Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells by Wijianto, Diski Wahyu, Sri Wahyuni, Arifah, Wardani, Rizkiananda, Nugraheni, Ambar Yunita, Abu Bakar, Fazleen Izzany

“…The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. …”
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A Randomized, Double Blind, Placebo-Controlled Human Clinical Trial On The Effects Of Sacha Inchi (Plukenetia Volubilis L.) Oil Supplementation In Hyperglycaemia, Hypertension And... by Mhd Rodzi, Nur Anis Raihana

“…Fifty-four (n=54) 3Hs patients were recruited from Specialist Day Care Clinic, Pusat Perubatan USM Bertam, and randomised into two groups: the SIO group (n=27) (received 1000mg of SIO soft gel per day) or placebo group (n=27) (received 1000mg corn oil soft gel for 12 weeks). Fasting blood samples were collected at baseline and post week-12 to assess clinical and laboratory biochemical markers.…”
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Comparative blood and urine metabolomics analysis of healthy elderly and young male Singaporeans by Chen, Liwei, Zhang, Jingtao, Teh, Jean Pui Yi, Cheon, Bobby Kyungbeom, Yang, Yifan, Schlundt, Joergen, Wang, Yulan, Conway, Patricia L.

“…To investigate the signature of multiple metabolic profiles associated with aging in an Asian population, we performed a pilot study in healthy Singaporeans, including 33 elderly and 33 young males. Fasting whole bloods were analyzed by routine hematology; the serum and urine metabolome profiles were obtained using NMR-based nontargeted metabolomics analysis and targeted lipoprotein analysis. …”
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Global burden of Alzheimer’s disease and other dementias attributed to metabolic risks from 1990 to 2021: results from the global burden of disease study 2021 by Zhang, X, Guo, T, Zhang, Y, Jiao, M, Ji, L, Dong, Z, Li, H, Chen, S, Zheng, W, Jing, Q

“…Methods: The Global Burden of Disease Study (GBD) 2021 collected data on the number of deaths and disability-adjusted life-years (DALYs) related to AD and other dementias caused by metabolic risks, including high fasting plasma glucose (FPG) and high body mass index (BMI). …”

Mitofusins Mfn1 and Mfn2 are required to preserve glucose- but not incretin-stimulated β-cell connectivity and insulin secretion by Georgiadou, Eleni, Muralidharan, Charanya, Martinez, Michelle, Chabosseau, Pauline, Akalestou, Elina, Tomas, Alejandra, Yong, Fiona Su Wern, Stylianides, Theodoros, Wretlind, Asger, Legido-Quigley, Cristina, Jones, Ben, Lopez-Noriega, Livia, Xu, Yanwen, Gu, Guoqiang, Alsabeeh, Nour, Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Ali, Yusuf, Soleimanpour, Scott A., Linnemann, Amelia K., Rodriguez, Tristan A., Rutter, Guy A.

“…Here, we generated mice with β-cell-selective, adult-restricted deletion knock-out (dKO) of the mitofusin genes Mfn1 and Mfn2 (βMfn1/2 dKO). βMfn1/2-dKO mice displayed elevated fed and fasted glycemia and a more than fivefold decrease in plasma insulin. …”
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Lower serum uric acid and impairment of right cerebral hemisphere structural brain networks are related to depressive symptoms in cerebral small vessel disease: a cross-sectional s... by Yu, Lei, Yi, Ming, Guo, Jiayu, Li, Jinbiao, Zeng, Huixing, Cui, Liqian, Xu, Xiangming, Liu, Gang, Fan, Yuhua, Zeng, Jinsheng, Xing, Shihui, Chen, Yicong, Wang, Meng, Tan, Shuangquan, Jin, Leow Yi, Kumar, Dilip, Vipin, Ashwati, Ann, Soo See, Fatin Zahra Binte Zailan, Sandhu, Gurveen Kaur, Kandiah, Nagaendran, Dang, Chao

“…We recruited 208 SVD inpatients and collected fasting blood samples upon admission. Depressive symptoms were assessed using the 24-item Hamilton Depression Rating Scale (HAMD-24). …”
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Combined effects of meal frequency and exercise on postprandial lipaemia by Mok, Alexander

“…On day-2 mornings, venous blood triacylglycerol concentrations were measured fasting and 7-hours postprandially, after consuming 1-large or 2-smaller high-fat meals (1.21 g fat, 0.62 g carbohydrate, 0.29 g protein and 14.5 kcal/kg/bodymass). …”
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Characterizing the function of the Arl15 gene and its role in the development of metabolic traits by Bai, Y

“…<p>The ARL15 human Genome Wide Association (GWA) locus is associated with increased risk of type 2 diabetes, lower plasma adiponectin, higher fasting plasma insulin, sexually dimorphic altered body composition, lower HDL cholesterol and lipodystrophy. …”

The interaction between ketone bodies and carbohydrate in human metabolism by Holdsworth, D

“…After glycogen-depleting exercise, endogenous insulin levels rose two-fold, glucose disposal increased 32% and glycogen synthesis increased 50% during a 2-hour hyperglycaemic (10 mM glucose) clamp following the KE drink. In overnight fasted healthy controls and type-2 diabetic participants (T2DM), KE increased insulin and lowered glucose concentrations vs. control (zero calorie) drink. …”

Coloration and functionalization of organic cotton fabric using Chinese fringe leaf extraction: A greener approach by Hossain, Md Shazzat, Ullah, Mohammad, Mia, Rony, Assiri, Mohammed Ail, Zhou, Yahui, Saeed, Haroon A.M., Mahmud, Sakil

