Assessing the permeability of supersaturating drug delivery system of amorphous drug-polyelectrolyte/protein nanoplexes in Caco-2 cell monolayer by Tran, The-Thien, Cheow, Wean Sin, Chua, Angeline, Yang, Guang, Poenar, Daniel Puiu, Hadinoto, Kunn

Get full text

Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

Get full text

Waffle-inspired hydrogel-based macrodevice for spatially controlled distribution of encapsulated therapeutic microtissues and pro-angiogenic endothelial cells by Pham, Chi H. L., Zuo, Yicong, Chen, Yang, Tran, Nam M., Nguyen, Dang T., Dang, Tram T.

Get full text

DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11 by Loh Jia Tong, Teo, Joey Kay Hui, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Andiappan, Anand Kumar, Lim, Hong-Hwa, Lam, Kong-Peng

Get full text

Nontoxic, biodegradable hyperbranched poly(β-amino ester)s for efficient siRNA delivery and gene silencing by Ooi, Ying Jie, Huang, Chongquan, Lau, Kieran, Chew, Sing Yian, Park, Jong Gu, Chan-Park, Mary B.

Get full text

Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults by Ho, Vanda W. T., Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki Y. J., Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa F. P., Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K., Ong, Catherine W. M., Macary, Paul A.

Get full text

Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells by Kirkham, Frances, Pera, Alejandra, Simanek, Amanda M., Bano, Aalia, Morrow, George, Reus, Bernhard, Caserta, Stefano, Smith, Helen Elizabeth, Davies, Kevin A., Rajkumar, Chakravarthi, Kern, Florian

Get full text

Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8⁺ T cells by Kang, Xing, Liu, Changan, Ding, Yanqiang, Ni, Yunbi, Ji, Fenfen, Lau, Harry Cheuk Hay, Jiang, Lanping, Sung, Joseph Jao Yiu, Wong, Sunny Hei, Yu, Jun

Get full text

Dual role of Cu-chalcogenide as hole-transporting layer and interface passivator for p–i–n architecture perovskite solar cell by Sadhu, Anupam, Rai, Monika, Salim, Teddy, Jin, Xin, Tan, Joel Ming Rui, Leow, Shin Woei, Ahmed, Mahmoud Gamal, Magdassi, Shlomo, Mhaisalkar, Subodh Gautam, Wong, Lydia Helena

Get full text

Development of ISB 1442, a CD38 and CD47 bispecific biparatopic antibody innate cell modulator for the treatment of multiple myeloma by Grandclément, C, Estoppey, C, Dheilly, E, Panagopoulou, M, Monney, T, Dreyfus, C, Loyau, J, Labanca, V, Drake, A, De Angelis, S, Rubod, A, Frei, J, Caro, LN, Blein, S, Martini, E, Chimen, M, Matthes, T, Kaya, Z, Edwards, CM, Edwards, JR, Menoret, E, Kervoelen, C, Pellat-Deceunynck, C, Moreau, P, Mbow, ML, Srivastava, A, Dyson, MR, Zhukovsky, EA, Perro, M, Sammicheli, S

“…ISB 1442 consists of two anti-CD38 arms targeting two distinct epitopes that preferentially drive binding to tumor cells and enable avidity-induced blocking of proximal CD47 receptors on the same cell while preventing on-target off-tumor binding on healthy cells. …”

Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer by Akıncılar, Semih Can, Chua, Joelle Yi Heng, Ng, Qin Feng, Chan, Claire Hian Tzer, Eslami-S, Zahra, Chen, Kaijing, Low, Joo-Leng, Arumugam, Surendar, Aswad, Luay, Chua, Clarinda, Tan, Iain Beehuat, DasGupta, Ramanuj, Fullwood, Melissa Jane, Tergaonkar, Vinay

Get full text

Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood by Rabcuka, J, Smethurst, P, Dammert, K, Saker, J, Aran, G, Walsh, G, Tan, J, Codinach, M, McTaggart, K, Marks, D, Bakker, S, McMahon, A, Di Angelantonio, E, Roberts, D, Blonski, S, Korczyk, P, Shirakami, A, Cardigan, R, Swietach, P

