Elucidating the non-apoptotic role of the caspases in the Drosophila intestinal system by Arthurton, L

“…<p>The deregulation of caspase activity and stem cell properties are often correlated with the appearance and propagation of cancer, including colorectal cancer. …”

Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood by Rabcuka, J, Smethurst, P, Dammert, K, Saker, J, Aran, G, Walsh, G, Tan, J, Codinach, M, McTaggart, K, Marks, D, Bakker, S, McMahon, A, Di Angelantonio, E, Roberts, D, Blonski, S, Korczyk, P, Shirakami, A, Cardigan, R, Swietach, P

“…<p><strong>Background: </p></strong>Metrics evaluating the functional quality of red blood cells (RBCs) must consider their role in oxygen delivery. …”

Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer by Akıncılar, Semih Can, Chua, Joelle Yi Heng, Ng, Qin Feng, Chan, Claire Hian Tzer, Eslami-S, Zahra, Chen, Kaijing, Low, Joo-Leng, Arumugam, Surendar, Aswad, Luay, Chua, Clarinda, Tan, Iain Beehuat, DasGupta, Ramanuj, Fullwood, Melissa Jane, Tergaonkar, Vinay

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In situ growth of [hk1]-oriented Sb2S3 for solution-processed planar heterojunction solar cell with 6.4% efficiency by Jin, Xin, Fang, Yanan, Salim, Teddy, Feng, Minjun, Hadke, Shreyash, Leow, Shin Woei, Sum, Tze Chien, Wong, Lydia Helena

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Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics by Perochon, T, Krsnik, Z, Massimo, M, Ruchiy, Y, Romero, AL, Mohammadi, E, Li, X, Long, KR, Parkkinen, L, Blomgren, K, Lagache, T, Menassa, DA, Holcman, D

“…This pipeline is designed to map microglial organization during normal and pathological brain development and has the potential to be adapted to any cell type. Using DeepCellMap, we capture the morphological diversity of microglia, identify strong coupling between proliferative and phagocytic phenotypes, and show that distinct spatial clusters rarely overlap as human brain development progresses. …”

Studies on the antioxidant mechanisms of betacyanins from improved fermented red dragon fruit (Hylocereus polyrhizus) drink in HepG2 cells by Lim, Teck Wei, Lim, Renee Lay Hong, Pui, Liew Phing, Tan, Chin Ping, Ho, Chun Wai

“…Red dragon fruit (RDF, Hylocereus polyrhizus) is high in betacyanins content but is understudied for its antioxidant mechanisms in liver cells. The present study aimed to investigate the antioxidant mechanisms of the stabilised betacyanins in a novel RDF functional drink, Improved-FRDFD-dH2O (produced from mild, sustainable approaches) using HepG2 cell line. …”
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The hollow fiber bioreactor as a stroma-supported, serum-free ex vivo expansion platform for human umbilical cord blood cells by Xue, Cao, Kwek, Kenneth Y. C., Chan, Jerry Kok Yen, Chen, Qingfeng, Lim, Mayasari

“…These findings demonstrate the feasibility of utilizing the HFBR for creating a complex cell matrix architecture, which may provide good in vitro mimicry of the bone marrow, supporting large-scale expansion of HSCs.…”
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Influence Of Different Ratios Of Gdc-Sdc On Ssc/Gdc–Sdc Dual Composite Cathode For Intermediate-Temperature Solid Oxide Fuel Cells by Roslan, Mohammad Fikrey, Abd Rahman, Hamimah, Azmi, Mohd Azham, MohdTukimon, Mohd Faizal, Jaidi, Zolhafizi, Abdul Ghani, Muhammad Zul Idzham

“…Solid oxide fuel cells (SOFCs) have emerged as highly promising contenders in the field of energy conversion, offering enhanced efficiency and environmental sustainability. …”
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In vitro anti-proliferative mechanism of combination therapy with tannic acid and cisplatin against human osteosarcoma cell line U2OS by Kasiram, Mohamad Zahid Mohd

“…Hence, this study aimed to investigate the effect of TA treatment combined with cisplatin on human osteosarcoma cell line (U2OS). The half-maximal inhibitory concentration (IC50) values of TA and its combination with cisplatin against U2OS cells were determined using MTT assay. …”
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PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism by Salvadó, Laia, Barroso, Emma, Gómez-Foix, Anna Maria, Palomer, Xavier, Michalik, Liliane, Wahli, Walter, Vázquez-Carrera, Manuel

