Reconciling founder variant multiplicity of HIV-1 infection with the rate of CD4+ decline by Baxter, J, Villabona-Arenas, J, Thompson, RN, Hue, S, Regoes, R, Kouyos, R, Gunthard, H, Albert, J, Brown, AL, Atkins, K

“…Where multiple variants initiate infection, recipient set point viral load (SpVL) and the rate of CD4+ 4 T cell decline may be elevated, but these findings remain inconsistent. …”

The opioid receptor influences circadian rhythms in human keratinocytes through the β-arrestin pathway by Bigliardi, Paul, Junnarkar, Seetanshu, Markale, Chinmay, Lo, Sydney, Bigliardi, Elena, Kalyuzhny, Alex, Ong, Sheena, Dunn, Ray, Wahli, Walter, Bigliardi-Qi, Mei

“…The recent emphasis on circadian rhythmicity in critical skin cell functions related to homeostasis, regeneration and aging has shed light on the importance of the PER2 circadian clock gene as a vital antitumor gene. …”
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Cryogelation of human hair keratins by Chua, Huei Min

“…In a nutshell, the major findings of this dissertation serve to elucidate the mechanism of HHK cryogelation while demonstrating the possibility of developing a cell compliant 3D HHK scaffold with tuneable properties through a facile and clean process.…”
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Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes by Zarei, Mohammad, Barroso, Emma, Palomer, Xavier, Escolà-Gil, Joan Carles, Cedó, Lidia, Wahli, Walter, Vázquez-Carrera, Manuel

“…Finally, treatment with another PPARβ/δ agonist increased VLDLR levels in the liver of wild-type mice, but not PPARβ/δ-deficient mice, confirming the regulation of hepatic VLDLR by this nuclear receptor. …”
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Investigation of wavelength-tunable supercontinuum light sources by Shao, Qikang.

“…Discussions are made upon these findings. Furthermore, based on these findings, a method to control supercontinuum generation is brought forward.…”
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Yeast9: a consensus genome-scale metabolic model for S. cerevisiae curated by the community by Zhang, Chengyu, Sánchez, Benjamín J., Li, Feiran, Cheng, Eiden Wei Quan, Scott, William T., Liebal, Ulf W., Blank, Lars M., Mengers, Hendrik G., Anton, Mihail, Rangel, Albert Tafur, Mendoza, Sebastián N., Zhang, Lixin, Nielsen, Jens, Lu, Hongzhong, Kerkhoven, Eduard J.

“…To evaluate its predictive performance, we generated 163 condition-specific GEMs constrained by single-cell transcriptomics from osmotic pressure or reference conditions. …”
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Compositionally graded alloys fabricated using the laser powder bed fusion technique by Wei, Siyuan

“…Therefore, metal AM is still in its nascent stage, with the exploration of new alloy chemistries and/or fabrication of components with unique functional and/or mechanical properties being relatively unexplored. …”
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Phylogenomic analysis of the plastid genome of the Peruvian purple maize zea mays subsp. mays cv. 'INIA 601' by Montenegro, Juan D., Julca, Irene, Chumbe-Nolasco, Lenin D., Rodríguez-Pérez, Lila M., Panizo, Ricardo Sevilla, Medina-Hoyos, Alicia, Gutiérrez-Reynoso, Dina L., Guerrero-Abad, Juan Carlos, Guerra, Carlos A. Amasifuen, García-Serquén, Aura L.

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Mimicking localized surface plasmons with structural dispersion by Li, Zhuo, Liu, Liangliang, Fernández-Domínguez, Antonio I., Shi, Jianfeng, Gu, Changqing, García-Vidal, Francisco J., Luo, Yu

“…The results reveal that structured-dispersion-induced localized surface plasmons are quite sensitive to the background refractive index but relatively robust to the size and shape of the resonator. These findings open up a new avenue for designer localized surface waves at low frequencies and may find applications in miniaturization of microwave resonators, filters, and terahertz biosensors.…”
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4-V flexible all-solid-state lithium polymer batteries by Chen, Zhen, Kim, Guk-Tae, Wang, Zeli, Bresser, Dominic, Qin, Bingsheng, Geiger, Dorin, Kaiser, Ute, Wang, Xuesen, Shen, Zexiang, Passerini, Stefano

