Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site by Banach, Bailey B, Pletnev, Sergei, Olia, Adam S, Xu, Kai, Zhang, Baoshan, Rawi, Reda, Bylund, Tatsiana, Doria-Rose, Nicole A, Nguyen, Thuy Duong, Fahad, Ahmed S, Lee, Myungjin, Lin, Bob C, Liu, Tracy, Louder, Mark K, Madan, Bharat, McKee, Krisha, O’Dell, Sijy, Sastry, Mallika, Schön, Arne, Bui, Natalie, Shen, Chen-Hsiang, Wolfe, Jacy R, Chuang, Gwo-Yu, Mascola, John R, Kwong, Peter D, DeKosky, Brandon J

“…Here we evolve the FP-targeting antibody VRC34.01 in vitro to enhance FP-neutralization using site saturation mutagenesis and yeast display. Successive rounds of directed evolution by iterative selection of antibodies for binding to resistant HIV-1 strains establish a variant, VRC34.01_mm28, as a best-in-class antibody with 10-fold enhanced potency compared to the template antibody and ~80% breadth on a cross-clade 208-strain neutralization panel. …”
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Crystal structure of the FK506 binding domain of plasmodium falciparum FKBP35 in complex with FK506 by Kotaka, Masayo, Ye, Hong, Alag, Reema, Hu, Guangan, Bozdech, Zbynek, Preiser, Peter Rainer, Yoon, Ho Sup, Lescar, Julien

“…It binds to a α/β protein module of approximately 120 amino acids known as the FK506 binding domain (FKBD), which is found in various organisms, including human, yeast, and Plasmodium falciparum (PfFKBD). Antiparasitic effects of FK506 and its analogues devoid of immunosuppressive activities have been demonstrated. …”
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Finding transcription factor binding motifs for coregulated genes by combining sequence overrepresentation with cross-species conservation by Jia, Hui., Li, Jinming.

“…Compared with the prevailing motif finding software, our method has some advantages in finding transcriptional factor binding motifs for potential coregulated genes if the gene upstream sequences of multiple closely related species are available. Although we used yeast genomes to assess our method in this study, it might also be applied to other organisms if suitable related species are available and the upstream sequences of coregulated genes can be obtained for the multiple closely related species.…”
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Niemann-Pick type c disease: pathogenesis and therapy by Colaco, A

“…To gain further insight into the function of NPC1 and proteins it interacts with we used the yeast orthologue, Ncr1p. I recreated the Δncr1 mutant and characterized the mutant using an array of systematic screens to identify different processes and pathways that may play a role in NPC pathogenesis. …”

Isolation of Bifidobacteria infantis and its antagonistic activity against ETEC 0157 and Salmonella typhimurium S-285 in weaning foods by Mohd Yusof, Rokiah, Haque, Formuzul, Ismail, Maznah, Hassan, Zaiton

“…Trypticase phytone peptone yeast extract agar (TPY) was used as a selective media for the isolation. …”

Structural investigation, computational analysis, and theoretical cryoprotectant approach of antifreeze protein type IV mutants by Eskandari, Azadeh, Leow, Thean Chor, Abdul Rahman, Mohd Basyaruddin, Oslan, Siti Nurbaya

“…In this in silico study, the helical peptide afp1m from an Antarctic yeast AFP was modeled into a sculpin AFPIV, to replace each of its four α-helices in turn, using various computational tools. …”

Modal tense: if and wish by Crowley, Paul

“…This paper is concerned with uses of certain morphemes, most notably the past, to represent meanings of distance from reality in modal expressions. …”
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UMPSA hosts RBTX Petrosains Challenge Eastern Zone 2024 by Naqiah, Puaad

“…PEKAN, 4 September 2024 - Universiti Malaysia Pahang Al-Sultan Abdullah (UMPSA) hosted the RBTX Petrosains Challenge East Zone 2024 Competition at the Multipurpose Hall, UMPSA Pekan.…”
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International market entry. by Lim, Ley Yen., Soh, Stephanie Yan Ling., Tan, Yee Fei.

“…This Applied Research Project attempts to provide an insight on international expansion by Singapore businesses into South East Asia, specifically in the food service industry. …”
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Tourism in Thailand : factors behind its growth and resilience. by Nino Gruettke., Karthik Naga., Kartika Surja., Tan, Kiam Hong.

“…Tourism has been contributing an average of 6% to the GDP of Thailand in the last 20 years, one of the highest in South East Asia. In the same period, Thailand has been hit by financial crises, political upheavals, the SARS epidemic and a tsunami. …”
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Putting distance through cleansing : the mediating role of temporal distancing on the embodiment of moral purity by Nurul Mira Fatin Abdulkahar

“…More specifically, it is hypothesized that compared to individuals who do not clean their hands, those who do so after recalling a past immoral act would be more likely to temporally distance their present selves away from their past immoral selves so as to preserve favorable self-view, and hence are more likely to perceive their past moral transgressions as less severe than they would have normally believed. …”
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Empowering the employability of people with disability (PWD) through a skills intervention program by Omar, Muhd Khaizer, Mohd Puad, Mohd Hazwan, Yaakub, Mohamad, Muslim, Marlinah, Gui, Qing

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Contraceptive experience and factors associated with desire for postpartum family planning among pregnant women of the nkongsamba health district, Littoral Region, Cameroon by Ajong, AB, Yakum, MN, Mangala, FN, Bekolo, CE, Agbor, VN, Waffo, LM, Kenfack, B

“…This study aimed to evaluate past contraceptive experience and identify factors associated with the desire for postpartum family planning among women in late pregnancy. …”

Modeling downward counterfactual events : unrealized disasters and why they matter by Lin, Yolanda C., Jenkins, Susanna F., Chow, Jun Rui, Biass, Sébastien, Woo, Gordon, Lallemant, David

“…Disaster risk research’s reliance on past events has proved inadequate when it comes to extreme events. …”
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Empirical examination of economic linkages between Japan and rest of Asia. by Lim, Kok Soon., Yong, Kin Loong.

“…The overall objective of our paper is to use econometric analysis to empirically examine whether the Japanese economy does, in fact, have strong effects on other East Asian economies. Our results indicate that although Japanese economic performance does affect the performance of the region’s economies, the effects are weaker than might be expected. …”
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Xi's 'balance of interest solution': pre-empting an Asian NATO? by Suryanarayana, P. S.

“…He seems to suggest that the balance of national interests, not balance of power, is better at promoting a regional order for Asia or East Asia too.…”
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100 news @ wall projection by Sun, Zhongyinan

“…Then a word frequency analysis scheme was incorporated to interpret the top 100 keywords for the past hour and retrieve the related pictures and news stories for each keyword. …”
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Growing Uighur Militancy: Challenges for China by Nodirbek, Soliev

“…With the emergence of a new generation of Uighur militants drawn to conflict in the Middle East, there has been a shift in the threat landscape of China. …”
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North Korea Threat and Asian Markets: A Paradox? by Kumada, Mikio, Raska, Michael

“…How are East Asian stock exchanges reacting to North Korea’s sabre rattling? …”
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The issue of Arab Jews : manipulating a justified cause by Dorsey, James M.

“…A recent United Nations conference on the rights of Jews forced to flee Arab countries in the wake of the establishment of the State of Israel focuses attention on a long overlooked consequence of the Middle East conflict. It also complicates the revival of Palestinian-Israeli peace negotiations.…”
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