Relationship between irregularities of the nuclear envelope and mitochondria in HeLa cells observed with electron microscopy by Brito-Pacheco, Daniel, Karabağ, Cefa, Brito-Loeza, Carlos, Giannopoulos, Panos, Reyes-Aldasoro, Constantino Carlos

“…Whilst these results were obtained from a single cell line and a relatively small number of cells, they encourage further study as the methodology proposed can be easily applied to other cells and settings. …”
Get full text

Investigating the role of phosphatases in the regulation of mitosis by Leitch, I

“…</p> <p>This study also demonstrates the role of PLK1 activity in the initial recruitment of the phosphatase PP2A-B56 to kinetochores using a fluorescently labelled B56 CRISPR cell line. Additional tools for investigating the role of PLK1 in the formation of stable kinetochore-microtubule attachments are also generated and preliminary experiments carried out.…”

Chloroquine has shown high therapeutic efficacy against uncomplicated Plasmodium vivax malaria in southern Ethiopia: seven decades after its introduction by Mare, AK, Mohammed, H, Sime, H, Hailgiorgis, H, Gubae, K, Gidey, B, Haile, M, Assefa, G, Bekele, W, Auburn, S, Price, R, Parr, JB, Juliano, JJ, Tasew, G, Abay, SM, Assefa, A

“…<p><strong>Background: </strong><em>Plasmodium vivax</em> malaria is a leading cause of morbidity in Ethiopia. The first-line treatment for <em>P. vivax</em> is chloroquine (CQ) and primaquine (PQ), but there have been local reports of CQ resistance. …”

The mechanisms of sleep restriction therapy for insomnia disorder by Maurer, LF

“…While pharmacological treatment is available, the current recommended first-line intervention is a multi-component psychological therapy called cognitive behavioural therapy for insomnia (CBT-I). …”

Literary metatranslation: understanding the multiple in post-communist Poland by Szymanska, K

“…In discussing the ethical ideas underpinning these works, I demonstrate how literary metatranslations and their gesture of acknowledging more than one view and line of thinking could also undermine totalised discourses and put forward a more democratic agenda.…”

Structural basis of haptoglobin-haemoglobin scavenging by CD163 by Zhou, X

“…Haptoglobin (Hp) acts as the first line of defence by scavenging Hb in the serum. Humans produce three major Hp phenotypes, the dimeric Hp 1-1 as well as the multimeric Hp 2-1 and 2-2. …”

The bHLH transcription factor OsPRI1 activates the Setaria viridis PEPC1 promoter in rice by Carvalho, P, Gomes, C, Gonçalves, I, Lourenço, TF, Vlad, D, Langdale, JA, Saibo, NJM

“…The role of OsPRI1 <i>in planta</i> was characterized using a rice line harbouring <i>SvPEPC1_pro::GUS</i>.…”

Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background by Nayak, S, Peto, TJ, Kucharski, M, Tripura, R, Callery, JJ, Quang Huy, DT, Gendrot, M, Lek, D, Nghia, HDT, van der Pluijm, RW, Dong, N, Long, LT, Vongpromek, R, Rekol, H, Hoang Chau, N, Miotto, O, Mukaka, M, Dhorda, M, von Seidlein, L, Imwong, M, Roca, X, Day, NPJ, White, NJ, Dondorp, AM

“…The emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment. Artemisinin resistance is a complex genetic trait in which nonsynonymous SNPs in PfK13 cooperate with other genetic variations. …”

Board characteristics and financial performance: evidence from Bursa Malaysia Financial Times Stock Exchange (FTSE) top 100 index firms by Nur Hafizah Abdul Puhat, Suhaily Hasnan, Khairul Ayuni Mohd Kharuddin, Hafizah Marzuki, Mazurina Mohd Ali

“…The small percentage of politically-connected directors (19%) and military-experienced directors (5%) reported in this study can be viewed favourably in line with the recent MCCG 2021 recommendation that the appointment of the directors should be apolitical or politically neutral without having any executive powers in politics. …”
Get full text

Building the semiotic meaning of critical thinking from the Prophet Ibrahim's discourses in the scene of da'wah to his father in the Qur'anic story by Mhd Ramli, Mhd Faizal, Othman, Mohd Sukki, Hajimaming, Pabiyah, Wan Sulong, Wan Muhammad