“…In this study, we assessed whether peroxisome proliferator-activated receptor (PPAR)β/δ prevented ER stress-associated inflammation and insulin resistance in skeletal muscle cells. Methods Studies were conducted in mouse C2C12 myotubes, in the human myogenic cell line LHCN-M2 and in skeletal muscle from wild-type and PPARβ/δ-deficient mice and mice exposed to a high-fat diet. …”
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Improved mobility and photovoltaic performance of two-dimensional Ruddlesden−Popper (ThMA)₂(MA)₂M₃I₁₀ perovskites applied in perovskite solar cells by Sun, Ping-Ping, Kripalani, Devesh Raju, Chi, Weijie

“…However, lead pollution is still a problem that may hinder the development and widespread use of (ThMA)2(MA)2Pb3I10 perovskites. …”
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Leucine-rich α-2-glycoprotein 1 suppresses endothelial cell activation through ADAM10-mediated shedding of TNF-α receptor by Pang, Kuin Tian, Ghim, Mean, Liu, Chenghao, Tay, Hui Min, Fhu, Chee Wai, Chia, Rui Ning, Qiu, Beiying, Sarathchandra, Padmini, Chester, Adrian H., Yacoub, Magdi H., Wilkinson, Fiona L., Weston, Ria, Warboys, Christina M., Hou, Han Wei, Weinberg, Peter D., Wang, Xiaomeng

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On the composition of Sr₂Fe₁.₅Mo₀.₅O₆₋δ – Sm₀.₂Ce₀.₈O₂₋δ composite as fuel electrodes for hydrogen reversible solid oxide cells by Li, Hao-Yang, Kamlungsua, Kittiwat, Ng, Kelvin, Shin, Ji-Yoon, Su, Pei-Chen

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Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells by Kitajima, Shojiro, Lee, Kian Leong, Fujioka, Masaki, Sun, Wendi, You, Jia, Chia, Grace Sushin, Wanibuchi, Hideki, Tomita, Shuhei, Araki, Marito, Kato, Hiroyuki, Poellinger, Lorenz

“…In addition, the expression of CD70 and colony forming efficiency in soft agar were decreased by knockdown of HIF-2α. These findings indicate that CD70 expression and an aggressive phenotype of cancer cells is driven under hypoxic conditions and mediated by HIF-2α functions and epigenetic modifications. …”
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Assessing nanotoxicity of food-relevant particles: a comparative analysis of cellular responses in cell monolayers versus 3D gut epithelial cultures by Gautam, Archana, Lim, Hui Kheng, Li, Jasmine Jia’En, Hughes, Christopher Owen, Yeo, Calvin Wee Sing, Rakshit, Moumita, Leavesley, David Ian, Lim, Michelle Jing Sin, Tan, Joseph Choon Wee, Tan, Li Yi, Chan, Joanne Sheot Harn, Smith, Benjamin Paul Chapman, Ng, Kee Woei

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Cytotoxicity assessment of α helix Antarctic yeast oriented antifreeze peptide (Afp1m) on M. dunni (Clone III8C) cells by Khan, Muhammad Shuaib, Abdul Rahman, Mohd Basyaruddin, Abu Bakar, Mohd Zuki, Noordin, Mohammed Mustapha, Ullah, Shakeeb, Abdul Abubakar, Adamu, Rehman, Saifur, Saddiqua, Aisha, Mohammad Yusof, Loqman

“…Development was observed, albeit more slowly than in the positive control and treated with lesser concentrations. The findings of this work indicate that Afp1m exhibits cryoprotective properties without inducing toxicity when used for the cryopreservation of M. dunni (Clone III8C) cells.…”
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DNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells by Ye, Y, Xie, W, Wang, X, Tan, S, Yang, L, Ma, Z, Zhu, Z, Chen, X, Liu, X, O’Neill, E, Chang, L, Zhang, W

“…Here we show the impact of ionizing irradiation on the maintenance and early differentiation of mouse embryonic stem cells (ESCs). Our findings demonstrate that irradiation induces the upregulation of the p53 family genes, including p53, p63, and p73, resulting in elevated expression of the E3 ubiquitin ligases Itch and Trim32. …”

A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression by Fisher, KD, Ulbrich, K, Subr, V, Ward, CM, Mautner, V, Blakey, D, Seymour, LW

“…The resulting nanoparticulate vectors resist attack by serum proteins and can be modified for cell-specific delivery by incorporation of targeting ligands onto the polymer coating. …”

Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling by Witmer, Kathrin, Schmid, Christoph D., Brancucci, Nicolas M. B., Luah, Yen-Hoon, Preiser, Peter Rainer, Bozdech, Zbynek, Voss, Till S.

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Whole genome analysis of Hawksbill turtles in Singapore reveals their genetic adaptations to disease and sensory perception by Desai, Archita Sanjay

“…These genes are mainly associated with disease response, olfactory system, cell signalling and cellular transport. This study's findings explain how Hawksbill turtles are adapted to navigate using olfaction, fight against infections, and survive during their unique life-cycles and large-scale migrations. …”
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