Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1 by Li, Yan, Pillay, Shubhadra, Frolova, Ludmila, Pervushin, Konstantin, Wong, Leo E.

“…By solving the solution structures of the wild-type N-domain of human eRF1 exhibited omnipotent specificity, i.e. recognition of all three stop codons, and its unipotent mutant with UGA-only specificity, we found the conserved GTS loop adopting alternate conformations. …”
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Gobo: A System for Exploring User Control of Invisible Algorithms in Social Media by Bhargava, Rahul, Chung, Anna, Gaikwad, Neil S, Hope, Alexis, Jen, Dennis, Rubinovitz, Jasmin, Saldías-Fuentes, Belén, Zuckerman, Ethan

“…Through an iterative design process, we've built and deployed Gobo in the wild and conducted a pilot study in the form of a survey to understand how the users respond to the shift of control from invisible algorithms to themselves. …”
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Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…These findings confirmed that TMED2 and TMED10 are novel regulators of hepatic insulin signalling.…”

Sorptive properties of biofilm matrix for heavy metal sequestering by Elisa Tiaras

“…The characteristics and the ability to treat heavy metals in 4 strains, namely PAO1 wild-type, ΔPelA strain, ΔPslBCD strain and double mutant ΔPelA- ΔPslBCD strain, were compared in the study. 2 types of metals that are commonly found in the environment were used in the study: copper (Cu) and zinc (Zn). …”
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Current state of multiracialism in singapore: the youth perspective by Nabilah Binte Roslee

“…Together, these findings suggest that multiracialism in Singapore is still largely a work in progress, and that more especially needs to be done to combat racism.…”
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Application of COLD-PCR for improved detection of EGFR mutations in clinical samples. by Zhang, Zhi Xuan.

“…As such, this project was carried out to find out whether COLD-PCR would pick up low level mutant alleles that were missed by regular PCR. …”
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Surface composition dependent ligand effect in tuning the activity of nickel–copper bimetallic electrocatalysts toward hydrogen evolution in alkaline by Wei, Chao, Sun, Yuanmiao, Scherer, Günther G., Fisher, Adrian C., Sherburne, Matthew, Ager, Joel W., Xu, Zhichuan Jason

“…Unfortunately, the principles that governs alkaline HER performance remain unclear and are still under debate. By studying the alkaline HER at a series of NiCu bimetallic surfaces, where the electronic structure is modulated by ligand effect, we demonstrate that alkaline HER activity can be correlated with either the calculated or the experimental-measured d band center (an indicator of hydrogen binding energy) via a volcano-type relationship. …”
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Impact of Singapore’s ageing population on the macroeconomy. by Park, Sun Jung., Tan, Yi Jun.

“…Therefore, the authority might lose an effective inflation management tool. Our findings show that an ageing population will also affect the current account due to the fall in savings. …”
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Navigating an invisible labyrinth: the effect of involuntary bogus self-employment on female Greek-Cypriot educators’ job satisfaction and subjective well-being by Meletiadou, Eleni

“…Implications of the findings are discussed to unveil the gendered challenges that women with caregiving responsibilities still face in the workplace due to insufficient childcare and caregiving support.…”
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Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function by Liu, Y, Kretz, CA, Maeder, ML, Richter, CE, Tsao, P, Vo, AH, Huarng, MC, Rode, T, Hu, Z, Mehra, R, Olson, ST, Joung, JK, Shavit, JA

“…Genetic predisposition to thrombosis is still poorly understood, and we hypothesize that there are many additional risk alleles and modifying factors remaining to be discovered. …”

Fabrication and characterization of hybrid perovskite thin films for solar cell application by Dayal, Akhilesh

“…The aim of this project is to examine ligands presence and chemical binding on perovskite surface using infrared spectroscopy. …”
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Identification of potent new brain cancer EGFR inhibitor from usimine A and usimine B: computer-aided drug design perspective by Roney, Miah, Issahaku, Abdul Rashid, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Brain cancer ranks 10th among cancer-related causes of death for patients worldwide. Medical chemists still have many challenges because of the high side effects, increasing tumor resistance, and low selectivity of new chemotherapeutic medications despite the enormous effort put out to extract, develop, and synthesize them. …”
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Studies of gallium nitride (GaN) based high electron mobility transistor (HEMTS) by Ong, Eugene Wei Han

“…GaN (Gallium Nitride) on High Electron Mobility Transistors (HEMTs) has been developed since the early 2000s, however, it is not till recent times that it is commercialised and used for an impressive array of technologically advanced advents. …”
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Unveiling the future of budget hotels in Singapore by Chua, Hwee Lian, Kew, Wong Yip, Soh, Wee Li

“…These include using Porter's five forces model to define the external environment in which budget hotels operate and a SWOT analysis to function as an internal check. The findings of this study point towards a shortage of budget hotels that is likely to persist till 1995. …”
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Identification of alternative-splicing events in human monocyte differentiation by Sim, Donald Yuhui

“…The data obtained from RNA-seq still required verification through traditional methods, such as RT-PCR. …”
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Loss of caveolin-1 impairs light flicker-induced neurovascular coupling at the optic nerve head by Loo, Jing Hong, Lee, Ying Shi, Woon, Chang Yi, Yong, Victor H. K., Tan, Bingyao, Schmetterer, Leopold, Chong, Rachel S.

“…However, there was no significant difference in RGC density between Cav-1 KO and wild type mice. These findings highlight the role of Cav-1 in regulating neurovascular coupling and IOP and suggest that the loss of Cav-1 may predispose to vascular dysfunction and decreased RGC signaling in the absence of structural loss. …”
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NMR structure and activity relationship of defensin-analogous peptides by Bai, Yang

“…Despite intensive research, detailed bactericidal and cytotoxic mechanisms of AMPs are still largely unknown. In this thesis, molecular template evolution based on the peptide sequence modifications, biophysical studies using fluorescence labeling and NMR spectroscopy, virtual screening utilizing large scale molecular dynamics simulations are exploited for rational antimicrobial drug discovery. …”
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Load-carrying mechanism to resist progressive collapse of RC buildings by Qian, Kai, Li, Bing, Ma, Jiaxing

“…A series of analyses are also carried out to better quantify the findings made in the study.…”
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Unveiling the importance of longer paths in quantum networks by Hu, X, Dong, G, Lambiotte, R, Christensen, K, Fan, J, Tian, Z, Havlin, S, Meng, X

“…Notably, we find that concurrence percolation relies on non-shortest paths and shows a higher resilience to detouring when these paths are rerouted and extended. …”

Factors Influencing Students Being Deceived in Pyramid Scheme in Malaysia by Mustaffa, Hawa Nur Sai’dah, Ishak, Nor Syahidah

“…This study’s findings are able for universities and industries can revise their policies to discern the extent of student involvement in the pyramid scheme businesses and take the initiative to help students who fall into this scheme.…”
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