and ISO standards : a case study by See, Tingting

“…There was no standardized quality assessment for legal translations till April 2020, when the International Organization for Standardization (ISO) published ISO 20771:2020. …”
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Spatial proteomics of immune microenvironment in nonalcoholic steatohepatitis-associated hepatocellular carcinoma by Li, Meiyi, Wang, Lina, Cong, Liang, Wong, Chi Chun, Zhang, Xiang, Chen, Huarong, Zeng, Tao, Li, Bin, Jia, Xian, Huo, Jihui, Huang, Yuhua, Ren, Xiaoxue, Peng, Sui, Fu, Guo, Xu, Lixia, Sung, Joseph Jao Yiu, Kuang, Ming, Li, Xiaoxing, Yu, Jun

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Construction and characterization of a Lactococcus lactis in-trans surface display system harboring murine glycosylated tyrosinase related protein-2 by Kalyanasundram, Jeevanathan

“…Subsequent mTRP-2-cA anchoring to the cell wall of L. lactis showed excitation of FITC conjugate on secondary antibody which signified successful binding of glycosylated TRP-2 on the surface of L. lactis.…”
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Herding in equity crowdfunding by Åstebro, T, Fernández, M, Lovo, S, Vulkan, N

“…We build a model of equity crowdfunding that incorporates the two major funding models: all-or-nothing (AoN) and keep-it-all (KIA). …”

The development of crosslinked keratin-alginate sponges as novel biomaterials by Hartrianti, Pietradewi

“…As one of the prospective alternative biomaterials that has recently been explored, keratin offered several advantages over other natural protein-based biomaterials such as its natural abundance, biocompatibility, presence of cell binding motifs that could improve cellular attachment and possibility to obtain autologous material that could minimize immunoresponse. …”
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A study of human monoclonal antibodies to influenza and ebola viruses by Rijal, P

“…We isolated monoclonal antibodies (mAbs) from individuals using single B cell cloning and PCR technology, and defined their epitopes, binding characteristics and neutralisation properties. …”

Molecular interaction of tumor suppressor protein p53 and anti-apoptotic proteins Bcl-2 and Bcl-XL. by Yoon, Ho Sup.

“…Second, to define the binding interface of the molecular interaction, which is not previously characterized, we employed a NMR-based binding study, showing that the binding site on Bel-XL is located in the region including a4, the N- and C-termini of a3, the N-terminus of a5, and the central part of a2. …”
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Chromatin structuring factor HMGA2 controls subtelomere stability and cancer chemosensitivity by Syed Moiz Ahmed

“…The oncofetal architectural factor HMGA2, by utilizing its three DNA binding domains has been shown to bind stalled replication forks and prevent their collapse into genotoxic DNA strand breaks in fast replicating cancer cells, hESCs as well as in other heterologous yeast and bacterial cell systems. …”
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Development of new methods in membrane protein science : tools in aquaporin-based research by To, Janet Yiu Ying

“…Aquaporins are a family of small, integral membrane proteins which facilitate water transport across the plasma membrane of cells in response to osmotic gradients. Since the discovery of these water channels more than 20 years ago, there has been an encouraging advancement in the understanding of their structural and functional roles in human physiology, in particular in water balance disorders, and in cell migration and angiogenesis. …”
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Understanding droplet jetting on varying substrate for biological applications by Lee, Jia Min, Huang, Xi, Goh, Guo Liang, Tran, Tuan, Yeong, Wai Yee

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Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds by Wamhoff, Eike-Christian, Ronsard, Larance, Feldman, Jared, Knappe, Grant A., Hauser, Blake M., Romanov, Anna, Case, James Brett, Sanapala, Shilpa, Lam, Evan C., Denis, Kerri J. St., Boucau, Julie, Barczak, Amy K., Balazs, Alejandro B., Diamond, Michael S., Schmidt, Aaron G., Lingwood, Daniel, Bathe, Mark

“…However, P-VLPs are thymus-dependent antigens that are themselves immunogenic and can induce B cell responses that may neutralize the platform. …”
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Enantiomeric separation of racemic mixtures using chiral-selective and organic-solvent-resistant thin-film composite membranes by Ong, Chi Siang, Oor, Jia Zheng, Tan, Jonathan Shiliang, Chew, Jia Wei

“…However, engineering membranes for chiral molecular separation in harsh organic solvent environments is still a big challenge. In this study, we fabricated a novel thin-film composite nanofiltration membrane composed of (2-hydroxypropyl)-beta-cyclodextrin (HP-β-CD) as the chiral selector for the enantiomeric separation of racemic 1-phenylethanol chiral compounds in organic solvents. …”
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Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1 by Li, Yan, Pillay, Shubhadra, Frolova, Ludmila, Pervushin, Konstantin, Wong, Leo E.

“…By solving the solution structures of the wild-type N-domain of human eRF1 exhibited omnipotent specificity, i.e. recognition of all three stop codons, and its unipotent mutant with UGA-only specificity, we found the conserved GTS loop adopting alternate conformations. …”
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Rewilding in Southeast Asia: Singapore as a case study by Lamperty, Therese, Chiok, Wen Xuan, Khoo, Max D. Y., Amir, Zachary, Baker, Nick, Chua, Marcus A. H., Chung, Yi Fei, Chua, Yen Kheng, Koh, Joshua J.-M, Lee, Benjamin P. Y.-H., Lum, Shawn K. Y., Mendes, Calebe P., Ngiam, Jonathan, O Dempsey A., Png, Kenny G. C., Sovie, Adia R., Tan, Lorraine, Teo, Robert, Thomas, Noel, Li, Tianjiao, Lim, Bryan Tze-Ming, Loo, Adrian H. B., Wardle, David A., Luskin, Matthew Scott

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Development of metal complexes for specific targeting G-quadruplexes and the application studies by He, Lei

“…Metal complexes with extensive aromatic ligands could bind GQ with high specificity and possess unique features in biomedicine, biotechnology and nanotechnology. …”
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Exploring the kinetics of the interactions controlling the gating of the Ca2+-release activated Ca2+ channel by Zhang, Ai

“…Calcium- release activated calcium channels (ORAI) are essential for sustained cytosol [Ca2+] elevation which is required for T cell activation and adaptive immunity. Upon ER luminal Ca2+ depletion, ER Ca2+ sensor STIM1 aggregates and translocates to the ER-PM junction, where it binds and activates ORAI1 channel. …”
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Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila by Fitz-James, MH, Sabarís, G, Sarkies, P, Bantignies, F, Cavalli, G

Mixed lead-tin perovskite films with >7 μs charge carrier lifetimes realized by maltol post-treatment by Hu, S, Truong, MA, Otsuka, K, Handa, T, Yamada, T, Nishikubo, R, Iwasaki, Y, Saeki, A, Murdey, R, Kanemitsu, Y, Wakamiya, A

“…Mixed lead–tin (Pb–Sn) halide perovskites with optimum band gaps near 1.3 eV are promising candidates for next-generation solar cells. However, the performance of solar cells fabricated with Pb–Sn perovskites is restricted by the facile oxidation of Sn(II) to Sn(IV), which induces self-doping. …”