“…Optimal dyeing conditions were established with a 10 % Al2(SO4)3 mordant, resulting in dyed OCF exhibiting a significant color strength (K/S) of 5.90 and excellent fastness including rubbing, washing and light. Comprehensive characterization techniques, such as optical microscopy, scanning electron microscopy (SEM), elemental mapping, and FTIR, validated the successful dyeing process which ensure the bonding between natural dyes and fabrics in the presence of mordant. …”
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Relationship between selected biopsychosocial factors on cognitive functions among Malaysian community-dwelling older adults by Foong, Hui Foh

“…Predictors of poorer cognitive function were being women, being older, being divorced or separated, lower year of education, lower household income, higher fasting blood sugar, higher cholesterol ratio, higher depressive symptoms, and lower intrinsic religiosity. …”
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Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…By modulating rates of hepatic glucose output and glucose uptake into skeletal muscle and adipose tissue, it is at the core of blood glucose homeostasis, ensuring normoglycaemia during fasting and feeding. The liver is one of the three major tissues that acts in sustaining appropriate blood glucose levels. …”

Investigating the functional and metabolic role of carnitine in the diabetic heart using hyperpolarized MRI by Savic, D

“…A neonatal model of diabetes showed decreased aerobic to anaerobic metabolism (50 %) in conjunction with functional impairment, which could be reversed with Glibenclamide treatment. A fasted streptozotocin induced rat model showed superior SNR on MRI and was pursued further. …”

A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals by Röhling, Martin, Kempf, Kerstin, Banzer, Winfried, Braumann, Klaus-Michael, Führer-Sakel, Dagmar, Halle, Martin, McCarthy, H. David, Martin, Stephan, Scholze, Jürgen, Toplak, Hermann, Berg, Aloys, Predel, Hans-Georg

“…Changes in SBP, DBP, and PWV were significantly associated positively with changes in body weight and fat mass (all p 0.05) and resting HR correlated positively with fasting insulin (p 0.001) after 12 months. Combining a lifestyle intervention with a high-protein and low-glycemic formula diet improves hemodynamic parameters to a greater extent than lifestyle intervention alone in high-risk individuals with overweight and obesity.…”
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Circadian rhythm and misalignment in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD): an experimental medicine approach by Marjot, T

“…</p> <p>In the DECIMAL study, 12 patients with MASLD and 12 control participants underwent detailed metabolic phenotyping including a 2-step hyperinsulinaemic euglycaemic clamp with stable isotope assessments of glucose utilization during the day (07:00–13:00) and at night (19:00–01:00) under standardised fasting conditions. Identical day and night investigations were then performed in patients with MASLD after a 12-week weight loss programme. …”

Adipose tissue fatty acid composition, serum lipids, and serum alpha-tocopherol in continuous ambulatory peritoneal dialysis patients living on the island of Crete by Nikolakakis, N, Kounali, D, Tornaritis, M, Anastassou, A, Papadakis, E, Kassotakis, G, Kafatos, A

“…</p> <br> <p><strong>Main Outcome Measures:</strong> Adipose tissue was aspirated, and a 12-hour fasting blood sample was collected for determination of serum lipid parameters and serum α-tocopherol levels; dietary data from a 3-day recall were recorded.…”

Anti-leukaemic and chemotherapy supportive effects of berberis vulgaris l. Fruit crude extract on in vitro and in vivo models by Saedi, Tayebeh Azam

“…After the treatment period (5 weeks), the mice were fasted overnight and sacrificed for biochemical, haematological and histological analyses of their liver, kidney, heart and spleen. …”
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Effectiveness of health education intervention based on health belief model among elderly women in Urmia, Iran by Iranagh, Jamileh Amirzadeh

“…Second outcome was determination level of fasting blood glucose, lipid profiles and anthropometric parameters before and during intervention program period. …”
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The iHealth-T2D study, prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes: study protocol for a randomised controlled trial by Kasturiratne, Anuradhani, Khawaja, Khadija I., Ahmad, Sajjad, Siddiqui, Samreen, Shahzad, Khurram, Athauda, Lathika K., Jayawardena, Ranil, Mahmood, Sara, Muilwijk, Mirthe, Batool, Tayyaba, Burney, Saira, Glover, Matthew, Palaniswamy, Saranya, Bamunuarachchi, Vodathi, Panda, Manju, Madawanarachchi, Suren, Rai, Baldeesh, Sattar, Iqra, Silva, Wnurinham, Waghdhare, Swati, Jarvelin, Marjo-Riitta, Rannan-Eliya, Ravindra P., Gage, Heather M., van Valkengoed, Irene G. M., Valabhji, Jonathan, Frost, Gary S., Loh, Marie, Wickremasinghe, Ananda R., Kooner, Jaspal S., Katulanda, Prasad, Jha, Sujeet, Chambers, John C.

“…Secondary endpoints at 1 and 3 years are the following: (i) physical measures: waist circumference, weight and blood pressure; (ii) lifestyle measures: smoking status, alcohol intake, physical activity and dietary intake; (iii) biochemical measures: fasting glucose, insulin and lipids (total and HDL cholesterol, triglycerides); and (iv) treatment compliance. …”
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Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... by Brauer, M, Roth, GA, Aravkin, AY, Bandyopadhyay, S, Bennett, DA, Browne, AJ, Graham, SM, Rodriguez, JAB, Runghien, T, Sartorius, B

“…<p><b>Findings</b></p> Among the specific risk factors analysed for this study, particulate matter air pollution was the leading contributor to the global disease burden in 2021, contributing 8·0% (95% UI 6·7–9·4) of total DALYs, followed by high systolic blood pressure (SBP; 7·8% [6·4–9·2]), smoking (5·7% [4·7–6·8]), low birthweight and short gestation (5·6% [4·8–6·3]), and high fasting plasma glucose (FPG; 5·4% [4·8–6·0]). For younger demographics (ie, those aged 0–4 years and 5–14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. …”