“…Although the study of critical thinking is of interest to researchers in the field of contemporary education, many people still neglect and ignore the logical and rational aspects of Prophet Ibrahim's discourses as a comprehensive scientific approach to critical thinking based on divine revelation.This has led to Muslims being accused of stagnation and backwardness due to their inability to provide evidence and produce new knowledge from the Holy Quran in line with the development of contemporary knowledge.The research adopted the descriptive analytical approach through the semiotic pragmatic method pioneered by Peirce, which consists of components namelyrepresentamen, object and interpretant, and the research relied on thecritical thinking elements by the Delphi Report, as the basis for this research. …”
Get full text

Learning moral values through cartoons for Malaysian preschool-aged children by Abdullah, Muhammad Alif Redzuan

“…The families&#039; explanations helped the preschoolers distinguish between good and bad moral values in line with Malay culture and Islamic teachings. The analysis was limited by the small sample size and geographical location of this study. …”
Get full text

A case study on the application of new media technology and market expansion of rural enterprises in Central China by Liu, Meng, Wan Abas, Wan Antia, Mamat, Roslina

“…In the process of brand building, this article emphasizes the combination of product characteristics and local culture to ensure that the brand image is more in line with the tastes and needs of local consumers. …”
Get full text

Development of a recombinant non-replicating Newcastle disease virus by Cheow, Pheik-Sheen, Tan, Tiong Kit, Song, Adelene Ai-Lian, Yusoff, Khatijah, Chia, Suet Lin

“…The virus retained its oncolytic activities similar to that of the replicating rAF-GFP as observed in a cell viability assay when a breast cancer cell line, MCF-7, was treated with the virus. In conclusion, this study has successfully generated a system to produce a non-replicating NDV which can be used as a viral vector for heterologous protein delivery, as a safer alternative compared to the virulent strains as an oncolytic virus. …”

Development and in vitro bioevaluation of cockle shell-calcium carbonate (Aragonite) nanoparticles for intracellular drug delivery by Isa, Tijani

“…Biocompatibilities were evaluated on macrophage cell line (J774.A1) using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and 5-Bromo-2ʹ-deoxyuridine (BrdU) assays. …”
Get full text

Synthesis, Characterisation Of Stilbene–Arylcinnamide Hybrids And Cytotoxic Studies Against Lung Cancer Cell A549 by Mohd Zaki, Nurain Syazwani

“…The cytotoxicity against human lung cancer A549 cell line was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay, using cisplatin as the positive control. …”
Get full text

Experimental investigation assessment of railway ground vibration: a case study in Kluang-Gemas, Kluang District, Johor, Malaysia by Sougui, Oumar Orozi, Othman, Mohd Hanifi, Tong, Yean Ghing, Mat Said, Khairun Nissa, Nicholas, Brian Mclair, Tay, Swee Ching, Mohd Masirin, Mohd Idrus, Madun, Aziman, Ling, Felix Ngee Leh, Yusof, Mohd Fairus

“…A series of field measurements were accomplished in a straight line in Kluang City, southern Malaysia, using accelerometers and DEWESoft X2. …”
Get full text

An eco-friendly synthesis of titanium oxide nanoparticles mediated from Syringodium isoetifolium and evaluate its biological activity and photocatalytic dye degradation. by Sundar, Velmani, Balasubramanian, Balamuralikrishnan, Sivakumar, Mani, Chinnaraj, Santhosh, Palani, Vino, Maluventhen, Viji, Kamyab, Hesam, Chelliapan, Shreeshivadasan, Arumugam, Maruthupandian, Zuleta Mediavilla, Diana Patricia

“…The green synthesis of TiO2 NPs emphases to be cost effective and eco-friendly with antimicrobial and anti-cancer effects against breast cancer cell lines.…”

Electoral Reforms During the Pakatan Harapan Government by Mohd. Zain, Zawiyah, Ahmad, Zalinah, Omar, Salmah, Ajis, Mohd Na'eim, Othman, Zaheruddin

“…However, many reforms still need to be done in line with the recommendations of BERSIH and NGOs. …”
Get full text

Value Co-creation with Customers by Facebook Community: A Successful Example of PKT Logistics by Belal, H. M., Noordin, Alminnourliza, Hasan, Quamrul, Ahmad Zaidi, Mohamad Faizal

“…Cisco company is providing an on-line service for giving its customers open access to Cisco’s resources, information and systems, thereby Cisco and its customers can get involved with each other and make user community. …”
Get full text

N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5 by Zou, Shui, Toh, Joel D. W., Wong, Kendra H. Q., Gao, Yong-Gui, Hong, Wanjin, Woon, Esther C. Y.

“…The mechanism identified in this work is likely of significance to other m6A-recognising proteins.…”
Get full text
Get full text