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Phosphorized CoNi₂S₄ yolk-shell spheres for highly efficient hydrogen production via water and urea electrolysis by Lu, Xue Feng, Zhang, Song Lin, Sim, Wei Lok, Gao, Shuyan, Lou, David Xiong Wen

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Intermittent actuation attenuates fibrotic behaviour of myofibroblasts by Ward, Niamh A., Hanley, Shirley, Tarpey, Ruth, Schreiber, Lucien H.J., O'Dwyer, Joanne, Roche, Ellen T., Duffy, Garry P., Dolan, Eimear B.

“…These findings can be harnessed to improve functional outcomes for a wide range of medical implants, particularly drug delivery and cell encapsulation devices.…”
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Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…However, it is conspicuously absent from human cells, thus establishing its biosynthetic pathways as important potential drug targets. …”
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Slit-Robo signalling establishes a sphingosine-1-phosphate gradient to polarise fin mesenchyme by Mahabaleshwar, Harsha, Asharani, P. V., Loo, Tricia Yi, Koh, Shze Yung, Pitman, Melissa R., Kwok, Samuel, Ma, Jiajia, Hu, Bo, Lin, Fang, Li Lok, Xue, Pitson, Stuart M., Saunders, Timothy E., Carney, Tom J.

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Nanostructured bimetallic sulfides as Na ion battery anodes by Chen, Jingwei

“…Nonetheless, the capacity fading issues caused by volume change of metal sulfides during electrochemical testing are still unsolved problems. This thesis hypothesized that by employing nanostructured bimetallic sulfides with open frameworks and carbon incorporation, the degradation in capacity can be alleviated. …”
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A comparative analysis of vitrification and two slow freezing methods for gonocyte-containing neonatal calf testicular tissue and subsequent in vitro culture by Tang, S, Jones, C, Davies, J, Lane, S, Coward, K

“…In addition, the proportions of Sertoli cells (vimentin-positive) and proliferating cells (Ki67- positive) were similar across the three cryopreservation methods. …”

Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis by Beter, M, Pulkkinen, HH, Örd, T, Sormunen, A, Kilpeläinen, L, Dunford, JE, Kaikkonen, MU, Aavik, E, Laham-Karam, N, Oppermann, U, Laakkonen, JP, Ylä-Herttuala, S

“…Compared to the established model using primary human umbilical vein endothelial cells, TeloHAECs needed a higher-density fibrin gel for optimal sprouting, successfully forming sprouts under both normoxic and hypoxic cell culture conditions. …”

The α-globin super-enhancer acts in an orientation-dependent manner by Kassouf, MT, Francis, HS, Gosden, M, Suciu, MC, Downes, DJ, Harrold, C, Larke, M, Oudelaar, M, Cornell, L, Blayney, J, Telenius, J, Xella, B, Shen, Y, Sousos, N, Sharpe, JA, Sloane-Stanley, J, Smith, AJH, Babbs, C, Hughes, JR, Higgs, DR

“…Individual enhancers are defined as short genomic regulatory elements, bound by transcription factors, and able to activate cell-specific gene expression at a distance, in an orientation-independent manner. …”

Multi-level encoding of reward, effort and choice across the frontal cortex and basal ganglia during cost-benefit decision making by Härmson, O, Grennan, I, Perry, B, Toth, R, McNamara, C, Denison, T, Cagnan, H, Manohar, S, Walton, M, Sharott, A

“…Single neurons encoding combinations of decision variables (reward, effort and choice) were represented within all recorded regions. Co-active cell assemblies, ensembles of neurons that repeatedly co-activated within short time windows (<25ms), represented the same decision variables, despite the members often having diverse individual coding properties. …”

An exploratory study for a new method to search for heavy neutrinos with data at the Large Hadron Collider (LHC) by Tan, Cherlene Shu Ning

“…However, there still is much potential mass of the HNL $M_N$ combined with its mixing probability $|V_{\ell N}|$ unexplored, especially at the lower limit of couplings. …”
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