“…<p><strong>Background: </p></strong>Metrics evaluating the functional quality of red blood cells (RBCs) must consider their role in oxygen delivery. …”

In situ growth of [hk1]-oriented Sb2S3 for solution-processed planar heterojunction solar cell with 6.4% efficiency by Jin, Xin, Fang, Yanan, Salim, Teddy, Feng, Minjun, Hadke, Shreyash, Leow, Shin Woei, Sum, Tze Chien, Wong, Lydia Helena

Get full text

Leucine-rich α-2-glycoprotein 1 suppresses endothelial cell activation through ADAM10-mediated shedding of TNF-α receptor by Pang, Kuin Tian, Ghim, Mean, Liu, Chenghao, Tay, Hui Min, Fhu, Chee Wai, Chia, Rui Ning, Qiu, Beiying, Sarathchandra, Padmini, Chester, Adrian H., Yacoub, Magdi H., Wilkinson, Fiona L., Weston, Ria, Warboys, Christina M., Hou, Han Wei, Weinberg, Peter D., Wang, Xiaomeng

Get full text

On the composition of Sr₂Fe₁.₅Mo₀.₅O₆₋δ – Sm₀.₂Ce₀.₈O₂₋δ composite as fuel electrodes for hydrogen reversible solid oxide cells by Li, Hao-Yang, Kamlungsua, Kittiwat, Ng, Kelvin, Shin, Ji-Yoon, Su, Pei-Chen

Get full text

Improved mobility and photovoltaic performance of two-dimensional Ruddlesden−Popper (ThMA)₂(MA)₂M₃I₁₀ perovskites applied in perovskite solar cells by Sun, Ping-Ping, Kripalani, Devesh Raju, Chi, Weijie

Get full text

Assessing nanotoxicity of food-relevant particles: a comparative analysis of cellular responses in cell monolayers versus 3D gut epithelial cultures by Gautam, Archana, Lim, Hui Kheng, Li, Jasmine Jia’En, Hughes, Christopher Owen, Yeo, Calvin Wee Sing, Rakshit, Moumita, Leavesley, David Ian, Lim, Michelle Jing Sin, Tan, Joseph Choon Wee, Tan, Li Yi, Chan, Joanne Sheot Harn, Smith, Benjamin Paul Chapman, Ng, Kee Woei

Get full text

DNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells by Ye, Y, Xie, W, Wang, X, Tan, S, Yang, L, Ma, Z, Zhu, Z, Chen, X, Liu, X, O’Neill, E, Chang, L, Zhang, W

“…DNA damage and repair mechanisms have been largely elucidated in mutated cancer cells or simple eukaryotes, making valid interpretations on early development difficult. …”

Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone... by Raimondo, Domenico, Remoli, Cristina, Astrologo, Letizia, Burla, Romina, La Torre, Mattia, Vernì, Fiammetta, Tagliafico, Enrico, Corsi, Alessandro, Del Giudice, Simona, Persichetti, Agnese, Giannicola, Giuseppe, Robey, Pamela G., Riminucci, Mara, Saggio, Isabella

“…In order to dissect the molecular pathways rooted in skeletal stem/progenitor cells by FD mutations, we engineered human skeletal stem/progenitor cells with the GsαR201C mutation and performed transcriptomic analysis. …”
Get full text

Design, synthesis, structural characterization, cytotoxicity and computational studies of Usnic acid derivative as potential anti-breast cancer agent against MCF7 and T47D cell lin... by Roney, Miah, Wong, Kelvin Khai Voon, Uddin, Md. Nazim, Rullah, Kamal, Septama, Abdi Wira, Antika, Lucia Dwi, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…The anticancer potential of UA1 was assessed using the MTT assay on two different cell lines of BC including MCF7 and T47D. To ascertain the binding affinity and stability of the docking complex, further procedures included the in silico molecular docking, molecular dynamic simulation, principal component analysis, and binding free energy experiments. …”
Get full text